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Conserved domains on  [gi|193210853|ref|NP_508880|]
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DREV methyltransferase [Caenorhabditis elegans]

Protein Classification

methyltransferase-like protein 9( domain architecture ID 11155959)

methyltransferase-like protein 9 (METTL9) is a protein-histidine N-methyltransferase that specifically catalyzes the 1-methylhistidine (pros-methylhistidine) methylation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DREV pfam05219
DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. ...
 16-281 5.35e-167

DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. The function of this protein is unknown. However, these proteins appear to be related to other methyltransferases (Bateman A pers obs).


:

Pssm-ID: 253097  Cd Length: 265  Bit Score: 464.36  E-value: 5.35e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853   16 WYQPETSLSDVAQNLFAASLPDGETQQFLDNSNKIASNFFWQTVRNLGVMILSTIYSKTDINGMTGFGNMFLFSENQFAK 95
Cdd:pfam05219   1 WYCLNHELPPRFQSKFVPSEPDATTQSFLENSKALSANIFTQLWHALARSILSFFMSQTDINGFLGRGSMFIFSEEQFRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853   96 FLAIEKESWNS--TDKKVLDLGAGNGDITEHMRPFFEHVYATELSSKMRNRLSWKGYNVLSALEWAETDVKFDLVTAFNL 173
Cdd:pfam05219  81 LLVIGGFQPASgqEPVTLLDLGAGDGEITLRMAPTFEEVYATELSWTMRDRLKKKNYNVLTEIEWQETDVNLDLILCLNL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  174 LDRHYSPGKLLNDLWNvARRSNCNVIVSLVLPVSHYVEFNPnGRSTRPDNYLNVAGRTYADHVHHMIvNVFKPANFEVLR 253
Cdd:pfam05219 161 LDRCFDPFKLLEDIHL-ALAPNGRVIVALVLPYMHYVETNT-GSHLPPRPLLENNGASFEEEVARFM-EVFENAGFRVEA 237

                         250       260
                  ....*....|....*....|....*...
gi 193210853  254 WTRLPYLCEGDMNNSAYYLPDAIFLLKP 281
Cdd:pfam05219 238 WTRLPYLCEGDMHNSFYWLIDAIFVLKP 265
 
Name Accession Description Interval E-value
DREV pfam05219
DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. ...
 16-281 5.35e-167

DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. The function of this protein is unknown. However, these proteins appear to be related to other methyltransferases (Bateman A pers obs).


Pssm-ID: 253097  Cd Length: 265  Bit Score: 464.36  E-value: 5.35e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853   16 WYQPETSLSDVAQNLFAASLPDGETQQFLDNSNKIASNFFWQTVRNLGVMILSTIYSKTDINGMTGFGNMFLFSENQFAK 95
Cdd:pfam05219   1 WYCLNHELPPRFQSKFVPSEPDATTQSFLENSKALSANIFTQLWHALARSILSFFMSQTDINGFLGRGSMFIFSEEQFRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853   96 FLAIEKESWNS--TDKKVLDLGAGNGDITEHMRPFFEHVYATELSSKMRNRLSWKGYNVLSALEWAETDVKFDLVTAFNL 173
Cdd:pfam05219  81 LLVIGGFQPASgqEPVTLLDLGAGDGEITLRMAPTFEEVYATELSWTMRDRLKKKNYNVLTEIEWQETDVNLDLILCLNL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  174 LDRHYSPGKLLNDLWNvARRSNCNVIVSLVLPVSHYVEFNPnGRSTRPDNYLNVAGRTYADHVHHMIvNVFKPANFEVLR 253
Cdd:pfam05219 161 LDRCFDPFKLLEDIHL-ALAPNGRVIVALVLPYMHYVETNT-GSHLPPRPLLENNGASFEEEVARFM-EVFENAGFRVEA 237

