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Conserved domains on  [gi|17136834|ref|NP_476939|]
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TBP-related factor [Drosophila melanogaster]

Protein Classification

TBP family protein( domain architecture ID 10139969)

TBP family protein similar to TATA-box-binding protein (TBP), a general transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID

Gene Ontology:  GO:0006352|GO:0003677|GO:0005669

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 50-221 4.03e-108

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


:

Pssm-ID: 239952  Cd Length: 174  Bit Score: 307.99  E-value: 4.03e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  50 RLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARILQK 129
Cdd:cd04516   3 KIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARIIQK 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 130 LGFPVKFMEYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIMD 209
Cdd:cd04516  83 LGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEIYQ 162

                       170
                ....*....|..
gi 17136834 210 CLEAISPILLSF 221
Cdd:cd04516 163 AFENIYPILLQF 174
 
Name Accession Description Interval E-value
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 50-221 4.03e-108

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 307.99  E-value: 4.03e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  50 RLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARILQK 129
Cdd:cd04516   3 KIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARIIQK 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 130 LGFPVKFMEYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIMD 209
Cdd:cd04516  83 LGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEIYQ 162

                       170
                ....*....|..
gi 17136834 210 CLEAISPILLSF 221
Cdd:cd04516 163 AFENIYPILLQF 174
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 49-224 7.58e-92

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 266.95  E-value: 7.58e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834   49 IRLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARILQ 128
Cdd:PLN00062   2 PTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARIIQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  129 KLGFPVKFMEYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIM 208
Cdd:PLN00062  82 KLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEIY 161

                        170
                 ....*....|....*.
gi 17136834  209 DCLEAISPILLSFRKT 224
Cdd:PLN00062 162 TAFENIYPVLTEFRKR 177
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
48-207 2.13e-55

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 174.62  E-value: 2.13e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  48 EIRLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARIL 127
Cdd:COG2101   3 TIEIENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 128 QKLGFPV-KFMEYKLQNIVATVDLRFPIrleNLNHVHGQF----SSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAK 202
Cdd:COG2101  83 RKLGIEIpDEPEITVQNIVASADLGREI---NLNALAIGLglenIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAK 159


                ....*
gi 17136834 203 SRKDI 207
Cdd:COG2101 160 DEEEA 164
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
138-221 3.10e-36

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 122.55  E-value: 3.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834   138 EYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIMDCLEAISPI 217
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80


                  ....
gi 17136834   218 LLSF 221
Cdd:pfam00352  81 LQKL 84
 
Name Accession Description Interval E-value
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 50-221 4.03e-108

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 307.99  E-value: 4.03e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  50 RLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARILQK 129
Cdd:cd04516   3 KIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARIIQK 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 130 LGFPVKFMEYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIMD 209
Cdd:cd04516  83 LGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEIYQ 162

                       170
                ....*....|..
gi 17136834 210 CLEAISPILLSF 221
Cdd:cd04516 163 AFENIYPILLQF 174
TBP_TLF cd00652
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
 48-219 3.50e-98

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


Pssm-ID: 238352 [Multi-domain]  Cd Length: 174  Bit Score: 282.90  E-value: 3.50e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  48 EIRLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARIL 127
Cdd:cd00652   1 SPKIQNIVATVNLGCELDLRKIALAARNAEYNPKRFPGVIMRLREPKTTALIFSSGKMVITGAKSEEDAKLAARKYARIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 128 QKLGFPV-KFMEYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKD 206
Cdd:cd00652  81 QKLGFPVeKFPEFKVQNIVASCDLGFPIRLEELALKHPENASYEPELFPGLIYRMDEPKVVLLIFVSGKIVITGAKSRED 160

                       170
                ....*....|...
gi 17136834 207 IMDCLEAISPILL 219
Cdd:cd00652 161 IYEAVEKIYPILK 173
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 49-224 7.58e-92

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 266.95  E-value: 7.58e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834   49 IRLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARILQ 128
Cdd:PLN00062   2 PTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARIIQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  129 KLGFPVKFMEYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIM 208
Cdd:PLN00062  82 KLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEIY 161

                        170
                 ....*....|....*.
gi 17136834  209 DCLEAISPILLSFRKT 224
Cdd:PLN00062 162 TAFENIYPVLTEFRKR 177
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
 48-219 1.53e-58

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 182.53  E-value: 1.53e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  48 EIRLQNIVATFSVNCELDLKAINSRTRNSEYSPkRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARIL 127
Cdd:cd04517   2 DILIVNVVCQFSLRCHIDLRKLALAGRNVEYNP-RYPKVTMRLREPRATASVWSSGKITITGATSEEEAKQAARRAARLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 128 QKLGFPV-KFMEYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKD 206
Cdd:cd04517  81 QKLGFKVvRFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTGARSMED 160

                       170
                ....*....|...
gi 17136834 207 IMDCLEAISPILL 219
Cdd:cd04517 161 VREAVEKIYPIVF 173
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
48-207 2.13e-55

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 174.62  E-value: 2.13e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  48 EIRLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARIL 127
Cdd:COG2101   3 TIEIENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 128 QKLGFPV-KFMEYKLQNIVATVDLRFPIrleNLNHVHGQF----SSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAK 202
Cdd:COG2101  83 RKLGIEIpDEPEITVQNIVASADLGREI---NLNALAIGLglenIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAK 159


