BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  673 SLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSA-VEDGVLTQRVLLGDVSTEAARTF 751
Cdd:cd18288    1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVeEEGGVTTRRVLLGDVSGEAARCF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 63252863  752 LHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCE 787
Cdd:cd18288   81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 63252863   1754 EALRCYIRSKPALYQKVLLYQPFELRELQAELRQNG--LRVSSRRLLDFLDTHCITFTT 1810
Cdd:pfam09494    2 EAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  673 SLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSA-VEDGVLTQRVLLGDVSTEAARTF 751
Cdd:cd18288    1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVeEEGGVTTRRVLLGDVSGEAARCF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 63252863  752 LHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCE 787
Cdd:cd18288   81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 63252863   1754 EALRCYIRSKPALYQKVLLYQPFELRELQAELRQNG--LRVSSRRLLDFLDTHCITFTT 1810
Cdd:pfam09494    2 EAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863     699 SGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDgvltqRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFG 778
Cdd:smart00225    7 GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-----EIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQ 81

                            90
                    ....*....|
gi 63252863     779 VSELVHLCEQ 788
Cdd:smart00225   82 IPGLVELCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  673 SLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSA-VEDGVLTQRVLLGDVSTEAARTF 751
Cdd:cd18288    1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVeEEGGVTTRRVLLGDVSGEAARCF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 63252863  752 LHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCE 787
Cdd:cd18288   81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  677 LVADFGAMVNNPHLSDVQFQ-TDSGEVLYAHKFVLYARCPLlIQYVNNEGFSAVEDgvlTQRVLLGDVSTEAARTFLHYL 755
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLvGPERQEIFAHKCILAARCEV-FRAMFLTGPQKEST---QSPLVLSDIEPEVFRAVLEFI 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 63252863  756 YTADTGLPPGLSSELSSLAHRFGVSELVHLCEQ 788
Cdd:cd18294   77 YTNCVTLSNHTVIEVLAAAVEYGLDELRKLCER 109

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 63252863   1754 EALRCYIRSKPALYQKVLLYQPFELRELQAELRQNG--LRVSSRRLLDFLDTHCITFTT 1810
Cdd:pfam09494    2 EAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  680 DFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCP---LLIqyvnnegfsavedGVLTQRVLLGDVSTEAARTFLHYLY 756
Cdd:cd18299    2 DLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSvfaDLF-------------LMMTVVTLDSDITPEAFRRVLEFLY 68

                         90       100       110
                 ....*....|....*....|....*....|...
gi 63252863  757 TADTGLPPGLSSELSSLAHRFGVSELVHLCEQV 789
Cdd:cd18299   69 TGVLDENEDDLKELKDAAELLELFDLVMMCTNV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  686 NNPHLSDVQFQTDsGEVLYAHKFVLYARCplliQYVNNEgFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPG 765
Cdd:cd18298    8 NDPRTSDLKFRVD-GKYIYVHKAILKIRC----EYFRSM-FQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPE 81

                         90       100
                 ....*....|....*....|...
gi 63252863  766 LSSELSSLAHRFGVSELVHLCEQ 788
Cdd:cd18298   82 DAIGLLDLANSYCEERLKKLCED 104

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863    681 FGAMVNNPHLSDVQFQTDsGEVLYAHKFVLYARCPLLiqyvnNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTaDT 760
Cdd:pfam00651    1 LNELREQGELCDVTLVVG-DKEFRAHKAVLAACSPYF-----KALFSGQESESSVSEITLDDVSPEDFEALLEFMYT-GK 73

                           90       100
                   ....*....|....*....|....*...
gi 63252863    761 GLPPGLSSELSSLAHRFGVSELVHLCEQ 788
Cdd:pfam00651   74 LISEENVDDLLAAADKLQIPSLVDKCEE 101

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  682 GAMVNNPHLSDVQFQTdSGEVLYAHKFVLYARCPLLIQYVNneGFSAVEDGVLtqrVLLGDVSTEAARTFLHYLYTaDTG 761
Cdd:cd18360    2 GLFFNSPLLADVVFKI-QGTTVPAHRAVLVARCEVMAAMFN--GNYAEAKSFL---VPIYGVSKDTFLSFLEYLYT-DSC 74

                         90       100
                 ....*....|....*....|....*...
gi 63252863  762 LPPGLSSELSSL--AHRFGVSELVHLCE 787
Cdd:cd18360   75 CPASILQAMALLicAEMYQVSRLQHICE 102

