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Conserved domains on  [gi|40254353|ref|NP_077787|]
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zinc finger protein 319 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-348 1.31e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 190 NIAPVEQPEKPYSCPVCQKPFKHLSELSRHER--IHTGE--KPYKCT--LCDKSFSQSSHLVHHKRTHSSERPYKC--AV 261
Cdd:COG5048 279 DSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLN 358

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 262 CEKTFKHRSHLVRH--MYAHSGEHH--LFRCNV--CELHFKESSELLQHPCT--PSGERPFRCGECQKAFKRPSDLRQHE 333
Cdd:COG5048 359 SSSKFSPLLNNEPPqsLQQYKDLKNdkKSETLSnsCIRNFKRDSNLSLHIIThlSFRPYNCKNPPCSKSFNRHYNLIPHK 438

                       170
                ....*....|....*
gi 40254353 334 RTHSAERPFKCDLCP 348
Cdd:COG5048 439 KIHTNHAPLLCSILK 453
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 419-504 5.55e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.03  E-value: 5.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 419 LPTSTERPFKCPV--CNKAYKRASALQKHQL-SHCAAAEKPlrctlcerrffsSSEFVQHRCDPAREKPLKCPDCEKRFK 495
Cdd:COG5189 342 LKVKDGKPYKCPVegCNKKYKNQNGLKYHMLhGHQNQKLHE------------NPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                ....*....
gi 40254353 496 YASDLQRHR 504
Cdd:COG5189 410 NLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-524 4.07e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.07e-05
                          10        20
                  ....*....|....*....|....*.
gi 40254353   499 DLQRHRRVHTGEKPYKCPSCDKAFKQ 524
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 365-445 3.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 365 KTEEPFKCGL--CEKGFGQPSHLLYHQ---HVHTLETLFKCPVCQKGFdqsaellrhkclpTSTERPFKCPVCNKAYKRA 439
Cdd:COG5189 345 KDGKPYKCPVegCNKKYKNQNGLKYHMlhgHQNQKLHENPSPEKMNIF-------------SAKDKPYRCEVCDKRYKNL 411


                ....*.
gi 40254353 440 SALQKH 445
Cdd:COG5189 412 NGLKYH 417
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-348 1.31e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 190 NIAPVEQPEKPYSCPVCQKPFKHLSELSRHER--IHTGE--KPYKCT--LCDKSFSQSSHLVHHKRTHSSERPYKC--AV 261
Cdd:COG5048 279 DSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLN 358

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 262 CEKTFKHRSHLVRH--MYAHSGEHH--LFRCNV--CELHFKESSELLQHPCT--PSGERPFRCGECQKAFKRPSDLRQHE 333
Cdd:COG5048 359 SSSKFSPLLNNEPPqsLQQYKDLKNdkKSETLSnsCIRNFKRDSNLSLHIIThlSFRPYNCKNPPCSKSFNRHYNLIPHK 438

                       170
                ....*....|....*
gi 40254353 334 RTHSAERPFKCDLCP 348
Cdd:COG5048 439 KIHTNHAPLLCSILK 453
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 419-504 5.55e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.03  E-value: 5.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 419 LPTSTERPFKCPV--CNKAYKRASALQKHQL-SHCAAAEKPlrctlcerrffsSSEFVQHRCDPAREKPLKCPDCEKRFK 495
Cdd:COG5189 342 LKVKDGKPYKCPVegCNKKYKNQNGLKYHMLhGHQNQKLHE------------NPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                ....*....
gi 40254353 496 YASDLQRHR 504
Cdd:COG5189 410 NLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-524 4.07e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.07e-05
                          10        20
                  ....*....|....*....|....*.
gi 40254353   499 DLQRHRRVHTGEKPYKCPSCDKAFKQ 524
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 40254353   215 ELSRHERIHTGEKPYKCTLCDKSFSQ 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 365-445 3.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 365 KTEEPFKCGL--CEKGFGQPSHLLYHQ---HVHTLETLFKCPVCQKGFdqsaellrhkclpTSTERPFKCPVCNKAYKRA 439
Cdd:COG5189 345 KDGKPYKCPVegCNKKYKNQNGLKYHMlhgHQNQKLHENPSPEKMNIF-------------SAKDKPYRCEVCDKRYKNL 411


