|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
458-1067 |
8.04e-129 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 408.07 E-value: 8.04e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 458 TELTDTPKGFKLELMPHQKAGLTWMrWRETQPQPGGILADDMGLGKTLSMISLIAHQKAARRARRedgnddkdkekrkvv 537
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWL-LFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARP--------------- 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 538 keqglipsngTLIVAPASLIHQWDAEIDRRLDDsvLSTYMFHGTKKqRDIDARRLARYDVVITTFNLIAneliekirtks 617
Cdd:COG0553 293 ----------VLIVAPTSLVGNWQRELAKFAPG--LRVLVLDGTRE-RAKGANPFEDADLVITSYGLLR----------- 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 618 kaddssdgesdsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYS 697
Cdd:COG0553 349 ----------------------RDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWS 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 698 LVRFLRirP--FSDDKYWKE----SIMPMKPIMADRVNLLTKNLLLRRTKDQTcavtnqkLVQLPPKNVEVHELELDGDE 771
Cdd:COG0553 407 LLDFLN--PglLGSLKAFRErfarPIEKGDEEALERLRRLLRPFLLRRTKEDV-------LKDLPEKTEETLYVELTPEQ 477
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 772 AQAYEimmeAAKKFVKKLLQDSNDMKNHGFIprrnrragkegevqnpfnfgprdlaagsnfekmscvLMLLLRLRQACVH 851
Cdd:COG0553 478 RALYE----AVLEYLRRELEGAEGIRRRGLI------------------------------------LAALTRLRQICSH 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 852 FNItktgvdmdafsliggdnaeeanvddlneLLEKTMNMTLGNGdneerdkprattrifdpdylscKIKNTLEIVENIME 931
Cdd:COG0553 518 PAL----------------------------LLEEGAELSGRSA----------------------KLEALLELLEELLA 547
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 932 KKEKVVIVSQWTSVLNLIEIHIKSSGFKYTSITGQVLVKDRQERVDSFnREKGGARVMLLSLAAGGVGLNLTGGNHLVMV 1011
Cdd:COG0553 548 EGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRF-QEGPEAPVFLISLKAGGEGLNLTAADHVIHY 626
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 17540630 1012 DLHWNPALEQQAFDRIYRMGQKKDVFIHRLVTKGTIEQRVVMLQKDKVALASSVLD 1067
Cdd:COG0553 627 DLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
471-739 |
2.44e-84 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 273.01 E-value: 2.44e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRetqpqpGGILADDMGLGKTLSMISLIAHQKAARRARREDGNDDKDKEKRKVVkeqglipSNGTLI 550
Cdd:cd18008 1 LLPYQKQGLAWMLPR------GGILADEMGLGKTIQALALILATRPQDPKIPEELEENSSDPKKLYL-------SKTTLI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 551 VAPASLIHQWDAEIDRRLDDSVLSTYMFHGtkKQRDIDARRLARYDVVITTFNLIANELiekirTKSKADDSSDGESdsn 630
Cdd:cd18008 68 VVPLSLLSQWKDEIEKHTKPGSLKVYVYHG--SKRIKSIEELSDYDIVITTYGTLASEF-----PKNKKGGGRDSKE--- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 631 htgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFSDD 710
Cdd:cd18008 138 ---------KEASPLHRIRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDY 208
|
250 260 270
....*....|....*....|....*....|...
gi 17540630 711 KYWKESIMPM----KPIMADRVNLLTKNLLLRR 739
Cdd:cd18008 209 PWFNSDISKPfsknDRKALERLQALLKPILLRR 241
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
471-739 |
2.24e-81 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 265.11 E-value: 2.24e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQPQPGGILADDMGLGKTLSMISLIAHQKAARRARR-EDGNDDKDKEKRKvvkEQGLIPSNGTL 549
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGGILADDMGLGKTLTMIALILAQKNTQNRKEeEKEKALTEWESKK---DSTLVPSAGTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTkkQRDIDARRLARYDVVITTFNLIANEliekIRTKSKADDSsdgesds 629
Cdd:cd18072 78 VVCPASLVHQWKNEVESRVASNKLRVCLYHGP--NRERIGEVLRDYDIVITTYSLVAKE----IPTYKEESRS------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 630 nhtgirravgkddSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFSD 709
Cdd:cd18072 145 -------------SPLFRIAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDD 211
|
250 260 270
....*....|....*....|....*....|
gi 17540630 710 DKYWKESIMPMKPIMADRVNLLTKNLLLRR 739
Cdd:cd18072 212 LKVWKKQVDNKSRKGGERLNILTKSLLLRR 241
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
474-851 |
4.15e-68 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 230.26 E-value: 4.15e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 474 HQKAGLTWMRWRETQPQPGGILADDMGLGKTLSMISLIAHqkaarrarredgnddkdkekrkvVKEQGLIPSNGTLIVAP 553
Cdd:pfam00176 1 YQIEGVNWMLSLENNLGRGGILADEMGLGKTLQTISLLLY-----------------------LKHVDKNWGGPTLIVVP 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 554 ASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDI---DARRLARYDVVITTFNLIaneliekirtkskaddssdgesdsn 630
Cdd:pfam00176 58 LSLLHNWMNEFERWVSPPALRVVVLHGNKRPQERwknDPNFLADFDVVITTYETL------------------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 631 htgirravGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFSDD 710
Cdd:pfam00176 113 --------RKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 711 KYWKE--SIMPMKPIMADRVNLL---TKNLLLRRTKDQTCAvtnqklvQLPPKNVEVHELELDGDEAQAYeimmeaakkf 785
Cdd:pfam00176 185 STFRNwfDRPIERGGGKKGVSRLhklLKPFLLRRTKKDVEK-------SLPPKVEYILFCRLSKLQRKLY---------- 247
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17540630 786 vkkllqdsndmknHGFIPRRNRRAGKEGEvqnpfnfgprdlaagSNFEKMSCVLMLLLRLRQACVH 851
Cdd:pfam00176 248 -------------QTFLLKKDLNAIKTGE---------------GGREIKASLLNILMRLRKICNH 285
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
471-739 |
7.00e-56 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 193.84 E-value: 7.00e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQPQP----------------------------GGILADDMGLGKTLSMISLIAHQKaarrarr 522
Cdd:cd18071 1 LLPHQKQALAWMVSRENSQDLppfweeavglflntitnfsqkkrpelvrGGILADDMGLGKTLTTISLILANF------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 523 edgnddkdkekrkvvkeqglipsngTLIVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRdiDARRLARYDVVITTF 602
Cdd:cd18071 74 -------------------------TLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNR--DPKLLSKYDIVLTTY 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 603 NLIANELiekirtkskaddssdgesdsnhtgirraVGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWC 682
Cdd:cd18071 127 NTLASDF----------------------------GAKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWV 178
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17540630 683 LSGTPIHNNLWDLYSLVRFLRIRPFSDDKYWKESImpMKPI-MADRVNL-----LTKNLLLRR 739
Cdd:cd18071 179 LTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLI--QRPLtMGDPTGLkrlqvLMKQITLRR 239
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
471-715 |
7.60e-55 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 191.40 E-value: 7.60e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWretqpqPGGILADDMGLGKTLSMISLI-AHQKAARRARREDGNDDKDKEKRKVVKEQGLIPSNGTL 549
Cdd:cd18070 1 LLPYQRRAVNWMLV------PGGILADEMGLGKTVEVLALIlLHPRPDNDLDAADDDSDEMVCCPDCLVAETPVSSKATL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDSvLSTYMFHGTKKQ---RDIDARRLARYDVVITTFNLIANELIEKIRtkskaddssdge 626
Cdd:cd18070 75 IVCPSAILAQWLDEINRHVPSS-LKVLTYQGVKKDgalASPAPEILAEYDIVVTTYDVLRTELHYAEA------------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 627 sdsNHTGIRRAVGK----DDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFL 702
Cdd:cd18070 142 ---NRSNRRRRRQKryeaPPSPLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFL 218
|
250
....*....|...
