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Conserved domains on  [gi|31542571|ref|NP_083182|]
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dipeptidyl peptidase 8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dpp_8_9_N pfam19520
Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are ...
 1-156 1.70e-108

Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are similar to DPP4, consisting of one N-terminal beta-propeller and a C-terminal alpha/beta hydrolase domain, which form a functional homodimer. This entry represents the N-terminal beta-propeller of DPP8 and 9 which consists of eight blades and enlaces a central round pore. It provides the key arginine residue fundamental for substrate fixation which is located in the R-segment, at the interconnecting loop between blades 1 and 2. Ligand binding to DPP8/9 induces a rearrangement at the active site through a disorder-order transition in a loop segment which includes the key arginine residue and partially folds in an alpha-helix (R-helix). DPP8 and DPP9 play a role in the immune system and in preadipocyte differentiation. DPP9 is also essential for neonatal survival and plays a role in antigen maturation, cell migration, and cell adhesion.


:

Pssm-ID: 466112  Cd Length: 155  Bit Score: 330.38  E-value: 1.70e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571     1 MKIPSGRCNMAAAMETEQLGVEIFETAECEEgNGESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFV 80
Cdd:pfam19520   1 MSVPSTACNMAAAMETEQLGLEIFETAECEE-NVESEDSPKLEPFYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31542571    81 KRTDPDGPHSDRVYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 156
Cdd:pfam19520  80 KKNDPEGPHSDRVYYLAMSGENRENTLFYSEIPKTINKAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 155
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 169-589 1.18e-89

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 288.45  E-value: 1.18e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   169 SGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPN--IRMDPKLCPaDPDWIAFIHSNDIWISNLVTREERRITYv 246
Cdd:pfam00930   3 DGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGegKIQDAKWSP-DGDRLAFVRDNNLYVRELATGKEIQITS- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   247 hnelanMEEDPRSAGVATFVLQEE-FDRYSGYWWCPQAERtpsggkilrILYEENDESEVEIIHVTSPMLETR--RADSF 323
Cdd:pfam00930  81 ------DGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGSR---------LAFLRFDESEVPIITLPYYTDEGPgpEVREI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   324 RYPKTGTANPKVTFKmseiVVDAAGGIIDvidkeLVQPFEILFEGVEYIARAGWTPEGKhAWSILLDRSQTHLQIVLISP 403
Cdd:pfam00930 146 KYPKAGAPNPTVELF----VYDLASGKTV-----EVVPPDDLSDADYYITRVKWVPDGK-LLVQWLNRDQNRLKVVLCDA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   404 ElfipveddamdrqrliesvpdSVTPLIIYEETTDIWINIHDIFHVFPQtheDEIEFIFASEcKTGFRHLYKItsilkes 483
Cdd:pfam00930 216 E---------------------TGRTVVILEETSDGWVELHQDPHFIKR---DGSGFLWISE-RDGYNHLYLY------- 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   484 kykrssgglpaPSDFKCPIKeeitITSGEWEVlgrhGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGEVVRLTDR 563
Cdd:pfam00930 264 -----------DLDGKSPIQ----LTSGNWEV----TSILGVDETRDLVYFTATEDSPTERHLYSVSLDSGGEPTCLTDD 324

                         410       420
                  ....*....|....*....|....*...
gi 31542571   564 GYSH--SCCLSRHCDFFISKYSNQKNPH 589
Cdd:pfam00930 325 SGDHdySASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
681-885 8.70e-70

Prolyl oligopeptidase family;


:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 229.81  E-value: 8.70e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   681 FRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYdFIDLDRVGIHGWSYGGYLSLMALM 760
Cdd:pfam00326   5 WNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQG-YTDPDRLAIWGGSYGGYLTGAALN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   761 QRSDIFRVAIAGAPVTLWIFYDTG----YTERYMGH--PDQNEQGY-YLGSVAMQAEKFpsEPNRLLLLHGFLDENVHFA 833
Cdd:pfam00326  84 QRPDLFKAAVAHVPVVDWLAYMSDtslpFTERYMEWgnPWDNEEGYdYLSPYSPADNVK--VYPPLLLIHGLLDDRVPPW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 31542571   834 HTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSR 885
Cdd:pfam00326 162 QSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYLGGT 213
 
Name Accession Description Interval E-value
Dpp_8_9_N pfam19520
Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are ...
 1-156 1.70e-108

Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are similar to DPP4, consisting of one N-terminal beta-propeller and a C-terminal alpha/beta hydrolase domain, which form a functional homodimer. This entry represents the N-terminal beta-propeller of DPP8 and 9 which consists of eight blades and enlaces a central round pore. It provides the key arginine residue fundamental for substrate fixation which is located in the R-segment, at the interconnecting loop between blades 1 and 2. Ligand binding to DPP8/9 induces a rearrangement at the active site through a disorder-order transition in a loop segment which includes the key arginine residue and partially folds in an alpha-helix (R-helix). DPP8 and DPP9 play a role in the immune system and in preadipocyte differentiation. DPP9 is also essential for neonatal survival and plays a role in antigen maturation, cell migration, and cell adhesion.


Pssm-ID: 466112  Cd Length: 155  Bit Score: 330.38  E-value: 1.70e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571     1 MKIPSGRCNMAAAMETEQLGVEIFETAECEEgNGESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFV 80
Cdd:pfam19520   1 MSVPSTACNMAAAMETEQLGLEIFETAECEE-NVESEDSPKLEPFYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31542571    81 KRTDPDGPHSDRVYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 156
Cdd:pfam19520  80 KKNDPEGPHSDRVYYLAMSGENRENTLFYSEIPKTINKAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 155
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 169-589 1.18e-89

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 288.45  E-value: 1.18e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   169 SGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPN--IRMDPKLCPaDPDWIAFIHSNDIWISNLVTREERRITYv 246
Cdd:pfam00930   3 DGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGegKIQDAKWSP-DGDRLAFVRDNNLYVRELATGKEIQITS- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   247 hnelanMEEDPRSAGVATFVLQEE-FDRYSGYWWCPQAERtpsggkilrILYEENDESEVEIIHVTSPMLETR--RADSF 323
Cdd:pfam00930  81 ------DGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGSR---------LAFLRFDESEVPIITLPYYTDEGPgpEVREI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   324 RYPKTGTANPKVTFKmseiVVDAAGGIIDvidkeLVQPFEILFEGVEYIARAGWTPEGKhAWSILLDRSQTHLQIVLISP 403
Cdd:pfam00930 146 KYPKAGAPNPTVELF----VYDLASGKTV-----EVVPPDDLSDADYYITRVKWVPDGK-LLVQWLNRDQNRLKVVLCDA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   404 ElfipveddamdrqrliesvpdSVTPLIIYEETTDIWINIHDIFHVFPQtheDEIEFIFASEcKTGFRHLYKItsilkes 483
Cdd:pfam00930 216 E---------------------TGRTVVILEETSDGWVELHQDPHFIKR---DGSGFLWISE-RDGYNHLYLY------- 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   484 kykrssgglpaPSDFKCPIKeeitITSGEWEVlgrhGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGEVVRLTDR 563
Cdd:pfam00930 264 -----------DLDGKSPIQ----LTSGNWEV----TSILGVDETRDLVYFTATEDSPTERHLYSVSLDSGGEPTCLTDD 324

                         410       420
                  ....*....|....*....|....*...
gi 31542571   564 GYSH--SCCLSRHCDFFISKYSNQKNPH 589
Cdd:pfam00930 325 SGDHdySASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
681-885 8.70e-70

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 229.81  E-value: 8.70e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   681 FRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYdFIDLDRVGIHGWSYGGYLSLMALM 760
Cdd:pfam00326   5 WNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQG-YTDPDRLAIWGGSYGGYLTGAALN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   761 QRSDIFRVAIAGAPVTLWIFYDTG----YTERYMGH--PDQNEQGY-YLGSVAMQAEKFpsEPNRLLLLHGFLDENVHFA 833
Cdd:pfam00326  84 QRPDLFKAAVAHVPVVDWLAYMSDtslpFTERYMEWgnPWDNEEGYdYLSPYSPADNVK--VYPPLLLIHGLLDDRVPPW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 31542571   834 HTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSR 885
Cdd:pfam00326 162 QSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYLGGT 213
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
631-883 3.21e-54

