splicing factor 1 isoform 2 [Rattus norvegicus]
Protein Classification
C2HC-type zinc finger protein( domain architecture ID 13420122)
C2HC-type zinc finger protein similar to caulimoviridae capsid protein
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| MSL5 super family | cl34926 | Splicing factor (branch point binding protein) [RNA processing and modification]; |
17-257 | 2.90e-69 | |||||
Splicing factor (branch point binding protein) [RNA processing and modification]; The actual alignment was detected with superfamily member COG5176: Pssm-ID: 227503 [Multi-domain] Cd Length: 269 Bit Score: 224.08 E-value: 2.90e-69
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| ZnF_C2HC | smart00343 | zinc finger; |
278-293 | 2.44e-03 | |||||
zinc finger; : Pssm-ID: 197667 [Multi-domain] Cd Length: 17 Bit Score: 35.50 E-value: 2.44e-03
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| Name | Accession | Description | Interval | E-value | |||||
| MSL5 | COG5176 | Splicing factor (branch point binding protein) [RNA processing and modification]; |
17-257 | 2.90e-69 | |||||
Splicing factor (branch point binding protein) [RNA processing and modification]; Pssm-ID: 227503 [Multi-domain] Cd Length: 269 Bit Score: 224.08 E-value: 2.90e-69
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| KH-I_SF1 | cd22382 | type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar ... |
135-227 | 5.76e-58 | |||||
type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar proteins; SF1, also called branch point-binding protein, or BBP, or transcription factor ZFM1, or zinc finger gene in MEN1 locus, or zinc finger protein 162, is necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. It may act as transcription repressor. Pssm-ID: 411810 [Multi-domain] Cd Length: 93 Bit Score: 187.90 E-value: 5.76e-58
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| SF1-HH | pfam16275 | Splicing factor 1 helix-hairpin domain; This domain, approximately 100 residues in length, is ... |
18-130 | 8.01e-58 | |||||
Splicing factor 1 helix-hairpin domain; This domain, approximately 100 residues in length, is mainly found in splicing factor 1 from yeast to human. It is a helix-hairpin domain, which forms a secondary, hydrophobic interface with U2AF65(UHM) to lock the orientation of the two subunits, which is essential for cooperative formation of the ternary SF1-U2AF65-RNA complex. In this domain, it contains a highly conserved SPSP motif in its C terminal and phophorylation of SPSP motif induces a disorder-to-order transition within a novel SF1/U2AF65 interface, indicating a phosphorylation-dependent control of pre-mRNA splicing factors. Pssm-ID: 465080 Cd Length: 114 Bit Score: 188.20 E-value: 8.01e-58
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| KH | smart00322 | K homology RNA-binding domain; |
134-226 | 1.78e-09 | |||||
K homology RNA-binding domain; Pssm-ID: 197652 [Multi-domain] Cd Length: 68 Bit Score: 53.84 E-value: 1.78e-09
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| PRK11824 | PRK11824 | polynucleotide phosphorylase/polyadenylase; Provisional |
124-225 | 1.41e-03 | |||||
polynucleotide phosphorylase/polyadenylase; Provisional Pssm-ID: 236995 [Multi-domain] Cd Length: 693 Bit Score: 41.57 E-value: 1.41e-03
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| ZnF_C2HC | smart00343 | zinc finger; |
278-293 | 2.44e-03 | |||||
zinc finger; Pssm-ID: 197667 [Multi-domain] Cd Length: 17 Bit Score: 35.50 E-value: 2.44e-03
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| zf-CCHC | pfam00098 | Zinc knuckle; The zinc knuckle is a zinc binding motif composed of the the following ... |
278-293 | 5.06e-03 | |||||
Zinc knuckle; The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger. Pssm-ID: 395050 [Multi-domain] Cd Length: 18 Bit Score: 34.43 E-value: 5.06e-03
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| arCOG04150 | TIGR03665 | arCOG04150 universal archaeal KH domain protein; This family of proteins is universal among ... |
140-225 | 8.06e-03 | |||||
arCOG04150 universal archaeal KH domain protein; This family of proteins is universal among the 41 archaeal genomes analyzed, and is not observed outside of the archaea. The proteins contain a single KH domain (pfam00013) which is likely to confer the ability to bind RNA. Pssm-ID: 274711 [Multi-domain] Cd Length: 172 Bit Score: 37.54 E-value: 8.06e-03
