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Conserved domains on  [gi|148747331|ref|NP_084481|]
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coronin-7 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 468-877 3.04e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 227.47  E-value: 3.04e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 468 SKFRHTQGSLLHRDSHITNLKGLNLTTPGESDGFCANRLrVAVPLLSSGGqVAVLELQKPGRLPDTALPTLQNGTAVMDL 547
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDCSNTIACNDRF-IAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 548 VWDPFDPHRLAVAGEDARIRLWRVPPGGLENVLTTPETVLTGHTEKIYSLRFHPLAADVLASSSYDLTVRIWDLQTGAER 627
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 628 LKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRSSPLpLQEGPGPEGGRGARIVWVCDGGCLLVSGFDSRSERQLQ 707
Cdd:PTZ00421 162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTI-VSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 708 LYIADALAQgPSALLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYEVLPEAPFFleCNSFTSPDPHKGFVLLPKTEC 787
Cdd:PTZ00421 241 LWDTRKMAS-PYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 788 DIQDVEFARCLRLRQTSLEPVAFRLPRVRK-EFFQDDVFPDTAVTwEPALSAKAWFEGANGQPRLLSLQ-------PPGM 859
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgtsPELM 396

                        410
                 ....*....|....*...
gi 148747331 860 TPVSQAPREVPARRAPSS 877
Cdd:PTZ00421 397 GASALSPSGKPRHSGVSV 414
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-379 2.83e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 182.40  E-value: 2.83e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331   6 VSKFRHMEARPSRREAWISDIRAVTTP-TCGNHIKSSCSLIAFNSDRPGVLGVIslegheenkRHVTY----------LG 74
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIAVPWQQLGSTAVL---------KHTDYgklasnppilLG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  75 CHSDLVtDLDFSPFDDFLLASGSADRTIKLWRLSGTG-EALPSVPGVVLGPEELPVEVLQFHPTVDGVLVST-AGKTVKV 152
Cdd:PTZ00421  74 QEGPII-DVAFNPFDPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVVNV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 153 WDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDPRARTQASqSTQAHENNRDIRLAWTGIQEHLVSTGF 232
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGC 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 233 NQMREREAKLWDTRLFSSALASVTLDTSPGPLIPLLDPDSGLLVLAGKGENQLYCYEVTPQQpaLSPVTQCILENVLRGA 312
Cdd:PTZ00421 232 SKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGL 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148747331 313 ALVPRRALAVMSCEVLQVLQLSDTAIIPISHHVPRKA--VEFHEDLFPDTAGSVPASDAHMWWAGDNQQ 379
Cdd:PTZ00421 310 CMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAE 378
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 468-877 3.04e-65

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 227.47  E-value: 3.04e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 468 SKFRHTQGSLLHRDSHITNLKGLNLTTPGESDGFCANRLrVAVPLLSSGGqVAVLELQKPGRLPDTALPTLQNGTAVMDL 547
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDCSNTIACNDRF-IAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 548 VWDPFDPHRLAVAGEDARIRLWRVPPGGLENVLTTPETVLTGHTEKIYSLRFHPLAADVLASSSYDLTVRIWDLQTGAER 627
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 628 LKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRSSPLpLQEGPGPEGGRGARIVWVCDGGCLLVSGFDSRSERQLQ 707
Cdd:PTZ00421 162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTI-VSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 708 LYIADALAQgPSALLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYEVLPEAPFFleCNSFTSPDPHKGFVLLPKTEC 787
Cdd:PTZ00421 241 LWDTRKMAS-PYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 788 DIQDVEFARCLRLRQTSLEPVAFRLPRVRK-EFFQDDVFPDTAVTwEPALSAKAWFEGANGQPRLLSLQ-------PPGM 859
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgtsPELM 396

                        410
                 ....*....|....*...
gi 148747331 860 TPVSQAPREVPARRAPSS 877
Cdd:PTZ00421 397 GASALSPSGKPRHSGVSV 414
PTZ00421 PTZ00421
coronin; Provisional
 6-379 2.83e-49