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 187.92  E-value: 3.21e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 631 SFESTTGFTLYGMLYKPHDlqpGKKYPTVLFIYGGPQVQLVNNRFkgvkyfRLNTLASLGYVVVVIDNRGschRGLKFEg 710
Cdd:COG1506   1 TFKSADGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP------LAQALASRGYAVLAPDYRG---YGESAG- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 711 afkyKMGQIEIDDQVEGLQYLASQyDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTG---YTE 787
Cdd:COG1506  68 ----DWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTE 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 788 RYMGHPDQNEQGYYLGSVAMQAEKFPSepnRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESG 867
Cdd:COG1506 143 RLMGGPWEDPEAYAARSPLAYADKLKT---PLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAP 219

                       250
                ....*....|....*.
gi 31542571 868 EHYElHLLHYLQENLG 883
Cdd:COG1506 220 DYLE-RILDFLDRHLK 234
 
Name Accession Description Interval E-value
Dpp_8_9_N pfam19520
Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are ...
 1-156 1.70e-108

Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are similar to DPP4, consisting of one N-terminal beta-propeller and a C-terminal alpha/beta hydrolase domain, which form a functional homodimer. This entry represents the N-terminal beta-propeller of DPP8 and 9 which consists of eight blades and enlaces a central round pore. It provides the key arginine residue fundamental for substrate fixation which is located in the R-segment, at the interconnecting loop between blades 1 and 2. Ligand binding to DPP8/9 induces a rearrangement at the active site through a disorder-order transition in a loop segment which includes the key arginine residue and partially folds in an alpha-helix (R-helix). DPP8 and DPP9 play a role in the immune system and in preadipocyte differentiation. DPP9 is also essential for neonatal survival and plays a role in antigen maturation, cell migration, and cell adhesion.


Pssm-ID: 466112  Cd Length: 155  Bit Score: 330.38  E-value: 1.70e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571     1 MKIPSGRCNMAAAMETEQLGVEIFETAECEEgNGESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFV 80
Cdd:pfam19520   1 MSVPSTACNMAAAMETEQLGLEIFETAECEE-NVESEDSPKLEPFYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31542571    81 KRTDPDGPHSDRVYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 156
Cdd:pfam19520  80 KKNDPEGPHSDRVYYLAMSGENRENTLFYSEIPKTINKAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 155
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 169-589 1.18e-89

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 288.45  E-value: 1.18e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   169 SGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPN--IRMDPKLCPaDPDWIAFIHSNDIWISNLVTREERRITYv 246
Cdd:pfam00930   3 DGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGegKIQDAKWSP-DGDRLAFVRDNNLYVRELATGKEIQITS- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   247 hnelanMEEDPRSAGVATFVLQEE-FDRYSGYWWCPQAERtpsggkilrILYEENDESEVEIIHVTSPMLETR--RADSF 323
Cdd:pfam00930  81 ------DGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGSR---------LAFLRFDESEVPIITLPYYTDEGPgpEVREI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   324 RYPKTGTANPKVTFKmseiVVDAAGGIIDvidkeLVQPFEILFEGVEYIARAGWTPEGKhAWSILLDRSQTHLQIVLISP 403
Cdd:pfam00930 146 KYPKAGAPNPTVELF----VYDLASGKTV-----EVVPPDDLSDADYYITRVKWVPDGK-LLVQWLNRDQNRLKVVLCDA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   404 ElfipveddamdrqrliesvpdSVTPLIIYEETTDIWINIHDIFHVFPQtheDEIEFIFASEcKTGFRHLYKItsilkes 483
Cdd:pfam00930 216 E---------------------TGRTVVILEETSDGWVELHQDPHFIKR---DGSGFLWISE-RDGYNHLYLY------- 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   484 kykrssgglpaPSDFKCPIKeeitITSGEWEVlgrhGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGEVVRLTDR 563
Cdd:pfam00930 264 -----------DLDGKSPIQ----LTSGNWEV----TSILGVDETRDLVYFTATEDSPTERHLYSVSLDSGGEPTCLTDD 324

                         410       420
                  ....*....|....*....|....*...
gi 31542571   564 GYSH--SCCLSRHCDFFISKYSNQKNPH 589
Cdd:pfam00930 325 SGDHdySASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
681-885 8.70e-70