gi 17540630 703 RIRPFSDDKYWKE 715
Cdd:cd18070 219 GVEPFCDSDWWAR 231
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
915-1042 |
4.83e-51 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 175.74 E-value: 4.83e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 915 LSCKIKNTLEIVENIMEKKEKVVIVSQWTSVLNLIEIHIKSSGFKYTSITGQVLVKDRQERVDSFNrEKGGARVMLLSLA 994
Cdd:cd18793 9 VSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFN-EDPDIRVFLLSTK 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 17540630 995 AGGVGLNLTGGNHLVMVDLHWNPALEQQAFDRIYRMGQKKDVFIHRLV 1042
Cdd:cd18793 88 AGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
471-702 |
2.36e-47 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 167.36 E-value: 2.36e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWREtQPQPGGILADDMGLGKTLSMISLIAHQKAARRARRedgnddkdkekrkvvkeqgliPsngTLI 550
Cdd:cd17919 1 LRPYQLEGLNFLLELY-ENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERG---------------------P---VLV 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 551 VAPASLIHQWDAEIDRRLDDsvLSTYMFHGTKKQRDIDA--RRLARYDVVITTFNLIaneliekirtkskaddssdgesd 628
Cdd:cd17919 56 VCPLSVLENWEREFEKWTPD--LRVVVYHGSQRERAQIRakEKLDKFDVVLTTYETL----------------------- 110
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17540630 629 snhtgirravGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFL 702
Cdd:cd17919 111 ----------RRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFL 174
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
467-741 |
8.03e-47 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 166.97 E-value: 8.03e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 467 FKLELMPHQKAGLTWMRWRETQpQPGGILADDMGLGKTLSMISLIAHQKAARRARredgnddkdkekrkvvkeqgliPSn 546
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHY-GLGGILADDMGLGKTLQTLALLLSRKEEGRKG----------------------PS- 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 547 gtLIVAPASLIHQWDAEIDRRLDDsvLSTYMFHGTKKQRDIDaRRLARYDVVITTFNLIANElIEKIRTKSkaddssdge 626
Cdd:cd18012 57 --LVVAPTSLIYNWEEEAAKFAPE--LKVLVIHGTKRKREKL-RALEDYDLVITSYGLLRRD-IELLKEVK--------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 627 sdsnhtgirravgkddsvlaqicWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFL---- 702
Cdd:cd18012 122 -----------------------FHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLnpgl 178
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 17540630 703 --RIRPFSddKYWKESIMPMKPIMA-DRVNLLTKNLLLRRTK 741
Cdd:cd18012 179 lgSYKRFK--KRFAKPIEKDGDEEAlEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
458-1066 |
2.68e-42 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 168.44 E-value: 2.68e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 458 TELTDTPKGFKLELMPHQKAGLTWMrWRETQPQPGGILADDMGLGKTLSMISLIAHQKaarrarredgnddkdkEKRKVv 537
Cdd:PLN03142 157 TRLLVQPSCIKGKMRDYQLAGLNWL-IRLYENGINGILADEMGLGKTLQTISLLGYLH----------------EYRGI- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 538 keqglipSNGTLIVAPASLIHQWDAEIDRRLddSVLSTYMFHGTKKQRDIDARRL---ARYDVVITTFNLIAneliekir 614
Cdd:PLN03142 219 -------TGPHMVVAPKSTLGNWMNEIRRFC--PVLRAVKFHGNPEERAHQREELlvaGKFDVCVTSFEMAI-------- 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 615 tkskaddssdgesdsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWD 694
Cdd:PLN03142 282 -------------------------KEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHE 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 695 LYSLVRFLRIRPFSDDKYWKESI-MPMKPIMADRVNLLTKNL---LLRRTKDQTcavtnQKlvQLPPKNVEVHELEldgd 770
Cdd:PLN03142 337 LWALLNFLLPEIFSSAETFDEWFqISGENDQQEVVQQLHKVLrpfLLRRLKSDV-----EK--GLPPKKETILKVG---- 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 771 eaqayeiMMEAAKKFVKKLLQDSNDMKNHGFIPRRnrragkegevqnpfnfgprdlaagsnfekmscVLMLLLRLRQACV 850
Cdd:PLN03142 406 -------MSQMQKQYYKALLQKDLDVVNAGGERKR--------------------------------LLNIAMQLRKCCN 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 851 H---FNITKTGVdmdafSLIGGDNaeeanvddlneLLEKTMNMTLgngdneeRDKprattrifdpdylsckikntleIVE 927
Cdd:PLN03142 447 HpylFQGAEPGP-----PYTTGEH-----------LVENSGKMVL-------LDK----------------------LLP 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 928 NIMEKKEKVVIVSQWTSVLNLIEIHIKSSGFKYTSITGQVLVKDRQERVDSFNREKGGARVMLLSLAAGGVGLNLTGGNH 1007
Cdd:PLN03142 482 KLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADI 561
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 17540630 1008 LVMVDLHWNPALEQQAFDRIYRMGQKKDVFIHRLVTKGTIEQRVVMLQKDKVALASSVL 1066
Cdd:PLN03142 562 VILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVI 620
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
471-727 |
1.57e-36 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 137.87 E-value: 1.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQpQPGGILADDMGLGKTLSMISLIAhqkaarrarredgnddKDKEKRKVVKEQGLIPSngtLI 550
Cdd:cd17999 1 LRPYQQEGINWLAFLNKY-NLHGILCDDMGLGKTLQTLCILA----------------SDHHKRANSFNSENLPS---LV 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 551 VAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDIDARRLARYDVVITTFNLIANeliekirtkskaddssdgesdsn 630
Cdd:cd17999 61 VCPPTLVGHWVAEIKKYFPNAFLKPLAYVGPPQERRRLREQGEKHNVIVASYDVLRN----------------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 631 htgirravgkDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFSDD 710
Cdd:cd17999 118 ----------DIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTE 187
|
250
....*....|....*..
