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Conserved domains on  [gi|47059474|ref|NP_082860|]
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MARVEL domain-containing protein 3 isoform a [Mus musculus]

Protein Classification

MARVEL domain-containing protein( domain architecture ID 10472694)

MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing protein may be involved in membrane apposition and vesicle-trafficking events

Gene Ontology:  GO:0016020
PubMed:  12468223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 230-355 2.91e-06

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


:

Pssm-ID: 366555  Cd Length: 136  Bit Score: 46.17  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059474   230 AQQLDVQFYQLKLPTVTAAMAYSGALMTFscltLLAGALRVPWHCPLWLVIEGLMDALIAGAYVPGLYFFfqhlsAAYSS 309
Cdd:pfam01284  28 IAYAGSYPSAVNFAVFVAVFSFLIALFFL----LLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIAL-----AAALR 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 47059474   310 DVCkeretlyqSKGYSGFNCGVHGGDIGAGVFAAMAIGVFAVGAVL 355
Cdd:pfam01284  99 GHS--------ENQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
SF-CC1 super family cl36939
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 33-96 2.98e-05

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


The actual alignment was detected with superfamily member TIGR01622:

Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 45.68  E-value: 2.98e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47059474    33 RSRDRGGDRHRERNGDVR--------GNGDRRAGREQRTDRDQRQDRHRDAG-HRASEQRALEKSRQSRARPE 96
Cdd:TIGR01622   1 RYRDRERERLRDSSSAGDrdrrrdkgRERSRDRSRDRERSRSRRRDRHRDRDyYRGRERRSRSRRPNRRYRPR 73
 
Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 230-355 2.91e-06

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 46.17  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059474   230 AQQLDVQFYQLKLPTVTAAMAYSGALMTFscltLLAGALRVPWHCPLWLVIEGLMDALIAGAYVPGLYFFfqhlsAAYSS 309
Cdd:pfam01284  28 IAYAGSYPSAVNFAVFVAVFSFLIALFFL----LLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIAL-----AAALR 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 47059474   310 DVCkeretlyqSKGYSGFNCGVHGGDIGAGVFAAMAIGVFAVGAVL 355
Cdd:pfam01284  99 GHS--------ENQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 33-96 2.98e-05

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 45.68  E-value: 2.98e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47059474    33 RSRDRGGDRHRERNGDVR--------GNGDRRAGREQRTDRDQRQDRHRDAG-HRASEQRALEKSRQSRARPE 96
Cdd:TIGR01622   1 RYRDRERERLRDSSSAGDrdrrrdkgRERSRDRSRDRERSRSRRRDRHRDRDyYRGRERRSRSRRPNRRYRPR 73
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 25-94 3.63e-05

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 45.67  E-value: 3.63e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059474   25 PDRDHHVERSRDRGGDRHRERNGDVRGNGDRRAGREQRTDRDQRQDRHRDAGHRASEQRALEKSRQSRAR 94
Cdd:PRK12678 165 EEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRD 234
 
Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 230-355 2.91e-06

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 46.17  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059474   230 AQQLDVQFYQLKLPTVTAAMAYSGALMTFscltLLAGALRVPWHCPLWLVIEGLMDALIAGAYVPGLYFFfqhlsAAYSS 309
Cdd:pfam01284  28 IAYAGSYPSAVNFAVFVAVFSFLIALFFL----LLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIAL-----AAALR 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 47059474   310 DVCkeretlyqSKGYSGFNCGVHGGDIGAGVFAAMAIGVFAVGAVL 355
Cdd:pfam01284  99 GHS--------ENQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 33-96 2.98e-05

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 45.68  E-value: 2.98e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47059474    33 RSRDRGGDRHRERNGDVR--------GNGDRRAGREQRTDRDQRQDRHRDAG-HRASEQRALEKSRQSRARPE 96
Cdd:TIGR01622   1 RYRDRERERLRDSSSAGDrdrrrdkgRERSRDRSRDRERSRSRRRDRHRDRDyYRGRERRSRSRRPNRRYRPR 73
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 25-94 3.63e-05

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 45.67  E-value: 3.63e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059474   25 PDRDHHVERSRDRGGDRHRERNGDVRGNGDRRAGREQRTDRDQRQDRHRDAGHRASEQRALEKSRQSRAR 94
Cdd:PRK12678 165 EEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRD 234
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 25-92 4.43e-05

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 45.30  E-value: 4.43e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059474    25 PDRDHHVERSRDRGGDRHRERN--GDVRGNGDRRAGREQRTDRDQRQDRHRDAGHRASEQRALEKSRQSR 92
Cdd:TIGR01622  21 RRRDKGRERSRDRSRDRERSRSrrRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRRRGDSYRRRRDDR 90
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 26-96 8.70e-05

