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Conserved domains on  [gi|392889373|ref|NP_494294|]
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protein of unknown function WSN domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WSN smart00453
Worm-specific (usually) N-terminal domain;
32-99 3.12e-16

Worm-specific (usually) N-terminal domain;


:

Pssm-ID: 197734  Cd Length: 69  Bit Score: 74.15  E-value: 3.12e-16
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392889373     32 LHDAIDKLSIVARVTNAITIQKGLNDKSMKVDNLLDELLNISPgDGFSYLQSLDVKKAKEGYIGIAKD 99
Cdd:smart00453    3 LQTVIERLSMLARVTNAISLQAGLINGSIPIDDVIAELLNIDS-SKLSDIINVDLTKIDEGLNKLKEI 69
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
824-924 1.26e-11

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.90  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889373  824 NYSRHNGLTIQNQIRVPGPNDYNRNRYIKLHEAIREKNYETFKRCVDEGADVNAFggDYEFFTPLHMAVQEGLPNFVEYL 903
Cdd:COG0666    62 ALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLL 139

                          90       100
                  ....*....|....*....|.
gi 392889373  904 IRNGADVNKIDSNYQLPIELA 924
Cdd:COG0666   140 LEAGADVNAQDNDGNTPLHLA 160
 
Name Accession Description Interval E-value
WSN smart00453
Worm-specific (usually) N-terminal domain;
32-99 3.12e-16

Worm-specific (usually) N-terminal domain;


Pssm-ID: 197734  Cd Length: 69  Bit Score: 74.15  E-value: 3.12e-16
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392889373     32 LHDAIDKLSIVARVTNAITIQKGLNDKSMKVDNLLDELLNISPgDGFSYLQSLDVKKAKEGYIGIAKD 99
Cdd:smart00453    3 LQTVIERLSMLARVTNAISLQAGLINGSIPIDDVIAELLNIDS-SKLSDIINVDLTKIDEGLNKLKEI 69
WSN pfam02206
Domain of unknown function;
32-91 6.58e-15

Domain of unknown function;


Pssm-ID: 426657  Cd Length: 66  Bit Score: 70.17  E-value: 6.58e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889373    32 LHDAIDKLSIVARVTNAITIQKGLNDKSMKVDNLLDELLNISPGDgFSYLQSLDVKKAKE 91
Cdd:pfam02206    2 LSLIVEKLSILARITNAISLQAGLIDGSIPVDDVISELLNLGSVT-LSDIIKIDVDKLKE 60
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
824-924 1.26e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.90  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889373  824 NYSRHNGLTIQNQIRVPGPNDYNRNRYIKLHEAIREKNYETFKRCVDEGADVNAFggDYEFFTPLHMAVQEGLPNFVEYL 903
Cdd:COG0666    62 ALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLL 139

                          90       100
                  ....*....|....*....|.
gi 392889373  904 IRNGADVNKIDSNYQLPIELA 924
Cdd:COG0666   140 LEAGADVNAQDNDGNTPLHLA 160
Ank_2 pfam12796
Ankyrin repeats (3 copies);
841-914 1.87e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 1.87e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392889373   841 GPNDYNRNRYIKLHEAIREKNYETFKRCVDEgADVNAFGGDYeffTPLHMAVQEGLPNFVEYLIRNGADVNKID 914
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR---TALHYAARSGHLEIVKLLLEKGADINVKD 91
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 885-912 1.11e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.11e-04
                            10        20
                    ....*....|....*....|....*...
gi 392889373    885 FTPLHMAVQEGLPNFVEYLIRNGADVNK 912
Cdd:smart00248    3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 853-924 4.19e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.67  E-value: 4.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392889373  853 LHEAIREKN-YETFKRCVDEGADVNAFGGDYEffTPLHMAVQEGL-PNFVEYLIRNGADVNKIDSNYQLPIELA 924
Cdd:PHA02876  412 LHFALCGTNpYMSVKTLIDRGANVNSKNKDLS--TPLHYACKKNCkLDVIEMLLDNGADVNAINIQNQYPLLIA 483
 
Name Accession Description Interval E-value
WSN smart00453
Worm-specific (usually) N-terminal domain;
32-99 3.12e-16

Worm-specific (usually) N-terminal domain;


Pssm-ID: 197734  Cd Length: 69  Bit Score: 74.15  E-value: 3.12e-16
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392889373     32 LHDAIDKLSIVARVTNAITIQKGLNDKSMKVDNLLDELLNISPgDGFSYLQSLDVKKAKEGYIGIAKD 99
Cdd:smart00453    3 LQTVIERLSMLARVTNAISLQAGLINGSIPIDDVIAELLNIDS-SKLSDIINVDLTKIDEGLNKLKEI 69
WSN pfam02206
Domain of unknown function;
32-91 6.58e-15

Domain of unknown function;


Pssm-ID: 426657  Cd Length: 66  Bit Score: 70.17  E-value: 6.58e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889373    32 LHDAIDKLSIVARVTNAITIQKGLNDKSMKVDNLLDELLNISPGDgFSYLQSLDVKKAKE 91
Cdd:pfam02206    2 LSLIVEKLSILARITNAISLQAGLIDGSIPVDDVISELLNLGSVT-LSDIIKIDVDKLKE 60
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
824-924 1.26e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.90  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889373  824 NYSRHNGLTIQNQIRVPGPNDYNRNRYIKLHEAIREKNYETFKRCVDEGADVNAFggDYEFFTPLHMAVQEGLPNFVEYL 903
Cdd:COG0666    62 ALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLL 139