gi 17540630 711 KYWKESImpMKPIMADR 727
Cdd:cd17999 188 KQFQRRF--LKPILASR 202
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
471-698 |
4.54e-35 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 134.04 E-value: 4.54e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQPQpGGILADDMGLGKTLSMISLIAhqkaarRARREDGNDDKDKEKRKVVKEQGLIPSNG--T 548
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGR-GGILGDDMGLGKTVQVIAFLA------AVLGKTGTRRDRENNRPRFKKKPPASSAKkpV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 549 LIVAPASLIHQWDAEIDRRlddSVLSTYMFHGTKKQRDIDAR-RLARYDVVITTFNLIANELiekirtkskaddssdges 627
Cdd:cd18005 74 LIVAPLSVLYNWKDELDTW---GHFEVGVYHGSRKDDELEGRlKAGRLEVVVTTYDTLRRCI------------------ 132
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17540630 628 dsnhtgirravgkddSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSL 698
Cdd:cd18005 133 ---------------DSLNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCL 188
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
471-702 |
9.66e-28 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 112.46 E-value: 9.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMrWRETQPQPGGILADDMGLGKTLSMISL---IAHQKAARRArredgnddkdkekrkvvkeqglipsng 547
Cdd:cd18001 1 LYPHQREGVAWL-WSLHDGGKGGILADDMGLGKTVQICAFlsgMFDSGLIKSV--------------------------- 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 548 tLIVAPASLIHQWDAEIDRRLDDsvLSTYMFHGT-KKQRDIDARRLAR-YDVVITTFNLIaneliekirtkskaddssdg 625
Cdd:cd18001 53 -LVVMPTSLIPHWVKEFAKWTPG--LRVKVFHGTsKKERERNLERIQRgGGVLLTTYGMV-------------------- 109
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17540630 626 esdSNHTGIRRAVGKDDSVlaqicWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFL 702
Cdd:cd18001 110 ---LSNTEQLSADDHDEFK-----WDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFA 178
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
471-701 |
3.75e-27 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 109.72 E-value: 3.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMrWRETQPQPGGILADDMGLGKTLSMISLIAHQKAARRARRedgnddkdkekrkvvkeqgliPSngtLI 550
Cdd:cd18000 1 LFKYQQTGVQWL-WELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLG---------------------PS---LI 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 551 VAPASLIHQWDAEIDR---RLDDSVL---STYMFHGTKKQRDIDARRLAR-----YDVVITTFnlianeliEKIRTKSKA 619
Cdd:cd18000 56 VCPATVLKQWVKEFHRwwpPFRVVVLhssGSGTGSEEKLGSIERKSQLIRkvvgdGGILITTY--------EGFRKHKDL 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 620 ddssdgesdsnhtgirravgkddsvLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLV 699
Cdd:cd18000 128 -------------------------LLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLF 182
|
..
gi 17540630 700 RF 701
Cdd:cd18000 183 DF 184
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
470-741 |
4.28e-27 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 110.49 E-value: 4.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 470 ELMPHQKAGLTWMRwreTQPQPG--GILADDMGLGKTLSMISLIAHQKaarrarredgnddkdkEKRKVvkeqglipsNG 547
Cdd:cd17997 3 TMRDYQIRGLNWLI---SLFENGinGILADEMGLGKTLQTISLLGYLK----------------HYKNI---------NG 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 548 T-LIVAPASLIHQWDAEIDRRLDDsvLSTYMFHGTKKQR-DIDARRL--ARYDVVITTFNLIANELiekirtkskaddss 623
Cdd:cd17997 55 PhLIIVPKSTLDNWMREFKRWCPS--LRVVVLIGDKEERaDIIRDVLlpGKFDVCITSYEMVIKEK-------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 624 dgesdsnhtgirravgkddSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLR 703
Cdd:cd17997 119 -------------------TVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLL 179
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 17540630 704 IRPFSD----DKYWK-ESIMPMKPIMADRVNLLTKNLLLRRTK 741
Cdd:cd17997 180 PDVFTSsedfDEWFNvNNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
471-739 |
2.43e-26 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 108.10 E-value: 2.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM--RWRETQpqpGGILADDMGLGKTLSMISLIAHQkaarrarredgnddkdkekRKVVKEQGLIpsngt 548
Cdd:cd17995 1 LRDYQLEGVNWLlfNWYNRR---NCILADEMGLGKTIQSIAFLEHL-------------------YQVEGIRGPF----- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 549 LIVAPASLIHQWDAEIDRRLDDSVLstyMFHGTKKQRDID--------------ARRLARYDVVITTFNLIaneliekir 614
Cdd:cd17995 54 LVIAPLSTIPNWQREFETWTDMNVV---VYHGSGESRQIIqqyemyfkdaqgrkKKGVYKFDVLITTYEMV--------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 615 tkskaddssdgesdsnhtgirravGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWD 694
Cdd:cd17995 122 ------------------------IADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEE 177
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 17540630 695 LYSLVRFLRIRPFSDDKYWKESIMPMKPimADRVNLLTKNL---LLRR 739
Cdd:cd17995 178 LWSLLNFLEPEKFPSSEEFLEEFGDLKT--AEQVEKLQALLkpyMLRR 223
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
471-709 |
3.57e-24 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 102.46 E-value: 3.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRwreTQPQPG--GILADDMGLGKTLSMISLIAHqkaarrarredgnddkdkekrkvVKEQGLI-Psng 547
Cdd:cd18009 4 MRPYQLEGMEWLR---MLWENGinGILADEMGLGKTIQTIALLAH-----------------------LRERGVWgP--- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 548 TLIVAPASLIHQWDAEIDRRLDDsvLSTYMFHGTKKQRDIDAR-------RLARYDVVITTFNLIANeliekirtkskad 620
Cdd:cd18009 55 FLVIAPLSTLPNWVNEFARFTPS--VPVLLYHGTKEERERLRKkimkregTLQDFPVVVTSYEIAMR------------- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 621 dssdgesdsnhtgirravgkDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVR 700
Cdd:cd18009 120 --------------------DRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLN 179
|
....*....
