|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
73-492 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 630.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 73 AILANMGFMISFGIRCNFGAAKTHMYKNYTDPYG---KVHMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNK 149
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGgkvIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 150 LFGFGIGVGAFLNILLPYGFKVkSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPL 229
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAARV-HYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 230 SAFLVSYVSWAAPFYLYGVCGVIWAILWFCVtfekpafhptisqeekifiedaighvsnthptirsipwkaivtSKPVWA 309
Cdd:cd17382 160 SGILVQYVGWSSPFYVYGVFGIIWYMFWMLV-------------------------------------------SMPVYA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 310 IIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVRKIFNCGGFG 389
Cdd:cd17382 197 IIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 390 GEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAFTAH-SKH 468
Cdd:cd17382 277 MEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHkTRE 356
|
410 420
....*....|....*....|....
gi 71997452 469 GWTSVFLLASLIHFTGVTFYAVYA 492
Cdd:cd17382 357 EWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
73-492 |
6.56e-120 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 359.63 E-value: 6.56e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 73 AILANMGFMISFGIRCNFGAAKTHM------YKNYTDPYGKVHMH----EFNWTIDELSVMESSYFYGYLVTQIPAGFLA 142
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMvnstatHDNNNTSTDKDTLPveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 143 AKFPPNKLFGFGIGVGAFLNILLPYgFKVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAG 222
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPL-AARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 223 AVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFcvtfekpafhptisqeekifiedaighvsnthptirsipwkaiV 302
Cdd:cd17318 160 TVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWF-------------------------------------------F 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 303 TSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVRKI 382
Cdd:cd17318 197 LVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 383 FNCGGFGGEAAFMLIVAYTTSD-TTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEA 461
Cdd:cd17318 277 FTSIGFLGPGVFLIALGYLGSNaTLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGA 356
|
410 420 430
....*....|....*....|....*....|...
gi 71997452 462 FTA--HSKHGWTSVFLLASLIHFTGVTFYAVYA 492
Cdd:cd17318 357 IVKndQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
72-492 |
1.24e-91 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 287.06 E-value: 1.24e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 72 LAILANMGFMISFGIRCNFGAAKTHMYKNYTD---------------PYGKVHMH---EFNWTIDELSVMESSYFYGYLV 133
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTlpsnnssnacpehssSPSVEHNEtgkKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 134 TQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVKSDYLVAfIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLAT 213
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIA-VRALEGLGEGVTFPAMHAMWASWAPPLERSRLLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 214 TAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFekpafhptisqeekifiedaighvsnthpti 293
Cdd:cd17381 160 ISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVM------------------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 294 rsipwkaivtskPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKI 373
Cdd:cd17381 209 ------------PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQN 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 374 LSTTAVRKIFNCGGFGGEAAFMLIVAYTTSD-TTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAG 452
Cdd:cd17381 277 FSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNySLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 71997452 453 LTCPFVTEAFT-AHSKHGWTSVFLLASLIHFTGVTFYAVYA 492
Cdd:cd17381 357 MVGPVIAKSLThNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
66-497 |
2.07e-79 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 257.75 E-value: 2.07e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 66 CRKRWLLAILANMGFMISFGIRCNFGAAKTHMyKNYTDPYG-----------KVHMHEFNWTIDELSVMESSYFYGYLVT 134
Cdd:TIGR00894 14 CSFRLFLSFLLHICNVIIIAQRICLSLTMVAM-VNKENSTDlaclsaeneldNIKNPNFKWSGALQGLILSSHFYGQIII 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 135 QIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVkSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATT 214
Cdd:TIGR00894 93 QIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGG-GIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGM 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 215 AFTGSYAGAVLGLPLSAFLV-SYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFHPTISQEEKIFIEDAIghVSNTHPTI 293
Cdd:TIGR00894 172 STSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSL--QGQKGSTR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 294 RSIPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKI 373
Cdd:TIGR00894 250 QSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKT 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 374 LSTTAVRKIFNCGGFGGEAAFMLIVAYTTSD-TTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAG 452
Cdd:TIGR00894 330 LSLTAARKIFNGIGGLGPGIFAYALPYLSAAfYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGG 409
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 71997452 453 LTCPFVTEAF-TAHSKHGWTSVFLLASLIHFTGVTFYAVYASGELQ 497
Cdd:TIGR00894 410 LIASTLAGNIlSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQ 455
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
111-492 |
9.26e-75 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 242.08 E-value: 9.26e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 111 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgFKVKSDYLVAFIQITQGLVQGV 190
Cdd:cd17380 27 KEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL-LAYSSLPLLILSRILLGLGEGV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 191 CYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTfekpafhpt 270
Cdd:cd17380 106 HFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 271 isqeekifiedaighvsnthptirsipwkaivtsKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGmKIADSGLLAAIP 350
Cdd:cd17380 177 ----------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 351 HLVMGCVVLMGGQLADYLRSNKIlSTTAVRKIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHL 430