                ....*.
gi 40254353 440 SALQKH 445
Cdd:COG5189 412 NGLKYH 417
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-348 1.31e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 190 NIAPVEQPEKPYSCPVCQKPFKHLSELSRHER--IHTGE--KPYKCT--LCDKSFSQSSHLVHHKRTHSSERPYKC--AV 261
Cdd:COG5048 279 DSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLN 358

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 262 CEKTFKHRSHLVRH--MYAHSGEHH--LFRCNV--CELHFKESSELLQHPCT--PSGERPFRCGECQKAFKRPSDLRQHE 333
Cdd:COG5048 359 SSSKFSPLLNNEPPqsLQQYKDLKNdkKSETLSnsCIRNFKRDSNLSLHIIThlSFRPYNCKNPPCSKSFNRHYNLIPHK 438

                       170
                ....*....|....*
gi 40254353 334 RTHSAERPFKCDLCP 348
Cdd:COG5048 439 KIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-523 1.20e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 190 NIAPVEQPeKPYSCPVCQKPFKHLSELSRHERIHTGEKPYKCTL--CDKSFSQSSHLVHHKRTHSSE-----------RP 256
Cdd:COG5048  24 LKSLSNAP-RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplSN 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 257 YKCAVCEKTFKH---------RSHLVRHMYA-----------HSGEHHLFRCNVCELHFKESSELLQ------------- 303
Cdd:COG5048 103 SKASSSSLSSSSsnsndnnllSSHSLPPSSRdpqlpdllsisNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpss 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 304 ------HPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEK 377
Cdd:COG5048 183 nlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 378 GFGQPSHLLYHQHVHTLE-------TLFKCPVCQKGFDQSAELLRHK-CLPTSTE--RPFKCPV--CNKAYKRASALQKH 445
Cdd:COG5048 263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 446 QLSH---CAAAEKPLRCTLCERRFF--SSSEFVQHRCDPAREKPLKC--PDCEKRFKYASDLQRHRRVHTGEKP--YKCP 516
Cdd:COG5048 343 ILLHtsiSPAKEKLLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNP 422


                ....*..
gi 40254353 517 SCDKAFK 523
Cdd:COG5048 423 PCSKSFN 429
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 419-504 5.55e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.03  E-value: 5.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 419 LPTSTERPFKCPV--CNKAYKRASALQKHQL-SHCAAAEKPlrctlcerrffsSSEFVQHRCDPAREKPLKCPDCEKRFK 495
Cdd:COG5189 342 LKVKDGKPYKCPVegCNKKYKNQNGLKYHMLhGHQNQKLHE------------NPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                ....*....
gi 40254353 496 YASDLQRHR 504
Cdd:COG5189 410 NLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-445 1.31e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 205 VCQKPFKHLSELSRHERIHTGEKP--YKCTLCDKSFSQSSHLVHHKRTHSSER-PYKCAVCEKTFKHRSHLVRHMYAHSg 281
Cdd:COG5048 235 LSPKSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSVN- 313

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 282 ehhlfrcnvcelhfKESSELLQHPCTPSGerpfrcgeCQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYAL---- 357
Cdd:COG5048 314 --------------HSGESLKPFSCPYSL--------CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 358 ---MRHRRTHKTEEPFKC--GLCEKGFGQPSHLLYHQHVHTLET--LFKCPVCQKGFDQSAELLRHKcLPTSTERPFkCP 430
Cdd:COG5048 372 pqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPHK-KIHTNHAPL-LC 449

