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Conserved domains on  [gi|1088681551|ref|NP_495141|]
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Leukocyte cell-derived chemotaxin-2 homolog [Caenorhabditis elegans]

Protein Classification

M23 family metallopeptidase( domain architecture ID 10480195)

metallopeptidase of the M23 family, that include a variety of zinc metallo-endopeptidases with a range of specificities, not all members are active enzymes

CATH:  2.70.70.10
EC:  3.4.-.-
Gene Ontology:  GO:0046872|GO:0006508
MEROPS:  M23
SCOP:  4000931

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M23 pfam01551
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ...
 60-166 1.09e-13

Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.


:

Pssm-ID: 460250 [Multi-domain]  Cd Length: 96  Bit Score: 66.03  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088681551  60 DGVDVRCHLGEPIYAPIEGEMYFWRPYGGkrekscADQGVRIEGTGQWQGYAVHISSVKLSfFGGHVEAGDEIGEALNRY 139
Cdd:pfam01551   4 KGIDIAAPTGTPVYAAADGVVVFAGWLGG------YGNLVIIDHGNGYSTLYAHLSSILVK-VGQRVKAGQVIGTVGSTG 76

                          90       100
                  ....*....|....*....|....*..
gi 1088681551 140 CFNdrgqndvEPHVEIRLYKEGRLIDP 166
Cdd:pfam01551  77 RST-------GPHLHFEIRKNGKPVDP 96
 
Name Accession Description Interval E-value
Peptidase_M23 pfam01551
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ...
 60-166 1.09e-13

Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.


Pssm-ID: 460250 [Multi-domain]  Cd Length: 96  Bit Score: 66.03  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088681551  60 DGVDVRCHLGEPIYAPIEGEMYFWRPYGGkrekscADQGVRIEGTGQWQGYAVHISSVKLSfFGGHVEAGDEIGEALNRY 139
Cdd:pfam01551   4 KGIDIAAPTGTPVYAAADGVVVFAGWLGG------YGNLVIIDHGNGYSTLYAHLSSILVK-VGQRVKAGQVIGTVGSTG 76

                          90       100
                  ....*....|....*....|....*..
gi 1088681551 140 CFNdrgqndvEPHVEIRLYKEGRLIDP 166
Cdd:pfam01551  77 RST-------GPHLHFEIRKNGKPVDP 96
NlpD COG0739
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ...
 37-171 2.98e-05

Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440502 [Multi-domain]  Cd Length: 196  Bit Score: 44.19  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088681551  37 RRCPDTDGscGNYHTertsgeiidGVDVRCHLGEPIYAPIEGEMYF--WRPYGGKRekscadqgVRIEGTGQWQ-GYAvH 113
Cdd:COG0739    86 RRHPVTGR--RRFHK---------GIDIAAPTGTPVYAAADGTVVFagWNGGYGNL--------VIIDHGNGYTtLYA-H 145

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1088681551 114 ISSVKLSfFGGHVEAGDEIGEALNrycfndRGQNDVePHVEIRLYKEGRLIDPTHHLQ 171
Cdd:COG0739   146 LSSILVK-VGQRVKAGQVIGYVGN------TGRSTG-PHLHFEVRVNGKPVDPLPFLP 195
 
Name Accession Description Interval E-value
Peptidase_M23 pfam01551
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ...
 60-166 1.09e-13

Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.


Pssm-ID: 460250 [Multi-domain]  Cd Length: 96  Bit Score: 66.03  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088681551  60 DGVDVRCHLGEPIYAPIEGEMYFWRPYGGkrekscADQGVRIEGTGQWQGYAVHISSVKLSfFGGHVEAGDEIGEALNRY 139
Cdd:pfam01551   4 KGIDIAAPTGTPVYAAADGVVVFAGWLGG------YGNLVIIDHGNGYSTLYAHLSSILVK-VGQRVKAGQVIGTVGSTG 76

                          90       100
                  ....*....|....*....|....*..
gi 1088681551 140 CFNdrgqndvEPHVEIRLYKEGRLIDP 166
Cdd:pfam01551  77 RST-------GPHLHFEIRKNGKPVDP 96
NlpD COG0739
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ...
 37-171 2.98e-05

Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440502 [Multi-domain]  Cd Length: 196  Bit Score: 44.19  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088681551  37 RRCPDTDGscGNYHTertsgeiidGVDVRCHLGEPIYAPIEGEMYF--WRPYGGKRekscadqgVRIEGTGQWQ-GYAvH 113
Cdd:COG0739    86 RRHPVTGR--RRFHK---------GIDIAAPTGTPVYAAADGTVVFagWNGGYGNL--------VIIDHGNGYTtLYA-H 145

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1088681551 114 ISSVKLSfFGGHVEAGDEIGEALNrycfndRGQNDVePHVEIRLYKEGRLIDPTHHLQ 171
Cdd:COG0739   146 LSSILVK-VGQRVKAGQVIGYVGN------TGRSTG-PHLHFEVRVNGKPVDPLPFLP 195
SpoIIQ2 COG5821
Stage II sporulation protein SpoIIQ, clostridial version, metallopeptidase M23 family [Cell ...
 60-170 5.77e-03

Stage II sporulation protein SpoIIQ, clostridial version, metallopeptidase M23 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444523 [Multi-domain]  Cd Length: 200  Bit Score: 37.31  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088681551  60 DGVDVRCHLGEPIYAPIEGEMYF--WRPYGGKRekscadqgVRIEGTGQWQG-YAvHISSVKLSFFGGHVEAGDEIGEAl 136
Cdd:COG5821    98 TGIDIAAKEGTPVKAAADGVVVEvgKDPKYGIT--------VVIDHGNGIKTvYA-NLDSKIKVKVGQKVKKGQVIGKV- 167

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1088681551 137 nrycfNDRGQNDV--EPHVEIRLYKEGRLIDPTHHL 170
Cdd:COG5821   168 -----GSTALFESseGPHLHFEVLKNGKPVDPMKYL 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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