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 44.52  E-value: 8.70e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47059474    26 DRDHHVERSRDRGGDRHRERngdvrgngDRRAGREQRTDRDQRQDRHRDAGHRASEQRALEKSRQ---SRARPE 96
Cdd:TIGR01622  16 AGDRDRRRDKGRERSRDRSR--------DRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPrekRRRRGD 81
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 26-92 2.22e-04

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 42.96  E-value: 2.22e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47059474    26 DRDHHVERSRDRGGDRHRERNGDVRGNGDRRagREQRTDRDQRQDRHRDAGHRASEQRALEKSRQSR 92
Cdd:TIGR01642  22 ERPRRRSRDRSRFRDRHRRSRERSYREDSRP--RDRRRYDSRSPRSLRYSSVRRSRDRPRRRSRSVR 86
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 26-92 5.57e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.81  E-value: 5.57e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47059474   26 DRDHHVERSRDRGGDRHRERNGDVRGNGDRRAGREQRTDRDQRQDRHR-DAGHRASEQRALEKSRQSR 92
Cdd:PRK12678 197 GRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNReDRGDRDGDDGEGRGGRRGR 264
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 26-95 5.60e-04

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 41.80  E-value: 5.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47059474    26 DRDHHVERSRDRGGDRHRERNGDVRGNGDRRagREQRTDRDQRQDRHRDAGHRASEQ-RALEKS--RQSRARP 95
Cdd:TIGR01642   8 EREKSRGRDRDRSSERPRRRSRDRSRFRDRH--RRSRERSYREDSRPRDRRRYDSRSpRSLRYSsvRRSRDRP 78
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 26-100 7.92e-04

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 41.44  E-value: 7.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47059474    26 DRDHHVERSRDRGGDRHRERNgdvRGNGDRRAGREQR-TDRDQRQDRHRDAGHRASEQRALEKSRQSRARPEPWGP 100
Cdd:TIGR01622  32 DRSRDRERSRSRRRDRHRDRD---YYRGRERRSRSRRpNRRYRPREKRRRRGDSYRRRRDDRRSRREKPRARDGTP 104
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 26-94 9.99e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.04  E-value: 9.99e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47059474   26 DRDHHVERSRDRGGDRHRERNGDvRGNGDRRAGREQRTDRDQRQDRHRDAGHRASEQRalEKSRQSRAR 94
Cdd:PRK12678 204 DRRDRREQGDRREERGRRDGGDR-RGRRRRRDRRDARGDDNREDRGDRDGDDGEGRGG--RRGRRFRDR 269
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 26-97 1.29e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 40.67  E-value: 1.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47059474    26 DRDHHVERSRDRG--GDRHRERNGDVRGNGDRRAGREqRTDRDQRQDRHRDagHRASEQRALEKSRQSRARPEP 97
Cdd:TIGR01622  36 DRERSRSRRRDRHrdRDYYRGRERRSRSRRPNRRYRP-REKRRRRGDSYRR--RRDDRRSRREKPRARDGTPEP 106
rne PRK10811
ribonuclease E; Reviewed
 32-97 3.06e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 39.64  E-value: 3.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47059474    32 ERSRDRGGDRH---RERNG--DVRGNGDRRAGREQRtdRDQRQDRHRDA--GHRASEQRALEKSRQSRARPEP 97
Cdd:PRK10811  601 ERQQDRRKPRQnnrRDRNErrDTRDNRTRREGRENR--EENRRNRRQAQqqTAETRESQQAEVTEKARTQDEQ 671
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 26-97 3.23e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 39.50  E-value: 3.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47059474   26 DRDHHVERSRDRGGDRHRERNGDVRGNGDRRAGREQRTDRDQRQDRHRDAGHRASEQRalEKSRQSRARPEP 97
Cdd:PRK12678 216 EERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDGEGRGGRRGRRFRDRDRRG--RRGGDGGNEREP 285
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 25-94 3.84e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.11  E-value: 3.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059474    25 PDRDHhvERSRDRGGDRHRERNgdvrgngdrragREQRTDRDQRQDRHRdaghRASEQRALEKSRQSRAR 94
Cdd:TIGR01642   5 PDRER--EKSRGRDRDRSSERP------------RRRSRDRSRFRDRHR----RSRERSYREDSRPRDRR 56
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 32-94 5.08e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 38.73  E-value: 5.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47059474   32 ERSRDRGGDRHRERNGDVRGNGDRRAGREQRtDRDQRQDRHRDAGHRASEQRALEKSRQSRAR 94
Cdd:PRK12678 191 GRREERGRDGDDRDRRDRREQGDRREERGRR-DGGDRRGRRRRRDRRDARGDDNREDRGDRDG 252
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 26-94 9.18e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 37.96  E-value: 9.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47059474   26 DRDHHVERSRDRGGDRHRERNGDVRGNGDRRAGREQRTDRDQRQDRHRDAGHRASEQRALEKSRQSRAR 94
Cdd:PRK12678 178 REDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNRED 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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