                ....*
gi 17136834 203 SRKDI 207
Cdd:COG2101 160 DEEEA 164
PRK00394 PRK00394
transcription factor; Reviewed
 49-207 1.78e-53

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 169.65  E-value: 1.78e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834   49 IRLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARILQ 128
Cdd:PRK00394   1 IKIENIVASTDLGQELDLEKVAEDLPNAEYNPEQFPGLVYRLEDPKIAALIFRSGKVVCTGAKSVEDLHEAVKIIIKKLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  129 KLGFPVKFM-EYKLQNIVATVDLRFPIrleNLNHVHGQFSS----YEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKS 203
Cdd:PRK00394  81 ELGIKVIDEpEIKVQNIVASADLGVEL---NLNAIAIGLGLenieYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKS 157


                 ....
gi 17136834  204 RKDI 207
Cdd:PRK00394 158 EEDA 161
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 48-214 2.10e-52

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 166.65  E-value: 2.10e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  48 EIRLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARIL 127
Cdd:cd04518   1 SLKIENIVASVDLGQELDLEKVAAELPNAEYNPDQFPGLVYRLEDPKIAALIFRSGKMVCTGAKSVEDLHRAVKEIIKKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 128 QKLGFPVKF-MEYKLQNIVATVDLRFPIrleNLNHVHGQF--SSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSR 204
Cdd:cd04518  81 KDYGIKVIEkPEIKVQNIVASADLGREV---NLDAIAIGLpnAEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSE 157

                       170
                ....*....|
gi 17136834 205 KDIMDCLEAI 214
Cdd:cd04518 158 EDAKRAVEKL 167
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
138-221 3.10e-36

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 122.55  E-value: 3.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834   138 EYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIMDCLEAISPI 217
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80


                  ....
gi 17136834   218 LLSF 221
Cdd:pfam00352  81 LQKL 84
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
48-130 1.04e-34

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 118.69  E-value: 1.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834    48 EIRLQNIVATFSVNCELDLKAINSR-TRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARI 126
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKlLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80


                  ....
gi 17136834   127 LQKL 130
Cdd:pfam00352  81 LQKL 84
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
48-132 1.41e-20

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 84.87  E-value: 1.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  48 EIRLQNIVATFSVNCELDLK--AINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFAR 125
Cdd:COG2101  94 EITVQNIVASADLGREINLNalAIGLGLENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEEAERAVDKLRE 173


                ....*..
gi 17136834 126 ILQKLGF 132
Cdd:COG2101 174 RLEELGL 180
PRK00394 PRK00394
transcription factor; Reviewed
 48-131 2.13e-19

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 81.82  E-value: 2.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834   48 EIRLQNIVATFSVNCELDLK--AINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFAR 125
Cdd:PRK00394  91 EIKVQNIVASADLGVELNLNaiAIGLGLENIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSEEDAEKAVEKILE 170


                 ....*.
gi 17136834  126 ILQKLG 131
Cdd:PRK00394 171 KLEELG 176
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 48-130 2.32e-19

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 81.53  E-value: 2.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  48 EIRLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARIL 127
Cdd:cd04518  92 EIKVQNIVASADLGREVNLDAIAIGLPNAEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSEEDAKRAVEKLLSRL 171


                ...
gi 17136834 128 QKL 130
Cdd:cd04518 172 KEL 174
TBP_TLF cd00652
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
 48-129 4.08e-19

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


Pssm-ID: 238352 [Multi-domain]  Cd Length: 174  Bit Score: 81.05  E-value: 4.08e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  48 EIRLQNIVATFSVNCELDLKAINSRTR-NSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGSRKFARI 126
Cdd:cd00652  92 EFKVQNIVASCDLGFPIRLEELALKHPeNASYEPELFPGLIYRMDEPKVVLLIFVSGKIVITGAKSREDIYEAVEKIYPI 171


                ...
gi 17136834 127 LQK 129
Cdd:cd00652 172 LKE 174
PRK00394 PRK00394
transcription factor; Reviewed
 139-218 3.28e-17

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 76.04  E-value: 3.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834  139 YKLQNIVATVDLRFPIRLENLNHVHGQfSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIMDCLEAISPIL 218
Cdd:PRK00394   1 IKIENIVASTDLGQELDLEKVAEDLPN-AEYNPEQFPGLVYRLEDPKIAALIFRSGKVVCTGAKSVEDLHEAVKIIIKKL 79
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 138-223 8.20e-16

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 72.28  E-value: 8.20e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 138 EYKLQNIVATVDLRFPIRLENLNHVHgQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIMdclEAISPI 217
Cdd:cd04518   1 SLKIENIVASVDLGQELDLEKVAAEL-PNAEYNPDQFPGLVYRLEDPKIAALIFRSGKMVCTGAKSVEDLH---RAVKEI 76


                ....*.
gi 17136834 218 LLSFRK 223
Cdd:cd04518  77 IKKLKD 82
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
138-223 2.11e-15

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 71.38  E-value: 2.11e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136834 138 EYKLQNIVATVDLRFPIRLENL-----NhvhgqfSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDImdcLE 212
Cdd:COG2101   3 TIEIENIVASGSLGQELDLEKLaedlpN------AEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDL---IE 73

                        90
                ....*....|.
gi 17136834 213 AISPILLSFRK 223
Cdd:COG2101  74 AVEKVIEKLRK 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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