|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
207-386 |
6.84e-126 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 379.57 E-value: 6.84e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGS 286
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 GNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMS 366
Cdd:cd17981 81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 167830433 367 ATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
215-776 |
1.15e-118 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 383.66 E-value: 1.15e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 215 ELVNLIDNHQVTVISGETGCGKTTQVTQFILDnyieRGKGSACRIVCTQPRRISAISVAERVAAERAESCGsgNSTGYQI 294
Cdd:COG1643 18 ELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVG--ETVGYRV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 295 RLQSRLpRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLL-NFRSDLKVILMSATLNAEK 373
Cdd:COG1643 92 RFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMSATLDAER 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 374 FSEYFGNCPMIHIPGFTFPVveylledviEkIRYVPeqkehrsqfkrgfmqghvnrqekeekeaiykerwpdyVRELRRR 453
Cdd:COG1643 171 FARLLGDAPVIESSGRTYPV---------E-VRYRP-------------------------------------LPADERD 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 454 YSASTVDVIEmmeddkvdlnlivaliryIVLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDKFLIIPLHSLMPTVNQ 533
Cdd:COG1643 204 LEDAVADAVR------------------EALAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQ 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 534 TQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYH 613
Cdd:COG1643 263 DRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYR 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 614 LYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFlsRLMDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHL 693
Cdd:COG1643 343 LWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRAL 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 694 ARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPfviplgkekiadaRRkelaKDTRSDHLTVVNAFEGWEEARRRG 773
Cdd:COG1643 421 ARLPLDPRLARMLLAAAELGCLREAAILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQQREF 483
|
...
gi 167830433 774 FRY 776
Cdd:COG1643 484 LSY 486
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
202-761 |
9.62e-87 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 304.68 E-value: 9.62e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 202 HFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERA 281
Cdd:PRK11131 68 TYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL----ELGRGVKGLIGHTQPRRLAARTVANRIAEELE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 282 ESCGSgnSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLK 361
Cdd:PRK11131 144 TELGG--CVGYKVRFNDQV-SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 362 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveylledvieKIRYVPeqkehrsqfkrgfMQGHVNRQEKEEKEAIYke 441
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRP-------------IVEEADDTERDQLQAIF-- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 442 rwpDYVRELRRrysastvdviemmeddkvdlnlivaliryivleEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDkflI 521
Cdd:PRK11131 276 ---DAVDELGR---------------------------------EGPGDILIFMSGEREIRDTADALNKLNLRHTE---I 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 522 IPLHSLMPTVNQTQVFKrtPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 601
Cdd:PRK11131 317 LPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 602 RAGRVQPGHCYHLYNGL----RASLLDdyqlPEILRTPLEELCLQIKILRLGGIAYFlsRLMDPPSNEAVLLSIRHLMEL 677
Cdd:PRK11131 395 RCGRVSEGICIRLYSEDdflsRPEFTD----PEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQDGVRLLEEL 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 678 NALDKQE-----ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAkDT 752
Cdd:PRK11131 469 GAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFA-DK 547
|
....*....
gi 167830433 753 RSDHLTVVN 761
Cdd:PRK11131 548 ESDFLAFVN 556
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
461-615 |
8.97e-77 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 248.60 E-value: 8.97e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 461 VIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-DKFLIIPLHSLMPTVNQTQVFKR 539
Cdd:cd18791 16 GISSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSSLPPEEQQRVFEP 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167830433 540 TPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLY 615
Cdd:cd18791 96 PPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
207-745 |
4.16e-75 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 264.32 E-value: 4.16e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsacrIVCTQPRRISAISVAERVAAERAESCGs 286
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGK-----IIMLEPRRLAARSAAQRLASQLGEAVG- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gNSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDV---LMTVVKDLLnfRSDLKVI 363
Cdd:TIGR01970 75 -QTVGYRVRGENKVSRRT-RLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLglaLALDVQSSL--REDLKIL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 364 LMSATLNAEKFSEYFGNCPMIHIPGFTFPVveylledvieKIRYVPEQKEhrsqfkrgfmqghvnrqekeekeaiykERW 443
Cdd:TIGR01970 151 AMSATLDGERLSSLLPDAPVVESEGRSFPV----------EIRYLPLRGD---------------------------QRL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 444 PDYVRelrrrysastvDVIEMMeddkvdlnlivaliryivLEEEDGAILVFLPGWDNI----STLHDLLMSQVmfksdkf 519
Cdd:TIGR01970 194 EDAVS-----------RAVEHA------------------LASETGSILVFLPGQAEIrrvqEQLAERLDSDV------- 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 520 LIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQR 599
Cdd:TIGR01970 238 LICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQR 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 600 KGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQikILRLGGIAYFLSRLMDPPSNEAVLLSIRHLMELNA 679
Cdd:TIGR01970 318 AGRAGRLEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALE--LAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGA 395
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 680 LDKQEELTPLGVHLARLPVEPHIGKMILFG------ALFCCLDPVLT-----------IAASLSFKDPFVIPLGKEKIAD 742
Cdd:TIGR01970 396 LDAQGRLTAHGKAMAALGCHPRLAAMLLSAhstglaALACDLAALLEerglprqggadLMNRLHRLQQGRQGRGQRAQQL 475
|
...
