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Conserved domains on  [gi|12707577|ref|NP_073207|]
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paired mesoderm homeobox protein 1 isoform pmx-1b [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11079034)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; also contains an OAR domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-151 5.69e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 96.03  E-value: 5.69e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 12707577    99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR 151
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 219-235 2.10e-03

OAR motif; The entry represents the OAR motif.


:

Pssm-ID: 461067  Cd Length: 19  Bit Score: 34.69  E-value: 2.10e-03
                          10
                  ....*....|....*..
gi 12707577   219 NMANSIANLRLKAKEYS 235
Cdd:pfam03826   2 RRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-151 5.69e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 96.03  E-value: 5.69e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 12707577    99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR 151
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 99-153 1.56e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 84.60  E-value: 1.56e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12707577  99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNE 153
Cdd:cd00086   5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 99-150 9.08e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 82.30  E-value: 9.08e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 12707577     99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFR 150
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
105-185 3.65e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 3.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12707577 105 QLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR----NERAMLANKNASLLKSYS---GDVTAVEQ 177
Cdd:COG5576  62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkrsgKVEQRPGEEEADLAKIGSlstGQISIIET 141


                ....*...
gi 12707577 178 PIVPRPAP 185
Cdd:COG5576 142 LEFSRTSY 149
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 219-235 2.10e-03

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 34.69  E-value: 2.10e-03
                          10
                  ....*....|....*..
gi 12707577   219 NMANSIANLRLKAKEYS 235
Cdd:pfam03826   2 RRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-151 5.69e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 96.03  E-value: 5.69e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 12707577    99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR 151
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 99-153 1.56e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 84.60  E-value: 1.56e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12707577  99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNE 153
Cdd:cd00086   5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 99-150 9.08e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 82.30  E-value: 9.08e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 12707577     99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFR 150
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
105-185 3.65e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 3.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12707577 105 QLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR----NERAMLANKNASLLKSYS---GDVTAVEQ 177
Cdd:COG5576  62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkrsgKVEQRPGEEEADLAKIGSlstGQISIIET 141


                ....*...
gi 12707577 178 PIVPRPAP 185
Cdd:COG5576 142 LEFSRTSY 149
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 219-235 2.10e-03

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 34.69  E-value: 2.10e-03
                          10
                  ....*....|....*..
gi 12707577   219 NMANSIANLRLKAKEYS 235
Cdd:pfam03826   2 RRSSSIASLRLKAKEHS 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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