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Conserved domains on  [gi|228008305|ref|NP_083189|]
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zinc finger protein 819 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-81 1.54e-20

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.54e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 228008305    27 VSFEDVTVNFSQEEWQHLDSAQRRLYQDVLLEIYSHLLVVGY--SRPEVILKMKKVK 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFqvPKPDLISQLEQGE 57
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-531 2.32e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 293 TNPLETHFICHICGKSFLQKSELSFHPGTDRgetHHGCPGCRKSLPSTSSLQARHGTH------TKEKPYRCPDCGKSFS 366
Cdd:COG5048  224 SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS---SSASESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFS 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 367 YASHLKIHLR--IHTGE--RPYVC--SDCGKAFSQKSVLTTHRRIHTGERPYTCnhcgklfVYASDLKKHSrfhtgekpy 440
Cdd:COG5048  301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFS--------- 364

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 441 ecrdcgKLFNNKSHLPVHYRIHTGEKPYRCCD---CGKSFRRKSHLKVHSRTHTGEKPYEC--PDCGRAFSHSSVLSTHQ 515
Cdd:COG5048  365 ------PLLNNEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHK 438

                        250
                 ....*....|....*.
gi 228008305 516 RIHTGERPYLCSDCGK 531
Cdd:COG5048  439 KIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 3.02e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.02e-04
                          10        20
                  ....*....|....*....|....*
gi 228008305  539 LNEHRRIHTGEKPYVCSECGKAFSC 563
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-81 1.54e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.54e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 228008305    27 VSFEDVTVNFSQEEWQHLDSAQRRLYQDVLLEIYSHLLVVGY--SRPEVILKMKKVK 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFqvPKPDLISQLEQGE 57
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 1.27e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.27e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 228008305   26 LVSFEDVTVNFSQEEWQHLDSAQRRLYQDVLLEIYSHLLVVG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-63 3.82e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.20  E-value: 3.82e-16
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 228008305  27 VSFEDVTVNFSQEEWQHLDSAQRRLYQDVLLEIYSHL 63
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-531 2.32e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 293 TNPLETHFICHICGKSFLQKSELSFHPGTDRgetHHGCPGCRKSLPSTSSLQARHGTH------TKEKPYRCPDCGKSFS 366
Cdd:COG5048  224 SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS---SSASESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFS 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 367 YASHLKIHLR--IHTGE--RPYVC--SDCGKAFSQKSVLTTHRRIHTGERPYTCnhcgklfVYASDLKKHSrfhtgekpy 440
Cdd:COG5048  301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFS--------- 364

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 441 ecrdcgKLFNNKSHLPVHYRIHTGEKPYRCCD---CGKSFRRKSHLKVHSRTHTGEKPYEC--PDCGRAFSHSSVLSTHQ 515
Cdd:COG5048  365 ------PLLNNEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHK 438

                        250
                 ....*....|....*.
gi 228008305 516 RIHTGERPYLCSDCGK 531
Cdd:COG5048  439 KIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-507 6.47e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.47e-05
                          10        20
                  ....*....|....*....|....*.
gi 228008305  482 HLKVHSRTHTGEKPYECPDCGRAFSH 507
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 3.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.02e-04
                          10        20
                  ....*....|....*....|....*
gi 228008305  539 LNEHRRIHTGEKPYVCSECGKAFSC 563
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 492-575 7.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 492 GEKPYECP--DCGRAFSHSSVLSTHqRIHtgerpylcSDCGKAMSSKAQLNEHRRIHTGEKPYVCSECGKAFSCRSSLQA 569
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 228008305 570 HrRTHS 575
Cdd:COG5189  417 H-RKHS 421
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-81 1.54e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.54e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 228008305    27 VSFEDVTVNFSQEEWQHLDSAQRRLYQDVLLEIYSHLLVVGY--SRPEVILKMKKVK 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFqvPKPDLISQLEQGE 57
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 1.27e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.27e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 228008305   26 LVSFEDVTVNFSQEEWQHLDSAQRRLYQDVLLEIYSHLLVVG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-63 3.82e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.20  E-value: 3.82e-16
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 228008305  27 VSFEDVTVNFSQEEWQHLDSAQRRLYQDVLLEIYSHL 63
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-531 2.32e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 293 TNPLETHFICHICGKSFLQKSELSFHPGTDRgetHHGCPGCRKSLPSTSSLQARHGTH------TKEKPYRCPDCGKSFS 366
Cdd:COG5048  224 SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS---SSASESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFS 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 367 YASHLKIHLR--IHTGE--RPYVC--SDCGKAFSQKSVLTTHRRIHTGERPYTCnhcgklfVYASDLKKHSrfhtgekpy 440
Cdd:COG5048  301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFS--------- 364

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 441 ecrdcgKLFNNKSHLPVHYRIHTGEKPYRCCD---CGKSFRRKSHLKVHSRTHTGEKPYEC--PDCGRAFSHSSVLSTHQ 515
Cdd:COG5048  365 ------PLLNNEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHK 438