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 182.40  E-value: 2.83e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331   6 VSKFRHMEARPSRREAWISDIRAVTTP-TCGNHIKSSCSLIAFNSDRPGVLGVIslegheenkRHVTY----------LG 74
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIAVPWQQLGSTAVL---------KHTDYgklasnppilLG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  75 CHSDLVtDLDFSPFDDFLLASGSADRTIKLWRLSGTG-EALPSVPGVVLGPEELPVEVLQFHPTVDGVLVST-AGKTVKV 152
Cdd:PTZ00421  74 QEGPII-DVAFNPFDPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVVNV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 153 WDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDPRARTQASqSTQAHENNRDIRLAWTGIQEHLVSTGF 232
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGC 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 233 NQMREREAKLWDTRLFSSALASVTLDTSPGPLIPLLDPDSGLLVLAGKGENQLYCYEVTPQQpaLSPVTQCILENVLRGA 312
Cdd:PTZ00421 232 SKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGL 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148747331 313 ALVPRRALAVMSCEVLQVLQLSDTAIIPISHHVPRKA--VEFHEDLFPDTAGSVPASDAHMWWAGDNQQ 379
Cdd:PTZ00421 310 CMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAE 378
WD40 COG2319
WD40 repeat [General function prediction only];
514-668 1.11e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 514 SSGGQVAVLELQKpGRLpdtaLPTLQNGT-AVMDLVWDPfDPHRLAVAGEDARIRLWRVPPGGLEnvlttpeTVLTGHTE 592
Cdd:COG2319  139 SADGTVRLWDLAT-GKL----LRTLTGHSgAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLL-------RTLTGHTG 205

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148747331 593 KIYSLRFHPlaaD--VLASSSYDLTVRIWDLQTGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRSSPL 668
Cdd:COG2319  206 AVRSVAFSP---DgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
65-279 5.76e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 5.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  65 ENKRHVTYLGCHSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSgTGEALPSVPGvvlgpEELPVEVLQFHPtvDGVLVS 144
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA-TGKLLRTLTG-----HSGAVTSVAFSP--DGKLLA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 145 TAG--KTVKVWDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDprARTQASQSTQAHENNRDIRLAWTG 222
Cdd:COG2319  179 SGSddGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD--LATGKLLRTLTGHSGSVRSVAFSP 256

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 148747331 223 IQEHLVSTGfnqmREREAKLWDTrlfSSALASVTLDTSPGPLIPL-LDPDSGLLVLAG 279
Cdd:COG2319  257 DGRLLASGS----ADGTVRLWDL---ATGELLRTLTGHSGGVNSVaFSPDGKLLASGS 307
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 543-665 1.78e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.34  E-value: 1.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 543 AVMDLVWDPfDPHRLAVAGEDARIRLWRVPPGglenvltTPETVLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWDLQ 622
Cdd:cd00200   95 YVSSVAFSP-DGRILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR 165

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 148747331 623 TGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRS 665
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 66-246 4.77e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 4.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  66 NKRHVTYLGcHSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSgTGEALPSVPGVvlgpeELPVEVLQFHPtvDGVLVST 145
Cdd:cd00200   83 GECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE-TGKCLTTLRGH-----TDWVNSVAFSP--DGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 146 AG--KTVKVWDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDPRArTQASQSTQAHENNrdIR-LAWTG 222
Cdd:cd00200  153 SSqdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENG--VNsVAFSP 229

                        170       180
                 ....*....|....*....|....
gi 148747331 223 IQEHLVSTGFNqmreREAKLWDTR 246
Cdd:cd00200  230 DGYLLASGSED----GTIRVWDLR 249
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 805-849 1.12e-16

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 74.47  E-value: 1.12e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148747331  805 LEPVAFRLPRVRKEFFQDDVFPDTAVTWePALSAKAWFEGANGQP 849
Cdd:pfam16300   1 IEPISFTVPRKSKEDFQDDLYPDTAGTE-PALTAEEWLSGKNAEP 44
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 338-380 8.82e-14

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 66.00  E-value: 8.82e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148747331  338 IIPISHHVPRKAVE-FHEDLFPDTAGSVPASDAHMWWAGDNQQV 380
Cdd:pfam16300   1 IEPISFTVPRKSKEdFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 623-662 9.53e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 9.53e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148747331   623 TGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYE 662
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-105 8.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 8.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148747331    66 NKRHVTYLGCHSDLVTDLDFSPfDDFLLASGSADRTIKLW 105
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 615-661 3.46e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 40.72  E-value: 3.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 148747331  615 TVRIWDLQTGAeRLKLQGHQDQIFSLAWSPDGKQLA-TVCKDGHVRVY 661
Cdd:TIGR02800 215 EIYVQDLATGQ-REKVASFPGMNGAPAFSPDGSKLAvSLSKDGNPDIY 261
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 468-877 3.04e-65