Cdd:cd17380 222 WLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQ 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71997452 431 DIAPRYAAILMGFSNGIGTLAGLTCPFVTeAFTAHSKHGWTSVFLLASLIHFTGVTFYAVYA 492
Cdd:cd17380 301 DIAPNYAGIVFGISNTAGTIPGIVGVYLT-GYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
67-490 |
2.96e-37 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 141.55 E-value: 2.96e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 67 RKRWLLAILANMGFMISFGIRCNFGAAKTHMyknytdpygkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFP 146
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPL------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 147 PNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLG 226
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 227 LPLSAFLVSYVSWAAPFYLYGVCGVIWAILwfcvtfekpafhptisqeekifiedaighvsnthptirsipwkaivtskP 306
Cdd:COG2271 151 PPLLGWLLAAFGWRAAFLILGLPGLLLALL-------------------------------------------------R 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 307 VWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSnkilsttaVRKIFNCG 386
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR--------RRKLVLAI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 387 GFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAP-RYAAILMGFSNGIGTLAGLTCPFVTEAFTAH 465
Cdd:COG2271 254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
410 420
....*....|....*....|....*
gi 71997452 466 SkhGWTSVFLLASLIHFTGVTFYAV 490
Cdd:COG2271 334 T--GYQAAFLLLAALALLAALLALL 356
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
69-480 |
4.45e-36 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 138.09 E-value: 4.45e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 69 RWLLAILANMGFMISFGIRCNFGAAKTHMyknytdpygkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPN 148
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI------------MKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGAR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 149 KLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLP 228
Cdd:cd17319 69 KVLAVSMLLWSLFTALTGF---ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPP 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 229 LSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVtfekpafhptisqeekifiedaighvsnthptIRSipwkaivtskpVW 308
Cdd:cd17319 146 LSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY--------------------------------LRQ-----------VW 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 309 AIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKilsttavRKIFNCGGF 388
Cdd:cd17319 183 GLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVIIIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 389 GGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAPR-YAAILMGFSNGIGTLAGLTCPFVTEAFTAHSk 467
Cdd:cd17319 256 LLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDAT- 334
|
410
....*....|...
gi 71997452 468 HGWTSVFLLASLI 480
Cdd:cd17319 335 GSYTAAFLFLAAV 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
110-453 |
3.45e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.59 E-value: 3.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 110 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLpygFKVKSDYLVAFIQITQGLVQG 189
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL---LFASSLWLLLVLRVLQGLGAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 190 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFcvTFEKPAFHP 269
Cdd:pfam07690 101 ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL--LPRPPPESK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 270 TISQEEKIFIedaighvsnthptIRSIPWKAIVTSKPVWAIIVanFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAI 349
Cdd:pfam07690 179 RPKPAEEARL-------------SLIVAWKALLRDPVLWLLLA--LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 350 PHLVMGCVVLMGGQLADYLRSNKILsttavrkIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNH 429
Cdd:pfam07690 244 GGLLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*
gi 71997452 430 LDIAP-RYAAILMGFSNGIGTLAGL 453
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGA 341
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
103-488 |
9.10e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.05 E-value: 9.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 103 DPYGKVHMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVksdYLVAFIQI 182
Cdd:cd06174 16 SPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF---WLLLLGRF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 183 TQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSY--VSWAAPFYLYGVCGVIWAILWFCV 260
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 261 TFEKPafhptisqeekifiEDAIGHVSNTHPTIRSIPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKI 340
Cdd:cd06174 173 VPDPP--------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 341 ADSGLLAAIPHLVMGCVVLMGGQLADYLRSnkilsttaVRKIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGF 420
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71997452 421 AISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAFTAHsKHGWTSVFLLASLIHFTGVTFY 488
Cdd:cd06174 311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA-TFGLTGAFLVLAVLLLLAAILL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
67-480 |
4.71e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 101.50 E-value: 4.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 67 RKRWLLAILANMGFMISFGIRCNFGAAKTHMyknytdpygkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFP 146
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 147 PNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLG 226
Cdd:COG2223 69 PRRVLLIGLLLLGIGLLLLAL---AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 227 LPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFHPtisqeekifiedaighvsnTHPTIRSIPWKAIVTSKP 306
Cdd:COG2223 146 AFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA-------------------AAAKASLRDQLEALRDPR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 307 VWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSttavrkifncG 386
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL----------I 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 387 GFGGEAAFMLIVAYTTSDTTAIMALIAAVgmsGFAISGFNVNHLDIAP-----RYAAILMGFSNGIGTLAGLTCPFVTEA 461
Cdd:COG2223 277 VFALMALGLLLLALALGSLWLFLVLFLLL---GLALGGGNGAVFALVPdifptKNAGAVYGLVGAAGGLGGFLGPLLFGA 353
|
410
....*....|....*....