gi 17540630 701 FLRIRPFSD 709
Cdd:cd18009 180 FLLPDVFDD 188
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
471-707 |
2.16e-23 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 98.61 E-value: 2.16e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQpQPGGILADDMGLGKTLSMISLIAHqkaarrarredgnddkdkekrkvVKEQGlipSNGT-L 549
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQK-KLSGILADEMGLGKTIQVIAFLAY-----------------------LKEIG---IPGPhL 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDSVLSTYmfHGTKKQ----RDIDARRLARYDVVITTFNLIANELIEKirtkskaddssdg 625
Cdd:cd17998 54 VVVPSSTLDNWLREFKRWCPSLKVEPY--YGSQEErkhlRYDILKGLEDFDVIVTTYNLATSNPDDR------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 626 esdsnhtgirravgkddSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIR 705
Cdd:cd17998 119 -----------------SFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPK 181
|
..
gi 17540630 706 PF 707
Cdd:cd17998 182 PF 183
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
471-739 |
5.18e-23 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 99.28 E-value: 5.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM----RWRETQPQPGGILADDMGLGKTLSMISLIAhqkaarrarredgnddkdkekrKVVK--EQGLIP 544
Cdd:cd18004 1 LRPHQREGVQFLydclTGRRGYGGGGAILADEMGLGKTLQAIALVW----------------------TLLKqgPYGKPT 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 545 SNGTLIVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKK--QRDIDARRLA-RYDVVIT---TFNLIANELIEKIRTksk 618
Cdd:cd18004 59 AKKALIVCPSSLVGNWKAEFDKWLGLRRIKVVTADGNAKdvKASLDFFSSAsTYPVLIIsyeTLRRHAEKLSKKISI--- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 619 addssdgesdsnhtgirravgkdDSVlaqICwsrvilDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSL 698
Cdd:cd18004 136 -----------------------DLL---IC------DEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFAL 183
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 17540630 699 VRFLRIRPFSDDKYWKEsiMPMKPIM------------------ADRVNLLTKNLLLRR 739
Cdd:cd18004 184 VDFVNPGILGSLASFRK--VFEEPILrsrdpdaseedkelgaerSQELSELTSRFILRR 240
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
471-739 |
1.20e-22 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 97.51 E-value: 1.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM-RWRETQPqpGGILADDMGLGKTLSMISLIAHQKAarrarredgnddKDKEKRKVvkeqglipsngtL 549
Cdd:cd18006 1 LRPYQLEGVNWLlQCRAEQH--GCILGDEMGLGKTCQTISLLWYLAG------------RLKLLGPF------------L 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDSVLSTYMfhGTKKQR-DI--DARRLARYDVVITTFNLianeliekirtkskaddssdge 626
Cdd:cd18006 55 VLCPLSVLDNWKEELNRFAPDLSVITYM--GDKEKRlDLqqDIKSTNRFHVLLTTYEI---------------------- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 627 sdsnhtgirraVGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRP 706
Cdd:cd18006 111 -----------CLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNV 179
|
250 260 270
....*....|....*....|....*....|....*....
gi 17540630 707 FSDD------KYWKEsiMPMKPIMADRVNLLTKNLLLRR 739
Cdd:cd18006 180 FPKDklddfiKAYSE--TDDESETVEELHLLLQPFLLRR 216
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
471-706 |
5.17e-22 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 96.21 E-value: 5.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMrWR------ETQPQPGG-ILADDMGLGKTLSMISLI-AHQKAARRARRedgnddkdkekrkvvkeqgl 542
Cdd:cd18007 1 LKPHQVEGVRFL-WSnlvgtdVGSDEGGGcILAHTMGLGKTLQVITFLhTYLAAAPRRSR-------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 543 ipsngTLIVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDIDARRLARYD------VVITTFNLIANeLIEKIRTK 616
Cdd:cd18007 60 -----PLVLCPASTLYNWEDEFKKWLPPDLRPLLVLVSLSASKRADARLRKINKwhkeggVLLIGYELFRN-LASNATTD 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 617 SKADDSSDGESDSNHTGIrravgkddsvlaqicwsrVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLY 696
Cdd:cd18007 134 PRLKQEFIAALLDPGPDL------------------LVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYW 195
|
250
....*....|
gi 17540630 697 SLVRFlrIRP 706
Cdd:cd18007 196 TMVDF--ARP 203
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
471-739 |
7.45e-21 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 92.42 E-value: 7.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRwRETQPQPGGILADDMGLGKTLSMISLIAHQKAarrarrEDGNddkdkekrkvvkeQGliPSngtLI 550
Cdd:cd18003 1 LREYQHIGLDWLA-TLYEKNLNGILADEMGLGKTIQTIALLAHLAC------EKGN-------------WG--PH---LI 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 551 VAPASLIHQWDAEIDRRLDDSVLSTYMfhGTKKQRdidarRLAR--------YDVVITTFNLianeliekirtkskadds 622
Cdd:cd18003 56 VVPTSVMLNWEMEFKRWCPGFKILTYY--GSAKER-----KLKRqgwmkpnsFHVCITSYQL------------------ 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 623 sdgesdsnhtgirraVGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFL 702
Cdd:cd18003 111 ---------------VVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFL 175
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 17540630 703 RIRPFSDDKYWKESIM-PMKPIM----------ADRVNLLTKNLLLRR 739
Cdd:cd18003 176 MPHIFQSHQEFKEWFSnPLTAMSegsqeeneelVRRLHKVLRPFLLRR 223
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
463-712 |
1.05e-19 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 88.32 E-value: 1.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 463 TPKGFKLELMPHQKAGLTWMRWRETqpqpGGILADDMGLGKTLSMISLIAHQKAARRARRedgnddkdkekrkvvkeqgl 542
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLR----DVILAAPTGSGKTLAALLPALEALKRGKGGR-------------------- 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 543 ipsngTLIVAP-ASLIHQWDAEIDRRLDDSVL-STYMFHGTKKQRDIDARRLARYDVVITTFNLIANELIEKIRTKSKad 620
Cdd:smart00487 57 -----VLVLVPtRELAEQWAEELKKLGPSLGLkVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSN-- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 621 dssdgesdsnhtgirravgkddsvlaqicWSRVILDEAHTIKN--RQSLASKAVCRL-SAFSRWCLSGTP---IHNNLWD 694
Cdd:smart00487 130 -----------------------------VDLVILDEAHRLLDggFGDQLEKLLKLLpKNVQLLLLSATPpeeIENLLEL 180
|
250
....*....|....*...
