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Conserved domains on  [gi|145386575|ref|NP_083557|]
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zinc finger protein 820 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 5.14e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 5.14e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 145386575   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-513 9.44e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 163 KVFDSKQKLKLKQTNNREKPYKCSECDKCFTKKCKLRQHQRIHTGEKPYKCS--ECDKCFTQKDRLIIHQRVHTGE---- 236
Cdd:COG5048   14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdl 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 237 -------------------------KPYKCSECDKGFTSKSRLNIHQRVHTGEKSYKCSEC------------------- 272
Cdd:COG5048   94 nskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpa 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 273 ---DKSFSQQGNLSIHLRIHTGEKPYKCSECDKCFTYKSGLRSHQIIHTGEKAYKCSECGKCFTHKGDLRRHQSIHMGEK 349
Cdd:COG5048  174 nslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 350 PYKCSECDKGFTQKCRLIIHQIIHTG-------KKGYKCSECDKCFILKSDLSIHQR--IHTGE--KPYECSE--CGKGF 416
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 417 TSKSRLNIHQRVHTGEKSYKCSECDKSFTQQGNLRI----HLRIHTGEKPYKCSECD-----KCFTYKSGLRSHQIIHT- 486
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLs 413

                        410       420
                 ....*....|....*....|....*...
gi 145386575 487 -GEKAYKCSECGKCFTHKGDLRRHQSVH 513
Cdd:COG5048  414 fRPYNCKNPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-530 3.69e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 145386575  505 DLRRHQSVHMGEKPYKCSECDKGFTQ 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 5.14e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 5.14e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 145386575   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 2.02e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.65  E-value: 2.02e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 145386575    13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVETH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 1.33e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.33e-18
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 145386575  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFF 51
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-513 9.44e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 163 KVFDSKQKLKLKQTNNREKPYKCSECDKCFTKKCKLRQHQRIHTGEKPYKCS--ECDKCFTQKDRLIIHQRVHTGE---- 236
Cdd:COG5048   14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdl 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 237 -------------------------KPYKCSECDKGFTSKSRLNIHQRVHTGEKSYKCSEC------------------- 272
Cdd:COG5048   94 nskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpa 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 273 ---DKSFSQQGNLSIHLRIHTGEKPYKCSECDKCFTYKSGLRSHQIIHTGEKAYKCSECGKCFTHKGDLRRHQSIHMGEK 349
Cdd:COG5048  174 nslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 350 PYKCSECDKGFTQKCRLIIHQIIHTG-------KKGYKCSECDKCFILKSDLSIHQR--IHTGE--KPYECSE--CGKGF 416
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 417 TSKSRLNIHQRVHTGEKSYKCSECDKSFTQQGNLRI----HLRIHTGEKPYKCSECD-----KCFTYKSGLRSHQIIHT- 486
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLs 413

                        410       420
                 ....*....|....*....|....*...
gi 145386575 487 -GEKAYKCSECGKCFTHKGDLRRHQSVH 513
Cdd:COG5048  414 fRPYNCKNPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-222 1.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|....*
gi 145386575  198 LRQHQRIHTGEKPYKCSECDKCFTQ 222
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-530 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 145386575  505 DLRRHQSVHMGEKPYKCSECDKGFTQ 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 5.14e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 5.14e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 145386575   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 2.02e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.65  E-value: 2.02e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 145386575    13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVETH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 1.33e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.33e-18
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 145386575  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFF 51
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-513 9.44e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 163 KVFDSKQKLKLKQTNNREKPYKCSECDKCFTKKCKLRQHQRIHTGEKPYKCS--ECDKCFTQKDRLIIHQRVHTGE---- 236
Cdd:COG5048   14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdl 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 237 -------------------------KPYKCSECDKGFTSKSRLNIHQRVHTGEKSYKCSEC------------------- 272
Cdd:COG5048   94 nskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpa 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 273 ---DKSFSQQGNLSIHLRIHTGEKPYKCSECDKCFTYKSGLRSHQIIHTGEKAYKCSECGKCFTHKGDLRRHQSIHMGEK 349
Cdd:COG5048  174 nslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 350 PYKCSECDKGFTQKCRLIIHQIIHTG-------KKGYKCSECDKCFILKSDLSIHQR--IHTGE--KPYECSE--CGKGF 416
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 417 TSKSRLNIHQRVHTGEKSYKCSECDKSFTQQGNLRI----HLRIHTGEKPYKCSECD-----KCFTYKSGLRSHQIIHT- 486
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLs 413