gi 167830433 743 ARR 745
Cdd:TIGR01970 476 AKK 478
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
670-759 |
5.21e-28 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 108.86 E-value: 5.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 670 SIRHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG------------- 736
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 167830433 737 -KEKIADARRKELAKDTRSDHLTV 759
Cdd:pfam04408 81 rRAADEKARAKFARLDLEGDHLTL 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
210-392 |
1.47e-25 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 105.27 E-value: 1.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 210 YGMQKELVN-LIDNHQVTVISGETGCGKTTQVTQFILDNYIergKGSACRIVCTQPRRISAISVAERVAAERAESCG--- 285
Cdd:smart00487 10 RPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALK---RGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLkvv 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 286 ---SGNSTGYQIRlqsRLPRKQGSILYCTTGIILQWLQSDP-YLSSVSHIVLDEIHER--NLQSDVLMTVVKDLlnfRSD 359
Cdd:smart00487 87 glyGGDSKREQLR---KLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLldGGFGDQLEKLLKLL---PKN 160
|
170 180 190
....*....|....*....|....*....|....*
gi 167830433 360 LKVILMSATL--NAEKFSEYFGNCPMIHIPGFTFP 392
Cdd:smart00487 161 VQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
676-760 |
8.23e-25 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 98.88 E-value: 8.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 676 ELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFviPLGKEKIADARRKELAkDTRSD 755
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFA-DPESD 77
|
....*
gi 167830433 756 HLTVV 760
Cdd:smart00847 78 HLTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
831-917 |
2.05e-17 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 77.68 E-value: 2.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 831 IKAVICAGLYPKVAKiRLNLGKKRKMVKvytkTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL 910
Cdd:pfam07717 1 LRAALAAGLYPNVAR-RDPKGKGYTTLS----DNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWL 75
|
....*..
gi 167830433 911 LFFGGDI 917
Cdd:pfam07717 76 LLFAPHI 82
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
213-372 |
3.96e-12 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 65.34 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 213 QKELVNLIDNHQVTVISGETGCGKTTqVTQF-ILDNYIERGKGSacRIVCTQPRRISAISVAERvAAERAESCG------ 285
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTL-AFLLpALEALDKLDNGP--QALVLAPTRELAEQIYEE-LKKLGKGLGlkvasl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 286 -SGNSTGYQIRLQSRLPrkqgsILYCTTGIILQWLQSDPYLSSVSHIVLDEIHE--RNLQSDVLMTVVKDLlnfRSDLKV 362
Cdd:pfam00270 80 lGGDSRKEQLEKLKGPD-----ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRllDMGFGPDLEEILRRL---PKKRQI 151
|
170
....*....|
gi 167830433 363 ILMSATLNAE 372
Cdd:pfam00270 152 LLLSATLPRN 161
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
207-386 |
6.84e-126 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 379.57 E-value: 6.84e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGS 286
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 GNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMS 366
Cdd:cd17981 81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 167830433 367 ATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
215-776 |
1.15e-118 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 383.66 E-value: 1.15e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 215 ELVNLIDNHQVTVISGETGCGKTTQVTQFILDnyieRGKGSACRIVCTQPRRISAISVAERVAAERAESCGsgNSTGYQI 294
Cdd:COG1643 18 ELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVG--ETVGYRV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 295 RLQSRLpRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLL-NFRSDLKVILMSATLNAEK 373
Cdd:COG1643 92 RFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMSATLDAER 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 374 FSEYFGNCPMIHIPGFTFPVveylledviEkIRYVPeqkehrsqfkrgfmqghvnrqekeekeaiykerwpdyVRELRRR 453
Cdd:COG1643 171 FARLLGDAPVIESSGRTYPV---------E-VRYRP-------------------------------------LPADERD 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 454 YSASTVDVIEmmeddkvdlnlivaliryIVLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDKFLIIPLHSLMPTVNQ 533
Cdd:COG1643 204 LEDAVADAVR------------------EALAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQ 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 534 TQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYH 613
Cdd:COG1643 263 DRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYR 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 614 LYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFlsRLMDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHL 693
Cdd:COG1643 343 LWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRAL 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 694 ARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPfviplgkekiadaRRkelaKDTRSDHLTVVNAFEGWEEARRRG 773
Cdd:COG1643 421 ARLPLDPRLARMLLAAAELGCLREAAILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQQREF 483
|
...