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 227.47  E-value: 3.04e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 468 SKFRHTQGSLLHRDSHITNLKGLNLTTPGESDGFCANRLrVAVPLLSSGGqVAVLELQKPGRLPDTALPTLQNGTAVMDL 547
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDCSNTIACNDRF-IAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 548 VWDPFDPHRLAVAGEDARIRLWRVPPGGLENVLTTPETVLTGHTEKIYSLRFHPLAADVLASSSYDLTVRIWDLQTGAER 627
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 628 LKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRSSPLpLQEGPGPEGGRGARIVWVCDGGCLLVSGFDSRSERQLQ 707
Cdd:PTZ00421 162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTI-VSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 708 LYIADALAQgPSALLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYEVLPEAPFFleCNSFTSPDPHKGFVLLPKTEC 787
Cdd:PTZ00421 241 LWDTRKMAS-PYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 788 DIQDVEFARCLRLRQTSLEPVAFRLPRVRK-EFFQDDVFPDTAVTwEPALSAKAWFEGANGQPRLLSLQ-------PPGM 859
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgtsPELM 396

                        410
                 ....*....|....*...
gi 148747331 860 TPVSQAPREVPARRAPSS 877
Cdd:PTZ00421 397 GASALSPSGKPRHSGVSV 414
PTZ00421 PTZ00421
coronin; Provisional
 6-379 2.83e-49

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 182.40  E-value: 2.83e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331   6 VSKFRHMEARPSRREAWISDIRAVTTP-TCGNHIKSSCSLIAFNSDRPGVLGVIslegheenkRHVTY----------LG 74
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIAVPWQQLGSTAVL---------KHTDYgklasnppilLG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  75 CHSDLVtDLDFSPFDDFLLASGSADRTIKLWRLSGTG-EALPSVPGVVLGPEELPVEVLQFHPTVDGVLVST-AGKTVKV 152
Cdd:PTZ00421  74 QEGPII-DVAFNPFDPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVVNV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 153 WDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDPRARTQASqSTQAHENNRDIRLAWTGIQEHLVSTGF 232
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGC 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 233 NQMREREAKLWDTRLFSSALASVTLDTSPGPLIPLLDPDSGLLVLAGKGENQLYCYEVTPQQpaLSPVTQCILENVLRGA 312
Cdd:PTZ00421 232 SKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGL 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148747331 313 ALVPRRALAVMSCEVLQVLQLSDTAIIPISHHVPRKA--VEFHEDLFPDTAGSVPASDAHMWWAGDNQQ 379
Cdd:PTZ00421 310 CMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAE 378
PTZ00420 PTZ00420
coronin; Provisional
 31-385 1.39e-41

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 161.27  E-value: 1.39e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  31 TPTCGNHIKSSCSLIAFNSDRPGVLGVISLEgHEENKRHVTYLGCHSDLVTDLDFSPFDDFLLASGSADRTIKLWRLSGT 110
Cdd:PTZ00420  29 IDSCGIACSSGFVAVPWEVEGGGLIGAIRLE-NQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHN 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 111 GEALPSV--PGVVLGPEELPVEVLQFHPTVDGVLVSTA-GKTVKVWDVAKQQPLTELEAHKDLvQSAVWSRDGAIVGTAC 187
Cdd:PTZ00420 108 DESVKEIkdPQCILKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDIENEKRAFQINMPKKL-SSLKWNIKGNLLSGTC 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 188 KDKQLRIFDPRARTQASqSTQAHENNRDIRLAWT----GIQEHLVSTGFNQMREREAKLWDTRLFSSALASVTLDTSPGP 263
Cdd:PTZ00420 187 VGKHMHIIDPRKQEIAS-SFHIHDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREMKLWDLKNTTSALVTMSIDNASAP 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 264 LIPLLDPDSGLLVLAGKGENQLYCYEVTpqQPALSPVTQCILENVLRGAALVPRRALAVMSCEVLQVLQ-LSDTAIIPIS 342
Cdd:PTZ00420 266 LIPHYDESTGLIYLIGKGDGNCRYYQHS--LGSIRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKnENNSSIRPIS 343

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 148747331 343 HHVPRK-AVEFHEDLFPDTAGSVPASDAHMWWAGDNQQVQKVSL 385
Cdd:PTZ00420 344 FYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINI 387
PTZ00420 PTZ00420
coronin; Provisional
 508-846 4.62e-36