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 229.81  E-value: 8.70e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   681 FRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYdFIDLDRVGIHGWSYGGYLSLMALM 760
Cdd:pfam00326   5 WNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQG-YTDPDRLAIWGGSYGGYLTGAALN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   761 QRSDIFRVAIAGAPVTLWIFYDTG----YTERYMGH--PDQNEQGY-YLGSVAMQAEKFpsEPNRLLLLHGFLDENVHFA 833
Cdd:pfam00326  84 QRPDLFKAAVAHVPVVDWLAYMSDtslpFTERYMEWgnPWDNEEGYdYLSPYSPADNVK--VYPPLLLIHGLLDDRVPPW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 31542571   834 HTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSR 885
Cdd:pfam00326 162 QSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYLGGT 213
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
631-883 3.21e-54

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 187.92  E-value: 3.21e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 631 SFESTTGFTLYGMLYKPHDlqpGKKYPTVLFIYGGPQVQLVNNRFkgvkyfRLNTLASLGYVVVVIDNRGschRGLKFEg 710
Cdd:COG1506   1 TFKSADGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP------LAQALASRGYAVLAPDYRG---YGESAG- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 711 afkyKMGQIEIDDQVEGLQYLASQyDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTG---YTE 787
Cdd:COG1506  68 ----DWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTE 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 788 RYMGHPDQNEQGYYLGSVAMQAEKFPSepnRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESG 867
Cdd:COG1506 143 RLMGGPWEDPEAYAARSPLAYADKLKT---PLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAP 219

                       250
                ....*....|....*.
gi 31542571 868 EHYElHLLHYLQENLG 883
Cdd:COG1506 220 DYLE-RILDFLDRHLK 234
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
628-860 2.68e-13

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 70.00  E-value: 2.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 628 EIFSFESTTGFTLYGMLYKPHDlqpGKKYPTVLFI--YGGpqvqlVNNRFKGVkyfrLNTLASLGYVVVVID--NRGSch 703
Cdd:COG0412   4 ETVTIPTPDGVTLPGYLARPAG---GGPRPGVVVLheIFG-----LNPHIRDV----ARRLAAAGYVVLAPDlyGRGG-- 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 704 RGLKFEGAFKYkMGQIEIDDQVE----GLQYLASQyDFIDLDRVGIHGWSYGGYLSLMALMQRSDIfRVAIAgapvtlwi 779
Cdd:COG0412  70 PGDDPDEARAL-MGALDPELLAAdlraALDWLKAQ-PEVDAGRVGVVGFCFGGGLALLAAARGPDL-AAAVS-------- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 780 FYdtgyterymGHPDQNEQGYYLGSVAMqaekfpsepnRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERH 859
Cdd:COG0412 139 FY---------GGLPADDLLDLAARIKA----------PVLLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVYPGAGH 199


                .
gi 31542571 860 S 860
Cdd:COG0412 200 G 200
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 628-765 1.76e-12

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 68.40  E-value: 1.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 628 EIFSFESTTGFTLYGMLYKPHDlqPGKKYPTVLFIYGgpqvqlvnnrFKGVKYFRL---NTLASLGYVVVVIDNRG---S 701
Cdd:COG1073  11 EDVTFKSRDGIKLAGDLYLPAG--ASKKYPAVVVAHG----------NGGVKEQRAlyaQRLAELGFNVLAFDYRGygeS 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31542571 702 chrglkfEGAFKYkMGQIEIDDQVEGLQYLaSQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDI 765
Cdd:COG1073  79 -------EGEPRE-EGSPERRDARAAVDYL-RTLPGVDPERIGLLGISLGGGYALNAAATDPRV 133
COG4099 COG4099
Predicted peptidase [General function prediction only];
644-861 9.42e-08

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 53.82  E-value: 9.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 644 LYKPHDLQPGKKYPTVLFIYGG------PQVQLVNnrfKGVKYFRLNTLASLGYVVVVidnrGSCHRGlkfegafKYKMG 717
Cdd:COG4099  37 LYLPKGYDPGKKYPLVLFLHGAgergtdNEKQLTH---GAPKFINPENQAKFPAIVLA----PQCPED-------DYWSD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 718 QIEIDDQVEGLQYLASQYDfIDLDRVGIHGWSYGGYLSLMALMQRSDIFR--VAIAGAPvtlwifyDTGYTERYmghpdq 795
Cdd:COG4099 103 TKALDAVLALLDDLIAEYR-IDPDRIYLTGLSMGGYGTWDLAARYPDLFAaaVPICGGG-------DPANAANL------ 168