gi 17540630 695 LYSLVRFLRIRPFSDDKY 712
Cdd:smart00487 181 FLNDPVFIDVGFTPLEPI 198
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
471-739 |
9.55e-19 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 86.40 E-value: 9.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQpQPGGILADDMGLGKTLSMISLIAHqkaarrarredgnddkdkekrkVVKEQGLIpsNGTLI 550
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQ-GINGILADEMGLGKTVQSIAVLAH----------------------LAEEHNIW--GPFLV 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 551 VAPASLIHQWDAEIDRRLDDsvLSTYMFHGTKKQRDI-----DARRLARYD----VVITTFNLIAneliekirtkskadd 621
Cdd:cd18002 56 IAPASTLHNWQQEISRFVPQ--FKVLPYWGNPKDRKVlrkfwDRKNLYTRDapfhVVITSYQLVV--------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 622 ssdgesdsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRF 701
Cdd:cd18002 119 ------------------QDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHF 180
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 17540630 702 LRIRPF-SDDKY--W--------KESIMPMKPIMADRVNLLTKNLLLRR 739
Cdd:cd18002 181 IMPTLFdSHDEFneWfskdieshAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
471-702 |
1.15e-18 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 85.42 E-value: 1.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTwmrwRETQPQPGG-ILADDMGLGKTLSMIsLIAHQKAARRarredgnddkdkEKRKVvkeqglipsngtL 549
Cdd:cd18011 1 PLPHQIDAVL----RALRKPPVRlLLADEVGLGKTIEAG-LIIKELLLRG------------DAKRV------------L 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDIdARRLARYDVVITtfnlianeliekirtkskaddssdgesds 629
Cdd:cd18011 52 ILCPASLVEQWQDELQDKFGLPFLILDRETAAQLRRLI-GNPFEEFPIVIV----------------------------- 101
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17540630 630 nHTGIRRAVGKDDSVLAQICWSRVILDEAHTIKNRQ----SLASKAVCRLSAFSRWC--LSGTPIHNNLWDLYSLVRFL 702
Cdd:cd18011 102 -SLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNSGggkeTKRYKLGRLLAKRARHVllLTATPHNGKEEDFRALLSLL 179
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
458-741 |
1.65e-18 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 86.26 E-value: 1.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 458 TELTDTPKGFKL-ELMPHQKAGLTWMrWRETQPQPGGILADDMGLGKTLSMISLIAHQKAARRarredgnddkdkekrkv 536
Cdd:cd18064 2 TRFEDSPSYVKWgKLRDYQVRGLNWL-ISLYENGINGILADEMGLGKTLQTISLLGYMKHYRN----------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 537 vkeqglIPSNgTLIVAPASLIHQWDAEIDRRLddSVLSTYMFHGTKKQRDIDARRL---ARYDVVITTFNLIAnelieki 613
Cdd:cd18064 64 ------IPGP-HMVLVPKSTLHNWMAEFKRWV--PTLRAVCLIGDKDQRAAFVRDVllpGEWDVCVTSYEMLI------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 614 rtkskaddssdgesdsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLW 693
Cdd:cd18064 128 --------------------------KEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLH 181
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 17540630 694 DLYSLVRFLRIRPFSD----DKYWKESIMPMKPIMADRVNLLTKNLLLRRTK 741
Cdd:cd18064 182 ELWALLNFLLPDVFNSaedfDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIK 233
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
471-702 |
2.66e-18 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 85.11 E-value: 2.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQpQPGGILADDMGLGKTLSMISLIAHQKaarrarredgnddkdkEKRKVvkeqglipsNGT-L 549
Cdd:cd17996 4 LKEYQLKGLQWMVSLYNN-NLNGILADEMGLGKTIQTISLITYLM----------------EKKKN---------NGPyL 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDsvLSTYMFHGTKKQRD--IDARRLARYDVVITTFNLIAneliekirtkskaddssdges 627
Cdd:cd17996 58 VIVPLSTLSNWVSEFEKWAPS--VSKIVYKGTPDVRKklQSQIRAGKFNVLLTTYEYII--------------------- 114
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17540630 628 dsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQS-LASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFL 702
Cdd:cd17996 115 ------------KDKPLLSKIKWKYMIIDEGHRMKNAQSkLTQTLNTYYHARYRLLLTGTPLQNNLPELWALLNFL 178
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
470-702 |
6.06e-18 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 83.94 E-value: 6.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 470 ELMPHQKAGLTWM--RWRETQpqpGGILADDMGLGKTLSMISLIAHqkaARRARREDGnddkdkekrkvvkeqgliPsng 547
Cdd:cd17993 1 ELRDYQLTGLNWLahSWCKGN---NGILADEMGLGKTVQTISFLSY---LFHSQQQYG------------------P--- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 548 TLIVAPASLIHQWDAEIDRRLDDSVLSTYMfhGTKKQRDI--------DARRLARYDVVITTFNLIAneliekirtkska 619
Cdd:cd17993 54 FLVVVPLSTMPAWQREFAKWAPDMNVIVYL--GDIKSRDTireyefyfSQTKKLKFNVLLTTYEIIL------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 620 ddssdgesdsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLV 699
Cdd:cd17993 119 --------------------KDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALL 178
|
...
gi 17540630 700 RFL 702
Cdd:cd17993 179 HFL 181
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
918-1031 |
1.76e-17 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 79.18 E-value: 1.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 918 KIKNTLEIVENimEKKEKVVIVSQWTSVLNlIEIHIKSSGFKYTSITGQVLVKDRQERVDSFNRekgGARVMLLSLAAGG 997
Cdd:pfam00271 2 KLEALLELLKK--ERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRK---GKIDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 17540630 998 VGLNLTGGNHLVMVDLHWNPALEQQAFDRIYRMG 1031
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
471-703 |
3.84e-17 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 81.48 E-value: 3.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTW-MRWRetqpqpGGIL-ADDMGLGKTLSMISLIAHQKAarrarredgnddkdkekrkvvkEQGLipsngt 548
Cdd:cd18010 1 LLPFQREGVCFaLRRG------GRVLiADEMGLGKTVQAIAIAAYYRE----------------------EWPL------ 46
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 549 LIVAPASLIHQWDAEIDRRLDD-SVLSTYMFHGTKkqrdiDARRLARYDVVITTFNLianeliekirtkskaddssdges 627
Cdd:cd18010 47 LIVCPSSLRLTWADEIERWLPSlPPDDIQVIVKSK-----DGLRDGDAKVVIVSYDL----------------------- 98
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17540630 628 dsnhtgirraVGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWC--LSGTPIHNNLWDLYSLVRFLR 703
Cdd:cd18010 99 ----------LRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVilLSGTPALSRPIELFTQLDALD 166
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
471-741 |
2.76e-15 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 76.59 E-value: 2.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMrWRETQPQPGGILADDMGLGKTLSMISLIAHQKAARRarredgnddkdkekrkvvkeqglIPSNGTLI 550
Cdd:cd18065 16 LRDYQVRGLNWM-ISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRN-----------------------IPGPHMVL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 551 VaPASLIHQWDAEIDRRLDDsvLSTYMFHGTKKQRDI---DARRLARYDVVITTFNLIAneliekirtkskaddssdges 627
Cdd:cd18065 72 V-PKSTLHNWMNEFKRWVPS--LRAVCLIGDKDARAAfirDVMMPGEWDVCVTSYEMVI--------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 628 dsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPF 707
Cdd:cd18065 128 ------------KEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVF 195
|
250 260 270
....*....|....*....|....*....|....*...