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863     699 SGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDgvltqRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFG 778
Cdd:smart00225    7 GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-----EIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQ 81

                            90
                    ....*....|
gi 63252863     779 VSELVHLCEQ 788
Cdd:smart00225   82 IPGLVELCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  686 NNPHLSDVQFQTDsGEVLYAHKFVLYARCP---LLIQYVNNEGFSAVedgvltqrVLLGDVSTEAARTFLHYLYTADTGL 762
Cdd:cd18353   16 DSPETSDLKFRVD-GKYIHVHKAVLKIRCEhfrTMFQSHWNEDMKEV--------IEIDQFSYPVYRAFLEYLYTDSVDL 86

                         90       100
                 ....*....|....*....|....*..
gi 63252863  763 PPGLSSELSSLAHRFGVSELVHLCEQV 789
Cdd:cd18353   87 PPEDAIGLLDLATSYCENRLKKLCQHI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  677 LVADFGAMVNNPHLSDVQFQTDsGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDGVLTqrvLLGDVSTEAA-RTFLHYL 755
Cdd:cd18292    4 FLQDIAQLYNNEELSDIVLRVG-GKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIE---LVEDPECAAVfEKFLRYL 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 63252863  756 YTA------DTGLPpglsseLSSLAHRFGVSELVHLCEQ 788
Cdd:cd18292   80 YTGqisvnlETALP------LLMLADKYNVTDLKQLCVD 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  677 LVADFGAMVNNPHLSDVQFQTdSGEVLYAHKFVLYARCPlliqyVNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLY 756
Cdd:cd18345    5 LSDDLGLLFERSAFSDVTLCV-GGREFQAHKAILAARSP-----VFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIY 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 63252863  757 TADTGLPPGLSSELSSLAHRFGVSELVHLCEQ 788
Cdd:cd18345   79 TGKAPNLDKMADDLLAAADKYALERLKVMCEE 110

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  675 GLLVADFGAMVNNPHL--SDVQFQTDSGEVLYAHKFVLYARCPLLIQYvnnegFSAVEDGVLTQRVLL--------GDVS 744
Cdd:cd18310    1 KKLSSDLENLLDSPDLfySDAEIIVEGGRPVPVHRCILAARSPFFRDI-----FASAKAEGANTKPKLelrelipgGIVG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63252863  745 TEAARTFLHYLYTADTGLPPGLSS--------------------ELSSLAHRFGVSELVHLCEQ 788
Cdd:cd18310   76 YDAFMLVLSYLYSGRLRLVPKEGSacvdsdcwhvacrpavdfalEVLYAASVFQIPELVSLFQR 139

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  690 LSDVQFQTDSGEVLyAHKFVLYARCPLLIQYVnneGFSAVEDGvlTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSS- 768
Cdd:cd18359   20 FSDVTFMLDDGTIS-AHKPLLISSCDWMAAMF---GGPFVESS--TTEVVFPYTSRSSMRAVLEYLYTGQFSSSPDLDDm 93

                         90       100
                 ....*....|....*....|
gi 63252863  769 ELSSLAHRFGVSELVHLCEQ 788
Cdd:cd18359   94 KLIILANRLCLPHLVALTEQ 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  684 MVNNPHLSDVQF---QTDSGEVLYAHKFVLYARCPLliqyvnnegFSAVEDGVL---TQRVLLGDVSTEAARTFLHYLYT 757
Cdd:cd18282    1 MFNNELMADVHFivgPPGGTQRIPAHKYVLATGSSV---------FYAMFYGGLaenKNEIEIPDVEPAAFLNLLRYLYC 71

                         90       100       110
                 ....*....|....*....|....*....|...
gi 63252863  758 ADTGLPPglSSELSSL--AHRFGVSELVHLCEQ 788
Cdd:cd18282   72 DEIDLEP--DTVLATLyaAKKYLVPHLARACVQ 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63252863  676 LLVADFGAMVNNPHLSDVQFQTdSGEVLYAHKFVLYARCPLLIQYVNNEgfsaVEDGVLTqRVLLGDVSTEAARTFLHYL 755
Cdd:cd18279    4 RLAEDLGNLWENSRFTDCCLCV-GGQEFQAHKAILAARSPVFSAMFEHE----MEESKKN-RVEINDVDPEVFKEMMRFI 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 63252863  756 YTADTGLPPGLSSELSSLAHRFGVSELVHLCEQV 789
Cdd:cd18279   78 YTGKAPNLDKMADDLLAAADKYALERLKVMCEDA 111