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Conserved domains on  [gi|12963827|ref|NP_076279|]
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WD repeat-containing protein 54 isoform a [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-280 6.28e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 6.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 131 HFICVGTCSGRVLVFDIPakgpNIVLSEELAGHQTPITDIAteraQGQDGvADMVTADDSGVLCVWRSgPEFTLLTRIPG 210
Cdd:cd00200 148 TFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVA----FSPDG-EKLLSSSSDGTIKLWDL-STGKCLGTLRG 217

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12963827 211 FGVPCPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWK 280
Cdd:cd00200 218 HENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-280 6.28e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 6.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 131 HFICVGTCSGRVLVFDIPakgpNIVLSEELAGHQTPITDIAteraQGQDGvADMVTADDSGVLCVWRSgPEFTLLTRIPG 210
Cdd:cd00200 148 TFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVA----FSPDG-EKLLSSSSDGTIKLWDL-STGKCLGTLRG 217

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12963827 211 FGVPCPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWK 280
Cdd:cd00200 218 HENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
135-282 7.52e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 7.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 135 VGTCSGRVLVFDIPAKgpniVLSEELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWrSGPEFTLLTRIPGFGVP 214
Cdd:COG2319 263 SGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAF-SPDGKL----LASGSDDGTVRLW-DLATGKLLRTLTGHTGA 332

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 215 CPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLN 282
Cdd:COG2319 333 VRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-280 6.28e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 6.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 131 HFICVGTCSGRVLVFDIPakgpNIVLSEELAGHQTPITDIAteraQGQDGvADMVTADDSGVLCVWRSgPEFTLLTRIPG 210
Cdd:cd00200 148 TFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVA----FSPDG-EKLLSSSSDGTIKLWDL-STGKCLGTLRG 217

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12963827 211 FGVPCPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWK 280
Cdd:cd00200 218 HENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
135-282 7.52e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 7.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 135 VGTCSGRVLVFDIPAKgpniVLSEELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWrSGPEFTLLTRIPGFGVP 214
Cdd:COG2319 263 SGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAF-SPDGKL----LASGSDDGTVRLW-DLATGKLLRTLTGHTGA 332

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 215 CPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLN 282
Cdd:COG2319 333 VRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
155-281 1.47e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 155 VLSEELAGHQTPITDIATERAQGQDGVADMVTADDSGVLCVWRSGPEFTLLTRIPGFGVPCPSVQLWQGIVAAGYGNGQV 234
Cdd:COG2319  23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 12963827 235 RLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKL 281
Cdd:COG2319 103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-282 1.72e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827  99 SDGSVMVyWHaLDSGDASSVQ---AMFARGIAASVHFICVGTCS--GRVLVFDIPAKgpniVLSEELAGHQTPITDIAte 173
Cdd:cd00200  29 GDGTIKV-WD-LETGELLRTLkghTGPVRDVAASADGTYLASGSsdKTIRLWDLETG----ECVRTLTGHTSYVSSVA-- 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 174 rAQGQDGVAdmVTADDSGVLCVWrSGPEFTLLTRIPGF--GVPCPSVQLWQGIVAAGYGNGQVRLYDASTGALHVQISAH 251
Cdd:cd00200 101 -FSPDGRIL--SSSSRDKTIKVW-DVETGKCLTTLRGHtdWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH 176

                       170       180       190
                ....*....|....*....|....*....|.
gi 12963827 252 ARTISALDLAPEVGKLLSAAEDTFVHIWKLN 282
Cdd:cd00200 177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
159-282 5.27e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 5.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 159 ELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWRSgPEFTLLTRIPGFGVPCPSVQLWQG--IVAAGYGNGQVRL 236
Cdd:COG2319 157 TLTGHSGAVTSVAF-SPDGKL----LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRL 230

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 12963827 237 YDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKLN 282
Cdd:COG2319 231 WDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLaSGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
224-282 3.84e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 3.84e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12963827 224 IVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKLN 282
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKLLaSGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
224-281 1.21e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 1.21e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 12963827 224 IVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKL 281
Cdd:COG2319 134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-GKLLaSGSDDGTVRLWDL 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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