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Conserved domains on  [gi|27229137|ref|NP_082200|]
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platelet-derived growth factor D isoform 1 precursor [Mus musculus]

Protein Classification

CUB domain-containing protein( domain architecture ID 10035934)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 270-365 4.37e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


:

Pssm-ID: 238079  Cd Length: 86  Bit Score: 99.75  E-value: 4.37e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137 270 YSCTPRNHSVNLREELKLT-NAVFFPRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEPGHFKRrgkaknMA 348
Cdd:cd00135   1 SSCKPRETLVEISEELPDEtNTIFKPPCVEVKRCGGCC-----NDESLECVPTETSNVTMQVLKISPKRKPR------SK 69

                        90
                ....*....|....*..
gi 27229137 349 LVDIQLDHHERCDCICS 365
Cdd:cd00135  70 LVEISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 55-169 3.17e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 90.55  E-value: 3.17e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137  55 NIQVTSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHqFGLEEAENdiCRYDFVEVEEVSESSTVVRGRWCGhK 134
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGPSTSSPLLGRFCG-S 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 27229137 135 EIPPRITSRTNQIKITFKSDDYfVAKPGFKIYYSF 169
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSS-VTGRGFKATYSA 113
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 270-365 4.37e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 99.75  E-value: 4.37e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137 270 YSCTPRNHSVNLREELKLT-NAVFFPRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEPGHFKRrgkaknMA 348
Cdd:cd00135   1 SSCKPRETLVEISEELPDEtNTIFKPPCVEVKRCGGCC-----NDESLECVPTETSNVTMQVLKISPKRKPR------SK 69

                        90
                ....*....|....*..
gi 27229137 349 LVDIQLDHHERCDCICS 365
Cdd:cd00135  70 LVEISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 55-169 3.17e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 90.55  E-value: 3.17e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137  55 NIQVTSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHqFGLEEAENdiCRYDFVEVEEVSESSTVVRGRWCGhK 134
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGPSTSSPLLGRFCG-S 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 27229137 135 EIPPRITSRTNQIKITFKSDDYfVAKPGFKIYYSF 169
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSS-VTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 62-167 6.30e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 80.90  E-value: 6.30e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137     62 GHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHqFGLEEAENdiCRYDFVEVEEVSESSTVVRGRWCGHKEIPPRIT 141
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGPSASSPLLGRFCGSEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*.
gi 27229137    142 SRTNQIKITFKSDDYFVAKpGFKIYY 167
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKR-GFSARY 102
CUB pfam00431
CUB domain;
59-167 8.44e-19

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 80.80  E-value: 8.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137    59 TSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHqFGLEeaENDICRYDFVEVEEVSESSTVVRGRWCGhKEIPP 138
Cdd:pfam00431   7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELE--DHDECGYDYVEIRDGPSASSPLLGRFCG-SGIPE 82

                          90       100
                  ....*....|....*....|....*....
gi 27229137   139 RITSRTNQIKITFKSDDYFVAKpGFKIYY 167
Cdd:pfam00431  83 DIVSSSNQMTIKFVSDASVQKR-GFKATY 110
PDGF pfam00341
PDGF/VEGF domain;
272-362 7.02e-18

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 77.33  E-value: 7.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137   272 CTPRNHSVNLREELKLTNAVFF-PRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEPghfkrRGKAKNMALV 350
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFkPSCVEVQRCSGCC-----NDEGLECVPTETHNVTMQVLKIEY-----APRRPSPELV 70

                          90
                  ....*....|..
gi 27229137   351 DIQLDHHERCDC 362
Cdd:pfam00341  71 EVSFEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 272-363 3.94e-06

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 44.33  E-value: 3.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137    272 CTPRNHSVNLREEL-KLTNAVFFPRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEPGHFKRrgkaknmaLV 350
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGGCC-----NDEGLECVPTETSNVTMQLLEISRPLSQH--------LV 69

                           90
                   ....*....|...
gi 27229137    351 DIQLDHHERCDCI 363
Cdd:smart00141  70 EVSFEEHTKCECR 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 271-369 9.26e-06

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 45.00  E-value: 9.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137  271 SCTPRNHSVNLREEL-KLTNAVFFPRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEpghfKRRGKAKNMAL 349
Cdd:PHA02661  47 SCQPRDTVVQLSDEYpGNTNDRYNPRCVTVRRCGGCC-----NDESQICTPTETSNVTVTVMLTS----VSGSTGATSNF 117