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 144.71  E-value: 4.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 508 VAVPL-LSSGGQVAVLELQKPGRLPdtalPTLQ---NGTAVMDLVWDPFDPHRLAVAGEDARIRLWRVPPGGlENV--LT 581
Cdd:PTZ00420  41 VAVPWeVEGGGLIGAIRLENQMRKP----PVIKlkgHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHND-ESVkeIK 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 582 TPETVLTGHTEKIYSLRFHPLAADVLASSSYDLTVRIWDLQTGAERLKLQgHQDQIFSLAWSPDGKQLATVCKDGHVRVY 661
Cdd:PTZ00420 116 DPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLSGTCVGKHMHII 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 662 EPRSSPLpLQEGPGPEGGRGARIVWV----CDGGCLLVSGFDSRSERQLQLYiadALAQGPSAL--LGLDVAPSTLLPSY 735
Cdd:PTZ00420 195 DPRKQEI-ASSFHIHDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREMKLW---DLKNTTSALvtMSIDNASAPLIPHY 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 736 DPDTGLVLLTGKGDTRVFLYEVLPEApfFLECNSFTSPDPHKGFVLLPKTECDIQDVEFARCLR-LRQTSLEPVAFRLPR 814
Cdd:PTZ00420 271 DESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKnENNSSIRPISFYVPR 348

                        330       340       350
                 ....*....|....*....|....*....|..
gi 148747331 815 VRKEFFQDDVFPDTaVTWEPALSAKAWFEGAN 846
Cdd:PTZ00420 349 KNPTKFQEDLYPPI-LMHDPERSSRNWIDGKD 379
WD40 COG2319
WD40 repeat [General function prediction only];
514-668 1.11e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 514 SSGGQVAVLELQKpGRLpdtaLPTLQNGT-AVMDLVWDPfDPHRLAVAGEDARIRLWRVPPGGLEnvlttpeTVLTGHTE 592
Cdd:COG2319  139 SADGTVRLWDLAT-GKL----LRTLTGHSgAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLL-------RTLTGHTG 205

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148747331 593 KIYSLRFHPlaaD--VLASSSYDLTVRIWDLQTGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRSSPL 668
Cdd:COG2319  206 AVRSVAFSP---DgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
514-665 2.56e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 2.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 514 SSGGQVAVLELQKpGRLpdtaLPTLQNGT-AVMDLVWDPfDPHRLAVAGEDARIRLWRVPPGglenvltTPETVLTGHTE 592
Cdd:COG2319  181 SDDGTVRLWDLAT-GKL----LRTLTGHTgAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSG 247

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148747331 593 KIYSLRFHPlaaD--VLASSSYDLTVRIWDLQTGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRS 665
Cdd:COG2319  248 SVRSVAFSP---DgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
543-665 4.03e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 4.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 543 AVMDLVWDPfDPHRLAVAGEDARIRLWRVPPGglenvltTPETVLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWDLQ 622
Cdd:COG2319  290 GVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLA 360

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 148747331 623 TGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRS 665
Cdd:COG2319  361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
503-668 3.63e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 3.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 503 ANRLRVAVPLLSSGGQVAVLELQKPGRLPDTALPTLQNGTAVMDLVWDPFDPHRLAVAGEDARIRLWRVPPGglenvltT 582
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG-------L 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 583 PETVLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWDLQTGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYE 662
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190


                 ....*.
gi 148747331 663 PRSSPL 668
Cdd:COG2319  191 LATGKL 196
WD40 COG2319
WD40 repeat [General function prediction only];
65-279 5.76e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 5.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  65 ENKRHVTYLGCHSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSgTGEALPSVPGvvlgpEELPVEVLQFHPtvDGVLVS 144
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA-TGKLLRTLTG-----HSGAVTSVAFSP--DGKLLA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 145 TAG--KTVKVWDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDprARTQASQSTQAHENNRDIRLAWTG 222
Cdd:COG2319  179 SGSddGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD--LATGKLLRTLTGHSGSVRSVAFSP 256

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 148747331 223 IQEHLVSTGfnqmREREAKLWDTrlfSSALASVTLDTSPGPLIPL-LDPDSGLLVLAG 279
Cdd:COG2319  257 DGRLLASGS----ADGTVRLWDL---ATGELLRTLTGHSGGVNSVaFSPDGKLLASGS 307
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 543-665 1.78e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.34  E-value: 1.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 543 AVMDLVWDPfDPHRLAVAGEDARIRLWRVPPGglenvltTPETVLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWDLQ 622
Cdd:cd00200   95 YVSSVAFSP-DGRILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR 165