                         250       260
                  ....*....|....*....|....*...
gi 193210853  254 WTRLPYLCEGDMNNSAYYLPDAIFLLKP 281
Cdd:pfam05219 238 WTRLPYLCEGDMHNSFYWLIDAIFVLKP 265
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 102-192 2.27e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 57.33  E-value: 2.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853 102 ESWNSTDKKVLDLGAGNGDITEHMRPFFEHVYATELSSKM----RNRLSWKG--YNVLSALEWAETDVKFDLVTAFNLLD 175
Cdd:COG2227   19 ARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEAleiaRERAAELNvdFVQGDLEDLPLEDGSFDLVICSEVLE 98

                         90
                 ....*....|....*..
gi 193210853 176 RHYSPGKLLNDLWNVAR 192
Cdd:COG2227   99 HLPDPAALLRELARLLK 115
 
Name Accession Description Interval E-value
DREV pfam05219
DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. ...
 16-281 5.35e-167

DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. The function of this protein is unknown. However, these proteins appear to be related to other methyltransferases (Bateman A pers obs).


Pssm-ID: 253097  Cd Length: 265  Bit Score: 464.36  E-value: 5.35e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853   16 WYQPETSLSDVAQNLFAASLPDGETQQFLDNSNKIASNFFWQTVRNLGVMILSTIYSKTDINGMTGFGNMFLFSENQFAK 95
Cdd:pfam05219   1 WYCLNHELPPRFQSKFVPSEPDATTQSFLENSKALSANIFTQLWHALARSILSFFMSQTDINGFLGRGSMFIFSEEQFRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853   96 FLAIEKESWNS--TDKKVLDLGAGNGDITEHMRPFFEHVYATELSSKMRNRLSWKGYNVLSALEWAETDVKFDLVTAFNL 173
Cdd:pfam05219  81 LLVIGGFQPASgqEPVTLLDLGAGDGEITLRMAPTFEEVYATELSWTMRDRLKKKNYNVLTEIEWQETDVNLDLILCLNL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  174 LDRHYSPGKLLNDLWNvARRSNCNVIVSLVLPVSHYVEFNPnGRSTRPDNYLNVAGRTYADHVHHMIvNVFKPANFEVLR 253
Cdd:pfam05219 161 LDRCFDPFKLLEDIHL-ALAPNGRVIVALVLPYMHYVETNT-GSHLPPRPLLENNGASFEEEVARFM-EVFENAGFRVEA 237

                         250       260
                  ....*....|....*....|....*...
gi 193210853  254 WTRLPYLCEGDMNNSAYYLPDAIFLLKP 281
Cdd:pfam05219 238 WTRLPYLCEGDMHNSFYWLIDAIFVLKP 265
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 102-192 2.27e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 57.33  E-value: 2.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853 102 ESWNSTDKKVLDLGAGNGDITEHMRPFFEHVYATELSSKM----RNRLSWKG--YNVLSALEWAETDVKFDLVTAFNLLD 175
Cdd:COG2227   19 ARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEAleiaRERAAELNvdFVQGDLEDLPLEDGSFDLVICSEVLE 98

                         90
                 ....*....|....*..
gi 193210853 176 RHYSPGKLLNDLWNVAR 192
Cdd:COG2227   99 HLPDPAALLRELARLLK 115
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 108-180 4.31e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 54.23  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853 108 DKKVLDLGAGNGDITEHMRPFFEHVYATELSSKM----RNRLSWKGYNVlsalEWAETDV--------KFDLVTAFNLLd 175
Cdd:COG2226   23 GARVLDLGCGTGRLALALAERGARVTGVDISPEMlelaRERAAEAGLNV----EFVVGDAedlpfpdgSFDLVISSFVL- 97


                 ....*
gi 193210853 176 rHYSP 180
Cdd:COG2226   98 -HHLP 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 111-193 1.36e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  111 VLDLGAGNGDITEHMRPFFE-HVYATELSSKM----RNRLSWKGYNV----LSALEWAETDVKFDLVTAFNLLdrHYSPG 181
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGaRVTGVDLSPEMleraRERAAEAGLNVefvqGDAEDLPFPDGSFDLVVSSGVL--HHLPD 78