gi 167830433 774 FRY 776
Cdd:COG1643 484 LSY 486
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
223-386 |
2.24e-87 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 277.03 E-value: 2.24e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 223 HQVTVISGETGCGKTTQVTQFILDNYIERGKGsaCRIVCTQPRRISAISVAERVAAERAESCGSgnSTGYQIRLQSRLPR 302
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGK--GRIVCTQPRRIAAISVAERVAEERGEKLGE--EVGYQIRFESKTSS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 303 KqGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCP 382
Cdd:cd17917 77 K-TRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAP 155
|
....
gi 167830433 383 MIHI 386
Cdd:cd17917 156 VIHI 159
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
202-761 |
9.62e-87 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 304.68 E-value: 9.62e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 202 HFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERA 281
Cdd:PRK11131 68 TYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL----ELGRGVKGLIGHTQPRRLAARTVANRIAEELE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 282 ESCGSgnSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLK 361
Cdd:PRK11131 144 TELGG--CVGYKVRFNDQV-SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 362 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveylledvieKIRYVPeqkehrsqfkrgfMQGHVNRQEKEEKEAIYke 441
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRP-------------IVEEADDTERDQLQAIF-- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 442 rwpDYVRELRRrysastvdviemmeddkvdlnlivaliryivleEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDkflI 521
Cdd:PRK11131 276 ---DAVDELGR---------------------------------EGPGDILIFMSGEREIRDTADALNKLNLRHTE---I 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 522 IPLHSLMPTVNQTQVFKrtPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 601
Cdd:PRK11131 317 LPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 602 RAGRVQPGHCYHLYNGL----RASLLDdyqlPEILRTPLEELCLQIKILRLGGIAYFlsRLMDPPSNEAVLLSIRHLMEL 677
Cdd:PRK11131 395 RCGRVSEGICIRLYSEDdflsRPEFTD----PEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQDGVRLLEEL 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 678 NALDKQE-----ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAkDT 752
Cdd:PRK11131 469 GAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFA-DK 547
|
....*....
gi 167830433 753 RSDHLTVVN 761
Cdd:PRK11131 548 ESDFLAFVN 556
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
461-615 |
8.97e-77 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 248.60 E-value: 8.97e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 461 VIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-DKFLIIPLHSLMPTVNQTQVFKR 539
Cdd:cd18791 16 GISSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSSLPPEEQQRVFEP 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167830433 540 TPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLY 615
Cdd:cd18791 96 PPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
207-745 |
4.16e-75 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 264.32 E-value: 4.16e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsacrIVCTQPRRISAISVAERVAAERAESCGs 286
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGK-----IIMLEPRRLAARSAAQRLASQLGEAVG- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gNSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDV---LMTVVKDLLnfRSDLKVI 363
Cdd:TIGR01970 75 -QTVGYRVRGENKVSRRT-RLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLglaLALDVQSSL--REDLKIL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 364 LMSATLNAEKFSEYFGNCPMIHIPGFTFPVveylledvieKIRYVPEQKEhrsqfkrgfmqghvnrqekeekeaiykERW 443
Cdd:TIGR01970 151 AMSATLDGERLSSLLPDAPVVESEGRSFPV----------EIRYLPLRGD---------------------------QRL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 444 PDYVRelrrrysastvDVIEMMeddkvdlnlivaliryivLEEEDGAILVFLPGWDNI----STLHDLLMSQVmfksdkf 519
Cdd:TIGR01970 194 EDAVS-----------RAVEHA------------------LASETGSILVFLPGQAEIrrvqEQLAERLDSDV------- 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 520 LIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQR 599
Cdd:TIGR01970 238 LICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQR 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 600 KGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQikILRLGGIAYFLSRLMDPPSNEAVLLSIRHLMELNA 679
Cdd:TIGR01970 318 AGRAGRLEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALE--LAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGA 395
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 680 LDKQEELTPLGVHLARLPVEPHIGKMILFG------ALFCCLDPVLT-----------IAASLSFKDPFVIPLGKEKIAD 742
Cdd:TIGR01970 396 LDAQGRLTAHGKAMAALGCHPRLAAMLLSAhstglaALACDLAALLEerglprqggadLMNRLHRLQQGRQGRGQRAQQL 475
|
...
