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Conserved domains on  [gi|58331179|ref|NP_079527|]
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rho GTPase-activating protein 39 isoform 2 [Homo sapiens]

Protein Classification

MFS transporter; MDR family MFS transporter( domain architecture ID 13365692)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides| MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 919-1104 6.70e-120

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239854  Cd Length: 187  Bit Score: 366.72  E-value: 6.70e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  919 FGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP-TGLEDPHVPASLL 997
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  998 KLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCL 1077
Cdd:cd04389   81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                        170       180
                 ....*....|....*....|....*..
gi 58331179 1078 RCQSDDPRVIFENTRKEMSFLRVLIQH 1104
Cdd:cd04389  161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 767-908 3.10e-32

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


:

Pssm-ID: 459939  Cd Length: 105  Bit Score: 121.15  E-value: 3.10e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179    767 ALEVATKGWSVQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVndtkvtqhik 846
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADDP---------- 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58331179    847 ellerntkkksklrkkpkpyveepdGVAISTYAKYCYHKLQKAALTGAKKglKKPNVEEIRH 908
Cdd:pfam00784   71 -------------------------SREVGKYAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
PHA03378 super family cl33729
EBNA-3B; Provisional
 245-543 1.43e-05

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.30  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   245 PSGSQHS--PSLQTFAPEADGtiffPERRPSPFLKRAELPGSSSPL-LAQPRKPSGDSQPSSPRYGYEPPLYEEPPVEYQ 321
Cdd:PHA03378  600 PHPSQTPepPTTQSHIPETSA----PRQWPMPLRPIPMRPLRMQPItFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQ 675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   322 ----------------------------APIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQGPPSPCQQLVL 373
Cdd:PHA03378  676 psptgantmlpiqwapgtmqpppraptpMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR 755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   374 TKQKCPERFLSLEYSPAGKEYVRQlvyvEQAGSSPKLRAGPRHKYAPNPGGGSYSLQPSPCLLRDQR------------L 441
Cdd:PHA03378  756 PPAAAPGRARPPAAAPGAPTPQPP----PQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQgptkqilrqlltG 831

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   442 GVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQDTLSSTGYSPGTRKRKSRKPSLCQATSAT--PTEGPGdllvE 519
Cdd:PHA03378  832 GVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGSVRAAAASTVTqaPTEYTG----E 907

                         330       340
                  ....*....|....*....|....
gi 58331179   520 QPLAEEQPPcgTSLAPVKRAEGEA 543
Cdd:PHA03378  908 RRGVGPMHP--TDIPPSKRAKTDA 929
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
19-95 3.37e-04

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.69  E-value: 3.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   19 SRIPGSNTRLEWVEIIEPRTRERMYaNLVTGECVWDPPAGV---RIKRTSENQWWElFDPNTSRFYYYNASTQRTVWHRP 95
Cdd:COG5104    6 LGMASGEARSEWEELKAPDGRIYYY-NKRTGKSSWEKPKELlkgSEEDLDVDPWKE-CRTADGKVYYYNSITRESRWKIP 83
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 115-369 6.71e-04

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 6.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   115 SPRASAESSPGRGSSV-----SREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE--KDYEIYR 187
Cdd:PHA03307  178 SPEETARAPSSPPAEPppstpPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgPENECPL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   188 DYSADGQLLHYRTSSLRWNSGAkermlikvADREPSFLAAQGNGYAPDGPPGVRSRRPSGSQHSPSLQTFAPEADGTiff 267
Cdd:PHA03307  258 PRPAPITLPTRIWEASGWNGPS--------SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS--- 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   268 PERRPSPFLKRAELPGSSSPL--LAQPRKPSGDSQPSSPRYGyePPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSP 345
Cdd:PHA03307  327 SSTSSSSESSRGAAVSPGPSPsrSPSPSRPPPPADPSSPRKR--PRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDAT 404

                         250       260
                  ....*....|....*....|....
gi 58331179   346 QRSPGRKPRPFLQPNKQGPPSPCQ 369
Cdd:PHA03307  405 GRFPAGRPRPSPLDAGAASGAFYA 428
 
Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 919-1104 6.70e-120

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 366.72  E-value: 6.70e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  919 FGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP-TGLEDPHVPASLL 997
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  998 KLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCL 1077
Cdd:cd04389   81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                        170       180
                 ....*....|....*....|....*..
gi 58331179 1078 RCQSDDPRVIFENTRKEMSFLRVLIQH 1104
Cdd:cd04389  161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 940-1081 1.72e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 155.01  E-value: 1.72e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179    940 PWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP---TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQ 1016
Cdd:pfam00620    1 PLIVRKCVEYLEK-RGLDTEGIFRVSGSASRIKELREAFDRGPDVdldLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58331179   1017 CI--AHYDSPEAAV----AVVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCQS 1081
Cdd:pfam00620   80 FIeaAKLPDEEERLealrELLRKLPPANRDTLRYLLAHLNRVAQ--NSDVNKMNAHNLAIVFGPTLLRPPD 148
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 767-908 3.10e-32

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 459939  Cd Length: 105  Bit Score: 121.15  E-value: 3.10e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179    767 ALEVATKGWSVQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVndtkvtqhik 846
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADDP---------- 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58331179    847 ellerntkkksklrkkpkpyveepdGVAISTYAKYCYHKLQKAALTGAKKglKKPNVEEIRH 908
Cdd:pfam00784   71 -------------------------SREVGKYAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 954-1104 1.23e-31

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 121.99  E-value: 1.23e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179     954 NGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE---DPHVPASLLKLWYRELEEPLIPHEFYEQCI--AHYDSPEAAV 1028
Cdd:smart00324   17 RGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLseyDVHDVAGLLKLFLRELPEPLITYELYEEFIeaAKLEDETERL 96

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179    1029 AVVHA----LPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKeMSFLRVLIQH 1104
Cdd:smart00324   97 RALREllslLPPANRATLRYLLAHLNRVAE--HSEENKMTARNLAIVFGPTLLRPPDGEVASLKDIRHQ-NTVIEFLIEN 173
MyTH4 smart00139
Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 ...
 722-907 2.17e-26

Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 214535  Cd Length: 152  Bit Score: 105.91  E-value: 2.17e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179     722 WSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVAL--EVATKGWSVQGLRDELYIQLCRQTTENFRLE 799
Cdd:smart00139    1 YTKDPIKTSLLKLESDELQKEAVKIFKAILKFMGDIPLPRPDSHLDLvqFILQKGLDHPELRDEIYCQLIKQLTDNPSRQ 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179     800 SLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKvtqhikellerntkkksklrkkpkpyveepdgvaistYA 879
Cdd:smart00139   81 SEERGWQLLYLCTSLFPPSERLLPYLLQFLSRRADPGSEQG-------------------------------------LA 123

                           170       180
                    ....*....|....*....|....*...
gi 58331179     880 KYCYHKLQKAALTGAKKglKKPNVEEIR 907
Cdd:smart00139  124 KYCLYRLERTLKNGARK--QPPSRLELE 149
PHA03378 PHA03378
EBNA-3B; Provisional
 245-543 1.43e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.30  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   245 PSGSQHS--PSLQTFAPEADGtiffPERRPSPFLKRAELPGSSSPL-LAQPRKPSGDSQPSSPRYGYEPPLYEEPPVEYQ 321
Cdd:PHA03378  600 PHPSQTPepPTTQSHIPETSA----PRQWPMPLRPIPMRPLRMQPItFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQ 675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   322 ----------------------------APIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQGPPSPCQQLVL 373
Cdd:PHA03378  676 psptgantmlpiqwapgtmqpppraptpMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR 755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   374 TKQKCPERFLSLEYSPAGKEYVRQlvyvEQAGSSPKLRAGPRHKYAPNPGGGSYSLQPSPCLLRDQR------------L 441
Cdd:PHA03378  756 PPAAAPGRARPPAAAPGAPTPQPP----PQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQgptkqilrqlltG 831

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   442 GVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQDTLSSTGYSPGTRKRKSRKPSLCQATSAT--PTEGPGdllvE 519
Cdd:PHA03378  832 GVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGSVRAAAASTVTqaPTEYTG----E 907

                         330       340
                  ....*....|....*....|....
gi 58331179   520 QPLAEEQPPcgTSLAPVKRAEGEA 543
Cdd:PHA03378  908 RRGVGPMHP--TDIPPSKRAKTDA 929
PRP40 COG5104
Splicing factor [RNA processing and modification];
19-95 3.37e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.69  E-value: 3.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   19 SRIPGSNTRLEWVEIIEPRTRERMYaNLVTGECVWDPPAGV---RIKRTSENQWWElFDPNTSRFYYYNASTQRTVWHRP 95
Cdd:COG5104    6 LGMASGEARSEWEELKAPDGRIYYY-NKRTGKSSWEKPKELlkgSEEDLDVDPWKE-CRTADGKVYYYNSITRESRWKIP 83
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 69-95 4.30e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 38.64  E-value: 4.30e-04
                           10        20
                   ....*....|....*....|....*..
gi 58331179     69 WWELFDPNtSRFYYYNASTQRTVWHRP 95
Cdd:pfam00397    5 WEERWDPD-GRVYYYNHETGETQWEKP 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 115-369 6.71e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 6.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   115 SPRASAESSPGRGSSV-----SREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE--KDYEIYR 187
Cdd:PHA03307  178 SPEETARAPSSPPAEPppstpPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgPENECPL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   188 DYSADGQLLHYRTSSLRWNSGAkermlikvADREPSFLAAQGNGYAPDGPPGVRSRRPSGSQHSPSLQTFAPEADGTiff 267
Cdd:PHA03307  258 PRPAPITLPTRIWEASGWNGPS--------SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS--- 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   268 PERRPSPFLKRAELPGSSSPL--LAQPRKPSGDSQPSSPRYGyePPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSP 345
Cdd:PHA03307  327 SSTSSSSESSRGAAVSPGPSPsrSPSPSRPPPPADPSSPRKR--PRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDAT 404

                         250       260
                  ....*....|....*....|....
gi 58331179   346 QRSPGRKPRPFLQPNKQGPPSPCQ 369
Cdd:PHA03307  405 GRFPAGRPRPSPLDAGAASGAFYA 428
 
Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 919-1104 6.70e-120

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 366.72  E-value: 6.70e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  919 FGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP-TGLEDPHVPASLL 997
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  998 KLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCL 1077
Cdd:cd04389   81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                        170       180
                 ....*....|....*....|....*..
gi 58331179 1078 RCQSDDPRVIFENTRKEMSFLRVLIQH 1104
Cdd:cd04389  161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 940-1081 1.72e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 155.01  E-value: 1.72e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179    940 PWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP---TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQ 1016
Cdd:pfam00620    1 PLIVRKCVEYLEK-RGLDTEGIFRVSGSASRIKELREAFDRGPDVdldLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58331179   1017 CI--AHYDSPEAAV----AVVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCQS 1081
Cdd:pfam00620   80 FIeaAKLPDEEERLealrELLRKLPPANRDTLRYLLAHLNRVAQ--NSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 940-1104 1.07e-40

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 147.83  E-value: 1.07e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  940 PWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE--DPHVPASLLKLWYRELEEPLIPHEFYEQC 1017
Cdd:cd00159    1 PLIIEKCIEYLEK-NGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEdyDVHDVASLLKLYLRELPEPLIPFELYDEF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1018 IAHYDSP------EAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCQSDDpRVIFENT 1091
Cdd:cd00159   80 IELAKIEdeeeriEALKELLKSLPPENRDLLKYLLKLLHKISQ--NSEVNKMTASNLAIVFAPTLLRPPDSD-DELLEDI 156

                        170
                 ....*....|...
gi 58331179 1092 RKEMSFLRVLIQH 1104
Cdd:cd00159  157 KKLNEIVEFLIEN 169
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 767-908 3.10e-32

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 459939  Cd Length: 105  Bit Score: 121.15  E-value: 3.10e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179    767 ALEVATKGWSVQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVndtkvtqhik 846
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADDP---------- 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58331179    847 ellerntkkksklrkkpkpyveepdGVAISTYAKYCYHKLQKAALTGAKKglKKPNVEEIRH 908
Cdd:pfam00784   71 -------------------------SREVGKYAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 954-1104 1.23e-31