gi 71997452 462 FTAHSkHGWTSVFLLASLI 480
Cdd:COG2223 354 LLDAT-GSYTAAFLVFAVL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
110-452 |
1.87e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.81 E-value: 1.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 110 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQG 189
Cdd:COG2814 37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL---APSLWLLLAARFLQGLGAG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 190 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVI-WAILWFCVTFEKPAFH 268
Cdd:COG2814 114 ALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAAR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 269 PTISQEekifiedaighvsnthptirsipWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAA 348
Cdd:COG2814 194 ARLRGS-----------------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 349 IPHLVMGCVVLMGGQLADYLRSNKILSttavrkifncGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVN 428
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLL----------IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
|
330 340
....*....|....*....|....*
gi 71997452 429 HLDIAP-RYAAILMGFSNGIGTLAG 452
Cdd:COG2814 321 VAELAPpEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
125-492 |
1.66e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.22 E-value: 1.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 125 SSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVksdYLVAFIQITQGLVQGVCYPAMHGVWRYWAP 204
Cdd:cd17325 38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY---WQLLLARFLQGLASAAVWPAAMALIADIAP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 205 PMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFHPTISQEEKIFIEdaig 284
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRS---- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 285 hvsnthptirsiPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQL 364
Cdd:cd17325 191 ------------GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 365 ADYLRSNKILSTtavrkifncgGFGGEAAFMLIVAYTTSdtTAIMALIAAVGMSGFAISGFNVNHL--DIAPRYA-AILM 441
Cdd:cd17325 259 SDRIGRKPLILI----------GLLLSAVALLLLPLATS--FWLLLLLLALLGLGLGLVFPATLALlaDIVPPEGrGTAM 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 71997452 442 GFSNGIGTLAGLTCPFVTEAFTAHskHGWTSVFLLASLIHFTGVTFYAVYA 492
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDA--FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
79-474 |
4.08e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 61.62 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 79 GFMISFGIRCNFGAAKTHMyknytdpygkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVG 158
Cdd:TIGR00881 3 GYAAYYLVRKNFALAMPYL------------VEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILC 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 159 AFLNILLpyGFKVKSDYLVAFIQITqGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVS-YV 237
Cdd:TIGR00881 71 AIVNLFF--GFSTSLWVMAALWALN-GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLY 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 238 SWAAPFYLYGVCGVIWAILWFCVTFEKPAfHPTISQEEKIFIEDAIGHVSNTHP--TIRSIPWKAIVTSKPVWAIIVANF 315
Cdd:TIGR00881 148 SWHWVFIVPGIIAIIVSLICFLLLRDSPQ-SCGLPPAEEMPNEEPDGDAEKKEEelTKKQIFLQYVLLNKVLWYISLGYV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 316 ARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVRKifnCGGFGGEAAFM 395
Cdd:TIGR00881 227 FVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFM---ALIIVSLLVYW 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 396 LIVAyttSDTTAIMALIAAVGMSGFA-ISGFNVNHLDIAPRYAAILMG-----FSNGIGTLAGLTCPFVTEAFtahskhG 469
Cdd:TIGR00881 304 LNPA---ANPLMDLICLFALGFLVYGpQMLIGVIASELAPKKAAGTAAgfvgfFAYLGGILAGLPLGYLADGF------G 374
|
....*
gi 71997452 470 WTSVF 474
Cdd:TIGR00881 375 WAGAF 379
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
69-480 |
1.94e-09 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 59.95 E-value: 1.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 69 RWLLAILANMGFMISFGIRCNFGAAKTHMYKNYTdpygkvhmhefnWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPN 148