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| Name | Accession | Description | Interval | E-value | |||||
| MSL5 | COG5176 | Splicing factor (branch point binding protein) [RNA processing and modification]; |
17-257 | 2.90e-69 | |||||
Splicing factor (branch point binding protein) [RNA processing and modification]; Pssm-ID: 227503 [Multi-domain] Cd Length: 269 Bit Score: 224.08 E-value: 2.90e-69
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| KH-I_SF1 | cd22382 | type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar ... |
135-227 | 5.76e-58 | |||||
type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar proteins; SF1, also called branch point-binding protein, or BBP, or transcription factor ZFM1, or zinc finger gene in MEN1 locus, or zinc finger protein 162, is necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. It may act as transcription repressor. Pssm-ID: 411810 [Multi-domain] Cd Length: 93 Bit Score: 187.90 E-value: 5.76e-58
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| SF1-HH | pfam16275 | Splicing factor 1 helix-hairpin domain; This domain, approximately 100 residues in length, is ... |
18-130 | 8.01e-58 | |||||
Splicing factor 1 helix-hairpin domain; This domain, approximately 100 residues in length, is mainly found in splicing factor 1 from yeast to human. It is a helix-hairpin domain, which forms a secondary, hydrophobic interface with U2AF65(UHM) to lock the orientation of the two subunits, which is essential for cooperative formation of the ternary SF1-U2AF65-RNA complex. In this domain, it contains a highly conserved SPSP motif in its C terminal and phophorylation of SPSP motif induces a disorder-to-order transition within a novel SF1/U2AF65 interface, indicating a phosphorylation-dependent control of pre-mRNA splicing factors. Pssm-ID: 465080 Cd Length: 114 Bit Score: 188.20 E-value: 8.01e-58
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| KH-I_BBP | cd02395 | type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) ... |
135-226 | 4.10e-39 | |||||
type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) and similar proteins; Yeast BBP, also called mud synthetic-lethal 5 protein, or splicing factor 1, or zinc finger protein BBP, is a mammalian splicing factor SF1 ortholog. It is involved in protein-protein interactions that bridge the 3' and 5' splice-site ends of the intron during the early steps of yeast pre-mRNA splicing. BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Pssm-ID: 411805 [Multi-domain] Cd Length: 92 Bit Score: 137.73 E-value: 4.10e-39
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| KH-I_Hqk_like | cd22383 | type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) family; The Hqk ... |
136-227 | 1.48e-25 | |||||
type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) family; The Hqk family includes Hqk and protein held out wings (how) found in Drosophila. Hqk, also called HqkI, is an RNA-binding protein that plays a central role in myelinization. It binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence and regulates target mRNA stability. It acts by regulating pre-mRNA splicing, mRNA export and protein translation. Hqk is a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. How, also called KH domain protein KH93F, or protein muscle-specific, or protein Struthio, or protein wings held out (who), or Quaking-related 93F (qkr93F), is an RNA-binding protein involved in the control of muscular and cardiac activity. It is required for integrin-mediated cell-adhesion in wing blade. It plays essential roles during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization. Pssm-ID: 411811 [Multi-domain] Cd Length: 101 Bit Score: 100.89 E-value: 1.48e-25
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| KH-I_HOW | cd22466 | type I K homology (KH) RNA-binding domain found in Drosophila protein held out wings (how) and ... |
132-226 | 2.95e-18 | |||||
type I K homology (KH) RNA-binding domain found in Drosophila protein held out wings (how) and similar proteins; How, also called KH domain protein KH93F, or protein muscle-specific, or protein Struthio, or protein wings held out (who), or Quaking-related 93F (qkr93F), is an RNA-binding protein involved in the control of muscular and cardiac activity. It is required for integrin-mediated cell-adhesion in wing blade. It plays essential roles during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization. Pssm-ID: 411894 [Multi-domain] Cd Length: 105 Bit Score: 80.35 E-value: 2.95e-18