gi 167830433 743 ARR 745
Cdd:TIGR01970 476 AKK 478
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
207-386 |
1.85e-72 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 237.43 E-value: 1.85e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGs 286
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVG- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gNSTGYQIRLQSRlpRKQGS-ILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILM 365
Cdd:cd17985 80 -QSVGYQIRLESV--KSSATrLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILM 156
|
170 180
....*....|....*....|.
gi 167830433 366 SATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17985 157 SATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
180-386 |
1.38e-69 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 231.65 E-value: 1.38e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 180 LDQKLLEDLQ-KKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACR 258
Cdd:cd17972 31 ISMDLKNELMyQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 259 IVCTQPRRISAISVAERVAAERAESCgsGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDpyLSSVSHIVLDEIHE 338
Cdd:cd17972 111 IVVTQPRRISAVSVAERVAFERGEEV--GKSCGYSVRFESVLPRPHASILFCTVGVLLRKLEAG--IRGISHVIVDEIHE 186
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 167830433 339 RNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17972 187 RDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
207-386 |
2.46e-67 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 223.13 E-value: 2.46e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGs 286
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLR- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMS 366
Cdd:cd17976 80 -RNVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMS 158
|
170 180
....*....|....*....|
gi 167830433 367 ATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17976 159 ATGDNQRLSRYFGGCPVVRV 178
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
207-710 |
9.16e-61 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 222.88 E-value: 9.16e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILdnyieRGKGSACRIVCTQPRRISAISVAERVAAERAESCGS 286
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLL-----QHGGINGKIIMLEPRRLAARNVAQRLAEQLGEKPGE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gnSTGYQIRLQSRL-PRKQGSILycTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDV---LMTVVKDLLnfRSDLKV 362
Cdd:PRK11664 79 --TVGYRMRAESKVgPNTRLEVV--TEGILTRMIQRDPELSGVGLVILDEFHERSLQADLalaLLLDVQQGL--RDDLKL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 363 ILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveylledvieKIRYVPeqkehrsqfkrgfMQGHvnrqekeekeaiykER 442
Cdd:PRK11664 153 LIMSATLDNDRLQQLLPDAPVIVSEGRSFPV----------ERRYQP-------------LPAH--------------QR 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 443 WPDYV-RELRRrysastvdviemmeddkvdlnlivaliryiVLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDKFLI 521
Cdd:PRK11664 196 FDEAVaRATAE------------------------------LLRQESGSLLLFLPGVGEIQRVQEQLASRV---ASDVLL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 522 IPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 601
Cdd:PRK11664 243 CPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAG 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 602 RAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQikILRLGgiAYFLSRLM--DPPSNEAVLLSIRHLMELNA 679
Cdd:PRK11664 323 RAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLE--LLQWG--CHDPAQLSwlDQPPAAALAAAKRLLQQLGA 398
|
490 500 510
....*....|....*....|....*....|.
gi 167830433 680 LDKQEELTPLGVHLARLPVEPHIGKMILFGA 710
Cdd:PRK11664 399 LDGQGRLTARGRKMAALGNDPRLAAMLVAAK 429
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
207-386 |
3.28e-60 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 203.14 E-value: 3.28e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIErgKGSACRIVCTQPRRISAISVAERVAAERAESCGS 286
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYA--NGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQS-DPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILM 365
Cdd:cd17987 79 --TVGYQIRLESRVSPKT-LLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILS 155
|
170 180
....*....|....*....|.