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYG------------LSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 149 KLFGFGIGVGAFLNILLPYGFKVKSDYLVAFI-QITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGL 227
Cdd:cd17345 69 RFLAIGLILSAIINILIGFVPSATSSVGLMFIlLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 228 PLSAFLVSYV---SWAAPFYLYGVCGVIWAILWFCVTFEKPAFH--PTISQEEKIFIEDAIGHVSNTHPTIRSIPWKAIV 302
Cdd:cd17345 149 PLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 303 TSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGL------LAAIPHlvmgcvVLMGGQLADYLRSNKilst 376
Cdd:cd17345 229 KNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWafslfeWAAIPG------TLLAGWLSDKLFKGR---- 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 377 tavRKIFNCGGFGGEAAfmLIVAYTTSdTTAIMALIAAVGMsGFAISG----FNVNHLDIAPRYAAilmgfsngiGTLAG 452
Cdd:cd17345 299 ---RAPTGIIFMILVIV--ALIVYWLA-PNVLVDLIALIAL-GFLIYGpvmlIGLQALELVPKKAA---------GTAAG 362
|
410 420 430
....*....|....*....|....*....|....*....
gi 71997452 453 LT--CPFVTEAFTAHS-------KHGWTSVF--LLASLI 480
Cdd:cd17345 363 LTglFGYLGGSVLATAligiivdHFGWNGGFivLLASCI 401
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
207-459 |
3.65e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.06 E-value: 3.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 207 ERSKLATTAFTGSYAGAVLGLPLSAFLVSYVS------WAAPFYLYGVCGVIWAILWFCVTFEKPAfhptisqeekifie 280
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPV-------------- 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 281 daighVSNTHPTIRSIpWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLM 360
Cdd:COG2211 210 -----PEEEKVSLKES-LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 361 GGQLADYLRSnkilsttavRKIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAavgMSGFAISGFNVNHL----DIAP-- 434
Cdd:COG2211 284 WPRLAKRFGK---------KKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAA---LAGIGLGAILVLPWamlaDVVDyd 351
|
250 260 270
....*....|....*....|....*....|.
gi 71997452 435 ------RYAAILMGFSNGIGTLAGLTCPFVT 459
Cdd:COG2211 352 ewktgrRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
111-258 |
7.47e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.59 E-value: 7.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 111 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLpyGFkVKSDYLVAFIQITQGLVQGV 190
Cdd:cd17312 31 EEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GF-STSLWFFAVLWGLNGLFQSM 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71997452 191 CYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWF 258
Cdd:cd17312 108 GWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF 175
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
110-493 |
1.83e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.70 E-value: 1.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 110 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNK-----LFGFGIGVGAFLNILLPYGFKVksdyLVAFIQITQ 184
Cdd:COG0738 35 KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRglllgLLLMALGLLLFALAPSYPLLLL----ALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 185 GLVQGVCYP--AMHGvwrywaPPMERSKLATT-AFTGsyAGAVLGLPLSAFLVSY---VSWAAPFYLYGVCGVIWAILWF 258
Cdd:COG0738 111 GLLDVAANPyvAALG------PETAASRLNLLhAFFS--LGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 259 CVTFekpafhPTISQEEKifiedaighvsntHPTIRSIPWKAIVTSKPVWAIIVANFarswtFYLLLQNQL-----TYMK 333
Cdd:COG0738 183 RSKL------PEIEEEEE-------------EAAGSAASLKSLLKNPRLLLGGLAIF-----LYVGAEGAIgdwlpLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 334 EALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVrkifncggfgGEAAFMLIVAYTTSDTTAIMALIA 413
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL----------LAAVGLLLALLAPGPWLALIGLAL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 414 AvgmsGFAISGF--NVNHL--DIAPRYAAILMGFSNGIGTLAGLTCPFVTeAFTAHSkHGWTSVFLLAsLIHFTGVTFYA 489
Cdd:COG0738 309 V----GLGLSLMfpTIFSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLI-GFLADA-FGLRAAFLVP-LVCYLLILLLA 381
|
....