gi 17540630 708 SD----DKYWKESIMPMKPIMADRVNLLTKNLLLRRTK 741
Cdd:cd18065 196 NSaddfDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIK 233
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
949-1031 |
5.32e-15 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 71.09 E-value: 5.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 949 IEIHIKSSGFKYTSITGQVLVKDRQERVDSFNRekgGARVMLLSLAAGGVGLNLTGGNHLVMVDLHWNPALEQQAFDRIY 1028
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFNN---GKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79
|
...
gi 17540630 1029 RMG 1031
Cdd:smart00490 80 RAG 82
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
471-703 |
2.31e-14 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 74.15 E-value: 2.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM--------RWRETQPQPGGILADDMGLGKTLSMISLIahqkaarrarredgnddkdkekRKVVKEQGL 542
Cdd:cd18068 1 LKPHQVDGVQFMwdccceslKKTKKSPGSGCILAHCMGLGKTLQVVTFL----------------------HTVLLCEKL 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 543 IPSNGTLIVAPASLIHQW---------DAEIDRRLDDSVLSTYmfhgtkkqRDIDARRLARYD------VVITTFNL--- 604
Cdd:cd18068 59 ENFSRVLVVCPLNTVLNWlnefekwqeGLKDEEKIEVNELATY--------KRPQERSYKLQRwqeeggVMIIGYDMyri 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 605 IANELIEKIRTKSKADdssdgesdsnhtgIRRAV---GKDdsvlaqicwsRVILDEAHTIKNRQSLASKAVCRLSAFSRW 681
Cdd:cd18068 131 LAQERNVKSREKLKEI-------------FNKALvdpGPD----------FVVCDEGHILKNEASAVSKAMNSIRTKRRI 187
|
250 260
....*....|....*....|..
gi 17540630 682 CLSGTPIHNNLWDLYSLVRFLR 703
Cdd:cd18068 188 VLTGTPLQNNLIEYHCMVNFVK 209
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
466-715 |
3.08e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 73.50 E-value: 3.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 466 GFKLELMPHQKAGLTWM--RWRETQPQpggILADDMGLGKTLSMISLIA---HQkaarrarredgnddkdkekrkvvkEQ 540
Cdd:cd18054 16 GENLELRDYQLEGLNWLahSWCKNNSV---ILADEMGLGKTIQTISFLSylfHQ------------------------HQ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 541 GLIPsngTLIVAPASLIHQWDAEIDRRLDDSVLSTYM--FHGTKKQRDID-----ARRLaRYDVVITTFNLIAnelieki 613
Cdd:cd18054 69 LYGP---FLLVVPLSTLTSWQREFEIWAPEINVVVYIgdLMSRNTIREYEwihsqTKRL-KFNALITTYEILL------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 614 rtkskaddssdgesdsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLW 693
Cdd:cd18054 138 --------------------------KDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLK 191
|
250 260
....*....|....*....|..
gi 17540630 694 DLYSLVRFLRIRPFsddKYWKE 715
Cdd:cd18054 192 ELWSLLHFIMPEKF---EFWED 210
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
471-701 |
3.35e-14 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 73.34 E-value: 3.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTW-------MRWRETQpqpGGILADDMGLGKTLSMISLIAhqkaarRARREDGNDDKDKEKRkvvkeqgli 543
Cdd:cd18066 1 LRPHQREGIEFlyecvmgMRVNERF---GAILADEMGLGKTLQCISLIW------TLLRQGPYGGKPVIKR--------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 544 psngTLIVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDIDARRLarYDVVITTFNLIANEL--IEKIRtkskadd 621
Cdd:cd18066 63 ----ALIVTPGSLVKNWKKEFQKWLGSERIKVFTVDQDHKVEEFIASPL--YSVLIISYEMLLRSLdqISKLN------- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 622 ssdgesdsnhtgirravgkddsvlaqicWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRF 701
Cdd:cd18066 130 ----------------------------FDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDF 181
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
471-739 |
4.21e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 69.70 E-value: 4.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM--RWRETQpqpGGILADDMGLGKTLSMISLIAHQKAArrarredgnddkdkekrkvvkeqGLipSNGT 548
Cdd:cd18060 1 LREYQLEGVNWLlfNWYNRQ---NCILADEMGLGKTIQSIAFLQEVYNV-----------------------GI--HGPF 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 549 LIVAPASLIHQWDAEIDRRLDdsvLSTYMFHGTKKQRDI----------DARRLA----RYDVVITTFNLIANELIEkir 614
Cdd:cd18060 53 LVIAPLSTITNWEREFNTWTE---MNTIVYHGSLASRQMiqqyemyckdSRGRLIpgayKFDALITTFEMILSDCPE--- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 615 tkskaddssdgesdsnhtgirravgkddsvLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWD 694
Cdd:cd18060 127 ------------------------------LREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEE 176
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 17540630 695 LYSLVRFLRIRPFSDDKYWKESIMPMKP-IMADRVNLLTKNLLLRR 739
Cdd:cd18060 177 LFSLLHFLEPSQFPSESEFLKDFGDLKTeEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
471-709 |
6.60e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 69.32 E-value: 6.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQPQpGGILADDMGLGKTLSMISLIahqkaarRARREDGNddkdkekrkvvkeqglipSNGTLI 550
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGT-DTILADEMGLGKTVQTAVFL-------YSLYKEGH------------------SKGPFL 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 551 V-APASLIHQWDAEIDRRLDDSVLSTYMfhgtkkqRDIDARRLARYDvvitTFNLIANelieKIRTKSKADDSSDGESDS 629
Cdd:cd18056 55 VsAPLSTIINWEREFEMWAPDMYVVTYV-------GDKDSRAIIREN----EFSFEDN----AIRGGKKASRMKKEASVK 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 630 NHTGIR--RAVGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPF 707
Cdd:cd18056 120 FHVLLTsyELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERF 199
|
..
