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Conserved domains on  [gi|124286820|ref|NP_080944|]
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leucine-rich repeat and IQ domain-containing protein 4 isoform 1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18077502)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
182-534 3.51e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 3.51e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 182 LFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVASNhlms 261
Cdd:COG4886   31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 262 lpESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINL 341
Cdd:COG4886  107 --EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 342 RFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLLSFPeEIFSLISLEKLYIGqdqGS 421
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLS---NN 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 422 KLSSLPEnIKRLMNLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNLLCCLPENLDH 501
Cdd:COG4886  261 QLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                        330       340       350
                 ....*....|....*....|....*....|...
gi 124286820 502 LVNLKVLTLMNNPMVDPPIYVCNQGNEAIWKHL 534
Cdd:COG4886  340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
IQCG cd23766
IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory ...
 534-573 1.30e-09

IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory complex protein 9 (DRC9), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The expression of IQCG is reduced in the sperm of human asthenospermia patients whose sperm have reduced mobility. It has also been shown to have a role in the calmodulin-mediated calcium signaling pathway in zebrafish haematopoietic development. The human IQCG gene was first reported to be involved in chromosome translocation in a case of acute lymphoid/myeloid leukemia. It expresses predominantly at mice testis during spermatogenesis which interacts with calmodulin in a calcium-dependent manner in the mouse testis. IQCG knockout mice are sterile due to the total immobility of their spermatozoa.


:

Pssm-ID: 467744  Cd Length: 40  Bit Score: 53.71  E-value: 1.30e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 124286820 534 LKENRIRKMMATTIQAWWRGIMVRKGYGSYeellKARKKG 573
Cdd:cd23766    4 KEQEELELRAAIKIQAWWRGIMVRKGLGPF----KKKKKK 39
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-306 3.60e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  45 EHLPKVLQKKEPhQLTDRTFfidgSNQGLKTIPSEILALKELEEVHLENNQIAEIPQG----IQQLQNT---KVLYLHNN 117
Cdd:cd00116   17 ELLPKLLCLQVL-RLEGNTL----GEEAAKALASALRPQPSLKELCLSLNETGRIPRGlqslLQGLTKGcglQELDLSDN 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 118 SLQ-DLCPELGALsslesldlsgnpLVISSLHVVSrlrtLRELRLYRTGLTEIPTGICKSLHHLELFGLSENFL-----E 191
Cdd:cd00116   92 ALGpDGCGVLESL------------LRSSSLQELK----LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLegascE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 192 SLPEEIVNQTKLREIYLKQNH-----FEVFPCDLCVLYNLEVIDLDENKLKSIpGDIghlvrlqkfyvasnhlmSLPESL 266
Cdd:cd00116  156 ALAKALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLTDE-GAS-----------------ALAETL 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 124286820 267 SQCSKLSVLDLTHNSIHS------LPSSLELLTELTEVGLSGNRLE 306
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDIT 263
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
182-534 3.51e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 3.51e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 182 LFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVASNhlms 261
Cdd:COG4886   31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 262 lpESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINL 341
Cdd:COG4886  107 --EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 342 RFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLLSFPeEIFSLISLEKLYIGqdqGS 421
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLS---NN 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 422 KLSSLPEnIKRLMNLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNLLCCLPENLDH 501
Cdd:COG4886  261 QLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                        330       340       350
                 ....*....|....*....|....*....|...
gi 124286820 502 LVNLKVLTLMNNPMVDPPIYVCNQGNEAIWKHL 534
Cdd:COG4886  340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-492 6.69e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.98  E-value: 6.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  50 VLQKKEPHQLTDRT---FFIDGSNQGLKTIPSEILALKELEEVHL-ENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPe 125
Cdd:PLN00113 175 VLVGKIPNSLTNLTsleFLTLASNQLVGQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIP- 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 126 lgalsslesldlsgnplviSSLHVVSRLRTLRELRLYRTGltEIPTGICkSLHHLELFGLSENFLESLPEEIVNQtklre 205
Cdd:PLN00113 254 -------------------SSLGNLKNLQYLFLYQNKLSG--PIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQ----- 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 206 iylkqnhfevfpcdlcvLYNLEVIDLDENKLK-SIPGDIGHLVRLQKFYVASNHLM-SLPESLSQCSKLSVLDLTHNSIH 283
Cdd:PLN00113 307 -----------------LQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLT 369