                       250
                ....*....|....*
gi 40254353 431 VCNKAYKRASALQKH 445
Cdd:COG5048 450 SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-524 4.07e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.07e-05
                          10        20
                  ....*....|....*....|....*.
gi 40254353   499 DLQRHRRVHTGEKPYKCPSCDKAFKQ 524
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 40254353   215 ELSRHERIHTGEKPYKCTLCDKSFSQ 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-548 3.08e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 227 KPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAV--CEKTFKHRSHLVRHMYAHSGEHHLFRCN-VCELHFKESSELL- 302
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLs 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 303 -------------QHPCTPSGERPFRCGECQKAFKRPSDLRQ-----HERTHSAERPFKCD---LCPMGFKQQYALMRHR 361
Cdd:COG5048 112 ssssnsndnnllsSHSLPPSSRDPQLPDLLSISNLRNNPLPGnnsssVNTPQSNSLHPPLPansLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 362 RTHKTEEPFKCGLCEKgFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPTSTERPFKCPVCNKAYKRASA 441
Cdd:COG5048 192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 442 LQKHQLSHCAAAEKplrctlcerrffsssefvqhrcdpAREKPLKCPDCEKRFKYASDLQRHRR--VHTGE--KPYKCPS 517
Cdd:COG5048 271 QSSSPNESDSSSEK------------------------GFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPY 326

                       330       340       350
                ....*....|....*....|....*....|...
gi 40254353 518 --CDKAFKQREHLNKHQGVHAREQQFKCVWCGE 548
Cdd:COG5048 327 slCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 254-337 1.10e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 254 ERPYKCAV--CEKTFKHRSHLVRHMYahsgEHHlfrcnvCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQ 331
Cdd:COG5189 347 GKPYKCPVegCNKKYKNQNGLKYHML----HGH------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 40254353 332 HeRTHS 337
Cdd:COG5189 417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
88-531 2.46e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353  88 SSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGV--CKMGFSLLTSLAQHHSSHTgMVKCSICDKT 165
Cdd:COG5048  19 TPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH-NNPSDLNSKS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 166 YKPAEAAepatttaPSLPSAPPPANIAPVEQPEKPYSCPVCQKPFKHLSELSRHERIHtgEKPYKCTLCDKSFSQSSHLV 245
Cdd:COG5048  98 LPLSNSK-------ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRN--NPLPGNNSSSVNTPQSNSLH 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 246 H-HKRTHSSERPYKCAVCE----KTFKHRSHLVRHMYAHSGEhhlfrcnvcelhfKESSELLQHPCTPSGERPfrCGECQ 320
Cdd:COG5048 169 PpLPANSLSKDPSSNLSLLissnVSTSIPSSSENSPLSSSYS-------------IPSSSSDQNLENSSSSLP--LTTNS 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 321 KAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEE-------PFKCGLCEKGFGQPSHLLYHQ--HV 391
Cdd:COG5048 234 QLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVN 313

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 392 HTLETL--FKCPV--CQKGFDQSAELLRHKCLPTS--------TERPFKCPVCNKAYKRASALQKHQLSHCAAAEKPLRC 459
Cdd:COG5048 314 HSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSispakeklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS 393

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40254353 460 TL--CERRFFSSSEFVQHRCDpaREKPLKCPDCEKRFKYASDLQRHRRVHTgEKPYKCPSCDKAFKQREHLNKH 531
Cdd:COG5048 394 CIrnFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 365-445 3.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254353 365 KTEEPFKCGL--CEKGFGQPSHLLYHQ---HVHTLETLFKCPVCQKGFdqsaellrhkclpTSTERPFKCPVCNKAYKRA 439
Cdd:COG5189 345 KDGKPYKCPVegCNKKYKNQNGLKYHMlhgHQNQKLHENPSPEKMNIF-------------SAKDKPYRCEVCDKRYKNL 411


                ....*.
gi 40254353 440 SALQKH 445
Cdd:COG5189 412 NGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 198-252 3.48e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.48e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40254353 198 EKPYSCPV--CQKPFKHLSELSRHeRIH--------------------TGEKPYKCTLCDKSFSQSSHLVHHkRTHS 252
Cdd:COG5189 347 GKPYKCPVegCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 225-271 5.14e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.14e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40254353 225 GEKPYKCTL--CDKSFSQSSHLVHHKRT-HSSE------------------RPYKCAVCEKTFK-------HRSH 271
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQklhenpspekmnifsakdKPYRCEVCDKRYKnlnglkyHRKH 420
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 229-251 6.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.86e-03
                          10        20
                  ....*....|....*....|...
gi 40254353   229 YKCTLCDKSFSQSSHLVHHKRTH 251
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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