gi 17540630 708 SD 709
Cdd:cd18056 200 HN 201
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
471-701 |
1.03e-12 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 69.04 E-value: 1.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMrWRETQPQP-----GGILADDMGLGKTLSMISLIAhqkaarrarredgnddkdkekrkVVKEQGLIPS 545
Cdd:cd18067 1 LRPHQREGVKFL-YRCVTGRRirgshGCIMADEMGLGKTLQCITLMW-----------------------TLLRQSPQCK 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 546 ---NGTLIVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDI--------DARRLARYDVVIT--TFNLIANELiek 612
Cdd:cd18067 57 peiDKAIVVSPSSLVKNWANELGKWLGGRLQPLAIDGGSKKEIDRklvqwasqQGRRVSTPVLIISyeTFRLHVEVL--- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 613 irtkskaddssdgesdsnHTGirrAVGkddsvlaqicwsRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNL 692
Cdd:cd18067 134 ------------------QKG---EVG------------LVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDL 180
|
....*....
gi 17540630 693 WDLYSLVRF 701
Cdd:cd18067 181 SEYFSLVNF 189
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
471-739 |
1.35e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 68.53 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM--RWRETQpqpGGILADDMGLGKTLSMISLIAhqkaarrarredgnddkdkekrkvvkEQGLIPSNGT 548
Cdd:cd18058 1 LREYQLEGMNWLlfNWYNRK---NCILADEMGLGKTIQSITFLS--------------------------EIFLMGIRGP 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 549 -LIVAPASLIHQWDAEIDRRLDdsvLSTYMFHGTKKQRDI---------DARR-----LARYDVVITTFNLIANELIEki 613
Cdd:cd18058 52 fLIIAPLSTITNWEREFRTWTE---MNAIVYHGSQISRQMiqqyemyyrDEQGnplsgIFKFQVVITTFEMILADCPE-- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 614 rtkskaddssdgesdsnhtgirravgkddsvLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLW 693
Cdd:cd18058 127 -------------------------------LKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVE 175
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 17540630 694 DLYSLVRFLRIRPFSDDKYWKESIMPMKP-IMADRVNLLTKNLLLRR 739
Cdd:cd18058 176 ELFSLLNFLEPSQFPSETTFLEEFGDLKTeEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
471-709 |
1.53e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 68.55 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQPQpGGILADDMGLGKTLSMISLIahqkaarRARREDGNddkdkekrkvvkeqglipSNGT-L 549
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGT-DTILADEMGLGKTVQTIVFL-------YSLYKEGH------------------SKGPyL 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDSVLSTYMfhGTKKQRDIdarrlarydVVITTFNLIANelieKIRTKSKADDSSDGESDS 629
Cdd:cd18057 55 VSAPLSTIINWEREFEMWAPDFYVVTYT--GDKESRSV---------IRENEFSFEDN----AIRSGKKVFRMKKEAQIK 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 630 NHTGIR--RAVGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPF 707
Cdd:cd18057 120 FHVLLTsyELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERF 199
|
..
gi 17540630 708 SD 709
Cdd:cd18057 200 NN 201
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
471-739 |
2.51e-12 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 68.17 E-value: 2.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQpQPGGILADDMGLGKTLSMISLIAHQKAARRArredgnddkdkekrkvvkeqglipsNGT-L 549
Cdd:cd18063 24 LKHYQLQGLEWMVSLYNN-NLNGILADEMGLGKTIQTIALITYLMEHKRL-------------------------NGPyL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDIDARRLARYDVVITTFNLIAneliekirtkskaddssdgesds 629
Cdd:cd18063 78 IIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYII----------------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 630 nhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAV-CRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFS 708
Cdd:cd18063 135 ----------KDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLnTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFK 204
|
250 260 270
....*....|....*....|....*....|...
gi 17540630 709 DDKYWKESIMPMKPIMADRVNLLTKN--LLLRR 739
Cdd:cd18063 205 SCSTFEQWFNAPFAMTGERVDLNEEEtiLIIRR 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
471-709 |
8.17e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 65.54 E-value: 8.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWMRWRETQpQPGGILADDMGLGKTLSMISLIahqkaarrarredgnddkdkekRKVVKEQGlipSNGT-L 549
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQ-GTDTILADEMGLGKTIQTIVFL----------------------YSLYKEGH---SKGPfL 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 550 IVAPASLIHQWDAEIDRRLDDSVLSTYmfHGTKkqrdidarrlarydVVITTFNLIAneliekirtkskaddssdgesds 629
Cdd:cd17994 55 VSAPLSTIINWEREFEMWAPDFYVVTY--VGDH--------------VLLTSYELIS----------------------- 95
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 630 nhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFSD 709
Cdd:cd17994 96 ----------IDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNN 165
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
470-702 |
1.53e-11 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 65.84 E-value: 1.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 470 ELMPHQKAGLTWMRWRETQpQPGGILADDMGLGKTLSMISLIAHQKAARRArredgnddkdkekrkvvkeqglipsNGT- 548
Cdd:cd18062 23 VLKQYQIKGLEWLVSLYNN-NLNGILADEMGLGKTIQTIALITYLMEHKRI-------------------------NGPf 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 549 LIVAPASLIHQWDAEIDRRLDDSVLSTYMFHGTKKQRDIDARRLARYDVVITTFNLIAneliekirtkskaddssdgesd 628
Cdd:cd18062 77 LIIVPLSTLSNWVYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYII---------------------- 134
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17540630 629 snhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAV-CRLSAFSRWCLSGTPIHNNLWDLYSLVRFL 702
Cdd:cd18062 135 -----------KDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLnTHYVAPRRLLLTGTPLQNKLPELWALLNFL 198
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
469-715 |
7.93e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 63.53 E-value: 7.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 469 LELMPHQKAGLTWM--RWRETQpqpGGILADDMGLGKTLSMISLIAHqkaarrarredgnddkdkekrkVVKEQGLIpsN 546
Cdd:cd18053 19 LELRDYQLNGLNWLahSWCKGN---SCILADEMGLGKTIQTISFLNY----------------------LFHEHQLY--G 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 547 GTLIVAPASLIHQWDAEIdrRLDDSVLSTYMFHGTKKQRDI---------DARRLaRYDVVITTFNLIAneliekirtks 617
Cdd:cd18053 72 PFLLVVPLSTLTSWQREI--QTWAPQMNAVVYLGDINSRNMirthewmhpQTKRL-KFNILLTTYEILL----------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 618 kaddssdgesdsnhtgirravgKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYS 697
Cdd:cd18053 138 ----------------------KDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWS 195
|
250
....*....|....*...