gi 71997452 490 VYAS 493
Cdd:COG0738 382 LALK 385
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
136-480 |
2.85e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.95 E-value: 2.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 136 IPAGFLAAKFPPNKLFGFG---IGVGAFLNILLPygfkvkSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPpmERSKLA 212
Cdd:COG2807 71 PLAPRLARRFGLERTLLLAlllLAAGLLLRSLAP------SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP--DRVGLM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 213 TTAFT-GSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAfhptisqeekifiedaighvsNTHP 291
Cdd:COG2807 143 TGLYTaAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA---------------------AAAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 292 TIRSIPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEAlGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSN 371
Cdd:COG2807 202 APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 372 KILSTTAVrkIFNCGGFGGeaafmliVAYTTSDTTAIMALIAAVGMSG-FAISGFNVNHLDIAPRYAAILMGFSNGIGTL 450
Cdd:COG2807 281 RPLLLLLG--LLGLAGLLG-------LLLAPGSLPWLWAVLLGLGQGGlFPLALTLIGLRARTPAEAAALSGMAQSVGYL 351
|
330 340 350
....*....|....*....|....*....|
gi 71997452 451 AGLTCPFVTEAFTAHSkHGWTSVFLLASLI 480
Cdd:COG2807 352 LAALGPLLVGALHDAT-GSWTAALLLLAAL 380
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
222-480 |
8.00e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 8.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 222 GAVLGLPLSAFLVSyVSWAAPFYLYGVCGVIWAILWFCVtfekpaFHPTISQEEKIFIEDAighvsnthpTIRSIPWkai 301
Cdd:cd17473 136 GGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFL------PEPARKSKSAASPGAA---------TAAALPW--- 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 302 vtsKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTtavrk 381
Cdd:cd17473 197 ---KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI----- 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 382 IFNCGGFGgeaafmLIVAYTTSDTTAIMALIAAVGMsGFAISGFNVNH--LDIAPRYA-AILMGFSNGIGTLAGLTCPFV 458
Cdd:cd17473 269 GFALMALG------FLLLALASGLWVVLLGAILAGL-GFGLLLPTLNSwaMSLVPPELrGRAMGIVTSAFFLGQFLSPLV 341
|
250 260
....*....|....*....|..
gi 71997452 459 TEAFtAHSKHGWTSVFLLASLI 480
Cdd:cd17473 342 LGPL-VNLTGGLSGAFLILGVL 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
111-477 |
3.89e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.08 E-value: 3.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 111 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGV 190
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL---APSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 191 CYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIwAILWFCVTFEK-PAFHP 269
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL-AALLLWRLLPSlPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 270 TisqeekifiedAIGHVSNthptirsipWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAI 349
Cdd:cd17324 183 G-----------SLGLLSS---------LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 350 PHLVMGCVVLMGGQLADYLRSNKILSttavrkifncGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNH 429
Cdd:cd17324 243 FGVAGVVGSPLAGRLADRGGRRALLI----------ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 71997452 430 LDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAFTAHskHGWTSVFLLA 477
Cdd:cd17324 313 LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH--GGWAGVGWVG 358
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
111-370 |
2.48e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 46.85 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 111 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLpyGFkVKSDYLVAFIQITQGLVQGV 190
Cdd:cd17328 27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS--SF-APNFWQLLLFRALVGIGEAS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 191 CYPAMHGVWRYWAPPMERSK-LATTAFtGSYAGAVLGLPLSAFLVSYV-SWAAPFYLYGVCGVIWAILWFCVTFEKPafh 268
Cdd:cd17328 104 YSPIAPTIIADLFPKEKRTRaLGVFYF-AIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPP--- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 269 ptisqeekifiEDAIGHVSNTHPTIRSIP--WKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLL 346
Cdd:cd17328 180 -----------RGAAEGGVMAKSTATSFLadLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADV 248
|
250 260
....*....|....*....|....*...
