Lon protease homolog, mitochondrial [Caenorhabditis elegans]
Protein Classification
endopeptidase La( domain architecture ID 11489643)
endopeptidase La is an ATP-dependent serine protease that degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long; it binds to DNA in a double-stranded, site-specific manner
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||||||
| lon | TIGR00763 | endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat ... |
90-970 | 0e+00 | |||||||||||||
endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat shock and other stresses in E. coli, B. subtilis, and other species. The yeast member, designated PIM1, is located in the mitochondrial matrix, required for mitochondrial function, and also induced by heat shock. [Protein fate, Degradation of proteins, peptides, and glycopeptides] : Pssm-ID: 273258 [Multi-domain] Cd Length: 775 Bit Score: 1143.57 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||||||||||
| lon | TIGR00763 | endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat ... |
90-970 | 0e+00 | |||||||||||||
endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat shock and other stresses in E. coli, B. subtilis, and other species. The yeast member, designated PIM1, is located in the mitochondrial matrix, required for mitochondrial function, and also induced by heat shock. [Protein fate, Degradation of proteins, peptides, and glycopeptides] Pssm-ID: 273258 [Multi-domain] Cd Length: 775 Bit Score: 1143.57 E-value: 0e+00
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| Lon | COG0466 | ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ... |
254-970 | 0e+00 | |||||||||||||
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440234 [Multi-domain] Cd Length: 785 Bit Score: 881.28 E-value: 0e+00
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| PRK10787 | PRK10787 | DNA-binding ATP-dependent protease La; Provisional |
309-965 | 1.41e-171 | |||||||||||||
DNA-binding ATP-dependent protease La; Provisional Pssm-ID: 182730 [Multi-domain] Cd Length: 784 Bit Score: 519.88 E-value: 1.41e-171
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| RecA-like_Lon | cd19500 | lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ... |
469-651 | 9.52e-121 | |||||||||||||
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410908 [Multi-domain] Cd Length: 182 Bit Score: 365.34 E-value: 9.52e-121
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| Lon_C | pfam05362 | Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP ... |
761-970 | 1.16e-75 | |||||||||||||
Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops. Pssm-ID: 428442 [Multi-domain] Cd Length: 205 Bit Score: 246.77 E-value: 1.16e-75
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| AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
505-642 | 1.50e-07 | |||||||||||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 51.61 E-value: 1.50e-07
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| Name | Accession | Description | Interval | E-value | |||||||||||||
| lon | TIGR00763 | endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat ... |
90-970 | 0e+00 | |||||||||||||
endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat shock and other stresses in E. coli, B. subtilis, and other species. The yeast member, designated PIM1, is located in the mitochondrial matrix, required for mitochondrial function, and also induced by heat shock. [Protein fate, Degradation of proteins, peptides, and glycopeptides] Pssm-ID: 273258 [Multi-domain] Cd Length: 775 Bit Score: 1143.57 E-value: 0e+00
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| Lon | COG0466 | ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ... |
254-970 | 0e+00 | |||||||||||||
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440234 [Multi-domain] Cd Length: 785 Bit Score: 881.28 E-value: 0e+00
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| PRK10787 | PRK10787 | DNA-binding ATP-dependent protease La; Provisional |
309-965 | 1.41e-171 | |||||||||||||
DNA-binding ATP-dependent protease La; Provisional Pssm-ID: 182730 [Multi-domain] Cd Length: 784 Bit Score: 519.88 E-value: 1.41e-171
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| RecA-like_Lon | cd19500 | lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ... |
469-651 | 9.52e-121 | |||||||||||||
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410908 [Multi-domain] Cd Length: 182 Bit Score: 365.34 E-value: 9.52e-121
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| Lon_C | pfam05362 | Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP ... |
761-970 | 1.16e-75 | |||||||||||||
Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops. Pssm-ID: 428442 [Multi-domain] Cd Length: 205 Bit Score: 246.77 E-value: 1.16e-75
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| AAA | pfam00004 | ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
508-646 | 2.32e-31 | |||||||||||||
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 119.24 E-value: 2.32e-31
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| LON_substr_bdg | pfam02190 | ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be ... |
88-357 | 4.97e-19 | |||||||||||||
ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be part of the PUA superfamily. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, pfam05362. ATP-dependent Lon proteases are conserved in all living organizms and catalyze rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. Pssm-ID: 426647 [Multi-domain] Cd Length: 195 Bit Score: 86.24 E-value: 4.97e-19
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| RecA-like_protease | cd19481 | proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ... |
486-640 | 4.64e-16 | |||||||||||||
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 76.55 E-value: 4.64e-16
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| SpoVK | COG0464 | AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ... |
340-724 | 7.92e-15 | |||||||||||||
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]; Pssm-ID: 440232 [Multi-domain] Cd Length: 397 Bit Score: 77.64 E-value: 7.92e-15
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| AAA | cd00009 | The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
487-646 | 8.95e-13 | |||||||||||||
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases. Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 66.79 E-value: 8.95e-13
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| COG1750 | COG1750 | Predicted archaeal serine protease, S18 family [General function prediction only]; |
823-970 | 6.42e-12 | |||||||||||||
Predicted archaeal serine protease, S18 family [General function prediction only]; Pssm-ID: 441356 [Multi-domain] Cd Length: 213 Bit Score: 65.77 E-value: 6.42e-12
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| SdrC | COG3480 | Predicted secreted protein YlbL, contains PDZ domain [Signal transduction mechanisms]; |
812-939 | 3.98e-09 | |||||||||||||
Predicted secreted protein YlbL, contains PDZ domain [Signal transduction mechanisms]; Pssm-ID: 442703 [Multi-domain] Cd Length: 344 Bit Score: 59.44 E-value: 3.98e-09
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| RecA-like_FtsH | cd19501 | ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ... |
482-591 | 1.30e-08 | |||||||||||||
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410909 [Multi-domain] Cd Length: 171 Bit Score: 55.32 E-value: 1.30e-08
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| AAA_2 | pfam07724 | AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ... |
510-669 | 4.41e-08 | |||||||||||||
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model. Pssm-ID: 400187 [Multi-domain] Cd Length: 168 Bit Score: 53.74 E-value: 4.41e-08
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| 44 | PHA02544 | clamp loader, small subunit; Provisional |
505-693 | 9.40e-08 | |||||||||||||
clamp loader, small subunit; Provisional Pssm-ID: 222866 [Multi-domain] Cd Length: 316 Bit Score: 55.00 E-value: 9.40e-08
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| AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
505-642 | 1.50e-07 | |||||||||||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 51.61 E-value: 1.50e-07
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| LON | smart00464 | Found in ATP-dependent protease La (LON); N-terminal domain of the ATP-dependent protease La ... |
89-151 | 1.85e-07 | |||||||||||||
Found in ATP-dependent protease La (LON); N-terminal domain of the ATP-dependent protease La (LON), present also in other bacterial ORFs. Pssm-ID: 197740 [Multi-domain] Cd Length: 92 Bit Score: 49.74 E-value: 1.85e-07
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| PRK04195 | PRK04195 | replication factor C large subunit; Provisional |
482-692 | 2.80e-07 | |||||||||||||
replication factor C large subunit; Provisional Pssm-ID: 235250 [Multi-domain] Cd Length: 482 Bit Score: 54.16 E-value: 2.80e-07
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| PRK13342 | PRK13342 | recombination factor protein RarA; Reviewed |
498-581 | 3.87e-07 | |||||||||||||
recombination factor protein RarA; Reviewed Pssm-ID: 237355 [Multi-domain] Cd Length: 413 Bit Score: 53.55 E-value: 3.87e-07