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31542571 796 neqgyylgsvamqaEKFPsepnrLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSI 861
Cdd:COG4099 169 --------------KKVP-----VWIFHGAKDDVVPVEESRAMVEALKAAGADVKYTEYPGVGHNS 215
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 644-758 6.12e-07

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 51.03  E-value: 6.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   644 LYKPhdLQPGKKYPTVLFIYGGPQvqlvnnrFKGVKY----FRLNTLASL---GYVVVVIDNRGSCHRglKFEGAfkykm 716
Cdd:pfam20434   3 IYLP--KNAKGPYPVVIWIHGGGW-------NSGDKEadmgFMTNTVKALlkaGYAVASINYRLSTDA--KFPAQ----- 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 31542571   717 gqieIDDQVEGLQYL---ASQYDfIDLDRVGIHGWSYGGYLSLMA 758
Cdd:pfam20434  67 ----IQDVKAAIRFLranAAKYG-IDTNKIALMGFSAGGHLALLA 106
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
644-784 7.79e-06

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 48.49  E-value: 7.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   644 LYKPhdLQPGKKYPTVLFI--YGGPqvqlvNNRFKGVKYFRLN-TLASLGYVVVVIDNRGSchRGLkfEGAFKYKMGQiE 720
Cdd:pfam02129   9 IYRP--TKTGGPVPALLTRspYGAR-----RDGASDLALAHPEwEFAARGYAVVYQDVRGT--GGS--EGVFTVGGPQ-E 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31542571   721 IDDQVEGLQYLASQYDFIDldRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLW--IFYDTG 784
Cdd:pfam02129  77 AADGKDVIDWLAGQPWCNG--KVGMTGISYLGTTQLAAAATGPPGLKAIAPESGISDLydYYREGG 140
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
686-769 1.80e-05

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 47.79  E-value: 1.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 686 LASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEI------D-----DQVEGLQYLASQY-DFIDLDRVGIHGWSYGGY 753
Cdd:COG4188  85 LASHGYVVAAPDHPGSNAADLSAALDGLADALDPEElwerplDlsfvlDQLLALNKSDPPLaGRLDLDRIGVIGHSLGGY 164

                        90
                ....*....|....*.
gi 31542571 754 LSLMALMQRSDIFRVA 769
Cdd:COG4188 165 TALALAGARLDFAALR 180
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
626-861 2.42e-05

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 46.53  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 626 PPEIFSFESTTGFTLYGMLYKPHDlQPGkkyPTVLFIYGGpqvqlvnnRFKGVKYFRL-NTLASLGYVVVVIDNRG---S 701
Cdd:COG2267   2 TRRLVTLPTRDGLRLRGRRWRPAG-SPR---GTVVLVHGL--------GEHSGRYAELaEALAAAGYAVLAFDLRGhgrS 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 702 CHRGLKFEGAFKYkmgqieIDDQVEGLQYLASQYDfidlDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPvtlwify 781
Cdd:COG2267  70 DGPRGHVDSFDDY------VDDLRAALDALRARPG----LPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP------- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 782 dtgyteRYMGHPDQNEQGYYLGSVAMQAE----KFPsepnrLLLLHGFLDENVHFAHTsilLSFLVRAGKPYDLQIYPQE 857
Cdd:COG2267 133 ------AYRADPLLGPSARWLRALRLAEAlariDVP-----VLVLHGGADRVVPPEAA---RRLAARLSPDVELVLLPGA 198


                ....
gi 31542571 858 RHSI 861
Cdd:COG2267 199 RHEL 202
COG2936 COG2936
Predicted acyl esterase [General function prediction only];
639-762 4.64e-05

Predicted acyl esterase [General function prediction only];


Pssm-ID: 442179 [Multi-domain]  Cd Length: 555  Bit Score: 47.23  E-value: 4.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 639 TLYGMLYKPHDLQpgKKYPTVLFI--YGgpqvqlVNNRFKGVKYFRLNTLASLGYVVVVIDNRG---SchrglkfEGAFk 713
Cdd:COG2936  24 RLAADIYRPKDAE--GPVPVILERtpYG------KRDGTAGRDLGPHPYFAERGYAVVVQDVRGtggS-------EGEF- 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 31542571 714 YKMGQIEIDDQVEGLQYLASQYDFidlD-RVGIHGWSYGGYLSLMALMQR 762
Cdd:COG2936  88 DPYRVDEQTDGYDTIDWLAKQPWS---NgKVGMIGISYGGFTQLAAAADR 134
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
644-883 8.32e-05