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 121.99  E-value: 1.23e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179     954 NGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE---DPHVPASLLKLWYRELEEPLIPHEFYEQCI--AHYDSPEAAV 1028
Cdd:smart00324   17 RGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLseyDVHDVAGLLKLFLRELPEPLITYELYEEFIeaAKLEDETERL 96

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179    1029 AVVHA----LPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKeMSFLRVLIQH 1104
Cdd:smart00324   97 RALREllslLPPANRATLRYLLAHLNRVAE--HSEENKMTARNLAIVFGPTLLRPPDGEVASLKDIRHQ-NTVIEFLIEN 173
MyTH4 smart00139
Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 ...
 722-907 2.17e-26

Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 214535  Cd Length: 152  Bit Score: 105.91  E-value: 2.17e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179     722 WSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVAL--EVATKGWSVQGLRDELYIQLCRQTTENFRLE 799
Cdd:smart00139    1 YTKDPIKTSLLKLESDELQKEAVKIFKAILKFMGDIPLPRPDSHLDLvqFILQKGLDHPELRDEIYCQLIKQLTDNPSRQ 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179     800 SLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKvtqhikellerntkkksklrkkpkpyveepdgvaistYA 879
Cdd:smart00139   81 SEERGWQLLYLCTSLFPPSERLLPYLLQFLSRRADPGSEQG-------------------------------------LA 123

                           170       180
                    ....*....|....*....|....*...
gi 58331179     880 KYCYHKLQKAALTGAKKglKKPNVEEIR 907
Cdd:smart00139  124 KYCLYRLERTLKNGARK--QPPSRLELE 149
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 918-1104 4.15e-26

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 106.76  E-value: 4.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  918 MFGSALQEVMGMQReRYPERQLPWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPT--GLEDPHVPAS 995
Cdd:cd04390    2 VFGQRLEDTVAYER-KFGPRLVPILVEQCVDFIRE-HGLKEEGLFRLPGQANLVKQLQDAFDAGERPSfdSDTDVHTVAS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  996 LLKLWYRELEEPLIPHEFYEQ---CIAHYDSPEAA-----VAVVHALPRINRMVLCYLIRFLQVfVQpANVAVTKMDVSN 1067
Cdd:cd04390   80 LLKLYLRELPEPVIPWAQYEDflsCAQLLSKDEEKglgelMKQVSILPKVNYNLLSYICRFLDE-VQ-SNSSVNKMSVQN 157

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 58331179 1068 LAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQH 1104
Cdd:cd04390  158 LATVFGPNILRPKVEDPATIMEGTPQIQQLMTVMISK 194
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 919-1109 1.04e-20

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 91.25  E-value: 1.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  919 FGSALQEVmgmqRERYPERQ-LPWVqTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKvP---TGLEDPHVPA 994
Cdd:cd04404    6 FGVSLQFL----KEKNPEQEpIPPV-VRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGE-PvdfDQYEDVHLPA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  995 SLLKLWYRELEEPLIPHEFYE-----QCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFL-QVfvqPANVAVTKMDVSNL 1068
Cdd:cd04404   80 VILKTFLRELPEPLLTFDLYDdivgfLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLvQV---SAHSDQNKMTNSNL 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 58331179 1069 AMVMAPNCLRCQSDdprvifENTRKEM----SFLRVLIQHLDTSF 1109
Cdd:cd04404  157 AVVFGPNLLWAKDA------SMSLSAInpinTFTKFLLDHQDEIF 195
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 954-1113 2.13e-20

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 90.59  E-value: 2.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  954 NGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE----DPHVPASLLKLWYRELEEPLIPHEFYE---QCIAHYDSPE- 1025
Cdd:cd04386   34 TGMNEEGLFRVGGGASKLKRLKAALDAGTFSLPLDefysDPHAVASALKSYLRELPDPLLTYNLYEdwvQAANKPDEDEr 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1026 --AAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLrcqsddpRVIFENTRKEM-------- 1095
Cdd:cd04386  114 lqAIWRILNKLPRENRDNLRYLIKFLSKLAQ--KSDENKMSPSNIAIVLAPNLL-------WAKNEGSLAEMaagtsvhv 184

                        170
                 ....*....|....*....
gi 58331179 1096 -SFLRVLIQHLDTSFMEGV 1113
Cdd:cd04386  185 vAIVELIISHADWFFPGEV 203
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 918-1085 6.10e-18

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 83.93  E-value: 6.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  918 MFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQ--------WKVPTgled 989
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEE-RGLETEGILRIPGSAQRVKFLCQELEAkfyegtflWDQVK---- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  990 PHVPASLLKLWYRELEEPLIPHEFYEQCIA------HYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVqpANVAVTKM 1063
Cdd:cd04391   76 QHDAASLLKLFIRELPQPLLTVEYLPAFYSvqglpsKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVV--DHEEKNKM 153

                        170       180
                 ....*....|....*....|..
gi 58331179 1064 DVSNLAMVMAPNCLRCQSDDPR 1085
Cdd:cd04391  154 NLWNVAMIMAPNLFPPRGKHSK 175
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 938-1109 8.06e-17

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 79.87  E-value: 8.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  938 QLPWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGL-----EDPHVPASLLKLWYRELEEPLIPHE 1012
Cdd:cd04372   15 QRPMVVDMCIREIEA-RGLQSEGLYRVSGFAEEIEDVKMAFDRDGEKADIsatvyPDINVITGALKLYFRDLPIPVITYD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1013 FYEQCIA---HYDSPEAAVAVVHA---LPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCQSDDPRV 1086
Cdd:cd04372   94 TYPKFIDaakISNPDERLEAVHEAlmlLPPAHYETLRYLMEHLKRVTL--HEKDNKMNAENLGIVFGPTLMRPPEDSALT 171

                        170       180
                 ....*....|....*....|...
gi 58331179 1087 IFENTRKEMSFLRVLIQHLDTSF 1109
Cdd:cd04372  172 TLNDMRYQILIVQLLITNEDVLF 194
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 955-1109 2.04e-16