gi 71997452 347 AAIPHLVM---GCV-VLMGGQLADYLRS 370
Cdd:cd17328 249 GLIFGAITciaGVLgVLLGGILADRLRR 276
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
70-477 |
3.51e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.50 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 70 WLLAILANMGFMISFGIRCNFGAakthmyknYTDPYgkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNK 149
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGV--------FIIPI----IAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 150 LFGFGIGVGAFLNILLPYGFKVKSDYLVAFIqiTQGLVQGVCY-PAMHGVWRYWAPPmERSKLATTAFTGSYAGAVLGLP 228
Cdd:cd17355 70 VMLLGLLLLAAGLVLLALATSLWQLYLLWGL--LGGGGAGTLAaVAFATVAAWWFER-RRGLALGILTAGGGLGSLVFLP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 229 LSAFLVSYVSWAAPFYLYG-VCGVIWAILWFcVTFEKPAFHPTISqeekifiEDAIGHVSNTHptirsiPWKAIVTSKPV 307
Cdd:cd17355 147 LGAALIEAFGWRTALLVLAlLALLVLVPVLL-LLRRRPADLALRA-------YDDASPASPGS------TLKEALRSASF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 308 WAIIVANFARSWTFYLLLQNQLTYMKEAlGMKIADSGLLAAiphLVMGCVV---LMGGQLADYLRSNKILSTtavrkifn 384
Cdd:cd17355 213 WLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALA---LIGLFNIvgrLLSGWLGDRYSPRRLLAA-------- 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 385 cgGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVN--HLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAF 462
Cdd:cd17355 281 --SYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAAlaARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
410
....*....|....*
gi 71997452 463 TAHSkHGWTSVFLLA 477
Cdd:cd17355 359 YDRT-GSYTAAWALA 372
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
111-256 |
1.27e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 111 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGI---GVGAFLNILLPygfkvkSDYLVAFIQITQGLV 187
Cdd:COG0477 42 ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLllfGLASLLCGLAP------SPELLIAARALQGIG 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71997452 188 QGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAIL 256
Cdd:COG0477 116 AGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVL 184
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
133-480 |
2.74e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.31 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 133 VTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPpmERSKLA 212
Cdd:cd17478 46 LLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF---APNYWLLLLLVALAGIGSAAFHPEGARLASQAAG--GRRGLA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 213 TTAF-TGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVtfeKPAFHPTISQEEKIFIEDAighvsnthp 291
Cdd:cd17478 121 MSIFsVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL---RPLKKPEAKKAAAKSSARS--------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 292 tirsipwKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEaLGMKIADSGLLAAIpHLVMGCV-VLMGGQLADYLRS 370
Cdd:cd17478 189 -------TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSL-FLFAGAIgTLIGGPLSDRFGR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 371 NKILSTTavrkifncggFGGEAAFMLIVAYTTSdtTAIMALIAAVGMsgFAISGFNVNHL---DIAPRYAA----ILMGF 443
Cdd:cd17478 260 RRVIIAS----------LLLAAPFLLLFLLTPG--IWSYILLVLAGF--LLFASFPVTVVlaqELLPGNVGlasgLMMGL 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 71997452 444 SNGIGTLAGLTCPFVTEAFTAHSKHGWTSVFLLASLI 480
Cdd:cd17478 326 SFGLGGIGAPVLGALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
118-477 |
4.04e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 43.09 E-value: 4.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 118 DELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHG 197
Cdd:cd17343 38 SDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSG---SSSVWVFSILWFLNGLAQGLGWPPCAK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 198 VWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKP--AFHPTISQEE 275
Cdd:cd17343 115 ILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPsdVGLNNIEEEE 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 276 KifiedaiGHVSNTHPTIRSIpWKAIVTSKPVWAIIVANFARSWTFYLLLQ-NQLTYMKEALGMKIADSGLLAAIPhlvM 354
Cdd:cd17343 195 S-------KGKKKKSPRGEST-LKELLLSPFLWLLSLGYLVVFGVKTAVTDwGQLFLIQDKGQSALTGSSFMSSLE---V 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 355 GCVV--LMGGQLADYLRSNKILSTTAVRKIFNCGGF--GGEAAFMLIVAYTTSDTT--AIMALIAAVGMSGFA-ISGFNV 427
Cdd:cd17343 264 GGFVgsIAAGYLSDWAVAKHGSSSRGNPRMPLALVFmaGLTVSLHLFRVHITSDSSelFILLLGFLIGFSLYGpIAIFGV 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 71997452 428 NHLDIAPRY-----AAILMGFSNGIGTLAGLtcPFVTEAftahSKHGWTSVFLLA 477
Cdd:cd17343 344 IANESAPSHlcgtsHAIVALAANVGGVLAGL--PFSYIA----KHYDWRTAFLLL 392
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
110-258 |
4.24e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 42.95 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 110 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQG 189