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 284 S-LPSSLELLTELTEVGLSGNRLE-KVPRLLCSWVSLHLLYLRNTSLHG-LRDSFKRLINLRFLDLSQNHIE-HFPVQIC 359
Cdd:PLN00113 370 GeIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQgRINSRKW 449

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 360 ALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLL-SFPEEIFSLISLEKLYIGQDQGSklSSLPENIKRLMNLKE 438
Cdd:PLN00113 450 DMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVS 527

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124286820 439 LYIENNRLE-QLPASLGLMPNLEVLDCRHNLLK-QLPDAICRTRNLRELLLEDNLL 492
Cdd:PLN00113 528 LDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 344-521 3.38e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 3.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 344 LDLSQNHIEHFPVqICALKNLEILALDDNKVRQLPpSISLLSNLKILGLTGNDLLSFpEEIFSLISLEKLYIGQDQGSKL 423
Cdd:cd21340    7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 424 sslpENIKRLMNLKELYIENNRL---EQL---PASL-GLMPNLEVLDCRHNLLKQLPDAICrTRNLRELLLEDNLLCCLP 496
Cdd:cd21340   84 ----EGLENLTNLEELHIENQRLppgEKLtfdPRSLaALSNSLRVLNISGNNIDSLEPLAP-LRNLEQLDASNNQISDLE 158

                        170       180
                 ....*....|....*....|....*...
gi 124286820 497 ENLD---HLVNLKVLTLMNNPMVDPPIY 521
Cdd:cd21340  159 ELLDllsSWPSLRELDLTGNPVCKKPKY 186
IQCG cd23766
IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory ...
 534-573 1.30e-09

IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory complex protein 9 (DRC9), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The expression of IQCG is reduced in the sperm of human asthenospermia patients whose sperm have reduced mobility. It has also been shown to have a role in the calmodulin-mediated calcium signaling pathway in zebrafish haematopoietic development. The human IQCG gene was first reported to be involved in chromosome translocation in a case of acute lymphoid/myeloid leukemia. It expresses predominantly at mice testis during spermatogenesis which interacts with calmodulin in a calcium-dependent manner in the mouse testis. IQCG knockout mice are sterile due to the total immobility of their spermatozoa.


Pssm-ID: 467744  Cd Length: 40  Bit Score: 53.71  E-value: 1.30e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 124286820 534 LKENRIRKMMATTIQAWWRGIMVRKGYGSYeellKARKKG 573
Cdd:cd23766    4 KEQEELELRAAIKIQAWWRGIMVRKGLGPF----KKKKKK 39
LRR_8 pfam13855
Leucine rich repeat;
435-492 7.69e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  435 NLKELYIENNRLEQLPASLGL-MPNLEVLDCRHNLLKQL-PDAICRTRNLRELLLEDNLL 492
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 45-306 3.60e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  45 EHLPKVLQKKEPhQLTDRTFfidgSNQGLKTIPSEILALKELEEVHLENNQIAEIPQG----IQQLQNT---KVLYLHNN 117
Cdd:cd00116   17 ELLPKLLCLQVL-RLEGNTL----GEEAAKALASALRPQPSLKELCLSLNETGRIPRGlqslLQGLTKGcglQELDLSDN 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 118 SLQ-DLCPELGALsslesldlsgnpLVISSLHVVSrlrtLRELRLYRTGLTEIPTGICKSLHHLELFGLSENFL-----E 191
Cdd:cd00116   92 ALGpDGCGVLESL------------LRSSSLQELK----LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLegascE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 192 SLPEEIVNQTKLREIYLKQNH-----FEVFPCDLCVLYNLEVIDLDENKLKSIpGDIghlvrlqkfyvasnhlmSLPESL 266
Cdd:cd00116  156 ALAKALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLTDE-GAS-----------------ALAETL 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 124286820 267 SQCSKLSVLDLTHNSIHS------LPSSLELLTELTEVGLSGNRLE 306
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDIT 263
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 540-560 6.73e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 34.22  E-value: 6.73e-03
                           10        20
                   ....*....|....*....|.
gi 124286820   540 RKMMATTIQAWWRGIMVRKGY 560
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKRY 22
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
182-534 3.51e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 3.51e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 182 LFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVASNhlms 261
Cdd:COG4886   31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 262 lpESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINL 341
Cdd:COG4886  107 --EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 342 RFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLLSFPeEIFSLISLEKLYIGqdqGS 421
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLS---NN 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 422 KLSSLPEnIKRLMNLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNLLCCLPENLDH 501
Cdd:COG4886  261 QLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                        330       340       350
                 ....*....|....*....|....*....|...
gi 124286820 502 LVNLKVLTLMNNPMVDPPIYVCNQGNEAIWKHL 534
Cdd:COG4886  340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-513 8.02e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 8.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 180 LELFGLSENFLESLPEEIVNQTKLREIYLKQNhfevfpCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVASNHL 259
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 260 MSLPESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLI 339
Cdd:COG4886  149 TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLT 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 340 NLRFLDLSQNHIEHFPvQICALKNLEILALDDNKVRQLPPSISLlSNLKILGLTGNDLlsfpeeifSLISLEKLYIGQDQ 419
Cdd:COG4886  229 NLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQL--------TDLKLKELELLLGL 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 420 GSKLSSLPENIKRLMNLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNLLCCLPENL 499
Cdd:COG4886  299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378