gi 17540630 698 LVRFLRIRPFSDDKYWKE 715
Cdd:cd18053 196 LLHFIMPEKFSSWEDFEE 213
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
474-709 |
8.99e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 60.41 E-value: 8.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 474 HQKAGLTWMRWRETQPQpGGILADDMGLGKTLSMISLIahqkaarRARREDGNddkdkekrkvvkEQGLIpsngtLIVAP 553
Cdd:cd18055 4 YQLEGLNWLRFSWAQGT-DTILADEMGLGKTIQTIVFL-------YSLYKEGH------------TKGPF-----LVSAP 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 554 ASLIHQWDAEIDRRLDDSVLSTYMfhgtkkqRDIDARRLARYDvvitTFNLIANelieKIRTKSKADDSSDGESDSNHTG 633
Cdd:cd18055 59 LSTIINWEREFQMWAPDFYVVTYT-------GDKDSRAIIREN----EFSFDDN----AVKGGKKAFKMKREAQVKFHVL 123
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17540630 634 IR--RAVGKDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFSD 709
Cdd:cd18055 124 LTsyELVTIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNN 201
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
471-739 |
1.26e-09 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 59.66 E-value: 1.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM--RWRETQpqpGGILADDMGLGKTLSMISLIAHqkaarrarredgnddkdkekrkvVKEQGLipSNGT 548
Cdd:cd18059 1 LREYQLEGVNWLlfNWYNTR---NCILADEMGLGKTIQSITFLYE-----------------------IYLKGI--HGPF 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 549 LIVAPASLIHQWDAEIDRRLDdsvLSTYMFHGTKKQR-----------DIDARRLA---RYDVVITTFNLIANELIEkir 614
Cdd:cd18059 53 LVIAPLSTIPNWEREFRTWTE---LNVVVYHGSQASRrtiqlyemyfkDPQGRVIKgsyKFHAIITTFEMILTDCPE--- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 615 tkskaddssdgesdsnhtgirravgkddsvLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWD 694
Cdd:cd18059 127 ------------------------------LRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEE 176
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 17540630 695 LYSLVRFLRIRPFSDDKYWKESIMPMKP-IMADRVNLLTKNLLLRR 739
Cdd:cd18059 177 LFSLLHFLEPSRFPSETTFMQEFGDLKTeEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
471-739 |
2.90e-08 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 55.40 E-value: 2.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM--RWRETQpqpGGILADDMGLGKTLSMISLIAHqkaarrarredgnddkdkekrkvVKEQGLipSNGT 548
Cdd:cd18061 1 LREYQLEGLNWLlfNWYNRR---NCILADEMGLGKTIQSITFLYE-----------------------ILLTGI--RGPF 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 549 LIVAPASLIHQWDAEIDRRLDDSVLstyMFHGT--KKQ---------RDIDARRLA---RYDVVITTFNLIANELIEkir 614
Cdd:cd18061 53 LIIAPLSTIANWEREFRTWTDLNVV---VYHGSliSRQmiqqyemyfRDSQGRIIRgayRFQAIITTFEMILGGCPE--- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 615 tkskaddssdgesdsnhtgirravgkddsvLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWD 694
Cdd:cd18061 127 ------------------------------LNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEE 176
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 17540630 695 LYSLVRFLRIRPFSDDKYWKESIMPMKP-IMADRVNLLTKNLLLRR 739
Cdd:cd18061 177 LFSLLHFLEPLRFPSESTFMQEFGDLKTeEQVQKLQAILKPMMLRR 222
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
473-702 |
6.19e-07 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 51.58 E-value: 6.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 473 PHQKAGltwMRWRETQPQpGGILADdMGLGKTLSMISLIAHQKAARRARRedgnddkdkekrkvvkeqglipsngTLIVA 552
Cdd:cd18013 3 PYQKVA---INFIIEHPY-CGLFLD-MGLGKTVTTLTALSDLQLDDFTRR-------------------------VLVIA 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 553 PASLI-HQWDAEIDR--RLDDSVLSTYMfhGTKKQRdidaRRLARYDVVITTFNLianELIEKIrtkskaddssdgesds 629
Cdd:cd18013 53 PLRVArSTWPDEVEKwnHLRNLTVSVAV--GTERQR----SKAANTPADLYVINR---ENLKWL---------------- 107
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17540630 630 nhtgirravgkDDSVLAQICWSRVILDEAHTIKNRQSLASKAVCRLSAFSRWC--LSGTPIHNNLWDLYSLVRFL 702
Cdd:cd18013 108 -----------VNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLigLTGTPSPNGLMDLWAQIALL 171
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
471-703 |
2.25e-06 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 49.81 E-value: 2.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 471 LMPHQKAGLTWM--------RWRETQPQPGGILADDMGLGKTLSMISLIahqKAARRArredgnddkdkekrkvvkeqgl 542
Cdd:cd18069 1 LKPHQIGGIRFLydniieslERYKGSSGFGCILAHSMGLGKTLQVISFL---DVLLRH---------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 543 IPSNGTLIVAPASLIHQWDAEIDRRLddsvlSTYMFHGTKKQRDIDARRLAryDVViTTFNLIANeLIEKIRTKSKADDS 622
Cdd:cd18069 56 TGAKTVLAIVPVNTLQNWLSEFNKWL-----PPPEALPNVRPRPFKVFILN--DEH-KTTAARAK-VIEDWVKDGGVLLM 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 623 sdgesdsNHTGIRRAVGKDdsvlaqicwsRVILDEAHTIKNRQSLASKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFL 702
Cdd:cd18069 127 -------GYEMFRLRPGPD----------VVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFV 189
|
.
gi 17540630 703 R 703
Cdd:cd18069 190 R 190
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
491-659 |
5.31e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 41.62 E-value: 5.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 491 PGGILADDMGLGKTLsMISLIAHQKAARRARRedgnddkdkekrkvvkeqglipsngTLIVAP-ASLIHQWDAEIDRRLD 569
Cdd:cd00046 2 ENVLITAPTGSGKTL-AALLAALLLLLKKGKK-------------------------VLVLVPtKALALQTAERLRELFG 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540630 570 DSvLSTYMFHGTKKQRDIDARRLARYDVVITTfnlianelIEKIRTKSKADdssdgesdsnhtgiRRAVGKDdsvlaqic 649
Cdd:cd00046 56 PG-IRVAVLVGGSSAEEREKNKLGDADIIIAT--------PDMLLNLLLRE--------------DRLFLKD-------- 104
|
170
....*....|
gi 17540630 650 WSRVILDEAH 659
Cdd:cd00046 105 LKLIIVDEAH 114
|
|
| PRK04914 |
PRK04914 |
RNA polymerase-associated protein RapA; |
979-1039 |
1.03e-03 |
|
RNA polymerase-associated protein RapA;
Pssm-ID: 235319 [Multi-domain] Cd Length: 956 Bit Score: 43.29 E-value: 1.03e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17540630 979 FNREKGGARVMLLSlAAGGVGLNLTGGNHLVMVDLHWNPALEQQAFDRIYRMGQKKDVFIH 1039
Cdd:PRK04914 540 FADEEDGAQVLLCS-EIGSEGRNFQFASHLVLFDLPFNPDLLEQRIGRLDRIGQKHDIQIH 599
|
|
| |