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL---ATSFWLLLLLLALLGLGLG 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71997452 190 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWF 258
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
110-260 |
4.93e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.55 E-value: 4.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 110 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFkVKSDYLVAFIQITQGLVQG 189
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL-LPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71997452 190 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCV 260
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
118-369 |
4.94e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 42.62 E-value: 4.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 118 DELSVMESSYFYGYLVTQIPAGFLAAKFPPNK-LFGFGIGVGAFlnILLPYGFKVKSDYLVafIQITQGLVQGVCYPAMH 196
Cdd:cd17327 41 NQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKwLSVFIVLWGLL--TLLTAAVKNFGGLIA--LRFFLGLFESGVFPGFI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 197 GVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYV------SWAAPFYLYGVCGVIWAILWFCVTFEKPAFHPT 270
Cdd:cd17327 117 LYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWF 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 271 ISQEEKIFI-----EDAIGHvSNTHPTIRSipWKAIVTSKPVWAIIVANFArSWTFYLLLQNQLTYMKEALGMKIADSGL 345
Cdd:cd17327 197 LTEEEKELAverlrANQTGK-GDQKFKWKQ--IKEAFKDPRTWLLFLFFFC-SQITNNGISNFLPLILKSLGFYSLQTNL 272
|
250 260
....*....|....*....|....
gi 71997452 346 LAAIPHLVMGCVVLMGGQLADYLR 369
Cdd:cd17327 273 LSVPIGALGAVSLLIAALLSDRFK 296
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
110-276 |
5.01e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 42.68 E-value: 5.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 110 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGfkvKSDYLVAFIQITQGLVQG 189
Cdd:cd06180 26 LAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALT---SGFAALLALRFLAGAASA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 190 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVL-GLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFH 268
Cdd:cd06180 103 FVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAP 182
|
....*...
gi 71997452 269 PTISQEEK 276
Cdd:cd06180 183 TEASAAES 190
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
130-480 |
9.06e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.84 E-value: 9.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 130 GYLVTQIPAGFLAAKFPPNKLFGFG--IGVGAFLNILLPYGFKVksdyLVAFIqITQGLVQGVCYPAMHGVWRYWAPPME 207
Cdd:cd17475 43 GVAVSMLPAGWLLDRFGERRVLAVGllLMGAAALLMALVGSYPV----LLVLL-FLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 208 RSkLAT----TAFTGSYAGAVLGLPlsaFLVSYVSWAAPFYLYGVCGVIWAILWFcvtfekpAFHPTisqeekifIEDAI 283
Cdd:cd17475 118 RG-LAMgirqTGVPLGGALAAALLP---PLALHYGWRAAFVVAGLVSILAAVLFW-------LFYRE--------PPAAS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 284 GHVSNTHPTIRSIpwKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHL--VMGCVVLmg 361
Cdd:cd17475 179 AATESASTLLRSL--KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLggALGRIGL-- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 362 GQLADYLRSNKilsttAVRKIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHL-DIAP-RYAAI 439
Cdd:cd17475 255 GRVSDRVFGGR-----RRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVaESAGpEQAGT 329
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 71997452 440 LMGFSNGIGTLAGLTCPFVTEAFTAHSkHGWTSVFLLASLI 480
Cdd:cd17475 330 ALGLANTINFIGIAIGPPLFGLLVDAT-HSYAPAWLALALL 369
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
305-485 |
1.20e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.43 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 305 KPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRsnkilsttavRKIFN 384
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 385 CGGFGGEAAFMLIVAYTTSDTTAIMaLIAAVGMSGFAISGFNVNHLDIA----PRYAAILMGFSNGIGTLAGLTCPFVTe 460
Cdd:cd17316 247 VIGLILSGILALPLFYLLSGSPTLL-LLLLFILSFFVGGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLI- 324
|
170 180
....*....|....*....|....*
gi 71997452 461 AFTAHSKHGWTSVFLLASLIHFTGV 485
Cdd:cd17316 325 ALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
310-480 |
1.27e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 310 IIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLrsnkilsttAVRKIFNCGGFG 389
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997452 390 GEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAFTAHskHG 469
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--FG 149
|
170
....*....|.
gi 71997452 470 WTSVFLLASLI 480
Cdd:pfam07690 150 WRAAFLILAIL 160
|
|
| |