                        330
                 ....*....|....
gi 124286820 500 DHLVNLKVLTLMNN 513
Cdd:COG4886  379 LLTLALLLLTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-500 2.27e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.81  E-value: 2.27e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 176 SLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVA 255
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 256 SNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPrllcswvslhllylrntslhglrdSF 335
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP------------------------EL 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 336 KRLINLRFLDLSQNHIEHFPvQICALKNLEILALDDNKVRQLP----PSISLLSNLKILGLTGNDLLSFPEEIFSLISLE 411
Cdd:COG4886  247 GNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 412 KLYIGQDQGSKLSSLPENIKRLMNLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNL 491
Cdd:COG4886  326 LLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405


                 ....*....
gi 124286820 492 LCCLPENLD 500
Cdd:COG4886  406 ALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-492 6.69e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.98  E-value: 6.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  50 VLQKKEPHQLTDRT---FFIDGSNQGLKTIPSEILALKELEEVHL-ENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPe 125
Cdd:PLN00113 175 VLVGKIPNSLTNLTsleFLTLASNQLVGQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIP- 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 126 lgalsslesldlsgnplviSSLHVVSRLRTLRELRLYRTGltEIPTGICkSLHHLELFGLSENFLESLPEEIVNQtklre 205
Cdd:PLN00113 254 -------------------SSLGNLKNLQYLFLYQNKLSG--PIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQ----- 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 206 iylkqnhfevfpcdlcvLYNLEVIDLDENKLK-SIPGDIGHLVRLQKFYVASNHLM-SLPESLSQCSKLSVLDLTHNSIH 283
Cdd:PLN00113 307 -----------------LQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLT 369

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 284 S-LPSSLELLTELTEVGLSGNRLE-KVPRLLCSWVSLHLLYLRNTSLHG-LRDSFKRLINLRFLDLSQNHIE-HFPVQIC 359
Cdd:PLN00113 370 GeIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQgRINSRKW 449

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 360 ALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLL-SFPEEIFSLISLEKLYIGQDQGSklSSLPENIKRLMNLKE 438
Cdd:PLN00113 450 DMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVS 527