gi 167830433 366 SATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17987 156 SAALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
207-386 |
7.31e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 202.45 E-value: 7.31e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYI-ERGKGSACRIVCTQPRRISAISVAERVAAERAESCG 285
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 286 SG--NS-TGYQIRLQSRlPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKV 362
Cdd:cd17975 81 PGgkNSlCGYQIRMESR-TGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170 180
....*....|....*....|....
gi 167830433 363 ILMSATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17975 160 ILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
207-393 |
6.34e-52 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 180.01 E-value: 6.34e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsACRIVCTQPRRISAISVAERVAAERAesCGS 286
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGK--YCNIVVTQPRRIAAISIARRVSQERE--WTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 GNSTGYQIRLQsRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSD-LKVILM 365
Cdd:cd17988 77 GSLVGYQVGLE-RPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILM 155
|
170 180
....*....|....*....|....*...
gi 167830433 366 SATLNAEKFSEYFGncpMIHIPGFTFPV 393
Cdd:cd17988 156 SATISCKEFADYFT---TPNNPAYVFEV 180
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
196-386 |
8.82e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 179.92 E-value: 8.82e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 196 RYIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNyiERGKGSACRIVCTQPRRISAISVAER 275
Cdd:cd17973 2 RYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDD--ELPHQPKKLVACTQPRRVAAMSVAQR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 276 VAAERAESCGSgnSTGYQIRLQSRLPRKqgSIL-YCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLL 354
Cdd:cd17973 80 VAEEMDVKLGE--EVGYSIRFEDCSSAK--TILkYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVV 155
|
170 180 190
....*....|....*....|....*....|..
gi 167830433 355 NFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17973 156 RRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
204-387 |
4.42e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 177.67 E-value: 4.42e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 204 REKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFIldnyIERGKGSACRIVCTQPRRISAISVAERVAAERAes 283
Cdd:cd17971 3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYL----AEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFG-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 284 CGSGNSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVI 363
Cdd:cd17971 77 CCLGQEVGYTIRFEDCTSPET-VIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLI 155
|
170 180
....*....|....*....|....
gi 167830433 364 LMSATLNAEKFSEYFGNCPMIHIP 387
Cdd:cd17971 156 VTSATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
207-386 |
1.46e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 173.01 E-value: 1.46e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERgkgsacrIVCTQPRRISAISVAERVAAERAESCGS 286
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH-------IACTQPRRIACISLAKRVAFESLNQYGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gnSTGYQIRLQ-SRLPRKQgsILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILM 365
Cdd:cd17979 74 --KVAYQIRFErTRTLATK--LLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILM 149
|
170 180
....*....|....*....|.
gi 167830433 366 SATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17979 150 SATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
207-386 |
2.80e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 169.61 E-value: 2.80e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGsacRIVCTQPRRISAISVAERVAAERaeSCGS 286
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGG---KIGCTQPRRVAAMSVAARVAEEM--GVKL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 GNSTGYQIRLQSRLPRKqgSIL-YCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILM 365
Cdd:cd17974 76 GNEVGYSIRFEDCTSEK--TVLkYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLIS 153
|
170 180
....*....|....*....|.
gi 167830433 366 SATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17974 154 SATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
207-386 |
1.09e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 167.92 E-value: 1.09e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsacRIVCTQPRRISAISVAERVAAERaeSCGS 286
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG----MIGITQPRRVAAVSVAKRVAEEM--GVEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 GNSTGYQIRLQSRLPRkQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFR-----SDLK 361
Cdd:cd17978 75 GQLVGYSVRFDDVTSE-ETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLK 153
|
170 180
....*....|....*....|....*
gi 167830433 362 VILMSATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17978 154 VIIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
207-386 |
2.88e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 166.48 E-value: 2.88e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFIL-DNYIERGKgsacrIVCTQPRRISAISVAERVAAERAESCG 285
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHeDGYTDYGM-----IGCTQPRRVAAMSVAKRVSEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 286 SgnSTGYQIRLQSrLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILM 365
Cdd:cd17983 76 E--EVGYAIRFED-CTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVT 152
|
170 180
....*....|....*....|.