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| AAA_5 | pfam07728 | AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
508-643 | 5.75e-07 | |||||||||||||
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model. Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 49.60 E-value: 5.75e-07
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| RPT1 | COG1222 | ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ... |
482-586 | 7.09e-07 | |||||||||||||
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440835 [Multi-domain] Cd Length: 326 Bit Score: 52.32 E-value: 7.09e-07
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| COG1223 | COG1223 | Predicted ATPase, AAA+ superfamily [General function prediction only]; |
481-585 | 1.95e-06 | |||||||||||||
Predicted ATPase, AAA+ superfamily [General function prediction only]; Pssm-ID: 440836 [Multi-domain] Cd Length: 246 Bit Score: 50.27 E-value: 1.95e-06
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| RarA | COG2256 | Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ... |
498-548 | 4.06e-06 | |||||||||||||
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair]; Pssm-ID: 441857 [Multi-domain] Cd Length: 439 Bit Score: 50.44 E-value: 4.06e-06
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| RecA-like_VPS4-like | cd19509 | ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ... |
482-644 | 4.59e-06 | |||||||||||||
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410917 [Multi-domain] Cd Length: 163 Bit Score: 47.73 E-value: 4.59e-06
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| RecA-like_Pch2-like | cd19508 | ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ... |
486-642 | 5.44e-06 | |||||||||||||
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion Pssm-ID: 410916 [Multi-domain] Cd Length: 199 Bit Score: 48.21 E-value: 5.44e-06
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| hflB | PRK10733 | ATP-dependent zinc metalloprotease FtsH; |
482-591 | 3.21e-05 | |||||||||||||
ATP-dependent zinc metalloprotease FtsH; Pssm-ID: 182683 [Multi-domain] Cd Length: 644 Bit Score: 47.72 E-value: 3.21e-05
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| MoxR | COG0714 | MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ... |
512-694 | 3.51e-05 | |||||||||||||
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis Pssm-ID: 440478 [Multi-domain] Cd Length: 292 Bit Score: 46.70 E-value: 3.51e-05
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| RecA-like_NVL_r1-like | cd19518 | first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ... |
482-586 | 3.93e-05 | |||||||||||||
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410926 [Multi-domain] Cd Length: 169 Bit Score: 45.09 E-value: 3.93e-05
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| ftsH | CHL00176 | cell division protein; Validated |
482-592 | 4.86e-05 | |||||||||||||
cell division protein; Validated Pssm-ID: 214386 [Multi-domain] Cd Length: 638 Bit Score: 47.35 E-value: 4.86e-05
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| T7SS_EccA | TIGR03922 | type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ... |
469-693 | 5.64e-05 | |||||||||||||
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking] Pssm-ID: 188437 [Multi-domain] Cd Length: 557 Bit Score: 46.76 E-value: 5.64e-05
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| RecA-like_CDC48_NLV2_r1-like | cd19503 | first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ... |
482-602 | 1.30e-04 | |||||||||||||
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410911 [Multi-domain] Cd Length: 165 Bit Score: 43.43 E-value: 1.30e-04
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| RecA-like_Ycf46-like | cd19507 | ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ... |
512-592 | 1.53e-04 | |||||||||||||
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410915 [Multi-domain] Cd Length: 161 Bit Score: 43.13 E-value: 1.53e-04
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| ChlI | pfam13541 | Subunit ChlI of Mg-chelatase; |
895-939 | 2.03e-04 | |||||||||||||
Subunit ChlI of Mg-chelatase; Pssm-ID: 433293 [Multi-domain] Cd Length: 121 Bit Score: 42.05 E-value: 2.03e-04
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| DnaX | COG2812 | DNA polymerase III, gamma/tau subunits [Replication, recombination and repair]; |
495-689 | 5.90e-04 | |||||||||||||
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair]; Pssm-ID: 442061 [Multi-domain] Cd Length: 340 Bit Score: 43.26 E-value: 5.90e-04
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| RecA-like_PEX6_r2 | cd19527 | second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ... |