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 78.87  E-value: 2.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  955 GDQTEGIFRVPGDIDEVNALKLQVDQWK-VPT-GLEDPHVPASLLKLWYRELEEPLIP---HEFYEQCIAHYDSPEAAVA 1029
Cdd:cd04382   32 GLTEEGLYRVSGSEREVKALKEKFLRGKtVPNlSKVDIHVICGCLKDFLRSLKEPLITfalWKEFMEAAEILDEDNSRAA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1030 ---VVHALPRINRMVLCYLIRFLQVFVQ-PANvavtKMDVSNLAMVMAPNCLRCQSDDPR--VIFENTRKEMSFLRVLIq 1103
Cdd:cd04382  112 lyqAISELPQPNRDTLAFLILHLQRVAQsPEC----KMDINNLARVFGPTIVGYSVPNPDpmTILQDTVRQPRVVERLL- 186


                 ....*.
gi 58331179 1104 HLDTSF 1109
Cdd:cd04382  187 EIPSDY 192
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 955-1109 2.60e-16

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 78.60  E-value: 2.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  955 GDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDP-----HVPASLLKLWYRELEEPLIPHEFYEQCIAHyDSPEAAVA 1029
Cdd:cd04395   33 GLETVGIYRVPGNNAAISALQEELNRGGFDIDLQDPrwrdvNVVSSLLKSFFRKLPEPLFTNELYPDFIEA-NRIEDPVE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1030 -------VVHALPRINRMVLCYLIRFLQVFVqpANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLI 1102
Cdd:cd04395  112 rlkelrrLIHSLPDHHYETLKHLIRHLKTVA--DNSEVNKMEPRNLAIVFGPTLVRTSDDNMETMVTHMPDQCKIVETLI 189


                 ....*..
gi 58331179 1103 QHLDTSF 1109
Cdd:cd04395  190 QHYDWFF 196
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 958-1105 1.04e-15

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 77.13  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  958 TEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIP---HEFYEQCI---AHYDSPEAAVAVV 1031
Cdd:cd04394   37 TEGLFRKSGSVVRQKELKAKLEGGEACLSSALPCDVAGLLKQFFRELPEPLLPydlHEALLKAQelpTDEERKSATLLLT 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58331179 1032 HALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCqSDDPRVIFENTRKEMSFLRVLIQHL 1105
Cdd:cd04394  117 CLLPDEHVNTLRYFFSFLYDVAQ--RCSENKMDSSNLAVIFAPNLFQS-EEGGEKMSSSTEKRLRLQAAVVQTL 187
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 918-1082 1.26e-15

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 76.35  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  918 MFGSALQEVmgmQRERYPERQLPWVQTRLSEeVLALNGDQTEGIFRVPGDIDEVNALKLQVDQwKVPTGLE---DPHVPA 994
Cdd:cd04393    2 VFGVPLQEL---QQAGQPENGVPAVVRHIVE-YLEQHGLEQEGLFRVNGNAETVEWLRQRLDS-GEEVDLSkeaDVCSAA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  995 SLLKLWYRELEEPLIPHEFYE---QCIAHYDSPE----AAVAVVHALPRINRMVLCYLIRFLqvfvqpANVA----VTKM 1063
Cdd:cd04393   77 SLLRLFLQELPEGLIPASLQIrlmQLYQDYNGEDefgrKLRDLLQQLPPVNYSLLKFLCHFL------SNVAsqhhENRM 150

                        170
                 ....*....|....*....
gi 58331179 1064 DVSNLAMVMAPNCLRCQSD 1082
Cdd:cd04393  151 TAENLAAVFGPDVFHVYTD 169
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 950-1104 1.78e-15

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 75.80  E-value: 1.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  950 VLALNGDQTEGIFRVPGDIDEVNALKLQVDqwkvpTGLEDP------HVPASLLKLWYRELEEPLIPHEFYEQCIAHYDS 1023
Cdd:cd04402   25 LLYQKGPSTEGIFRRSANAKACKELKEKLN-----SGVEVDlkaepvLLLASVLKDFLRNIPGSLLSSDLYEEWMSALDQ 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1024 P------EAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLrCQSDDPRVIFENTRKEMSF 1097
Cdd:cd04402  100 EneeekiAELQRLLDKLPRPNVLLLKHLICVLHNISQ--NSETNKMDAFNLAVCIAPSLL-WPPASSELQNEDLKKVTSL 176


                 ....*..
gi 58331179 1098 LRVLIQH 1104
Cdd:cd04402  177 VQFLIEN 183
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 936-1084 2.68e-15

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 75.17  E-value: 2.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  936 ERQLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLED--PHVPASLLKLWYRELEEPLIPHEF 1013
Cdd:cd04377   12 DRSVPLVLEKLLEHI-EMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDypIHVITSVLKQWLRELPEPLMTFEL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1014 YEQCIAHYDSPE------AAVAVVHALPRINRMVLCYLIRFLqvfvqpANVA----VTKMDVSNLAMVMAPNCLRCQ-SD 1082
Cdd:cd04377   91 YENFLRAMELEEkqervrALYSVLEQLPRANLNTLERLIFHL------VRVAlqeeVNRMSANALAIVFAPCILRCPdTA 164


                 ..
gi 58331179 1083 DP 1084
Cdd:cd04377  165 DP 166
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 919-1078 2.30e-14

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 72.81  E-value: 2.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  919 FGSALQEVMgmQRERypeRQLPWVqTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQ----WKVPTGLEDPHVPA 994
Cdd:cd04403    1 FGCHLEALC--QREN---STVPKF-VRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHdeklDLDDSKWEDIHVIT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  995 SLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAV------VHALPRINRMVLCYLIRFLQVFVQPANvaVTKMDVSNL 1068
Cdd:cd04403   75 GALKLFFRELPEPLFPYSLFNDFVAAIKLSDYEQRVsavkdlIKSLPKPNHDTLKMLFRHLCRVIEHGE--KNRMTTQNL 152

                        170
                 ....*....|
gi 58331179 1069 AMVMAPNCLR 1078
Cdd:cd04403  153 AIVFGPTLLR 162
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 936-1110 1.82e-13

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 70.55  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  936 ERQLPwvqtRLSEEV---LALNGDQTEGIFRVPGDIDEVNALKLQVDQWKvPTGLED---PHVPASLLKLWYRELEEPLI 1009
Cdd:cd04376    6 ARQVP----RLVESCcqhLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGI-DVVLDEnhsVHDVAALLKEFFRDMPDPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1010 PHEFYE-----QCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPAN---------VAVTKMDVSNLAMVMAPN 1075
Cdd:cd04376   81 PRELYTafigtALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAAdsidedgqeVSGNKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 58331179 1076 CLRCQSDDPRVI------FENTRKEMSFLRVLIQHLDTSFM 1110
Cdd:cd04376  161 LLHKQKSGEREFvqaslrIEESTAIINVVQTMIDNYEELFM 201
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 949-1083 4.42e-13