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| KH-I_Hqk | cd22465 | type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins; ... |
135-226 | 4.65e-17 | |||||
type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins; Hqk, also called HqkI, is an RNA-binding protein that plays a central role in myelinization. It binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence and regulates target mRNA stability. It acts by regulating pre-mRNA splicing, mRNA export and protein translation. Hqk is a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Pssm-ID: 411893 [Multi-domain] Cd Length: 103 Bit Score: 76.90 E-value: 4.65e-17
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| KH-I_KHDRBS | cd22384 | type I K homology (KH) RNA-binding domain found in the KH domain-containing, RNA-binding, ... |
135-209 | 5.48e-17 | |||||
type I K homology (KH) RNA-binding domain found in the KH domain-containing, RNA-binding, signal transduction-associated protein (KHDRBS) family; The KHDRBS family includes three members, KHDRBS1-3. KHDRBS1, also called GAP-associated tyrosine phosphoprotein p62, or Src-associated in mitosis 68 kDa protein, or Sam68, or p21 Ras GTPase-activating protein-associated p62, or p68, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS1 acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. It is recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. KHDRBS2, also called Sam68-like mammalian protein 1, or SLM-1, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds both poly(A) and poly(U) homopolymers. KHDRBS2 may function as an adapter protein for Src kinases during mitosis. KHDRBS3, also called RNA-binding protein T-Star, or Sam68-like mammalian protein 2, or SLM-2, or Sam68-like phosphotyrosine protein, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS3 may play a role as a negative regulator of cell growth. Pssm-ID: 411812 [Multi-domain] Cd Length: 102 Bit Score: 76.55 E-value: 5.48e-17
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| KH-I_SPIN1_like | cd22467 | type I K homology (KH) RNA-binding domain found in Oryza sativa SPL11-interacting protein 1 ... |
142-227 | 1.23e-15 | |||||
type I K homology (KH) RNA-binding domain found in Oryza sativa SPL11-interacting protein 1 (SPIN1) and similar proteins; SPIN1 is a K homology domain protein negatively regulated and ubiquitinated by the E3 ubiquitin ligase SPL11. It is involved in flowering time control in rice. SPIN1 binds DNA and RNA in vitro. Pssm-ID: 411895 Cd Length: 101 Bit Score: 72.52 E-value: 1.23e-15
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| KH-I_KHDC4_rpt2 | cd22386 | first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ... |
136-227 | 3.65e-14 | |||||
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the second one. Pssm-ID: 411814 [Multi-domain] Cd Length: 102 Bit Score: 68.35 E-value: 3.65e-14
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| KH-I_KHDRBS2 | cd22469 | type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal ... |
135-243 | 5.59e-12 | |||||
type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) and similar proteins; KHDRBS2, also called Sam68-like mammalian protein 1, or SLM-1, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds both poly(A) and poly(U) homopolymers. KHDRBS2 may function as an adapter protein for Src kinases during mitosis. Pssm-ID: 411897 [Multi-domain] Cd Length: 118 Bit Score: 62.83 E-value: 5.59e-12
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| KH-I_KHDRBS1 | cd22468 | type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal ... |
135-185 | 2.53e-11 | |||||
type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) and similar proteins; KHDRBS1, also called GAP-associated tyrosine phosphoprotein p62, or Src-associated in mitosis 68 kDa protein, or Sam68, or p21 Ras GTPase-activating protein-associated p62, or p68, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS1 acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. It is recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Pssm-ID: 411896 [Multi-domain] Cd Length: 106 Bit Score: 60.41 E-value: 2.53e-11