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124286820 439 LYIENNRLE-QLPASLGLMPNLEVLDCRHNLLK-QLPDAICRTRNLRELLLEDNLL 492
Cdd:PLN00113 528 LDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-384 1.45e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  66 IDGSNQGLKTIPSEILALKELEEVHLENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPELGALSSLESLDLSGNPlvis 145
Cdd:COG4886  118 LDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ---- 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 146 slhvvsrlrtlrelrlyrtgLTEIPTGICKsLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPcDLCVLYN 225
Cdd:COG4886  194 --------------------ITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 226 LEVIDLDENKLKSIPgDIGHLVRLQKFYVASNHLMSLpeSLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRL 305
Cdd:COG4886  252 LEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124286820 306 EKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINLRFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLL 384
Cdd:COG4886  329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
221-502 5.57e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.67  E-value: 5.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 221 CVLYNLEVIDLDENKLKSIPGDIGHlvRLQKFYVASNHLMSLPESLSqcSKLSVLDLTHNSIHSLPSSLELLTELTEvgL 300
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPDTIQEME--L 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 301 SGNRLEKVPRLLCSwvSLHLLYLRNTSLHGLRDSFKRliNLRFLDLSQNHI----EHFPVQICALKnleilaLDDNKVRQ 376
Cdd:PRK15370 249 SINRITELPERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIrtlpAHLPSGITHLN------VQSNSLTA 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 377 LPPSISLlsNLKILGLTGNDLLSFPEeifslisleklyigqdqgsklsSLPENikrlmnLKELYIENNRLEQLPASLGlm 456
Cdd:PRK15370 319 LPETLPP--GLKTLEAGENALTSLPA----------------------SLPPE------LQVLDVSKNQITVLPETLP-- 366

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 124286820 457 PNLEVLDCRHNLLKQLPDAIcrTRNLRELLLEDNLLCCLPENLDHL 502
Cdd:PRK15370 367 PTITTLDVSRNALTNLPENL--PAALQIMQASRNNLVRLPESLPHF 410
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
165-453 4.07e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.97  E-value: 4.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 165 GLTEIPTGICKSLHHLELfglSENFLESLPEEIvnQTKLREIYLKQNHFEVFPCDLCvlYNLEVIDLDENKLksipgdig 244
Cdd:PRK15370 189 GLTTIPACIPEQITTLIL---DNNELKSLPENL--QGNIKTLYANSNQLTSIPATLP--DTIQEMELSINRI-------- 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 245 hlvrlqkfyvasnhlMSLPESLSqcSKLSVLDLTHNSIHSLPSSLEllTELTEVGLSGNRLEKVPRLLCSwvSLHLLYLR 324
Cdd:PRK15370 254 ---------------TELPERLP--SALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 325 NTSLHGLRdsfkrlinlrfldlsqnhiEHFPVqicalkNLEILALDDNKVRQLPPsiSLLSNLKILGLTGNDLLSFPEEI 404
Cdd:PRK15370 313 SNSLTALP-------------------ETLPP------GLKTLEAGENALTSLPA--SLPPELQVLDVSKNQITVLPETL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 124286820 405 FSliSLEKLYIGQDQgskLSSLPENIKrlMNLKELYIENNRLEQLPASL 453
Cdd:PRK15370 366 PP--TITTLDVSRNA---LTNLPENLP--AALQIMQASRNNLVRLPESL 407
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 344-521 3.38e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 3.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 344 LDLSQNHIEHFPVqICALKNLEILALDDNKVRQLPpSISLLSNLKILGLTGNDLLSFpEEIFSLISLEKLYIGQDQGSKL 423
Cdd:cd21340    7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 424 sslpENIKRLMNLKELYIENNRL---EQL---PASL-GLMPNLEVLDCRHNLLKQLPDAICrTRNLRELLLEDNLLCCLP 496
Cdd:cd21340   84 ----EGLENLTNLEELHIENQRLppgEKLtfdPRSLaALSNSLRVLNISGNNIDSLEPLAP-LRNLEQLDASNNQISDLE 158

                        170       180
                 ....*....|....*....|....*...
gi 124286820 497 ENLD---HLVNLKVLTLMNNPMVDPPIY 521
Cdd:cd21340  159 ELLDllsSWPSLRELDLTGNPVCKKPKY 186
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-398 1.02e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  59 LTDRTFFIDGSNQGLKTIPSEILALKELEEVHLENNQIA-EIPQGIQQLQNTKVLYLHNNSLQDLCPE-LGALSSLESLD 136
Cdd:PLN00113 259 LKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVaLTSLPRLQVLQ 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 137 LSGNPL---VISSLHVVSRLRTLRELRLYRTGltEIPTGICKSLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHF 213
Cdd:PLN00113 339 LWSNKFsgeIPKNLGKHNNLTVLDLSTNNLTG--EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF 416

