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Conserved domains on  [gi|71988552|ref|NP_505395|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 10-258 5.07e-73

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10326:

Pssm-ID: 419896  Cd Length: 307  Bit Score: 226.18  E-value: 5.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    10 AEYLGFFVAFITNVTLIYLIITRTRQNFGSYKYLMLWFAAFSLWYSIIDILTQPAMHSYLNSFIVFC-ASWFKYDPLLAS 88
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVdLKDLGLSKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    89 IIIPTYCTSYGLTLVLLAIHFVYRYIAMIHPNEIRWFKYPRALI------------------------------------ 132
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILwflyplifgaiwgllvyfflgpdeetdeylreelle 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552   133 ------------------VGSQGEIQIQWKSCLAMTNVYCIAITTLVTIMSLGYSIYIKMQSVNDMVAEKTRALQRQLFH 194
Cdd:pfam10326 164 nynldidevayvgpvyypTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71988552   195 ALVLQTIVPIIFMYTPTTILFLCPIIGVELGMIANMTSVCLALYPALDPLVVMYFIKDYRSYLL 258
Cdd:pfam10326 244 ALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-258 5.07e-73

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 226.18  E-value: 5.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    10 AEYLGFFVAFITNVTLIYLIITRTRQNFGSYKYLMLWFAAFSLWYSIIDILTQPAMHSYLNSFIVFC-ASWFKYDPLLAS 88
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVdLKDLGLSKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    89 IIIPTYCTSYGLTLVLLAIHFVYRYIAMIHPNEIRWFKYPRALI------------------------------------ 132
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILwflyplifgaiwgllvyfflgpdeetdeylreelle 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552   133 ------------------VGSQGEIQIQWKSCLAMTNVYCIAITTLVTIMSLGYSIYIKMQSVNDMVAEKTRALQRQLFH 194
Cdd:pfam10326 164 nynldidevayvgpvyypTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71988552   195 ALVLQTIVPIIFMYTPTTILFLCPIIGVELGMIANMTSVCLALYPALDPLVVMYFIKDYRSYLL 258
Cdd:pfam10326 244 ALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-258 5.07e-73

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 226.18  E-value: 5.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    10 AEYLGFFVAFITNVTLIYLIITRTRQNFGSYKYLMLWFAAFSLWYSIIDILTQPAMHSYLNSFIVFC-ASWFKYDPLLAS 88
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVdLKDLGLSKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    89 IIIPTYCTSYGLTLVLLAIHFVYRYIAMIHPNEIRWFKYPRALI------------------------------------ 132
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILwflyplifgaiwgllvyfflgpdeetdeylreelle 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552   133 ------------------VGSQGEIQIQWKSCLAMTNVYCIAITTLVTIMSLGYSIYIKMQSVNDMVAEKTRALQRQLFH 194
Cdd:pfam10326 164 nynldidevayvgpvyypTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71988552   195 ALVLQTIVPIIFMYTPTTILFLCPIIGVELGMIANMTSVCLALYPALDPLVVMYFIKDYRSYLL 258
Cdd:pfam10326 244 ALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-254 5.64e-38

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 135.83  E-value: 5.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552     1 MRIPFYTVSAEYLGFFVAFITNVTLIYLIITRTRQNFGSYKYLMLWFAAFSLWYSIIDILTQPAMHSYLNSFIVFCA-SW 79
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSdGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    80 FKYDPLLASIIIPTYCTSYGLTLVLLAIHFVYRYIAMIHPNEIRWFKYPRAL---------------------------- 131
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGIlisilfflfhgsvwtaicyfllrandei 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552   132 --------------------IVGSQ---GEIQIQWKSCLAMTNVYCIAITTLVTIMSLGYSIYIKMQSVNDMVAEKTRAL 188
Cdd:pfam10319 161 rdyiredfretygvdsmdinMLGALyweASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71988552   189 QRQLFHALVLQTIVPIIFMYTPTTILFLCPIIGVELGMIANMTSVC-LALYPALDPLVVMYFIKDYR 254
Cdd:pfam10319 241 QKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYR 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 15-259 1.84e-14

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 71.81  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    15 FFVAFITNVTLIYLIITRTRQNFGSYKYLMLWFAAFSLWYSIIDILTQPAMHSYLNSFIVFCASWFKY-DPLLASIIIPT 93
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYfGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552    94 YCTSYGLTLVLLAIHFVYRYIAMIH--PNEIRWFK-----YPRALIVG--------SQGEIQIQWKS------------- 145
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRYYILKHvdPKRKKLILliiihYIPSLSQLiviflsptDFLPVEALTKElhpnynltdytvt 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552   146 -CLAMTNVYCIAITTLVTIMSLGYSIYI---------KMQSVNDMVAEKTRALQRQLFHALVLQTIVPIIFMYTPTTILF 215
Cdd:pfam10317 169 gFSDLQSFPALINTLIMTIPVFPIPIIIlilrrkilkLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLFSYIPGVTLYL 248

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 71988552   216 LCPIIGVELGMIANMTSVCLALYPALDPLVVMYFIKDYRSYLLK 259
Cdd:pfam10317 249 LSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 152-259 1.81e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 51.39  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988552   152 VYCIAITTLVTIMS----LGYSIYIKMQSVNDMVAEKTRALQRQLFHALVLQTIVPIIFMYTPTTILFLCPIIGVELGMI 227
Cdd:pfam10318 187 LICIVLLILILIIQilffVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQAL 266

                          90       100       110
                  ....*....|....*....|....*....|..
gi 71988552   228 ANMTSVCLALYPALDPLVVMYFIKDYRSYLLK 259
Cdd:pfam10318 267 NNLLFIIISLHGLLSTIAMLLVHKPYRKFVLS 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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