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Conserved domains on  [gi|72001644|ref|NP_503189|]
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SCP domain-containing protein [Caenorhabditis elegans]

Protein Classification

CAP domain-containing protein( domain architecture ID 10143468)

CAP (CSP/antigen 5/PR1) domain-containing protein similar to Venom allergen 5, CRISP/Allergen/PR-1 and scoloptoxins

CATH:  3.40.33.10
PubMed:  18824526
SCOP:  4001882

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 27-164 2.18e-19

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


:

Pssm-ID: 349399  Cd Length: 144  Bit Score: 80.19  E-value: 2.18e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001644  27 IVKVHNELGNDVACGKYQNhsdYPKASQMMMMKWNQSLAEAVGNVKHSC--QQLKERYLKkfIKGENLYRVYFYNTVVDG 104
Cdd:cd05380   4 ILDAHNELRSKVAKGKLKG---LPPAANMPKLKWDCELAKLAQNWAKTCvfAHSPCRNTG--GVGQNLASVSSSGKDLKE 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72001644 105 LQER------DEILR-RSEKAVSTGANFEVERFHKILHDKVTSIGCSYKNCENDqGYDMRYFICKYS 164
Cdd:cd05380  79 LIEDavnawfDELKDyGFGSNPNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKG-GGNKTYVVCNYS 144
 
Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 27-164 2.18e-19

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 80.19  E-value: 2.18e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001644  27 IVKVHNELGNDVACGKYQNhsdYPKASQMMMMKWNQSLAEAVGNVKHSC--QQLKERYLKkfIKGENLYRVYFYNTVVDG 104
Cdd:cd05380   4 ILDAHNELRSKVAKGKLKG---LPPAANMPKLKWDCELAKLAQNWAKTCvfAHSPCRNTG--GVGQNLASVSSSGKDLKE 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72001644 105 LQER------DEILR-RSEKAVSTGANFEVERFHKILHDKVTSIGCSYKNCENDqGYDMRYFICKYS 164
Cdd:cd05380  79 LIEDavnawfDELKDyGFGSNPNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKG-GGNKTYVVCNYS 144
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 27-165 7.17e-09

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 52.39  E-value: 7.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001644     27 IVKVHNELGNDVACGKYQNhsdyPKASQMMMMKWNQSLAEAVGNVKHSCQQLKERYLKKFikGENLYrvYFYNTVVDglq 106
Cdd:smart00198   6 ILDAHNKLRSQVAGGFLAA----PAASNMLKLTWDCELASSAQNWANQCPFGHSTPRPGY--GENLA--WWSSSTAL--- 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72001644    107 erdeiLRRSEKAVSTGANFEVERF-----------HKILH------DKVTSIGCSYKNCENDQGYDMrYFICKYSP 165
Cdd:smart00198  75 -----PDTYASAAVQLWYDEFQDYgyssntckdtnGKIGHytqvvwAKTYKVGCGVANCPDGTKKKT-VVVCNYDP 144
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 46-163 9.60e-05

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 40.26  E-value: 9.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001644    46 HSDYPKASQMMMMKWNQSLAEAVGnvKHSCQQLKERYLKKFIKGENLYRVYFYNTVVDGLQERDEILRRSEKA-VSTGAN 124
Cdd:pfam00188   4 HNEYRAAAGLPPLSWDNELAAAAQ--DHAKYCADNGSHNHRSPYGGNIYARVVAAGYALGDAGPDSAEDAVDGwYDSPGT 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 72001644   125 FEVERFHKILHDKVTSIGCSYKNCENDQGYdmrYFICKY 163
Cdd:pfam00188  82 YNCGHRTNLLWPKSTKVGCAVAKCGDGGTY---YFVCNY 117
 
Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 27-164 2.18e-19

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 80.19  E-value: 2.18e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001644  27 IVKVHNELGNDVACGKYQNhsdYPKASQMMMMKWNQSLAEAVGNVKHSC--QQLKERYLKkfIKGENLYRVYFYNTVVDG 104
Cdd:cd05380   4 ILDAHNELRSKVAKGKLKG---LPPAANMPKLKWDCELAKLAQNWAKTCvfAHSPCRNTG--GVGQNLASVSSSGKDLKE 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72001644 105 LQER------DEILR-RSEKAVSTGANFEVERFHKILHDKVTSIGCSYKNCENDqGYDMRYFICKYS 164
Cdd:cd05380  79 LIEDavnawfDELKDyGFGSNPNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKG-GGNKTYVVCNYS 144
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 27-165 7.17e-09

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 52.39  E-value: 7.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001644     27 IVKVHNELGNDVACGKYQNhsdyPKASQMMMMKWNQSLAEAVGNVKHSCQQLKERYLKKFikGENLYrvYFYNTVVDglq 106
Cdd:smart00198   6 ILDAHNKLRSQVAGGFLAA----PAASNMLKLTWDCELASSAQNWANQCPFGHSTPRPGY--GENLA--WWSSSTAL--- 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72001644    107 erdeiLRRSEKAVSTGANFEVERF-----------HKILH------DKVTSIGCSYKNCENDQGYDMrYFICKYSP 165
Cdd:smart00198  75 -----PDTYASAAVQLWYDEFQDYgyssntckdtnGKIGHytqvvwAKTYKVGCGVANCPDGTKKKT-VVVCNYDP 144
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 46-163 9.60e-05

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 40.26  E-value: 9.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001644    46 HSDYPKASQMMMMKWNQSLAEAVGnvKHSCQQLKERYLKKFIKGENLYRVYFYNTVVDGLQERDEILRRSEKA-VSTGAN 124
Cdd:pfam00188   4 HNEYRAAAGLPPLSWDNELAAAAQ--DHAKYCADNGSHNHRSPYGGNIYARVVAAGYALGDAGPDSAEDAVDGwYDSPGT 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 72001644   125 FEVERFHKILHDKVTSIGCSYKNCENDQGYdmrYFICKY 163
Cdd:pfam00188  82 YNCGHRTNLLWPKSTKVGCAVAKCGDGGTY---YFVCNY 117
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 25-93 8.96e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 38.10  E-value: 8.96e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72001644  25 DRIVKVHNELGNDVAcgkyqnhsdyPKASQMMMMKWNQSLAEAVGNVKHSCQQL----KERYLKKFIKGENLY 93
Cdd:cd05383   4 QEIVDLHNALRRSVN----------PPASNMLKMSWNPEAAENAQRWANRCNFThsppNGRTIPGIRCGENIF 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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