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 68.97  E-value: 4.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  949 EVLALNGDQTEGIFRVPGDIDEVNALKLQVDqwKVPTG---------LEDPHVPASLLKLWYRELEEPLIPHEFYEQCI- 1018
Cdd:cd04398   25 QAIENFGLNLEGIYRLSGNVSRVNKLKELFD--KDPLNvllispedyESDIHSVASLLKLFFRELPEPLLTKALSREFIe 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1019 -AHYDSP----EAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCQSDD 1083
Cdd:cd04398  103 aAKIEDEsrrrDALHGLINDLPDANYATLRALMFHLARIKE--HESVNRMSVNNLAIIWGPTLMNAAPDN 170
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 912-1108 5.71e-13

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 69.29  E-value: 5.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  912 AVFSPSMFGSALQEVMGMQR--ERYPERQL------PWVQTRLS---E-----EVLALNGDQTEGIFRVPGDIDEVNALK 975
Cdd:cd04380    6 GVYLPSCFGSSLETLIRLPDpgIRNLIDQLelgdnpDYSEVPLSipkEiwrlvDYLYTRGLAQEGLFEEPGLPSEPGELL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  976 LQV----DQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYDSP-EAAVAVV-HALPRINRMVLCYLIRFL 1049
Cdd:cd04380   86 AEIrdalDTGSPFNSPGSAESVAEALLLFLESLPDPIIPYSLYERLLEAVANNeEDKRQVIrISLPPVHRNVFVYLCSFL 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 58331179 1050 QVFVqpANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSflRVLIQHLDTS 1108
Cdd:cd04380  166 RELL--SESADRGLDENTLATIFGRVLLRDPPRAGGKERRAERDRKR--AFIEQFLLND 220
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 950-1078 2.49e-12

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 66.68  E-value: 2.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  950 VLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP-TGLEDPH---VPASLLKLWYRELEEPLIPHEFYEQCI--AHYDS 1023
Cdd:cd04383   28 FINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPlADDQNDHdinSVAGVLKLYFRGLENPLFPKERFEDLMscVKLEN 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 58331179 1024 PEAAV----AVVHALPRINRMVLCYLIRFLQVFVQPANVAVtkMDVSNLAMVMAPNCLR 1078
Cdd:cd04383  108 PTERVhqirEILSTLPRSVIIVMRYLFAFLNHLSQFSDENM--MDPYNLAICFGPTLMP 164
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 928-1078 5.00e-12

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 66.10  E-value: 5.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  928 GMQRERypeRQLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALK--LQVDQWKVPTGLEDPHVPA--SLLKLWYRE 1003
Cdd:cd04387    8 VTKRER---SKVPYIVRQCVEEV-ERRGMEEVGIYRISGVATDIQALKaaFDTNNKDVSVMLSEMDVNAiaGTLKLYFRE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1004 LEEPLIPHEFYEQCIAHYDSPEAAV------AVVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCL 1077
Cdd:cd04387   84 LPEPLFTDELYPNFAEGIALSDPVAkescmlNLLLSLPDPNLVTFLFLLHHLKRVAE--REEVNKMSLHNLATVFGPTLL 161


                 .
gi 58331179 1078 R 1078
Cdd:cd04387  162 R 162
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 939-1103 7.14e-12

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 65.40  E-value: 7.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  939 LPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALK--LQVDQWKVPtgLED-P-HVPASLLKLWYRELEEPLIPHEFY 1014
Cdd:cd04407   15 VPIVLEKLLEHV-EMHGLYTEGIYRKSGSANRMKELHqlLQADPENVK--LENyPiHAITGLLKQWLRELPEPLMTFAQY 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1015 EQCIAHYDSPE------AAVAVVHALPRINRMVLCYLIRFLqvfVQPANVA-VTKMDVSNLAMVMAPNCLRC-QSDDPRV 1086
Cdd:cd04407   92 NDFLRAVELPEkqeqlqAIYRVLEQLPTANHNTLERLIFHL---VKVALEEdVNRMSPNALAIVFAPCLLRCpDSSDPLT 168

                        170
                 ....*....|....*..
gi 58331179 1087 IFENTRKEMSFLRVLIQ 1103
Cdd:cd04407  169 SMKDVAKTTTCVEMLIK 185
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 919-1074 5.64e-11

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 62.76  E-value: 5.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  919 FGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQ----VDQWKVPTGLE-DPHVP 993
Cdd:cd04400    2 FGSPLEEAVELSSHKYNGRDLPSVVYRCIEYLDKNRAIYEEGIFRLSGSASVIKQLKERfnteYDVDLFSSSLYpDVHTV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  994 ASLLKLWYRELEEPLIP---HEFYEQCIAHYDSPEAAVA----VVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVS 1066
Cdd:cd04400   82 AGLLKLYLRELPTLILGgelHNDFKRLVEENHDRSQRALelkdLVSQLPQANYDLLYVLFSFLRKIIE--HSDVNKMNLR 159


                 ....*...
gi 58331179 1067 NLAMVMAP 1074
Cdd:cd04400  160 NVCIVFSP 167
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 959-1107 6.07e-11

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 63.15  E-value: 6.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  959 EGIFRVPGDIDEVNALKLQVDqwKVPTGLED-----PHVPASLLKLWYRELEEPLIPHEFYEQCI--AHYDSPEAAVAVV 1031
Cdd:cd04397   46 EGVFRKNGNIRRLKELTEEID--KNPTEVPDlskenPVQLAALLKKFLRELPDPLLTFKLYRLWIssQKIEDEEERKRVL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1032 H----ALPRINRMVLCYLIRFLQ---VFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPrvifeNTRKEmSFLRV---- 1100
Cdd:cd04397  124 HlvycLLPKYHRDTMEVLFSFLKwvsSFSHIDEETGSKMDIHNLATVITPNILYSKTDNP-----NTGDE-YFLAIeavn 197


                 ....*...
gi 58331179 1101 -LIQHLDT 1107
Cdd:cd04397  198 yLIENNEE 205
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 929-1102 3.35e-10