gi 167830433 366 SATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17983 153 SATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
207-378 |
3.24e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 161.10 E-value: 3.24e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACR-IVCTQPRRISAISVAERVAAERAesCG 285
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLA----EAGWTAGGRvVGCTQPRRVAAVTVAGRVAEEMG--AV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 286 SGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILM 365
Cdd:cd17980 75 LGHEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVA 154
|
170
....*....|...
gi 167830433 366 SATLNAEKFSEYF 378
Cdd:cd17980 155 SATLDAEKFRDFF 167
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
207-386 |
9.60e-43 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 153.38 E-value: 9.60e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERAESCGS 286
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICL----ELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMS 366
Cdd:cd17989 77 --AVGYKVRFTDQTSDET-CVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITS 153
|
170 180
....*....|....*....|
gi 167830433 367 ATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17989 154 ATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
207-386 |
3.30e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 146.54 E-value: 3.30e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERaeSCGS 286
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLY----EAGFSQHGMIGVTQPRRVAAISVAQRVAEEM--KCTL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 GNSTGYQIRLQSrLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRS-----DLK 361
Cdd:cd17984 75 GSKVGYQVRFDD-CSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrkeHLK 153
|
170 180
....*....|....*....|....*
gi 167830433 362 VILMSATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17984 154 VVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
207-376 |
7.36e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 143.26 E-value: 7.36e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILD-NYIERGKGSACRIVCTQPRRISAISVAERVAAERAescG 285
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEaGFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELN---V 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 286 SGNSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSD------ 359
Cdd:cd17982 78 FGKEVSYQIRYDSTV-SENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdq 156
|
170 180
....*....|....*....|.
gi 167830433 360 ----LKVILMSATLNAEKFSE 376
Cdd:cd17982 157 tvkpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
207-384 |
9.51e-35 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 130.53 E-value: 9.51e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsacRIVCTQPRRISAISVAERVAAERAESCGS 286
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG----KIIVLEPRRVAARAAARRLATLLGEAPGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 287 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLN-FRSDLKVILM 365
Cdd:cd17990 77 --TVGYRVRGESRVGRRT-RVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAM 153
|
170
....*....|....*....
gi 167830433 366 SATLNAEKFSEYFGNCPMI 384
Cdd:cd17990 154 SATLDGDGLAALLPEAPVV 172
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
670-759 |
5.21e-28 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 108.86 E-value: 5.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 670 SIRHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG------------- 736
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 167830433 737 -KEKIADARRKELAKDTRSDHLTV 759
Cdd:pfam04408 81 rRAADEKARAKFARLDLEGDHLTL 104
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
207-386 |
8.19e-26 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 105.29 E-value: 8.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 207 LPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQ----FILDNYIERGKgsacrIVCTQPRRISAISVAERVAAERae 282
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeYCLSAHYQHGV-----VVCTQVHKQTAVWLALRVADEM-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 283 SCGSGNSTGYQIRLQSRLprKQGSIL-YCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLK 361
Cdd:cd17977 74 DVNIGHEVGYVIPFENCC--TNETILrYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELK 151
|
170 180
....*....|....*....|....*
gi 167830433 362 VILMSATLNAEKFSEYFGNCPMIHI 386
Cdd:cd17977 152 LVIITCPHLSSKLLSYYGNVPLIEV 176
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
210-392 |
1.47e-25 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 105.27 E-value: 1.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 210 YGMQKELVN-LIDNHQVTVISGETGCGKTTQVTQFILDNYIergKGSACRIVCTQPRRISAISVAERVAAERAESCG--- 285
Cdd:smart00487 10 RPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALK---RGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLkvv 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 286 ---SGNSTGYQIRlqsRLPRKQGSILYCTTGIILQWLQSDP-YLSSVSHIVLDEIHER--NLQSDVLMTVVKDLlnfRSD 359
Cdd:smart00487 87 glyGGDSKREQLR---KLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLldGGFGDQLEKLLKLL---PKN 160
|
170 180 190
....*....|....*....|....*....|....*
gi 167830433 360 LKVILMSATL--NAEKFSEYFGNCPMIHIPGFTFP 392
Cdd:smart00487 161 VQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
676-760 |
8.23e-25 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 98.88 E-value: 8.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 676 ELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFviPLGKEKIADARRKELAkDTRSD 755
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFA-DPESD 77
|
....*
gi 167830433 756 HLTVV 760
Cdd:smart00847 78 HLTLL 82
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
225-386 |
4.04e-21 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 91.88 E-value: 4.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 225 VTVISGETGCGKTTQVTQFILDNYIERG--KGSacrIVCTQPRRISAISVAERVAAERaeSCGSGNSTGYQIRlQSRLPR 302
Cdd:cd17986 20 IVLVSGEPGSGKSTQVPQWCAEFALSRGfqKGQ---VTVTQPHPLAARSLALRVADEM--DLNLGHEVGYSIP-QEDCTG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 303 KQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCP 382
Cdd:cd17986 94 PNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPALEPKLRAFWGNPP 173
|
....
