BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  10 ITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDF 89
Cdd:cd18230   1 ITSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDF 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21312398  90 MYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIK 134
Cdd:cd18230  81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDISIK 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  10 ITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDF 89
Cdd:cd18230   1 ITSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDF 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21312398  90 MYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIK 134
Cdd:cd18230  81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDISIK 125

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398     32 DACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVThLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASF 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIY-LDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*
gi 21312398    112 LQMTDIVQACHDFIK 126
Cdd:smart00225  80 LQIPGLVELCEEFLL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  10 ITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDF 89
Cdd:cd18230   1 ITSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDF 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21312398  90 MYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIK 134
Cdd:cd18230  81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDISIK 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  13 HYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYS 92
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 21312398  93 AHLALTSRNVIEVMSAASFLQMTDIVQACHDFI 125
Cdd:cd18199  81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  13 HYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYS 92
Cdd:cd18330   1 YYTKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYS 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 21312398  93 AHLALTSRNVIEVMSAASFLQMTDIVQACHDFI 125
Cdd:cd18330  81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398    21 LNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVThLDIVTAQGFKAIIDFMYSAHLaLTSR 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEIT-LDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 21312398   101 NVIEVMSAASFLQMTDIVQACHDFIKA 127
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  13 HYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYcqvQKTSDQAT-VTHLDIVTAQGFKAIIDFMY 91
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLF---QNSSSQKNdVFHLDIKNVGGIGQILDFMY 77

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21312398  92 SAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18233  78 TSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398   8 MEITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYcqvQKTSDQATVTHL--DIVTAQGFKA 85
Cdd:cd18194   1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFY---RDRLDKRDLVRLnsDIVTAPAFGL 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21312398  86 IIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQAC 121
Cdd:cd18194  78 LLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  30 LCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAA 109
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEI-ELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                ...
gi 21312398 110 SFL 112
Cdd:cd18186  80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398   8 MEITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKtLYCQVQKTSDQATVTHLDIVTAQGFKAII 87
Cdd:cd18323   1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDKRDLVCINNEIVTAPAFSLLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21312398  88 DFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKA 127
Cdd:cd18323  80 EFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQA 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  17 LLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYC-QVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHL 95
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNyNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 21312398  96 ALTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18245  81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  13 HYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQvQKTSDQATVTHLDIVTAQGFKAIIDFMYS 92
Cdd:cd18198   8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                        90       100       110
                ....*....|....*....|....*....|....
gi 21312398  93 AHLALTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18198  87 ATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  13 HYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQvqktsdqatVTHLDIVTAQGFKAII----D 88
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGD---------GTSGSVVLPESFAEVFglllD 71

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21312398  89 FMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDF 124
Cdd:cd18232  72 FFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  10 ITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQvqktsDQATVTHLDIVTAQGFKAIIDF 89
Cdd:cd18333   1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVH-----DNLINLDHEMVSPGIFRLILDY 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21312398  90 MYSAHLA----LTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18333  76 IYTGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCKKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  12 SHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYcQVQKTSDQATVTHLDIVTAQGFKAIIDFMY 91
Cdd:cd18328   7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLF-TAGTLADQPYVYEIDFVTPEALSAILEFAY 85

                        90       100       110
                ....*....|....*....|....*....|....
gi 21312398  92 SAHLALTSRNVIEVMSAASFLQMTDIVQACHDFI 125
Cdd:cd18328  86 TSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  10 ITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQvqktsDQATVTHLDIVTAQGFKAIIDF 89
Cdd:cd18334   1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLH-----DNLINLDTDMVNPTVFRQILDF 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21312398  90 MYSAHLALTSR----NVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18334  76 IYTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALCRKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  21 LNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIvTAQGFKAIIDFMYSAHLALTSR 100
Cdd:cd18238   6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI-DEEAVELLVDFAYTGKLTLTVD 84

                        90       100       110
                ....*....|....*....|....*....|..
gi 21312398 101 NVIEVMSAASFLQMTDIVQACHDFIKAALDIS 132
Cdd:cd18238  85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHPS 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  13 HYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMYS 92
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEV-EFQCIDETALQAIVEYAYT 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21312398  93 AHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALD 130
Cdd:cd18257  80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLD 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398   8 MEITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSdqATVTHLDI-VTAQGFKAI 86
Cdd:cd18331   2 IQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCN--LSVINLDPeINPEGFNIL 79

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21312398  87 IDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFI 125
Cdd:cd18331  80 LDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  12 SHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCqvqktsdQATVTHLD--IVTAQGFKAIIDF 89
Cdd:cd18216   2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVL-------HDNLIHLDqdMVSPTVFQQILDF 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21312398  90 MYSAHLA---LTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18216  75 IYTGKLLdslFEEPNLSEVLAAANYLQLPDLAALCRSKLK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  13 HYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLY------CQVQKTSDQATVTHLDIVTAQGFKAI 86
Cdd:cd18327   8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFtgggggSGDLGAGGGQDVCELDFVGPEALGAL 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21312398  87 IDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18327  88 LEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  17 LLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIvTAQGFKAIIDFMYSAHLA 96
Cdd:cd18268  10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGI-DSDVLDQIVDYVYTGEIL 88

                        90       100       110
                ....*....|....*....|....*....|...
gi 21312398  97 LTSRNVIEVMSAASFLQMTDIVQACHDFIKAAL 129
Cdd:cd18268  89 ITRDNVLPLMEAASMLQYPKLFEACSLYLQDQL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  17 LLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFktlyCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLA 96
Cdd:cd18227  12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYF----CDQVLLKNSRRIVLPDVMNPRVFENILLSCYTGRLV 87

                        90       100       110
                ....*....|....*....|....*....|
gi 21312398  97 LTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18227  88 LPAPEIVSYLTAASFLQMWHVVDKCTELLE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398   8 MEITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYcqvqkTSDQATVTHLD-IVTAQGFKAI 86
Cdd:cd18290   5 MEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF-----NSSRSAVVELPaAVQPQSFQQI 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21312398  87 IDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDF 124
Cdd:cd18290  80 LSFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEF 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  12 SHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSdQATVTHLDIVTAQGFKAIIDFMY 91
Cdd:cd18264  10 SHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQES-KARVIHLPVVSAAGLQRVLDFIY 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21312398  92 SAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALD 130
Cdd:cd18264  89 TSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLA 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312398  30 LCDACVVVEGKVFKAHKNVLLGSSRYFktLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAA 109
Cdd:cd18955   1 LCDVTIVVEDQRFRAHRAVLAACSDYF--LSRVVGQTDGDLVITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCA 78

                        90
                ....*....|....*.
gi 21312398 110 SFLQMTDIVQACHDFI 125
Cdd:cd18955  79 EFLGVHNIEKACFDFL 94