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Conserved domains on  [gi|17563566|ref|NP_503667|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-315 1.16e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 265.47  E-value: 1.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566     7 FQIIQVIGFILSEVFHFTLLFLIHTRATRHFGSYKLLMASFSIFSILYALVEVLTQPIMHISGTGLMLYVGTTFLPISKE 86
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566    87 FGHFIAAFYCSTFGICVLFLSAHFFYRYSAVCSPRLLRHLHGPKVLRLLMPVFFLGALMFLNVTWFGEPTEFKMHYMRES 166
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566   167 LKREYGDDSFEVGQISSVFYIYNSTGSLEFFWKDCLGMAVVYIILSISISTIIYFSLNIFRTVyRHTKHRKSKKNWEIHR 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKM-KKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563566   247 QLFQTLIIQTLIPMCILFIPTGFLLTLPFFDVKyVGRVTNAPGVGASLYPALDALTAILMIREFRTAFK 315
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIE-IGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-315 1.16e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 265.47  E-value: 1.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566     7 FQIIQVIGFILSEVFHFTLLFLIHTRATRHFGSYKLLMASFSIFSILYALVEVLTQPIMHISGTGLMLYVGTTFLPISKE 86
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566    87 FGHFIAAFYCSTFGICVLFLSAHFFYRYSAVCSPRLLRHLHGPKVLRLLMPVFFLGALMFLNVTWFGEPTEFKMHYMRES 166
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566   167 LKREYGDDSFEVGQISSVFYIYNSTGSLEFFWKDCLGMAVVYIILSISISTIIYFSLNIFRTVyRHTKHRKSKKNWEIHR 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKM-KKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563566   247 QLFQTLIIQTLIPMCILFIPTGFLLTLPFFDVKyVGRVTNAPGVGASLYPALDALTAILMIREFRTAFK 315
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIE-IGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-315 1.16e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 265.47  E-value: 1.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566     7 FQIIQVIGFILSEVFHFTLLFLIHTRATRHFGSYKLLMASFSIFSILYALVEVLTQPIMHISGTGLMLYVGTTFLPISKE 86
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566    87 FGHFIAAFYCSTFGICVLFLSAHFFYRYSAVCSPRLLRHLHGPKVLRLLMPVFFLGALMFLNVTWFGEPTEFKMHYMRES 166
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566   167 LKREYGDDSFEVGQISSVFYIYNSTGSLEFFWKDCLGMAVVYIILSISISTIIYFSLNIFRTVyRHTKHRKSKKNWEIHR 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKM-KKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563566   247 QLFQTLIIQTLIPMCILFIPTGFLLTLPFFDVKyVGRVTNAPGVGASLYPALDALTAILMIREFRTAFK 315
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIE-IGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-314 4.74e-30

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 116.19  E-value: 4.74e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566     1 MCIPLEFQIIQVIGFILSEVFHFTLLFLIHTRATRHFGSYKLLMASFSIFSILYALVEVLTQPIMHISGTGLMLYVGTTF 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566    81 LPISKEFGHFIAAFYCSTFGICVLFLSAHFFYRYSAVCSPRLLRHLHGPK-VLRLLMPVFFLGALMFLNVTWFGEPTEFK 159
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWgILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566   160 MHYMRESLKREYGDDSFEVGQISSVFYiynsTGSLEFFWKDCLGMAVVYIILSISISTIIYFSLNIFRTVyRHTKHRKSK 239
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYW----EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKL-NKMSVTMSK 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563566   240 KNWEIHRQLFQTLIIQTLIPMCILFIPTGFLLTLPFFDVKYvGRVTNAPGVGA-SLYPALDALTAILMIREFRTAF 314
Cdd:pfam10319 236 KTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDL-GRWNNYLEVIAlSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 7-315 3.18e-09

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 57.18  E-value: 3.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566     7 FQIIQVIGFILSEVFHFTLLFLIHTRATRHFGSYKLLMASFSIFSILYALVEVLTQPIMhISGTGLMLYVGTTFLpisKE 86
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRI-IPNGVSMALISYGPC---KY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566    87 FGHFIAA----FYCSTFGICVLFLSAHFFYRYSAVCSPRLLRHLHGPKVLRLLMPVFFLGALMFLNVTWFgepteFKMHY 162
Cdd:pfam10317  77 FGPWFCYsgysLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDF-----LPVEA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566   163 MRESLKREYGDDSFEVGQISSVFYIYNSTGSLEFfwkdCLGMAVVYiilsisiSTIIYFSLNIFRTV-YRHTKHRKSKKn 241
Cdd:pfam10317 152 LTKELHPNYNLTDYTVTGFSDLQSFPALINTLIM----TIPVFPIP-------IIILILRRKILKLLnSNSVNMSPTTK- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563566   242 wEIHRQLFQTLIIQTLIPMCILFIPTGFLL-------TLPFFDvkyvgrvtNAPGVGASLYPALDALTAILMIREFRTAF 314
Cdd:pfam10317 220 -AQHRQLIKGLTIQALLPLFSYIPGVTLYLlsqltgtEFLILE--------YFIFVLPALPPLLDPLITIYFVTPYRRAI 290


                  .
gi 17563566   315 K 315
Cdd:pfam10317 291 L 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 220-277 1.68e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 42.92  E-value: 1.68e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17563566   220 YFSLNIFRTVYRHTKHRKSKKNWEIHRQLFQTLIIQTLIPMCILFIPTGFLLTLPFFD 277
Cdd:pfam10318 203 FFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFG 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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