gi 167830433 383 MIHI 386
Cdd:cd17986 174 VVHV 177
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
831-917 |
2.05e-17 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 77.68 E-value: 2.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 831 IKAVICAGLYPKVAKiRLNLGKKRKMVKvytkTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL 910
Cdd:pfam07717 1 LRAALAAGLYPNVAR-RDPKGKGYTTLS----DNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWL 75
|
....*..
gi 167830433 911 LFFGGDI 917
Cdd:pfam07717 76 LLFAPHI 82
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
212-609 |
4.67e-16 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 83.10 E-value: 4.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 212 MQKELVNLIDNHQVTVISGETGCGKTTQVTQFIL----------------DNYIERgkgsacRIVCTQPR----RISAIS 271
Cdd:PHA02653 168 VQLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggfdnldkidPNFIER------PIVLSLPRvalvRLHSIT 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 272 VAERVAAERAEscGSGNSTGY---QIRLQSRLPRKQGsILYCTTGIILQwlqsdpYLSSVSHIVLDEIHERNLQSDVLMT 348
Cdd:PHA02653 242 LLKSLGFDEID--GSPISLKYgsiPDELINTNPKPYG-LVFSTHKLTLN------KLFDYGTVIIDEVHEHDQIGDIIIA 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 349 VV-KDLLNFRSdlkVILMSATL--NAEKFSEYFGNCPMIHIPGFT-FPVVEylledVIEKIRYVPEQKehrsqfkrgfmq 424
Cdd:PHA02653 313 VArKHIDKIRS---LFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISE-----VYVKNKYNPKNK------------ 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 425 ghvnRQEKEEkeaiykerwpdyvrELRrrysastvdviemmeddkvdlNLIVALIRYIVLEEEDGaiLVFLPgwdNISTL 504
Cdd:PHA02653 373 ----RAYIEE--------------EKK---------------------NIVTALKKYTPPKGSSG--IVFVA---SVSQC 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 505 HDL--LMSQvMFKSDKFLIIplHSLMPTVNQ--TQVFKRTPPgvrKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQ 580
Cdd:PHA02653 409 EEYkkYLEK-RLPIYDFYII--HGKVPNIDEilEKVYSSKNP---SIIISTPYLESSVTIRNATHVYDTGRVYVPEPFGG 482
|
410 420
....*....|....*....|....*....
gi 167830433 581 NNIstmsaeWVSKANAKQRKGRAGRVQPG 609
Cdd:PHA02653 483 KEM------FISKSMRTQRKGRVGRVSPG 505
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
476-606 |
1.07e-14 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 71.09 E-value: 1.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 476 VALIRYIVLEEEDGAILVFLPGWDnistlhdLLMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAE 555
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKK-------TLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 167830433 556 TSITIDDVVYVIdggkiketHFDTQNNISTMsaewvskanaKQRKGRAGRV 606
Cdd:pfam00271 76 RGLDLPDVDLVI--------NYDLPWNPASY----------IQRIGRAGRA 108
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
226-368 |
3.84e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.51 E-value: 3.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 226 TVISGETGCGKTTQVTQFILDNYIERGKgsacRIVCTQPRRISAISVAERVAAERAE--SCGsGNSTGYQIRLQSRLPRK 303
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGK----KVLVLVPTKALALQTAERLRELFGPgiRVA-VLVGGSSAEEREKNKLG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167830433 304 QGSILYCTTGIILQWLQSD--PYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNF-RSDLKVILMSAT 368
Cdd:cd00046 79 DADIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAgLKNAQVILLSAT 146
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
513-605 |
1.59e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.85 E-value: 1.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 513 MFKSDKFLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIdggkiketHFDTqnnistmsaeWVS 592
Cdd:smart00490 6 LLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVI--------IYDL----------PWS 67
|
90
....*....|...