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| KH-I_KHDRBS3 | cd22470 | type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal ... |
135-185 | 1.51e-09 | |||||
type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) and similar proteins; KHDRBS3, also called RNA-binding protein T-Star, or Sam68-like mammalian protein 2, or SLM-2, or Sam68-like phosphotyrosine protein, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS3 may play a role as a negative regulator of cell growth. Pssm-ID: 411898 [Multi-domain] Cd Length: 113 Bit Score: 55.83 E-value: 1.51e-09
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| KH | smart00322 | K homology RNA-binding domain; |
134-226 | 1.78e-09 | |||||
K homology RNA-binding domain; Pssm-ID: 197652 [Multi-domain] Cd Length: 68 Bit Score: 53.84 E-value: 1.78e-09
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| KH-I | cd00105 | K homology (KH) RNA-binding domain, type I; KH binds single-stranded RNA or DNA. It is found ... |
138-223 | 2.26e-08 | |||||
K homology (KH) RNA-binding domain, type I; KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that belong to different protein folds, but they share a single KH motif. The KH motif is folded into a beta alpha alpha beta unit. In addition to the core, type II KH domains (e.g. ribosomal protein S3) include an N-terminal extension and type I KH domains (e.g. hnRNP K) contain a C-terminal extension. Some KH-I superfamily members contain a divergent KH domain that lacks the RNA-binding GXXG motif. Some others have a mutated GXXG motif which may or may not have nucleic acid binding ability. Pssm-ID: 411802 [Multi-domain] Cd Length: 63 Bit Score: 50.76 E-value: 2.26e-08
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| KH_1 | pfam00013 | KH domain; KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause ... |
137-224 | 7.89e-07 | |||||
KH domain; KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia. Pssm-ID: 459630 [Multi-domain] Cd Length: 65 Bit Score: 46.51 E-value: 7.89e-07
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| KH-I_PNPase | cd02393 | type I K homology (KH) RNA-binding domain found in polyribonucleotide nucleotidyltransferase ... |
139-227 | 3.19e-06 | |||||
type I K homology (KH) RNA-binding domain found in polyribonucleotide nucleotidyltransferase (PNPase) and similar proteins; PNPase, also called polynucleotide phosphorylase, is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. It is also involved, along with RNase II, in tRNA processing. The C-terminal region of PNPase contains domains homologous to those in other RNA binding proteins: a KH domain and an S1 domain. The model corresponds to the KH domain. Pssm-ID: 411803 [Multi-domain] Cd Length: 70 Bit Score: 44.77 E-value: 3.19e-06
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| KH-I_KHDC4_rpt1 | cd22385 | first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ... |
160-226 | 7.01e-06 | |||||
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the first one. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif. Pssm-ID: 411813 Cd Length: 84 Bit Score: 44.12 E-value: 7.01e-06
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| KH-I_Dim2p_like_rpt1 | cd22389 | first type I K homology (KH) RNA-binding domain found in Pyrococcus horikoshii Dim2p and ... |
140-180 | 9.34e-05 | |||||
first type I K homology (KH) RNA-binding domain found in Pyrococcus horikoshii Dim2p and similar proteins; The family includes a group of conserved KH domain-containing protein mainly from archaea, such as Dim2p homologues from Pyrococcus horikoshii and Aeropyrum pernix. Dim2p acts as a preribosomal RNA processing factor that has been identified as an essential protein for the maturation of 40S ribosomal subunit in Saccharomyces cerevisiae. It is required for the cleavage at processing site A2 to generate the pre-20S rRNA and for the dimethylation of the 18S rRNA by 18S rRNA dimethyltransferase, Dim1p. Dim2p contains two K-homology (KH) RNA-binding domains. The model corresponds to the first one. Pssm-ID: 411817 [Multi-domain] Cd Length: 70 Bit Score: 40.65 E-value: 9.34e-05
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| KH-I_ScSCP160_rpt6 | cd22451 | sixth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein ... |
136-228 | 2.12e-04 | |||||