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 60.40  E-value: 3.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  929 MQRERYPERQLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLED--PHVPASLLKLWYRELEE 1006
Cdd:cd04406    5 LSRLTSEDRSVPLVVEKLINYI-EMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDynIHVIASVFKQWLRDLPN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1007 PLIPHEFYEQ---CIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPA-NVAVTKMDVSNLAMVMAPNCLRC-QS 1081
Cdd:cd04406   84 PLMTFELYEEflrAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIAlQEETNRMSANALAIVFAPCILRCpDT 163

                        170       180
                 ....*....|....*....|.
gi 58331179 1082 DDPRVIFENTRKEMSFLRVLI 1102
Cdd:cd04406  164 TDPLQSVQDISKTTTCVELIV 184
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 954-1106 4.91e-10

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 60.89  E-value: 4.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  954 NGDQTEGIFRVPGDIDEVNALKLQVDqwKVP---TGLEDP----HVPASLLKLWYRELEEPLIPHEFYEQ---------C 1017
Cdd:cd04396   46 NATEVEGIFRVAGSSKRIRELQLIFS--TPPdygKSFDWDgytvHDAASVLRRYLNNLPEPLVPLDLYEEfrnplrkrpR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1018 IAHYDSP----------EAAV----AVVHALPRINRMVLCYLIRFLQVFVqpANVAVTKMDVSNLAMVMAPNCLRCQSDD 1083
Cdd:cd04396  124 ILQYMKGrineplntdiDQAIkeyrDLITRLPNLNRQLLLYLLDLLAVFA--RNSDKNLMTASNLAAIFQPGILSHPDHE 201

                        170       180
                 ....*....|....*....|...
gi 58331179 1084 prVIFENTRKEMSFLRVLIQHLD 1106
Cdd:cd04396  202 --MDPKEYKLSRLVVEFLIEHQD 222
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 959-1078 6.36e-10

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 59.82  E-value: 6.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  959 EGIFRVPGDIDEVNALKLQVDQWKVP-----TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCI--AHYDSPEAAVAVV 1031
Cdd:cd04384   36 DGIYRLSGIASNIQRLRHEFDSEQIPdltkdVYIQDIHSVSSLCKLYFRELPNPLLTYQLYEKFSeaVSAASDEERLEKI 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 58331179 1032 H----ALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLR 1078
Cdd:cd04384  116 HdviqQLPPPHYRTLEFLMRHLSRLAK--YCSITNMHAKNLAIVWAPNLLR 164
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 955-1074 1.64e-09

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 58.22  E-value: 1.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  955 GDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE-DPHVPASLLKLWYRELEEPLIPHEF---YEQCIAHYDSPEAAVAV 1030
Cdd:cd04381   35 GMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEyEPPTVASLLKQYLRELPEPLLTKELmprFEEACGRPTEAEREQEL 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 58331179 1031 VH---ALPRINRMVLCYLIRFLQVFVQPAnvAVTKMDVSNLAMVMAP 1074
Cdd:cd04381  115 QRllkELPECNRLLLAWLIVHMDHVIAQE--LETKMNIQNISIVLSP 159
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 949-1082 2.21e-09

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 58.56  E-value: 2.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  949 EVLALNGDQTEGIFRVPGDIDEVNAL-KLQVDQWKV-PTGLEDPHVP------ASLLKLWYRELEEPLIPHEFYEQCI-- 1018
Cdd:cd04374   37 EAVETRGINEQGLYRVVGVNSKVQKLlSLGLDPKTStPGDVDLDNSEweiktiTSALKTYLRNLPEPLMTYELHNDFIna 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58331179 1019 AHYDSPEAAV----AVVHALPRINRMVLCYLIRFLqvfvqpANVAV----TKMDVSNLAMVMAPNCLRCQSD 1082
Cdd:cd04374  117 AKSENLESRVnaihSLVHKLPEKNREMLELLIKHL------TNVSDhskkNLMTVSNLGVVFGPTLLRPQEE 182
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 955-1104 6.63e-09

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 56.55  E-value: 6.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  955 GDQTEGIFRVPGDIDEVNAL--KLQVDQWKVP--TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYDSP------ 1024
Cdd:cd04385   30 GLMSEGIYRKNGKNSSVKKLleAFRKDARSVQlrEGEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELEnkderi 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1025 EAAVAVVHALPRINRMVLCYLIRFLqVFVQpANVAVTKMDVSNLAMVMAPnCLrCQSDDPRVifENTRKEMSFLRVLIQH 1104
Cdd:cd04385  110 ARYKELIRRLPPINRATLKVLIGHL-YRVQ-KHSDENQMSVHNLALVFGP-TL-FQTDEHSV--GQTSHEVKVIEDLIDN 183
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 917-1074 7.30e-09

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 57.43  E-value: 7.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  917 SMFGSALqeVMGMQRERYPerqLPwVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHV--PA 994
Cdd:cd04375    3 NVFGVPL--LVNLQRTGQP---LP-RSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAydVA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  995 SLLKLWYRELEEPLIPHEFYE------QCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVqpANVAVTKMDVSNL 1068
Cdd:cd04375   77 DMLKQYFRDLPEPLLTNKLSEtfiaifQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVA--ANSQENQMTATNL 154


                 ....*.
gi 58331179 1069 AMVMAP 1074
Cdd:cd04375  155 AVCLAP 160
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 927-1078 1.14e-07

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 53.23  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  927 MGMQRERYPERQLPWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKvPTGLEDPHVP----ASLLKLWYR 1002
Cdd:cd04373    3 VPLANVVTSEKPIPIFLEKCVEFIEA-TGLETEGIYRVSGNKTHLDSLQKQFDQDH-NLDLVSKDFTvnavAGALKSFFS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1003 ELEEPLIP---HEFYEQCIAHYDSPEAAVA---VVHALPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNC 1076
Cdd:cd04373   81 ELPDPLIPysmHLELVEAAKINDREQRLHAlkeLLKKFPPENFDVFKYVITHLNKVSQ--NSKVNLMTSENLSICFWPTL 158


                 ..
gi 58331179 1077 LR 1078
Cdd:cd04373  159 MR 160
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 919-1085 4.08e-07