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 44.48  E-value: 8.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 644 LYKPHDlqPGKKYPTVLFIYGGpqvqlvnnrfkgvkYFRLNTL-----------ASLGYVVVVIDNRgschrgL----KF 708
Cdd:COG0657   3 VYRPAG--AKGPLPVVVYFHGG--------------GWVSGSKdthdplarrlaARAGAAVVSVDYR------LapehPF 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 709 EGAfkykmgqieIDDQVEGLQYLASQYDF--IDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGA----PVtlwifYD 782
Cdd:COG0657  61 PAA---------LEDAYAALRWLRANAAElgIDPDRIAVAGDSAGGHLAAALALRARDRGGPRPAAQvliyPV-----LD 126

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 783 TGYTerymghPdqneqgyylgsVAMQAEKFPsepnRLLLLHG----FLDENVHFAHTsillsfLVRAGKPYDLQIYPQER 858
Cdd:COG0657 127 LTAS------P-----------LRADLAGLP----PTLIVTGeadpLVDESEALAAA------LRAAGVPVELHVYPGGG 179

                       250       260
                ....*....|....*....|....*....
gi 31542571 859 HS----IRVPESGEHYElHLLHYLQENLG 883
Cdd:COG0657 180 HGfgllAGLPEARAALA-EIAAFLRRALA 207
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
685-780 1.98e-03

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 40.53  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 685 TLASLGYVVVVIDNRG---SchrglkfEGAFKYkmGQIEIDDQVEGLQYLASQYdfidLDRVGIHGWSYGGYLSLMALMQ 761
Cdd:COG2945  50 ALVAAGFAVLRFNFRGvgrS-------EGEFDE--GRGELDDAAAALDWLRAQN----PLPLWLAGFSFGAYVALQLAMR 116

                        90
                ....*....|....*....
gi 31542571 762 RSDIFRVAIAGAPVTLWIF 780
Cdd:COG2945 117 LPEVEGLILVAPPVNRYDF 135
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 657-829 2.30e-03

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 40.57  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   657 PTVLFIYGGPQVqlvnnrfkGVKYFRL-NTLASLGYVVVVIDNRGSCH-RGLKFEGAFkykmgqiEIDDQVEGLQYLASQ 734
Cdd:pfam00561   1 PPVLLLHGLPGS--------SDLWRKLaPALARDGFRVIALDLRGFGKsSRPKAQDDY-------RTDDLAEDLEYILEA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571   735 YDfidLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPS 814
Cdd:pfam00561  66 LG---LEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVAK 142

                         170
                  ....*....|....*
gi 31542571   815 EPNRLLLLHGFLDEN 829
Cdd:pfam00561 143 LLALLLLRLRLLKAL 157
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
730-860 4.07e-03

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 39.97  E-value: 4.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 730 YLASQYDfIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPvTLWIfydtgyterymghpdqnEQGYYLGSVAmQA 809
Cdd:COG2819 120 YIDKRYR-TDPERTGLIGHSLGGLFSLYALLKYPDLFGRYIAISP-SLWW-----------------DDGALLDEAE-AL 179

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31542571 810 EKFPSEPNRLLLLHGFLDE---NVHFAHTSILLSFLVRAGKP---YDLQIYPQERHS 860
Cdd:COG2819 180 LKRSPLPKRLYLSVGTLEGdsmDGMVDDARRLAEALKAKGYPglnVKFEVFPGETHG 236
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
644-771 5.05e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 39.84  E-value: 5.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542571 644 LYKPHD-LQPGKKYPTVLFIYGGPQVQlvnNRFkgVKYFRLNT-LASL-------GYVVVVIDNRGSCHRGLKFEGAFKY 714
Cdd:COG2382  99 VYLPPGyDNPGKKYPVLYLLDGGGGDE---QDW--FDQGRLPTiLDNLiaagkipPMIVVMPDGGDGGDRGTEGPGNDAF 173

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31542571 715 kmgQIEIDDQVegLQYLASQYDFI-DLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIA 771
Cdd:COG2382 174 ---ERFLAEEL--IPFVEKNYRVSaDPEHRAIAGLSMGGLAALYAALRHPDLFGYVGS 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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