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 148747331 623 TGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRS 665
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
76-246 6.69e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 6.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  76 HSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSgTGEALPSVPGvvlgpEELPVEVLQFHPtvDGVLVSTAG--KTVKVW 153
Cdd:COG2319  161 HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLA-TGKLLRTLTG-----HTGAVRSVAFSP--DGKLLASGSadGTVRLW 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 154 DVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDprARTQASQSTQAHENNRDIRLAWTGIQEHLVSTGFN 233
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170
                 ....*....|...
gi 148747331 234 QMrereAKLWDTR 246
Cdd:COG2319  310 GT----VRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
65-246 6.42e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 6.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  65 ENKRHVTYLGCHSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSgTGEALPSVPGvvlgpEELPVEVLQFHPtvDGVLVS 144
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA-TGELLRTLTG-----HSGGVNSVAFSP--DGKLLA 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 145 TAG--KTVKVWDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDPRARTQAsQSTQAHENnrDIR-LAWT 221
Cdd:COG2319  305 SGSddGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTG--AVTsVAFS 381

                        170       180
                 ....*....|....*....|....*
gi 148747331 222 GIQEHLVSTGFNqmreREAKLWDTR 246
Cdd:COG2319  382 PDGRTLASGSAD----GTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 544-662 4.79e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 4.79e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 544 VMDLVWDPfDPHRLAVAGEDARIRLWRVPPGglenvltTPETVLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWDLQT 623
Cdd:cd00200  180 VNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG-------KCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRT 250

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 148747331 624 GAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYE 662
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 66-246 4.77e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 4.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  66 NKRHVTYLGcHSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSgTGEALPSVPGVvlgpeELPVEVLQFHPtvDGVLVST 145
Cdd:cd00200   83 GECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE-TGKCLTTLRGH-----TDWVNSVAFSP--DGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 146 AG--KTVKVWDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDPRArTQASQSTQAHENNrdIR-LAWTG 222
Cdd:cd00200  153 SSqdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENG--VNsVAFSP 229

                        170       180
                 ....*....|....*....|....
gi 148747331 223 IQEHLVSTGFNqmreREAKLWDTR 246
Cdd:cd00200  230 DGYLLASGSED----GTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 544-665 5.20e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 5.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 544 VMDLVWDPfDPHRLAVAGEDARIRLWRVPPGglenvltTPETVLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWDLQT 623
Cdd:cd00200   12 VTCVAFSP-DGKLLATGSGDGTIKVWDLETG-------ELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 148747331 624 GAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRS 665
Cdd:cd00200   83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET 124
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 69-249 7.56e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 7.56e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  69 HVTYLGcHSDLVTDLDFSPFDDfLLASGSADRTIKLWRLSgTGEALPSVPGvvlgpEELPVEVLQFHPTVDGVLVSTAGK 148
Cdd:cd00200    2 RRTLKG-HTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLE-TGELLRTLKG-----HTGPVRDVAASADGTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 149 TVKVWDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDPRARTQaSQSTQAHENnrDIR-LAWTGiQEHL 227
Cdd:cd00200   74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-LTTLRGHTD--WVNsVAFSP-DGTF 149

                        170       180
                 ....*....|....*....|..
gi 148747331 228 VSTGfnqMREREAKLWDTRLFS 249
Cdd:cd00200  150 VASS---SQDGTIKLWDLRTGK 168
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-196 3.51e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 3.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  76 HSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSgTGEALpsvpgVVLGPEELPVEVLQFHPtvDGVLVSTAGK--TVKVW 153
Cdd:cd00200  176 HTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLS-TGKCL-----GTLRGHENGVNSVAFSP--DGYLLASGSEdgTIRVW 246

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 148747331 154 DVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFD 196
Cdd:cd00200  247 DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 805-849 1.12e-16

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 74.47  E-value: 1.12e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148747331  805 LEPVAFRLPRVRKEFFQDDVFPDTAVTWePALSAKAWFEGANGQP 849
Cdd:pfam16300   1 IEPISFTVPRKSKEDFQDDLYPDTAGTE-PALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 586-668 2.03e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 586 VLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWDLQTGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRS 665
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82


                 ...
gi 148747331 666 SPL 668
Cdd:cd00200   83 GEC 85
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 338-380 8.82e-14

