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Conserved domains on  [gi|32129199|ref|NP_149073|]
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SAP domain-containing ribonucleoprotein [Homo sapiens]

Protein Classification

SAP domain-containing protein( domain architecture ID 10649858)

SAP (SAF-A/B, Acinus and PIAS) domain-containing protein may bind DNA or RNA and act as a transcriptional regulator

CATH:  1.10.720.30
Gene Ontology:  GO:0003676|GO:0003700
PubMed:  10694879
SCOP:  4002795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
8-42 6.78e-08

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


:

Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 47.10  E-value: 6.78e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 32129199      8 LHKLKLAELKQECLARGLETKGIKQDLIHRLQAYL 42
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
PLN03124 super family cl33640
poly [ADP-ribose] polymerase; Provisional
 7-90 2.46e-03

poly [ADP-ribose] polymerase; Provisional


The actual alignment was detected with superfamily member PLN03124:

Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 38.28  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32129199    7 ELHKLKLAELKQECLARGLETKGIKQDLIHRLQAYLEEHAEEeaneedvlGDETEEEETKPIELPVKEEEPPEKtvDVAA 86
Cdd:PLN03124  78 EVKGMTVRELREAASERGLATTGRKKDLLERLCAALESDVKV--------GSANGTGEDEKEKGGDEEREKEEK--IVTA 147


                 ....
gi 32129199   87 EKKV 90
Cdd:PLN03124 148 TKKG 151
 
Name Accession Description Interval E-value
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
8-42 6.78e-08

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 47.10  E-value: 6.78e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 32129199      8 LHKLKLAELKQECLARGLETKGIKQDLIHRLQAYL 42
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 8-42 9.17e-07

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 43.93  E-value: 9.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 32129199     8 LHKLKLAELKQECLARGLETKGIKQDLIHRLQAYL 42
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 7-90 2.46e-03

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 38.28  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32129199    7 ELHKLKLAELKQECLARGLETKGIKQDLIHRLQAYLEEHAEEeaneedvlGDETEEEETKPIELPVKEEEPPEKtvDVAA 86
Cdd:PLN03124  78 EVKGMTVRELREAASERGLATTGRKKDLLERLCAALESDVKV--------GSANGTGEDEKEKGGDEEREKEEK--IVTA 147


                 ....
gi 32129199   87 EKKV 90
Cdd:PLN03124 148 TKKG 151
 
Name Accession Description Interval E-value
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
8-42 6.78e-08

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 47.10  E-value: 6.78e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 32129199      8 LHKLKLAELKQECLARGLETKGIKQDLIHRLQAYL 42
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 8-42 9.17e-07

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 43.93  E-value: 9.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 32129199     8 LHKLKLAELKQECLARGLETKGIKQDLIHRLQAYL 42
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 7-90 2.46e-03

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 38.28  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32129199    7 ELHKLKLAELKQECLARGLETKGIKQDLIHRLQAYLEEHAEEeaneedvlGDETEEEETKPIELPVKEEEPPEKtvDVAA 86
Cdd:PLN03124  78 EVKGMTVRELREAASERGLATTGRKKDLLERLCAALESDVKV--------GSANGTGEDEKEKGGDEEREKEEK--IVTA 147


                 ....
gi 32129199   87 EKKV 90
Cdd:PLN03124 148 TKKG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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