                          90
                  ....*....|..
gi 193210853  182 KLLNDLWNVARR 193
Cdd:pfam13649  79 PDLEAALREIAR 90
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
108-175 1.75e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 50.38  E-value: 1.75e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193210853 108 DKKVLDLGAGNGDITEHMRPFFEHVYATELSSKM----RNRLSWKGYNVLSALEWAETDVKFDLVTAFNLLD 175
Cdd:COG4976   47 FGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMlakaREKGVYDRLLVADLADLAEPDGRFDLIVAADVLT 118
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 110-193 3.89e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.83  E-value: 3.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853 110 KVLDLGAGNGDITEHM-RPFFEHVYATELSSKM----RNRLSWKGynvLSALEWAETDV---------KFDLVTAFNLLd 175
Cdd:COG0500   29 RVLDLGCGTGRNLLALaARFGGRVIGIDLSPEAialaRARAAKAG---LGNVEFLVADLaeldplpaeSFDLVVAFGVL- 104

                         90
                 ....*....|....*...
gi 193210853 176 rHYSPGKLLNDLWNVARR 193
Cdd:COG0500  105 -HHLPPEEREALLRELAR 121
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 104-252 4.22e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 45.88  E-value: 4.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  104 WNSTDKKVLDLGAGNGDITEHMRPFFEHVYATELSSKMRNRLSWKG-YNVLSALEWAETDVKFDLVTAFNLLDRHYSPGK 182
Cdd:pfam13489  19 KLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVrFDQFDEQEAAVPAGKFDVIVAREVLEHVPDPPA 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193210853  183 LLNDLWNvARRSNCNVIVSLVLPVSHYVEFNPNGRSTRPDNylnvagrtyaDHVHHM----IVNVFKPANFEVL 252
Cdd:pfam13489  99 LLRQIAA-LLKPGGLLLLSTPLASDEADRLLLEWPYLRPRN----------GHISLFsarsLKRLLEEAGFEVV 161
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 112-180 5.62e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.28  E-value: 5.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  112 LDLGAGNGDITEHMRPFFE--HVYATELSSKM----RNRLSWKGYNVLSALEWAETDV------KFDLVTAFNLLdrHYS 179
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPglEYTGLDISPAAleaaRERLAALGLLNAVRVELFQLDLgeldpgSFDVVVASNVL--HHL 78


                  .
gi 193210853  180 P 180
Cdd:pfam08242  79 A 79
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 112-192 3.24e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 41.88  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  112 LDLGAGNGDITEHMRPFFEHVYATELSSKM------RNRLSWKGYNVLSALEWAETDVKFDLVTAFNLLdrHY--SPGKL 183
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMlelareKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVL--HHveDPERA 78


                  ....*....
gi 193210853  184 LNDLWNVAR 192
Cdd:pfam08241  79 LREIARVLK 87
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
111-193 8.08e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 40.96  E-value: 8.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853 111 VLDLGAGNGDITEHMRPFFE--HVYATELSSKMRNRLSwkgyNVLSALEWAETDV-------KFDLVTAFNLLdrHYspg 181
Cdd:COG4106    5 VLDLGCGTGRLTALLAERFPgaRVTGVDLSPEMLARAR----ARLPNVRFVVADLrdldppePFDLVVSNAAL--HW--- 75

                         90
                 ....*....|..
gi 193210853 182 klLNDLWNVARR 193
Cdd:COG4106   76 --LPDHAALLAR 85
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 106-241 3.94e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.09  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  106 STDKKVLDLGAGNGDIT----EHMRPFFEHV---YATELSSKMRNRLSWKGYNVLS-------ALEWAETDVKFDLVTAF 171
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSfelaEELGPNAEVVgidISEEAIEKARENAQKLGFDNVEfeqgdieELPELLEDDKFDVVISN 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210853  172 NLLDRHYSPGKLLNDLWNVARRsncNVIVSLVLPVSHYvEFNPNGRSTRPDNYLNVAGRTYADHVHHMIV 241
Cdd:pfam13847  82 CVLNHIPDPDKVLQEILRVLKP---GGRLIISDPDSLA-ELPAHVKEDSTYYAGCVGGAILKKKLYELLE 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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