sixth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins; SCP160, also called protein HX, is a new yeast protein associated with the nuclear membrane and the endoplasmic reticulum. It is involved in the control of mitotic chromosome transmission. It is required during cell division for faithful partitioning of the ER-nuclear envelope membranes which enclose the duplicated chromosomes in yeast. SCP160 contains seven K-homology (KH) RNA-binding domains. The model corresponds to the sixth one. Pssm-ID: 411879 [Multi-domain] Cd Length: 69 Bit Score: 39.75 E-value: 2.12e-04
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| PRK11824 | PRK11824 | polynucleotide phosphorylase/polyadenylase; Provisional |
124-225 | 1.41e-03 | |||||
polynucleotide phosphorylase/polyadenylase; Provisional Pssm-ID: 236995 [Multi-domain] Cd Length: 693 Bit Score: 41.57 E-value: 1.41e-03
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| ZnF_C2HC | smart00343 | zinc finger; |
278-293 | 2.44e-03 | |||||
zinc finger; Pssm-ID: 197667 [Multi-domain] Cd Length: 17 Bit Score: 35.50 E-value: 2.44e-03
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| KH-I_DDX46_like | cd22387 | type I K homology (KH) RNA-binding domain found in the family of DEAD box protein 46 (DDX46); ... |
163-226 | 4.46e-03 | |||||
type I K homology (KH) RNA-binding domain found in the family of DEAD box protein 46 (DDX46); The DDX46 family includes DEAD box protein 46 (DDX46), fungal pre-mRNA-processing ATP-dependent RNA helicase PRP5, Arabidopsis thaliana DEAD-box ATP-dependent RNA helicase RH42 and similar proteins. DDX46, also called PRP5 homolog, is an ATP-dependent RNA helicase that plays an essential role in splicing, either prior to, or during splicing A complex formation. It inhibits antiviral innate responses by entrapping selected antiviral transcripts in the nucleus. It is also involved in the development of several tumors. PRP5 is an ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. It catalyzes an ATP-dependent conformational change of U2 snRNP. PRP5 interacts with the U2 snRNP and HSH155. RH42, also called DEAD-box RNA helicase RCF1, or REGULATOR OF CBF GENE EXPRESSION 1, is a helicase required for pre-mRNA splicing, cold-responsive gene regulation and cold tolerance. Members in this family contain a divergent KH domain that lacks the RNA-binding GXXG motif. Pssm-ID: 411815 Cd Length: 82 Bit Score: 36.49 E-value: 4.46e-03
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| PRK13763 | PRK13763 | putative RNA-processing protein; Provisional |
140-184 | 4.85e-03 | |||||
putative RNA-processing protein; Provisional Pssm-ID: 237494 [Multi-domain] Cd Length: 180 Bit Score: 38.31 E-value: 4.85e-03
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| zf-CCHC | pfam00098 | Zinc knuckle; The zinc knuckle is a zinc binding motif composed of the the following ... |
278-293 | 5.06e-03 | |||||
Zinc knuckle; The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger. Pssm-ID: 395050 [Multi-domain] Cd Length: 18 Bit Score: 34.43 E-value: 5.06e-03
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| KH-I_AKAP1 | cd22395 | type I K homology (KH) RNA-binding domain found in mitochondrial A-kinase anchor protein 1 ... |
151-178 | 7.60e-03 | |||||
type I K homology (KH) RNA-binding domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa, or AKAP 149, or dual specificity A-kinase-anchoring protein 1, or D-AKAP-1, or protein kinase A-anchoring protein 1 (PRKA1), or spermatid A-kinase anchor protein 84, or S-AKAP84, is a novel developmentally regulated A kinase anchor protein of male germ cells. It binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. Pssm-ID: 411823 [Multi-domain] Cd Length: 68 Bit Score: 35.19 E-value: 7.60e-03
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| arCOG04150 | TIGR03665 | arCOG04150 universal archaeal KH domain protein; This family of proteins is universal among ... |
140-225 | 8.06e-03 | |||||
arCOG04150 universal archaeal KH domain protein; This family of proteins is universal among the 41 archaeal genomes analyzed, and is not observed outside of the archaea. The proteins contain a single KH domain (pfam00013) which is likely to confer the ability to bind RNA. Pssm-ID: 274711 [Multi-domain] Cd Length: 172 Bit Score: 37.54 E-value: 8.06e-03
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