gi 167830433 593 KANAKQRKGRAGR 605
Cdd:smart00490 68 PASYIQRIGRAGR 80
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
213-372 |
3.96e-12 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 65.34 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 213 QKELVNLIDNHQVTVISGETGCGKTTqVTQF-ILDNYIERGKGSacRIVCTQPRRISAISVAERvAAERAESCG------ 285
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTL-AFLLpALEALDKLDNGP--QALVLAPTRELAEQIYEE-LKKLGKGLGlkvasl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 286 -SGNSTGYQIRLQSRLPrkqgsILYCTTGIILQWLQSDPYLSSVSHIVLDEIHE--RNLQSDVLMTVVKDLlnfRSDLKV 362
Cdd:pfam00270 80 lGGDSRKEQLEKLKGPD-----ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRllDMGFGPDLEEILRRL---PKKRQI 151
|
170
....*....|
gi 167830433 363 ILMSATLNAE 372
Cdd:pfam00270 152 LLLSATLPRN 161
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
213-387 |
9.80e-10 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 58.81 E-value: 9.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 213 QKELVNLIDNHQV-TVISGETGCGKTTQVTQFILDNYIERGKgsacRIVCTQPRRisAIsVAERVA--AERAESCGS--G 287
Cdd:cd17921 6 QREALRALYLSGDsVLVSAPTSSGKTLIAELAILRALATSGG----KAVYIAPTR--AL-VNQKEAdlRERFGPLGKnvG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 288 NSTGYQIRLQSRLPRKQgsILYCTTGIILQWLQ--SDPYLSSVSHIVLDEIHERNLQS--DVLMTVVKDLLNFRSDLKVI 363
Cdd:cd17921 79 LLTGDPSVNKLLLAEAD--ILVATPEKLDLLLRngGERLIQDVRLVVVDEAHLIGDGErgVVLELLLSRLLRINKNARFV 156
|
170 180
....*....|....*....|....*
gi 167830433 364 LMSATL-NAEKFSEYFGNCPMIHIP 387
Cdd:cd17921 157 GLSATLpNAEDLAEWLGVEDLIRFD 181
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
221-365 |
1.07e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 40.02 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 221 DNHQVTVISGETGCGKTTqVTQFILDNYIERGKGSAcRIVCTQPRriSAISVAERVAAERAESCGSGNSTgyqirlqSRL 300
Cdd:pfam13401 3 FGAGILVLTGESGTGKTT-LLRRLLEQLPEVRDSVV-FVDLPSGT--SPKDLLRALLRALGLPLSGRLSK-------EEL 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167830433 301 PRkqgsilycttgIILQWLQSdpyLSSVSHIVLDEIHerNLQSDVLMTvVKDLLNF-RSDLKVILM 365
Cdd:pfam13401 72 LA-----------ALQQLLLA---LAVAVVLIIDEAQ--HLSLEALEE-LRDLLNLsSKLLQLILV 120
|
|
| DEXSc_RecD-like |
cd17933 |
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
213-253 |
1.57e-03 |
|
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 40.23 E-value: 1.57e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 167830433 213 QKELVNLIDNHQVTVISGETGCGKTTqVTQFILDNYIERGK 253
Cdd:cd17933 2 QKAAVRLVLRNRVSVLTGGAGTGKTT-TLKALLAALEAEGK 41
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
211-335 |
3.59e-03 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 40.04 E-value: 3.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167830433 211 GMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIER-----GKGSACRIVCTQPRRISAISVAeRVAAERAESCG 285
Cdd:cd17948 15 TVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYkllaeGPFNAPRGLVITPSRELAEQIG-SVAQSLTEGLG 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 167830433 286 ------SGNSTGYQIRLqsrLPRKQGSILYCTTGIILQWLQSDPY-LSSVSHIVLDE 335
Cdd:cd17948 94 lkvkviTGGRTKRQIRN---PHFEEVDILVATPGALSKLLTSRIYsLEQLRHLVLDE 147
|
|
| |