                        250
                 ....*....|....*.
gi 228008305 516 RIHTGERPYLCSDCGK 531
Cdd:COG5048  439 KIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-607 4.82e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 352 KEKPYRCPDCGKSFSYASHLKIHLRIHTGERPYVCSD--CGKAFSQKSVLTTHRRIHTGERPYTC--------------- 414
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskassss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 415 -NHCGKLFVYASDLKKHS-------------RFHTGEKPYECRDCGKLFNN----------------------KSHLPVH 458
Cdd:COG5048  110 lSSSSSNSNDNNLLSSHSlppssrdpqlpdlLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 459 YRIHTGEKPYRCCDCGKSFRRKSHLKVHSRTHTGEKPYECPDCGRAFSHSSVLSTHQRIHTGERPYLCSDCGKAMSSKAQ 538
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 539 LNEHRRIHTGE-------KPYVCSECGKAFSCRSSLQAHRRT--HSRE--KPFVC--HTCGKGFLHKSQLSSHQQTHTGE 605
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349


                 ..
gi 228008305 606 NP 607
Cdd:COG5048  350 SP 351
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-587 4.90e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 334 RKSLPSTSSLQARHGTHTKEKPYRCPDCgKSFSYASHLKIHLRIHTGERPYVCSdcgkafSQKSVLTTHRRIHTGERPYT 413
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 414 CNhCGKLFVYASDLKKHSRFHTG-EKPYECRDCGKLFNNKSHLPVHYR--IHTGE--KPYRCC--DCGKSFRRKSHLKVH 486
Cdd:COG5048  264 SL-PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRH 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 487 SRTHTGEKPYECPDCGRAFSHS------SVLSTHQR-IHTGERPYLCSD--CGKAMSSKAQLNEHRRIHTGEKPYVC--S 555
Cdd:COG5048  343 ILLHTSISPAKEKLLNSSSKFSpllnnePPQSLQQYkDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknP 422

                        250       260       270
                 ....*....|....*....|....*....|..
gi 228008305 556 ECGKAFSCRSSLQAHRRTHSREKPFVCHTCGK 587
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-607 9.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 9.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 327 HHGCPGCRKSLPSTSSLQARHGTHTKEKPyrcpdcgkSFSYASHLKIHLRIHTGERPYVCSDCGKAFSQKSVLTTHRRIH 406
Cdd:COG5048  151 LPGNNSSSVNTPQSNSLHPPLPANSLSKD--------PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 407 -TGERPYTCNHCGK----LFVYASDLKKHSRFHTGEKPYECRDCGKLFNNKSHLPVHYRIHTG-EKPYRCCDCGKSFRRK 480
Cdd:COG5048  223 sSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRS 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 481 SHLKVHSRT--HTGE--KPYECP--DCGRAFSHSSVLSTHQRIHTGERP---YLCSDCGKAMSSKAQLNE----HRRIHT 547
Cdd:COG5048  303 SPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPakeKLLNSSSKFSPLLNNEPPqslqQYKDLK 382

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 228008305 548 GEKPYVC--SECGKAFSCRSSLQAHRRTHSREKPFVCH--TCGKGFLHKSQLSSHQQTHTGENP 607
Cdd:COG5048  383 NDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-507 6.47e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.47e-05
                          10        20
                  ....*....|....*....|....*.
gi 228008305  482 HLKVHSRTHTGEKPYECPDCGRAFSH 507
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 2.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 228008305  370 HLKIHLRIHTGERPYVCSDCGKAFSQ 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 3.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.02e-04
                          10        20
                  ....*....|....*....|....*
gi 228008305  539 LNEHRRIHTGEKPYVCSECGKAFSC 563
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 356-378 4.29e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 4.29e-04
                          10        20
                  ....*....|....*....|...
gi 228008305  356 YRCPDCGKSFSYASHLKIHLRIH 378
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-451 6.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 228008305  426 DLKKHSRFHTGEKPYECRDCGKLFNN 451
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 468-490 9.12e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 9.12e-04
                          10        20
                  ....*....|....*....|...
gi 228008305  468 YRCCDCGKSFRRKSHLKVHSRTH 490
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 380-458 1.08e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 380 GERPYVCS--DCGKAFSQKSVLTTHRrIHtgerpytcNHCGKLFVYASDLKKHSRFHTGEKPYECRDCGKLFNNKSHLPV 457
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 228008305 458 H 458
Cdd:COG5189  417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 394-491 6.76e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 394 SQKSVLTTHRRIHT-GERPYTCN--HCGKLFVYASDLKKHsRFHTGEKPyecrdcgKLFNNKSHLPvHYRIHTGEKPYRC 470
Cdd:COG5189  331 GERNIDTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRC 401

                         90       100
                 ....*....|....*....|.
gi 228008305 471 CDCGKSFRRKSHLKVHsRTHT 491
Cdd:COG5189  402 EVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 492-575 7.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008305 492 GEKPYECP--DCGRAFSHSSVLSTHqRIHtgerpylcSDCGKAMSSKAQLNEHRRIHTGEKPYVCSECGKAFSCRSSLQA 569
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 228008305 570 HrRTHS 575
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-423 7.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.57e-03
                          10        20
                  ....*....|....*....|....*
gi 228008305  399 LTTHRRIHTGERPYTCNHCGKLFVY 423
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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