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 214 E-VFPCDLCVLYNLEVIDLDENKLK-SIPGDIGHLVRLQKFYVASNHLM-SLPESlSQCSKLSVLDLTHNSIH-SLPSSL 289
Cdd:PLN00113 417 SgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDS-FGSKRLENLDLSRNQFSgAVPRKL 495

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 290 ELLTELTEVGLSGNRLE-KVPRLLCSWVSLHLLYLRNTSLHG-LRDSFKRLINLRFLDLSQNHIE-HFPVQICALKNLEI 366
Cdd:PLN00113 496 GSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQ 575

                        330       340       350
                 ....*....|....*....|....*....|..
gi 124286820 367 LALDDNKVRQLPPSISLLSNLKILGLTGNDLL 398
Cdd:PLN00113 576 VNISHNHLHGSLPSTGAFLAINASAVAGNIDL 607
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
387-519 5.71e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.49  E-value: 5.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 387 LKILGLTgNDLLSFPEEIFSLIsLEKlyigqdqgSKLSSLPENIKrlMNLKELYIENNRLEQLPASLglmPN-LEVLDCR 465
Cdd:PRK15370 185 LKILGLT-TIPACIPEQITTLI-LDN--------NELKSLPENLQ--GNIKTLYANSNQLTSIPATL---PDtIQEMELS 249

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 124286820 466 HNLLKQLPDAIcrTRNLRELLLEDNLLCCLPENLDHlvNLKVLTLMNNPMVDPP 519
Cdd:PRK15370 250 INRITELPERL--PSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLP 299
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
254-515 9.67e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 64.80  E-value: 9.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 254 VASNHLMSLPESLSqcSKLSVLDLTHNSIHSLPSsleLLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRD 333
Cdd:PRK15387 208 VGESGLTTLPDCLP--AHITTLVIPDNNLTSLPA---LPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 334 SFKRLInlrfldLSQNHIEHFPVQICALKNLEIlalDDNKVRQLPpsiSLLSNLKILGLTGNDLLSFPeeifSLIS-LEK 412
Cdd:PRK15387 283 GLCKLW------IFGNQLTSLPVLPPGLQELSV---SDNQLASLP---ALPSELCKLWAYNNQLTSLP----TLPSgLQE 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 413 LYIGQDQGSKLSSLPENIKRLM--------------NLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAicr 478
Cdd:PRK15387 347 LSVSDNQLASLPTLPSELYKLWaynnrltslpalpsGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSG--- 423

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 124286820 479 trnLRELLLEDNLLCCLPENLDHLVNLKVLTLMNNPM 515
Cdd:PRK15387 424 ---LLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPL 457
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
344-519 7.47e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.02  E-value: 7.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 344 LDLSQNHIEHFPVQICAlkNLEILALDDNKVRQLPPSisLLSNLKILGLTGNDLLSFPEEIFSliSLEKLYIGQDqgsKL 423
Cdd:PRK15370 204 LILDNNELKSLPENLQG--NIKTLYANSNQLTSIPAT--LPDTIQEMELSINRITELPERLPS--ALQSLDLFHN---KI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 424 SSLPENIKRlmNLKELYIENNRLEQLPASLGlmPNLEVLDCRHNLLKQLPDAIcrTRNLRELLLEDNLLCCLPENLDHlv 503
Cdd:PRK15370 275 SCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKTLEAGENALTSLPASLPP-- 346

                        170       180
                 ....*....|....*....|.
gi 124286820 504 NLKVLTLMNN-----PMVDPP 519
Cdd:PRK15370 347 ELQVLDVSKNqitvlPETLPP 367
IQCG cd23766
IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory ...
 534-573 1.30e-09

IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory complex protein 9 (DRC9), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The expression of IQCG is reduced in the sperm of human asthenospermia patients whose sperm have reduced mobility. It has also been shown to have a role in the calmodulin-mediated calcium signaling pathway in zebrafish haematopoietic development. The human IQCG gene was first reported to be involved in chromosome translocation in a case of acute lymphoid/myeloid leukemia. It expresses predominantly at mice testis during spermatogenesis which interacts with calmodulin in a calcium-dependent manner in the mouse testis. IQCG knockout mice are sterile due to the total immobility of their spermatozoa.