                         90       100
                 ....*....|....*....|
gi 27229137  350 VDIQLDHHERCDCICSSRPP 369
Cdd:PHA02661 118 QTISVEEHTKCKCEFKTTPP 137
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 270-365 4.37e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 99.75  E-value: 4.37e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137 270 YSCTPRNHSVNLREELKLT-NAVFFPRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEPGHFKRrgkaknMA 348
Cdd:cd00135   1 SSCKPRETLVEISEELPDEtNTIFKPPCVEVKRCGGCC-----NDESLECVPTETSNVTMQVLKISPKRKPR------SK 69

                        90
                ....*....|....*..
gi 27229137 349 LVDIQLDHHERCDCICS 365
Cdd:cd00135  70 LVEISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 55-169 3.17e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 90.55  E-value: 3.17e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137  55 NIQVTSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHqFGLEEAENdiCRYDFVEVEEVSESSTVVRGRWCGhK 134
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGPSTSSPLLGRFCG-S 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 27229137 135 EIPPRITSRTNQIKITFKSDDYfVAKPGFKIYYSF 169
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSS-VTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 62-167 6.30e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 80.90  E-value: 6.30e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137     62 GHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHqFGLEEAENdiCRYDFVEVEEVSESSTVVRGRWCGHKEIPPRIT 141
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGPSASSPLLGRFCGSEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*.
gi 27229137    142 SRTNQIKITFKSDDYFVAKpGFKIYY 167
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKR-GFSARY 102
CUB pfam00431
CUB domain;
59-167 8.44e-19

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 80.80  E-value: 8.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137    59 TSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHqFGLEeaENDICRYDFVEVEEVSESSTVVRGRWCGhKEIPP 138
Cdd:pfam00431   7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELE--DHDECGYDYVEIRDGPSASSPLLGRFCG-SGIPE 82

                          90       100
                  ....*....|....*....|....*....
gi 27229137   139 RITSRTNQIKITFKSDDYFVAKpGFKIYY 167
Cdd:pfam00431  83 DIVSSSNQMTIKFVSDASVQKR-GFKATY 110
PDGF pfam00341
PDGF/VEGF domain;
272-362 7.02e-18

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 77.33  E-value: 7.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137   272 CTPRNHSVNLREELKLTNAVFF-PRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEPghfkrRGKAKNMALV 350
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFkPSCVEVQRCSGCC-----NDEGLECVPTETHNVTMQVLKIEY-----APRRPSPELV 70

                          90
                  ....*....|..
gi 27229137   351 DIQLDHHERCDC 362
Cdd:pfam00341  71 EVSFEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 272-363 3.94e-06

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 44.33  E-value: 3.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137    272 CTPRNHSVNLREEL-KLTNAVFFPRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEPGHFKRrgkaknmaLV 350
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGGCC-----NDEGLECVPTETSNVTMQLLEISRPLSQH--------LV 69

                           90
                   ....*....|...
gi 27229137    351 DIQLDHHERCDCI 363
Cdd:smart00141  70 EVSFEEHTKCECR 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 271-369 9.26e-06

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 45.00  E-value: 9.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229137  271 SCTPRNHSVNLREEL-KLTNAVFFPRCLLVQRCGGNCgcgtvNWKSCTCSSGKTVKKYHEVLKFEpghfKRRGKAKNMAL 349
Cdd:PHA02661  47 SCQPRDTVVQLSDEYpGNTNDRYNPRCVTVRRCGGCC-----NDESQICTPTETSNVTVTVMLTS----VSGSTGATSNF 117

                         90       100
                 ....*....|....*....|
gi 27229137  350 VDIQLDHHERCDCICSSRPP 369
Cdd:PHA02661 118 QTISVEEHTKCKCEFKTTPP 137
Metallothio_2 pfam01439
Metallothionein; Members of this family are metallothioneins. These proteins are cysteine rich ...
 302-321 7.78e-03

Metallothionein; Members of this family are metallothioneins. These proteins are cysteine rich proteins that bind to heavy metals. Members of this family appear to be closest to Class II metallothioneins, seed pfam00131.


Pssm-ID: 396155  Cd Length: 80  Bit Score: 35.07  E-value: 7.78e-03
                          10        20
                  ....*....|....*....|
gi 27229137   302 CGGNCGCGTvnwkSCTCSSG 321
Cdd:pfam01439   4 CGGNCGCGS----GCKCGSG 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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