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 66.00  E-value: 8.82e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148747331  338 IIPISHHVPRKAVE-FHEDLFPDTAGSVPASDAHMWWAGDNQQV 380
Cdd:pfam16300   1 IEPISFTVPRKSKEdFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 467-529 2.32e-12

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 62.90  E-value: 2.32e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148747331  467 SSKFRHTQGSLLHRDSHITNLKglNLTTPGESDGFCANRLRVAVPLLSSG-GQVAVLELQKPGR 529
Cdd:pfam08953   5 ASKFRHVYGKPAKKELCYDNIK--VTKNAWDSNFIAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
76-246 8.96e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 8.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  76 HSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSGTGEALPsvpgvvLGPEELPVEVLQFHPTVDGVLVSTAGKTVKVWDV 155
Cdd:COG2319   35 LAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLAT------LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 156 AKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDprARTQASQSTQAHENNRDIRLAWTGIQEHLVSTGFNqm 235
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD-- 183

                        170
                 ....*....|.
gi 148747331 236 reREAKLWDTR 246
Cdd:COG2319  184 --GTVRLWDLA 192
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 2-61 2.17e-11

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 59.82  E-value: 2.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747331    2 SRFKVSKFRHMEARPSRREAWISDIRAVTTPTCGNHIKSSCSLIAFN--SDRPGVLGVISLE 61
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNweSSGGGAFAVLPLN 62
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 623-662 9.53e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 9.53e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148747331   623 TGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYE 662
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
556-671 6.53e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 6.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331 556 RLAVAGEDARIRLWRVPPGGLENVLTTPETVLTGHTEKIYSLRFHPLAAdVLASSSYDLTVRIWDLQTGAERLKLQGHQD 635
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 148747331 636 QIFSLAWSPDGKQLATVCKDGHVRVYEPRSSPLPLQ 671
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115
WD40 pfam00400
WD domain, G-beta repeat;
629-662 7.79e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 7.79e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 148747331  629 KLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYE 662
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-105 8.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 8.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148747331    66 NKRHVTYLGCHSDLVTDLDFSPfDDFLLASGSADRTIKLW 105
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 582-620 1.34e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 148747331   582 TPETVLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWD 620
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
582-620 3.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 3.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148747331  582 TPETVLTGHTEKIYSLRFHPlAADVLASSSYDLTVRIWD 620
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
73-105 3.97e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 3.97e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 148747331   73 LGCHSDLVTDLDFSPFDDFLlASGSADRTIKLW 105
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 617-662 1.43e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.19  E-value: 1.43e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 148747331  617 RIWDLQTGAERLKlqghqdqIFSLAWSPDGKQLATVCKDGHVRVYE 662
Cdd:pfam12894  28 RVWTLSPDKEDLE-------VTSLAWRPDGKLLAVGYSDGTVRLLD 66
WD40 COG2319
WD40 repeat [General function prediction only];
76-109 4.17e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 4.17e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 148747331  76 HSDLVTDLDFSPfDDFLLASGSADRTIKLWRLSG 109
Cdd:COG2319  371 HTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.01e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148747331   157 KQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
159-196 5.45e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.45e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148747331  159 QPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFD 196
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-106 2.54e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 2.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148747331  40 SSCSLIAFNSDRPGVLGVISLEgheeNKRHVTYLGCHSDLVTDLDFSPfDDFLLASGSADRTIKLWR 106
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 541-650 3.27e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.18  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747331  541 GTAVMDLVWDPfDPHRLAVA----GEDArirLWRVPPGGLEnvltTPETVLTGHTEKIYSLRFHPlaaDV--LASSSYDL 614
Cdd:COG4946   342 GVRERLPAWSP-DGKSIAYFsdasGEYE---LYIAPADGSG----EPKQLTLGDLGRVFNPVWSP---DGkkIAFTDNRG 410

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 148747331  615 TVRIWDLQTGAERLKLQG-HQDQIFSLAWSPDGKQLA 650
Cdd:COG4946   411 RLWVVDLASGKVRKVDTDgYGDGISDLAWSPDSKWLA 447
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 615-661 3.46e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 40.72  E-value: 3.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 148747331  615 TVRIWDLQTGAeRLKLQGHQDQIFSLAWSPDGKQLA-TVCKDGHVRVY 661
Cdd:TIGR02800 215 EIYVQDLATGQ-REKVASFPGMNGAPAFSPDGSKLAvSLSKDGNPDIY 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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