Pssm-ID: 467744  Cd Length: 40  Bit Score: 53.71  E-value: 1.30e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 124286820 534 LKENRIRKMMATTIQAWWRGIMVRKGYGSYeellKARKKG 573
Cdd:cd23766    4 KEQEELELRAAIKIQAWWRGIMVRKGLGPF----KKKKKK 39
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
166-409 6.59e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.02  E-value: 6.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 166 LTEIPtGICKSLHHLELFGlseNFLESLPeeiVNQTKLREIYLKQN---HFEVFPCDLCVLYnlevidLDENKLKSIP-- 240
Cdd:PRK15387 234 LTSLP-ALPPELRTLEVSG---NQLTSLP---VLPPGLLELSIFSNpltHLPALPSGLCKLW------IFGNQLTSLPvl 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 241 --GdighlvrLQKFYVASNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLEllteltEVGLSGNRLEKVPRLLCSWVSL 318
Cdd:PRK15387 301 ppG-------LQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSGLQ------ELSVSDNQLASLPTLPSELYKL 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 319 HLLYLRNTSLHGLRDSFKRLInlrfldLSQNHIEHFPVQICALKNLEIlalDDNKVRQLPpsiSLLSNLKILGLTGNDLL 398
Cdd:PRK15387 368 WAYNNRLTSLPALPSGLKELI------VSGNRLTSLPVLPSELKELMV---SGNRLTSLP---MLPSGLLSLSVYRNQLT 435

                        250
                 ....*....|.
gi 124286820 399 SFPEEIFSLIS 409
Cdd:PRK15387 436 RLPESLIHLSS 446
PLN03150 PLN03150
hypothetical protein; Provisional
 229-309 8.62e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 8.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 229 IDLDENKLKS-IPGDIGHLVRLQKFYVASNHLM-SLPESLSQCSKLSVLDLTHNSIH-SLPSSLELLTELTEVGLSGNRL 305
Cdd:PLN03150 423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 ....*
gi 124286820 306 E-KVP 309
Cdd:PLN03150 503 SgRVP 507
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 333-518 8.63e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 8.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 333 DSFKRLINLRFLDLSQNHIEHfPVQICALKNLEILALDDNKVR-QLPPSISLLSNLKILGLTGNDLLS-FPEEIFSLISL 410
Cdd:PLN00113 112 DIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLTSL 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 411 EKLYIGQDQgsKLSSLPENIKRLMNLKELYIENNRLE-QLPASLGLMPNLEVLDcrhnllkqlpdaicrtrnlrelLLED 489
Cdd:PLN00113 191 EFLTLASNQ--LVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLD----------------------LVYN 246

                        170       180
                 ....*....|....*....|....*....
gi 124286820 490 NLLCCLPENLDHLVNLKVLTLMNNPMVDP 518
Cdd:PLN00113 247 NLTGPIPSSLGNLKNLQYLFLYQNKLSGP 275
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 219-374 5.00e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 5.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 219 DLCVLYNLEVIDLDENKLKSIPGdIGHLVRLQKFYVASNHLMSLpESLSQCSKLSVLDLTHNSIHSLpSSLELLTELTEV 298
Cdd:cd21340   19 NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 299 GLSGNRL---EKV---PRLLCSwVSLHLLYLrNTSLHGLRD--SFKRLINLRFLDLSQNHIEHFPVQ---ICALKNLEIL 367
Cdd:cd21340   96 HIENQRLppgEKLtfdPRSLAA-LSNSLRVL-NISGNNIDSlePLAPLRNLEQLDASNNQISDLEELldlLSSWPSLREL 173


                 ....*..
gi 124286820 368 ALDDNKV 374
Cdd:cd21340  174 DLTGNPV 180
PLN03150 PLN03150
hypothetical protein; Provisional
 426-492 2.49e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 2.49e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124286820 426 LPENIKRLMNLKELYIENNRLE-QLPASLGLMPNLEVLDCRHNLLK-QLPDAICRTRNLRELLLEDNLL 492
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 544-573 3.01e-06