                          90       100
                  ....*....|....*....|.
gi 392889373  904 IRNGADVNKIDSNYQLPIELA 924
Cdd:COG0666   140 LEAGADVNAQDNDGNTPLHLA 160
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
842-924 1.37e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.90  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889373  842 PNDYNRNRYIKLHEAIREKNYETFKRCVDEGADVNAfgGDYEFFTPLHMAVQEGLPNFVEYLIRNGADVNKIDSNYQLPI 921
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA--QDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL 190


                  ...
gi 392889373  922 ELA 924
Cdd:COG0666   191 HLA 193
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
853-931 1.50e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 1.50e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392889373  853 LHEAIREKNYETFKRCVDEGADVNAfgGDYEFFTPLHMAVQEGLPNFVEYLIRNGADVNKIDSNYQLPIELAGKVEKRD 931
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNA--RDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
Ank_2 pfam12796
Ankyrin repeats (3 copies);
841-914 1.87e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 1.87e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392889373   841 GPNDYNRNRYIKLHEAIREKNYETFKRCVDEgADVNAFGGDYeffTPLHMAVQEGLPNFVEYLIRNGADVNKID 914
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR---TALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
853-917 3.98e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 3.98e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392889373   853 LHEAIREKNYETFKRCVDEGADVNAFGGDYEffTPLHMAVQEGLPNFVEYLIRNgADVNKIDSNY 917
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGR--TALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR 62
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
842-948 5.44e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 5.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889373  842 PNDYNRNRYIKLHEAIREKNYETFKRCVDEGADVNAFggDYEFFTPLHMAVQEGLPNFVEYLIRNGADVNKIDSNYQLPI 921
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK--DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256

                          90       100
                  ....*....|....*....|....*..
gi 392889373  922 ELAGKVEKRDELLAVFNKFKGKKFPRK 948
Cdd:COG0666   257 LLAAAAGAALIVKLLLLALLLLAAALL 283
Ank_4 pfam13637
Ankyrin repeats (many copies);
853-904 5.52e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 5.52e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 392889373   853 LHEAIREKNYETFKRCVDEGADVNAFggDYEFFTPLHMAVQEGLPNFVEYLI 904
Cdd:pfam13637    5 LHAAAASGHLELLRLLLEKGADINAV--DGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
873-924 3.37e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 3.37e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 392889373   873 ADVNAFggDYEFFTPLHMAVQEGLPNFVEYLIRNGADVNKIDSNYQLPIELA 924
Cdd:pfam13857    7 IDLNRL--DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 885-914 7.42e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 7.42e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 392889373   885 FTPLHMAV-QEGLPNFVEYLIRNGADVNKID 914
Cdd:pfam00023    3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 885-912 1.11e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.11e-04
                            10        20
                    ....*....|....*....|....*...
gi 392889373    885 FTPLHMAVQEGLPNFVEYLIRNGADVNK 912
Cdd:smart00248    3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 853-924 4.19e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.67  E-value: 4.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392889373  853 LHEAIREKN-YETFKRCVDEGADVNAFGGDYEffTPLHMAVQEGL-PNFVEYLIRNGADVNKIDSNYQLPIELA 924
Cdd:PHA02876  412 LHFALCGTNpYMSVKTLIDRGANVNSKNKDLS--TPLHYACKKNCkLDVIEMLLDNGADVNAINIQNQYPLLIA 483
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 886-912 6.68e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 6.68e-04
                           10        20
                   ....*....|....*....|....*..
gi 392889373   886 TPLHMAVQEGLPNFVEYLIRNGADVNK 912
Cdd:pfam13606    4 TPLHLAARNGRLEIVKLLLENGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 853-916 2.98e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 2.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392889373  853 LHEAIREKNYETFKRCVDEGADVNAFggDYEFFTPLHMAVQEGLPNFVEYLIRNGADVNKIDSN 916
Cdd:PHA03100  196 LHYAVYNNNPEFVKYLLDLGANPNLV--NKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA03095 PHA03095
ankyrin-like protein; Provisional
 863-923 3.72e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.16  E-value: 3.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392889373  863 ETFKRCVDEGADVNaFGGDYeFFTPLHMAVQEGLPN---FVEYLIRNGADVNKIDSNYQLPIEL 923
Cdd:PHA03095   28 EEVRRLLAAGADVN-FRGEY-GKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHL 89
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 872-934 4.44e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 4.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392889373  872 GADVNAFggDYEFFTPLHMAVQEGLPNFVEYLIRNGADVNKIDSNYQLPIELAGKVEKRD--ELL 934
Cdd:PTZ00322  105 GADPNCR--DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREvvQLL 167
Ank_2 pfam12796
Ankyrin repeats (3 copies);
888-924 6.04e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 6.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 392889373   888 LHMAVQEGLPNFVEYLIRNGADVNKIDSNYQLPIELA 924
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLA 37
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 841-924 9.61e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 9.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889373  841 GPNDYNRNRYIKLHEAIREKNYETFKRCVDEGADVNAFGGDYEFFTPLH---MAVQEGLPNFVEYLIRNGADVNKIDSNY 917
Cdd:PHA03100   27 LNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLsniKYNLTDVKEIVKLLLEYGANVNAPDNNG 106


                  ....*..
gi 392889373  918 QLPIELA 924
Cdd:PHA03100  107 ITPLLYA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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