                        410       420
                 ....*....|....*....|....*...
gi 145386575 487 -GEKAYKCSECGKCFTHKGDLRRHQSVH 513
Cdd:COG5048  414 fRPYNCKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-521 4.52e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 209 KPYKCSECDKCFTQKDRLIIHQRVHTGEKPYKCS--ECDKGFTSKSRLNIHQRVHTGEKSYKCS-ECDKSFSQQGNLSIH 285
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 286 LRIHTGEKPYKCSECDKCFTYKSGLRSHQIIHTGEKAYKCSEC-GKCFTHKGDLRRHQSIHMGekpykcSECDKGFTQKC 364
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPAN------SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 365 RLIIHQIIHTGKKGYKCSECDKcFILKSDLSIHQRIHTGEKPYECSECGKGFT------SKSRLNIHQRVHTGEKSYKCS 438
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 439 ECDKSFTQQGNLRIHLRIHTG-EKPYKCSECDKCFTYKSGLRSHQ--IIHTGEKAYKCSE----CGKCFTHKGDLRRHQS 511
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 145386575 512 VHMGEKPYKC 521
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-414 1.15e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 265 KSYKCSECDKSFSQQGNLSIHLR--IHTGE--KPYKCSE--CDKCFTYKSGLRSHQIIHTGEKAYKC--SECGKCFTHKG 336
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 337 DLRRHQSIHM--GEKPYKCSECD-----KGFTQKCRLIIHQIIHTGKKGY--KCSECDKCFILKSDLSIHQRIHTGEKPY 407
Cdd:COG5048  368 NNEPPQSLQQykDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*..
gi 145386575 408 ECSECGK 414
Cdd:COG5048  448 LCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-466 1.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 224 DRLIIHQRVHTGEKPYKCSECDKGFTSKSRLNIHQRVHTGEKSYKCSECDKSFSQQGNLSIHLRIHTGEKPYKCSECDKC 303
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 304 FTYKSGLRSHQIIHTGE-------KAYKCSECGKCFTHKGDLRRHQ--SIHMGE--KPYKCSE--CDKGFTQKCRLIIHQ 370
Cdd:COG5048  264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 371 IIHTGKKGYKCSECDKCFILKSDL-------SIHQRIHTGEKPYECSECGKGFTSKSRLNI--HQRVHTGEKSY--KCSE 439
Cdd:COG5048  344 LLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPYncKNPP 423

                        250       260
                 ....*....|....*....|....*..
gi 145386575 440 CDKSFTQQGNLRIHLRIHTGEKPYKCS 466
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-222 1.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|....*
gi 145386575  198 LRQHQRIHTGEKPYKCSECDKCFTQ 222
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
449-474 2.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 145386575  449 NLRIHLRIHTGEKPYKCSECDKCFTY 474
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 291-358 3.14e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.14e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 291 GEKPYKCS--ECDKCFTYKSGLRSHQiihtgekayKCSECGKCFTHKGDLRRHQSIHMGEKPYKCSECDK 358
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 459-526 3.83e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.83e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 459 GEKPYKCS--ECDKCFTYKSGLRSHQiihtgekayKCSECGKCFTHKGDLRRHQSVHMGEKPYKCSECDK 526
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 235-313 5.29e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 235 GEKPYKCS--ECDKGFTSKSRLNIHqRVHtGEKSYKCSECDKSFSQQGnlsihlrIHTGEKPYKCSECDKCFTYKSGLRS 312
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH-GHQNQKLHENPSPEKMNI-------FSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 145386575 313 H 313
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 6.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 145386575  281 NLSIHLRIHTGEKPYKCSECDKCFTY 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 1.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 145386575  337 DLRRHQSIHMGEKPYKCSECDKGFTQ 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-530 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 145386575  505 DLRRHQSVHMGEKPYKCSECDKGFTQ 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
393-418 4.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 145386575  393 DLSIHQRIHTGEKPYECSECGKGFTS 418
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
421-446 6.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 145386575  421 RLNIHQRVHTGEKSYKCSECDKSFTQ 446
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-278 6.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 145386575  253 RLNIHQRVHTGEKSYKCSECDKSFSQ 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 431-509 6.58e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145386575 431 GEKSYKCS--ECDKSFTQQGNLRIHlRIHtgekpykcSECDKCFTYKSGLRSHQIIHTGEKAYKCSECGKCFTHKGDLRR 508
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 145386575 509 H 509
Cdd:COG5189  417 H 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 435-457 6.62e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.62e-03
                          10        20
                  ....*....|....*....|...
gi 145386575  435 YKCSECDKSFTQQGNLRIHLRIH 457
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
478-502 7.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.42e-03
                          10        20
                  ....*....|....*....|....*
gi 145386575  478 LRSHQIIHTGEKAYKCSECGKCFTH 502
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-334 7.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.42e-03
                          10        20
                  ....*....|....*....|....*
gi 145386575  310 LRSHQIIHTGEKAYKCSECGKCFTH 334
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 323-345 8.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.47e-03
                          10        20
                  ....*....|....*....|...
gi 145386575  323 YKCSECGKCFTHKGDLRRHQSIH 345
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 491-513 8.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.72e-03
                          10        20
                  ....*....|....*....|...
gi 145386575  491 YKCSECGKCFTHKGDLRRHQSVH 513
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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