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 44.07  E-value: 3.01e-06
                         10        20        30
                 ....*....|....*....|....*....|
gi 124286820 544 ATTIQAWWRGIMVRKgygsyeELLKARKKG 573
Cdd:cd23767   12 ATLIQALWRGYKVRK------ELKKKKKKG 35
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 236-397 1.93e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 236 LKSIPGDIGHLVRLQKFYVASN----HLMSLPESLSQCSKLSVLDLTHNSI------HSLPSSLELLTELTEVGLSGNRL 305
Cdd:cd00116   70 LQSLLQGLTKGCGLQELDLSDNalgpDGCGVLESLLRSSSLQELKLNNNGLgdrglrLLAKGLKDLPPALEKLVLGRNRL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 306 EKVP-----RLLCSWVSLHLLYLRNTSLHG-----LRDSFKRLINLRFLDLSQNHIEHFPVQICA-----LKNLEILALD 370
Cdd:cd00116  150 EGAScealaKALRANRDLKELNLANNGIGDagiraLAEGLKANCNLEVLDLNNNGLTDEGASALAetlasLKSLEVLNLG 229

                        170       180       190
                 ....*....|....*....|....*....|...
gi 124286820 371 DNKVRQ------LPPSISLLSNLKILGLTGNDL 397
Cdd:cd00116  230 DNNLTDagaaalASALLSPNISLLTLSLSCNDI 262
LRR_8 pfam13855
Leucine rich repeat;
435-492 7.69e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  435 NLKELYIENNRLEQLPASLGL-MPNLEVLDCRHNLLKQL-PDAICRTRNLRELLLEDNLL 492
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
317-374 1.76e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  317 SLHLLYLRNTSLHGLRD-SFKRLINLRFLDLSQNHIEHF-PVQICALKNLEILALDDNKV 374
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
248-305 6.62e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 6.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  248 RLQKFYVASNHLMSL-PESLSQCSKLSVLDLTHNSIHSL-PSSLELLTELTEVGLSGNRL 305
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 321-397 7.77e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 7.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 321 LYLRNTSLHG-LRDSFKRLINLRFLDLSQNHIE-HFPVQICALKNLEILALDDNKVR-QLPPSISLLSNLKILGLTGNDL 397
Cdd:PLN03150 423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PLN03150 PLN03150
hypothetical protein; Provisional
 367-457 9.89e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 9.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 367 LALDDNKVR-QLPPSISLLSNLKILGLTGNDLL-SFPEEIFSLISLEKLYIGQDQGSklSSLPENIKRLMNLKELYIENN 444
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN--GSIPESLGQLTSLRILNLNGN 500

                         90
                 ....*....|....
gi 124286820 445 RLE-QLPASLGLMP 457
Cdd:PLN03150 501 SLSgRVPAALGGRL 514
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
164-307 1.25e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 164 TGLTEIPTGICKslhhLELFGlseNFLESLPeeiVNQTKLREIYLKQNHFE---VFPCDLCVL--YN------------L 226
Cdd:PRK15387 275 THLPALPSGLCK----LWIFG---NQLTSLP---VLPPGLQELSVSDNQLAslpALPSELCKLwaYNnqltslptlpsgL 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 227 EVIDLDENKLKSIPGDIGHLVRL-----------------QKFYVASNHLMSLPESLSQCSKLSV--------------- 274
Cdd:PRK15387 345 QELSVSDNQLASLPTLPSELYKLwaynnrltslpalpsglKELIVSGNRLTSLPVLPSELKELMVsgnrltslpmlpsgl 424

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 124286820 275 --LDLTHNSIHSLPSSLELLTELTEVGLSGNRLEK 307
Cdd:PRK15387 425 lsLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 185-436 1.56e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.78  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  185 LSENFLESLPEEIVNQTKLREIYLK--QNHFEVfPcDLCVLYNLEVIDL-DENKLKSIPGDIGHLVRLQKFYVAS-NHLM 260
Cdd:PLN03210  618 MQGSKLEKLWDGVHSLTGLRNIDLRgsKNLKEI-P-DLSMATNLETLKLsDCSSLVELPSSIQYLNKLEDLDMSRcENLE 695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  261 SLPE----------SLSQCSKL----------SVLDLTHNSIHSLPSSLElLTELTEVGLSGNRLEKV--------PRLL 312
Cdd:PLN03210  696 ILPTginlkslyrlNLSGCSRLksfpdistniSWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLwervqpltPLMT 774