486-592 | 1.21e-03 | |||||||||||||
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410935 [Multi-domain] Cd Length: 160 Bit Score: 40.57 E-value: 1.21e-03
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| rfc | PRK00440 | replication factor C small subunit; Reviewed |
474-535 | 1.33e-03 | |||||||||||||
replication factor C small subunit; Reviewed Pssm-ID: 234763 [Multi-domain] Cd Length: 319 Bit Score: 42.17 E-value: 1.33e-03
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| RecA-like_CDC48_r1-like | cd19519 | first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ... |
482-584 | 1.38e-03 | |||||||||||||
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410927 [Multi-domain] Cd Length: 166 Bit Score: 40.50 E-value: 1.38e-03
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| ruvB | PRK00080 | Holliday junction branch migration DNA helicase RuvB; |
474-530 | 2.23e-03 | |||||||||||||
Holliday junction branch migration DNA helicase RuvB; Pssm-ID: 234619 [Multi-domain] Cd Length: 328 Bit Score: 41.27 E-value: 2.23e-03
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| PRK06647 | PRK06647 | DNA polymerase III subunits gamma and tau; Validated |
492-642 | 2.84e-03 | |||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 235845 [Multi-domain] Cd Length: 563 Bit Score: 41.29 E-value: 2.84e-03
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| ruvB | TIGR00635 | Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ... |
482-530 | 2.84e-03 | |||||||||||||
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 129721 [Multi-domain] Cd Length: 305 Bit Score: 40.75 E-value: 2.84e-03
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| RecA-like_ClpB_Hsp104-like | cd19499 | Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ... |
508-630 | 3.29e-03 | |||||||||||||
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410907 [Multi-domain] Cd Length: 178 Bit Score: 39.47 E-value: 3.29e-03
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| AAA_16 | pfam13191 | AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ... |
488-539 | 3.59e-03 | |||||||||||||
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Pssm-ID: 433025 [Multi-domain] Cd Length: 167 Bit Score: 39.41 E-value: 3.59e-03
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| RecA-like_spastin | cd19524 | ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ... |
482-584 | 3.90e-03 | |||||||||||||
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410932 [Multi-domain] Cd Length: 164 Bit Score: 39.06 E-value: 3.90e-03
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| RecA-like_ATAD1 | cd19520 | ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ... |
482-582 | 4.15e-03 | |||||||||||||
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410928 [Multi-domain] Cd Length: 166 Bit Score: 38.94 E-value: 4.15e-03
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| RuvB_N | pfam05496 | Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ... |
482-530 | 5.14e-03 | |||||||||||||
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein. Pssm-ID: 398900 [Multi-domain] Cd Length: 159 Bit Score: 38.64 E-value: 5.14e-03
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| cbbX | CHL00181 | CbbX; Provisional |
465-531 | 5.23e-03 | |||||||||||||
CbbX; Provisional Pssm-ID: 177083 [Multi-domain] Cd Length: 287 Bit Score: 40.09 E-value: 5.23e-03
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| RNA_helicase | pfam00910 | RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ... |
508-533 | 5.73e-03 | |||||||||||||
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses. Pssm-ID: 459992 Cd Length: 102 Bit Score: 37.20 E-value: 5.73e-03
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| RecA-like_PAN_like | cd19502 | proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ... |
511-601 | 5.81e-03 | |||||||||||||
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410910 [Multi-domain] Cd Length: 171 Bit Score: 38.86 E-value: 5.81e-03
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| clpA | PRK11034 | ATP-dependent Clp protease ATP-binding subunit; Provisional |
500-712 | 8.62e-03 | |||||||||||||
ATP-dependent Clp protease ATP-binding subunit; Provisional Pssm-ID: 236828 [Multi-domain] Cd Length: 758 Bit Score: 39.82 E-value: 8.62e-03
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| PRK13341 | PRK13341 | AAA family ATPase; |
498-527 | 8.71e-03 | |||||||||||||
AAA family ATPase; Pssm-ID: 237354 [Multi-domain] Cd Length: 725 Bit Score: 40.04 E-value: 8.71e-03
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