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 51.70  E-value: 4.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  919 FGSALQEVMgmQRERyPERQLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVP----- 993
Cdd:cd04379    1 FGVPLSRLV--EREG-ESRDVPIVLQKCVQEI-ERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPdinvi 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  994 ASLLKLWYRELEEPLIPHEFYEQCI--AHYDSP-------EAAVAVVHALPRINRMVLCYLIRFLQVFVqpANVAVTKMD 1064
Cdd:cd04379   77 TGVLKDYLRELPEPLITPQLYEMVLeaLAVALPndvqtntHLTLSIIDCLPLSAKATLLLLLDHLSLVL--SNSERNKMT 154

                        170       180
                 ....*....|....*....|.
gi 58331179 1065 VSNLAMVMAPNCLRCQSDDPR 1085
Cdd:cd04379  155 PQNLAVCFGPVLMFCSQEFSR 175
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 930-1078 3.58e-06

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 49.04  E-value: 3.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  930 QRERYPERQLPWVQTRLSEEVLALNGDQtEGIFRVPGDIDEVNALKLQVDQWKVPTGLED--PHVPASLLKLWYRELEEP 1007
Cdd:cd04408    7 QLPRDFPEEVPFVVVRCTAEIENRALGV-QGIYRISGSKARVEKLCQAFENGRDLVDLSGhsPHDITSVLKHFLKELPEP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1008 LIPHEFYEQCIA-----------HYDSPEAAVAVVHA-------LPRINRMVLCYLIRFLqvFVQPANVAVTKMDVSNLA 1069
Cdd:cd04408   86 VLPFQLYDDFIAlakelqrdsekAAESPSIVENIIRSlkellgrLPVSNYNTLRHLMAHL--YRVAERFEDNKMSPNNLG 163


                 ....*....
gi 58331179 1070 MVMAPNCLR 1078
Cdd:cd04408  164 IVFGPTLLR 172
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 930-1078 5.74e-06

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 48.57  E-value: 5.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  930 QRERYPERQLPWVQTRLSEEV--LALNgdqTEGIFRVPGDIDEVNAL-------KLQVDqwkvptgLED--PHVPASLLK 998
Cdd:cd04378    7 QVPRDFPDEVPFIIKKCTSEIenRALG---VQGIYRVSGSKARVEKLcqafengKDLVE-------LSElsPHDISSVLK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  999 LWYRELEEPLIPHEFYEQCIA-------------HYDSPEAAVAVVHA-------LPRINRMVLCYLIRFLQVFVQPANv 1058
Cdd:cd04378   77 LFLRQLPEPLILFRLYNDFIAlakeiqrdteedkAPNTPIEVNRIIRKlkdllrqLPASNYNTLQHLIAHLYRVAEQFE- 155

                        170       180
                 ....*....|....*....|
gi 58331179 1059 aVTKMDVSNLAMVMAPNCLR 1078
Cdd:cd04378  156 -ENKMSPNNLGIVFGPTLIR 174
PHA03378 PHA03378
EBNA-3B; Provisional
 245-543 1.43e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.30  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   245 PSGSQHS--PSLQTFAPEADGtiffPERRPSPFLKRAELPGSSSPL-LAQPRKPSGDSQPSSPRYGYEPPLYEEPPVEYQ 321
Cdd:PHA03378  600 PHPSQTPepPTTQSHIPETSA----PRQWPMPLRPIPMRPLRMQPItFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQ 675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   322 ----------------------------APIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQGPPSPCQQLVL 373
Cdd:PHA03378  676 psptgantmlpiqwapgtmqpppraptpMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR 755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   374 TKQKCPERFLSLEYSPAGKEYVRQlvyvEQAGSSPKLRAGPRHKYAPNPGGGSYSLQPSPCLLRDQR------------L 441
Cdd:PHA03378  756 PPAAAPGRARPPAAAPGAPTPQPP----PQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQgptkqilrqlltG 831

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   442 GVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQDTLSSTGYSPGTRKRKSRKPSLCQATSAT--PTEGPGdllvE 519
Cdd:PHA03378  832 GVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGSVRAAAASTVTqaPTEYTG----E 907

                         330       340
                  ....*....|....*....|....
gi 58331179   520 QPLAEEQPPcgTSLAPVKRAEGEA 543
Cdd:PHA03378  908 RRGVGPMHP--TDIPPSKRAKTDA 929
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 958-1104 2.55e-05

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 46.69  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  958 TEGIFRVPGDIDEVNALKLQVDQwKVPTGLED----PHVPASLLKLWYRELEEPLIPHEFYeqcIAHYDSPEAAVAVVHA 1033
Cdd:cd04392   26 VEGLFRKPGNSARQQELRDLLNS-GTDLDLESggfhAHDCATVLKGFLGELPEPLLTHAHY---PAHLQIADLCQFDEKG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1034 ---------------------LPRINRMVLCYLIRFLQVFVQpaNVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTR 1092
Cdd:cd04392  102 nktsapdkerllealqlllllLPEENRNLLKLILDLLYQTAK--HEDKNKMSADNLALLFTPHLICPRNLTPEDLHENAQ 179

                        170
                 ....*....|..
gi 58331179 1093 KEMSFLRVLIQH 1104
Cdd:cd04392  180 KLNSIVTFMIKH 191
PRP40 COG5104
Splicing factor [RNA processing and modification];
19-95 3.37e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.69  E-value: 3.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   19 SRIPGSNTRLEWVEIIEPRTRERMYaNLVTGECVWDPPAGV---RIKRTSENQWWElFDPNTSRFYYYNASTQRTVWHRP 95
Cdd:COG5104    6 LGMASGEARSEWEELKAPDGRIYYY-NKRTGKSSWEKPKELlkgSEEDLDVDPWKE-CRTADGKVYYYNSITRESRWKIP 83
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 69-95 4.30e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 38.64  E-value: 4.30e-04
                           10        20
                   ....*....|....*....|....*..
gi 58331179     69 WWELFDPNtSRFYYYNASTQRTVWHRP 95
Cdd:pfam00397    5 WEERWDPD-GRVYYYNHETGETQWEKP 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 115-369 6.71e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 6.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   115 SPRASAESSPGRGSSV-----SREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE--KDYEIYR 187
Cdd:PHA03307  178 SPEETARAPSSPPAEPppstpPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgPENECPL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   188 DYSADGQLLHYRTSSLRWNSGAkermlikvADREPSFLAAQGNGYAPDGPPGVRSRRPSGSQHSPSLQTFAPEADGTiff 267
Cdd:PHA03307  258 PRPAPITLPTRIWEASGWNGPS--------SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS--- 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   268 PERRPSPFLKRAELPGSSSPL--LAQPRKPSGDSQPSSPRYGyePPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSP 345
Cdd:PHA03307  327 SSTSSSSESSRGAAVSPGPSPsrSPSPSRPPPPADPSSPRKR--PRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDAT 404