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  313 CSWVSLHLLYLRNT-SLHGLRDSFKRLINLRFLDLSQ-NHIEHFPVQIcalkNLEIL-ALDDNKVRQLP--PSISllSNL 387
Cdd:PLN03210  775 MLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENcINLETLPTGI----NLESLeSLDLSGCSRLRtfPDIS--TNI 848

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 124286820  388 KILGLTGNDLLSFPEEIFSLISLEklYIGQDQGSKLSSLPENIKRLMNL 436
Cdd:PLN03210  849 SDLNLSRTGIEEVPWWIEKFSNLS--FLDMNGCNNLQRVSLNISKLKHL 895
Adgb_C_mid-like cd22307
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ...
 505-573 1.77e-03

C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues.


Pssm-ID: 412094  Cd Length: 416  Bit Score: 41.00  E-value: 1.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124286820 505 LKVLTL-----MNNPMVDPPIYVCNQGNEAIWKHLKENRIRKMMA-TTIQAWWRGIMVRKgygsyeeLLKARKKG 573
Cdd:cd22307  105 LRALFLdpdigLEYKESPSSSLREIVEPDECDCRTREPTIEEHEAaTKIQAFFRGTLVRK-------LLKAHKPG 172
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 45-306 3.60e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820  45 EHLPKVLQKKEPhQLTDRTFfidgSNQGLKTIPSEILALKELEEVHLENNQIAEIPQG----IQQLQNT---KVLYLHNN 117
Cdd:cd00116   17 ELLPKLLCLQVL-RLEGNTL----GEEAAKALASALRPQPSLKELCLSLNETGRIPRGlqslLQGLTKGcglQELDLSDN 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 118 SLQ-DLCPELGALsslesldlsgnpLVISSLHVVSrlrtLRELRLYRTGLTEIPTGICKSLHHLELFGLSENFL-----E 191
Cdd:cd00116   92 ALGpDGCGVLESL------------LRSSSLQELK----LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLegascE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286820 192 SLPEEIVNQTKLREIYLKQNH-----FEVFPCDLCVLYNLEVIDLDENKLKSIpGDIghlvrlqkfyvasnhlmSLPESL 266
Cdd:cd00116  156 ALAKALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLTDE-GAS-----------------ALAETL 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 124286820 267 SQCSKLSVLDLTHNSIHS------LPSSLELLTELTEVGLSGNRLE 306
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDIT 263
IQCG-IQCD cd21098
IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD); IQCG and IQCD belong to ...
 544-558 5.91e-03

IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD); IQCG and IQCD belong to the IQ motif-containing protein family which contain a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQCG protein (also known as DRC9 and CFAP122) is essential for sperm flagellum formation in mice. The IQCD protein (also known as DRC10) is involved in sperm fertilization and the acrosome reaction. Both proteins are components of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility. IQCG and IQCD proteins contain a central coiled-coil domain and a C-terminal IQ (isoleucine-glutamine) motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, that interacts with calmodulin (CaM) in a calcium-independent manner. IQ motif-containing proteins that are known to bind calmodulin (CaM) have a wide diversity of biological functions, and they include neuronal growth proteins, myosins, voltage-operated channels, phosphatases, Ras exchange proteins, sperm surface proteins, Ras Gap-like proteins, spindle-associated proteins, and several proteins in plants.


Pssm-ID: 467743  Cd Length: 25  Bit Score: 34.66  E-value: 5.91e-03
                         10
                 ....*....|....*
gi 124286820 544 ATTIQAWWRGIMVRK 558
Cdd:cd21098   11 ATKIQALWRGYMVRR 25
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 540-560 6.73e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 34.22  E-value: 6.73e-03
                           10        20
                   ....*....|....*....|.
gi 124286820   540 RKMMATTIQAWWRGIMVRKGY 560
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKRY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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