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Conserved domains on  [gi|153218552|ref|NP_114169|]
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keratin-associated protein 9-8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 6-158 3.65e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 65.97  E-value: 3.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153218552    6 SPCCQPTCC-RTTCWKPTTVTTCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPICVTSCCQPSCCSTPCCQPTCCGQT 84
Cdd:pfam01500   7 SFCGFPTCStGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153218552   85 SCGSSCGQSSSCAPVYCRRTCYHPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCCrttcfQPTCVSSCCQPSC 158
Cdd:pfam01500  87 YGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 6-158 3.65e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 65.97  E-value: 3.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153218552    6 SPCCQPTCC-RTTCWKPTTVTTCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPICVTSCCQPSCCSTPCCQPTCCGQT 84
Cdd:pfam01500   7 SFCGFPTCStGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153218552   85 SCGSSCGQSSSCAPVYCRRTCYHPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCCrttcfQPTCVSSCCQPSC 158
Cdd:pfam01500  87 YGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
4-83 1.97e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 40.69  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153218552   4 CCSPCCQPTCCRTTCWKpttVTTCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPICVTSCCQpsCCSTPCCQPTCCGQ 83
Cdd:COG3901  610 CLLGLALAAAALARRRL---WRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCCLCCR--RCQDDPLCPPRIKK 684
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 6-158 3.65e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 65.97  E-value: 3.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153218552    6 SPCCQPTCC-RTTCWKPTTVTTCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPICVTSCCQPSCCSTPCCQPTCCGQT 84
Cdd:pfam01500   7 SFCGFPTCStGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153218552   85 SCGSSCGQSSSCAPVYCRRTCYHPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCCrttcfQPTCVSSCCQPSC 158
Cdd:pfam01500  87 YGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
32-79 6.65e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 51.61  E-value: 6.65e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 153218552   32 CCQPSCCVSSCCQP-CCRPTCCQNTCCQPicvtSCCQPSCCSTPCCQPT 79
Cdd:pfam13885   1 CCQPSCCQPSCCQPsCCQPSCCQPSCCQP----SCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
42-81 3.40e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 44.68  E-value: 3.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 153218552   42 CCQP-CCRPTCCQNTCCQPI-CVTSCCQPSCCSTPCCQPTCC 81
Cdd:pfam13885   1 CCQPsCCQPSCCQPSCCQPScCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
4-60 7.54e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.52  E-value: 7.54e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 153218552    4 CCSPCCQPTCCRTTcwkpttvttcsstpCCQPSCCVSSCCQP-CCRPTCCQNTCCQPI 60
Cdd:pfam13885   2 CQPSCCQPSCCQPS--------------CCQPSCCQPSCCQPsCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
46-109 1.11e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.14  E-value: 1.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 153218552   46 CCRPTCCQNTCCQPicvtSCCQPSCCSTPCCQPTCCgqtscgsscgqssscAPVYCRRTCYHPT 109
Cdd:pfam13885   1 CCQPSCCQPSCCQP----SCCQPSCCQPSCCQPSCC---------------RPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
8-65 2.24e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 2.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 153218552    8 CCQPTCCRTTCwkpttvttcsstpcCQPSCCVSSCCQP-CCRPTCCQNTCCQPICVTSC 65
Cdd:pfam13885   1 CCQPSCCQPSC--------------CQPSCCQPSCCQPsCCQPSCCRPSCCRSSCCQPT 45
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
4-83 1.97e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 40.69  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153218552   4 CCSPCCQPTCCRTTCWKpttVTTCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPICVTSCCQpsCCSTPCCQPTCCGQ 83
Cdd:COG3901  610 CLLGLALAAAALARRRL---WRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCCLCCR--RCQDDPLCPPRIKK 684
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-56 1.16e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.46  E-value: 1.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 153218552    2 THCCSPCCQPTCCRTTCWKPTTVttcsSTPCCQPSCCVSSCCQPCCRPTCCQNTC 56
Cdd:pfam01500 111 GTCLPPCCVVSCTPPTCCQLHHA----QASCCRPSYCGQSCCRPACCCQCSEPTC 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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