                         250       260
                  ....*....|....*....|....
gi 58331179   346 QRSPGRKPRPFLQPNKQGPPSPCQ 369
Cdd:PHA03307  405 GRFPAGRPRPSPLDAGAASGAFYA 428
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 233-380 2.20e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   233 APDG-PPGVRSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSP--FLKRAELPGSSSPLLAQPRKPSGDS--QPSSPRYG 307
Cdd:PRK10263  376 APEGyPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQpyYAPAPEQPAQQPYYAPAPEQPVAGNawQAEEQQST 455

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58331179   308 YEPPLYEEPPVEYQAPIYDEP----PMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQGPPSPCQQLVLTKQKCPE 380
Cdd:PRK10263  456 FAPQSTYQTEQTYQQPAAQEPlyqqPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREQLAAWYQPIPE 532
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 970-1111 2.66e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 40.39  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179  970 EVNALKLQVDQWKVP-------TGLEDPHVpASLLKLWYRELEEPLIPHEFYEQCIAHY--------DSPEAAVAVVHA- 1033
Cdd:cd04399   52 ETHQLRNLLNKPKKPdkeviilKKFEPSTV-ASVLKLYLLELPDSLIPHDIYDLIRSLYsayppsqeDSDTARIQGLQSt 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179 1034 ---LPRINRMVLCYLIRFLQVFVQpanvaVTKM------DVSNLAMVMAPNCLRCQSDDPRVIfeNTRKEMSFLRVLIQH 1104
Cdd:cd04399  131 lsqLPKSHIATLDAIITHFYRLIE-----ITKMgeseeeYADKLATSLSREILRPIIESLLTI--GDKHGYKFFRDLLTH 203


                 ....*..
gi 58331179 1105 LDTSFME 1111
Cdd:cd04399  204 KDQIFSE 210
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 102-365 8.26e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 8.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   102 PLAKLQTLKQNTESPRASAESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPgvflek 181
Cdd:PHA03307  258 PRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS------ 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   182 dyeiyRDYSADGQLLHYRTSSLRWNSGAKERmlikvADREPSFLAAQGNGYAPDGPPGVRSRRPSGSQHSPSLQTFAPEA 261
Cdd:PHA03307  332 -----SSESSRGAAVSPGPSPSRSPSPSRPP-----PPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRR 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   262 DGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQPSSP-------RYG----YEPPLYEEPPVEYQAPIYDEPPM 330
Cdd:PHA03307  402 DATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPppppgrvRYGglgdSRPGLWDAPEVREAAARYEASPG 481

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 58331179   331 DVQFEAGggyQAGSPQR----------SPGRKPRPFLQPNKQGPP 365
Cdd:PHA03307  482 PVPVYVP---EMGDSAKqyaalvrllyTPDREAMGWLQNPKLTGP 523
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-484 9.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   116 PRASAESSPGRGSSVSREGSTSSSLEPEPdteKAQELPARAGRPAAFGTVKEDSGSSSPPgvflekdyEIYRDYSADGQL 195
Cdd:PHA03247 2593 PQSARPRAPVDDRGDPRGPAPPSPLPPDT---HAPDPPPPSPSPAANEPDPHPPPTVPPP--------ERPRDDPAPGRV 2661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   196 -LHYRTSSL-----------RWNSGAKERMLIKVADR----------EPSFLAAQGNGYAPDGPPGVRSRRPSGS-QHSP 252
Cdd:PHA03247 2662 sRPRRARRLgraaqassppqRPRRRAARPTVGSLTSLadpppppptpEPAPHALVSATPLPPGPAAARQASPALPaAPAP 2741

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   253 SLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPR--KPSGDSQPSSPRYGYEPPLYEEPPVEYQAPIYDEPPm 330
Cdd:PHA03247 2742 PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRltRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP- 2820

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   331 dVQFEAGGGYQAGSPQRSPGRKPRPFLQP--------------NKQGPPSPCQQLVLTKQKCPERFL----------SLE 386
Cdd:PHA03247 2821 -AASPAGPLPPPTSAQPTAPPPPPGPPPPslplggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLarpavsrsteSFA 2899

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   387 YSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAPNPGGgsyslQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQP----- 461
Cdd:PHA03247 2900 LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP-----RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPgrvav 2974

                         410       420
                  ....*....|....*....|....*...
gi 58331179   462 -----PTPLPQAQEDAMSWSSQQDTLSS 484
Cdd:PHA03247 2975 prfrvPQPAPSREAPASSTPPLTGHSLS 3002
PHA03247 PHA03247
large tegument protein UL36; Provisional
 283-557 9.75e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 9.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   283 GSSSPLLAQPRKPSGDSQPSSPRYGYEPPlyeEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQ 362
Cdd:PHA03247 2550 DPPPPLPPAAPPAAPDRSVPPPRPAPRPS---EPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   363 GPPSPC----QQLVLTKQKCPERFLSLEYSPAGK----EYVRQLVYVEQAGSSPKlraGPRHKYAPNPGGGSYSLQ--PS 432
Cdd:PHA03247 2627 PPPSPSpaanEPDPHPPPTVPPPERPRDDPAPGRvsrpRRARRLGRAAQASSPPQ---RPRRRAARPTVGSLTSLAdpPP 2703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331179   433 PCLLRDQRLGVKSGDYSTMEGPEL-RHSQPPTPLPQAQEDAmswssqqdtlSSTGYSPGTRKRKSRKPSLCQATSATPTE 511
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAaRQASPALPAAPAPPAV----------PAGPATPGGPARPARPPTTAGPPAPAPPA 2773

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 58331179   512 GPgdllVEQPLAEEQPPCGTSLAPVKRAEGEAEGARGAAEPFLAQA 557
Cdd:PHA03247 2774 AP----AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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