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Conserved domains on  [gi|24661721|ref|NP_524005|]
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odorant receptor 67a [Drosophila melanogaster]

Protein Classification

odorant receptor( domain architecture ID 139944)

odorant receptor (OR) found in insects similar to Drosophila ORs, novel seven-transmembrane domain proteins that can signal independently of heterotrimeric G proteins, and which show no obvious sequence homology with G protein-coupled receptors (GPCRs) and display an inverted topology with an intracellular N-terminus and an extracellular C-terminus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_6 super family cl20237
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 75-396 9.83e-39

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


The actual alignment was detected with superfamily member pfam02949:

Pssm-ID: 251636  Cd Length: 313  Bit Score: 141.27  E-value: 9.83e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721    75 NFLESCILLSYVSFVVMGLSKIGAVMKKKPKMTALVRQLETCFPSPSAKVQEEY--AVKSWLKRCHIYTKGFGGLFMIMY 152
Cdd:pfam02949   1 NLTEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLLRELDPRCLEEEEERIfeRLVATASRVRFLLFIIYILAYALF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   153 FAHALIPLFIYFIQRVLLHYPdakqiMPFyqlePWEFRDS-WLFYPSYFHQSSAGYTATCGSIAGDLMIFAVVLQVIMHY 231
Cdd:pfam02949  81 CISALVSMVLSLERGLPLPYY-----LPF----PFDWEASrPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   232 ERLAKVLREFKiqaHNAPNGAKEDIRKLQSLVANHIDILRLTDLMNEVFGIPLLLNFIASALLVCLVGVQLTIALSPEYF 311
Cdd:pfam02949 152 RLLQLRLERLG---LDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFFSGPLQG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   312 CKQMLFLISVLLEVYLLCSFSQRLIDASENVGHAAYDMDWLGSDKRFKKILIFISMRSQKPVCLKATVVLDLSMPTMSIF 391
Cdd:pfam02949 229 IYYVLYLLAMLIQLFPYCYYGNELTEASEELANAIYSSNWYDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPTFISI 308


                  ....*
gi 24661721   392 LGMSY 396
Cdd:pfam02949 309 LKFAY 313
 
Name Accession Description Interval E-value
7tm_6 pfam02949
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 75-396 9.83e-39

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


Pssm-ID: 251636  Cd Length: 313  Bit Score: 141.27  E-value: 9.83e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721    75 NFLESCILLSYVSFVVMGLSKIGAVMKKKPKMTALVRQLETCFPSPSAKVQEEY--AVKSWLKRCHIYTKGFGGLFMIMY 152
Cdd:pfam02949   1 NLTEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLLRELDPRCLEEEEERIfeRLVATASRVRFLLFIIYILAYALF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   153 FAHALIPLFIYFIQRVLLHYPdakqiMPFyqlePWEFRDS-WLFYPSYFHQSSAGYTATCGSIAGDLMIFAVVLQVIMHY 231
Cdd:pfam02949  81 CISALVSMVLSLERGLPLPYY-----LPF----PFDWEASrPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   232 ERLAKVLREFKiqaHNAPNGAKEDIRKLQSLVANHIDILRLTDLMNEVFGIPLLLNFIASALLVCLVGVQLTIALSPEYF 311
Cdd:pfam02949 152 RLLQLRLERLG---LDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFFSGPLQG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   312 CKQMLFLISVLLEVYLLCSFSQRLIDASENVGHAAYDMDWLGSDKRFKKILIFISMRSQKPVCLKATVVLDLSMPTMSIF 391
Cdd:pfam02949 229 IYYVLYLLAMLIQLFPYCYYGNELTEASEELANAIYSSNWYDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPTFISI 308


                  ....*
gi 24661721   392 LGMSY 396
Cdd:pfam02949 309 LKFAY 313
 
Name Accession Description Interval E-value
7tm_6 pfam02949
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 75-396 9.83e-39

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


Pssm-ID: 251636  Cd Length: 313  Bit Score: 141.27  E-value: 9.83e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721    75 NFLESCILLSYVSFVVMGLSKIGAVMKKKPKMTALVRQLETCFPSPSAKVQEEY--AVKSWLKRCHIYTKGFGGLFMIMY 152
Cdd:pfam02949   1 NLTEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLLRELDPRCLEEEEERIfeRLVATASRVRFLLFIIYILAYALF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   153 FAHALIPLFIYFIQRVLLHYPdakqiMPFyqlePWEFRDS-WLFYPSYFHQSSAGYTATCGSIAGDLMIFAVVLQVIMHY 231
Cdd:pfam02949  81 CISALVSMVLSLERGLPLPYY-----LPF----PFDWEASrPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   232 ERLAKVLREFKiqaHNAPNGAKEDIRKLQSLVANHIDILRLTDLMNEVFGIPLLLNFIASALLVCLVGVQLTIALSPEYF 311
Cdd:pfam02949 152 RLLQLRLERLG---LDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFFSGPLQG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   312 CKQMLFLISVLLEVYLLCSFSQRLIDASENVGHAAYDMDWLGSDKRFKKILIFISMRSQKPVCLKATVVLDLSMPTMSIF 391
Cdd:pfam02949 229 IYYVLYLLAMLIQLFPYCYYGNELTEASEELANAIYSSNWYDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPTFISI 308


                  ....*
gi 24661721   392 LGMSY 396
Cdd:pfam02949 309 LKFAY 313
7tm_7 pfam08395
7tm Chemosensory receptor; This family includes a number of gustatory and odorant receptors ...
 218-367 6.53e-04

7tm Chemosensory receptor; This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family.


Pssm-ID: 462463  Cd Length: 370  Bit Score: 41.62  E-value: 6.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661721   218 LMIFAVVLQVIMHYERLAKVLREFKIQAHNAPNGA---KEDIRKLQSLVANHIDILRLTDLMNEVFGIPLLLNFIASALL 294
Cdd:pfam08395 171 LQYFLLVLLIYRRLRLLNRQLKQLVRELRGLSRSGqlrECCYLRLDKLLRLYRRLSDLVRELNRCFGLQLLLILLYSFIT 250

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24661721   295 VCLVG----VQLTIALSPEYFCKQMLFLISVLLEVYLLCSFSQRLIDASENVGHAAYDMDWLGSDKRFKKILIFISM 367
Cdd:pfam08395 251 ITVLIyylySSLLLDSSGFTLLVFVLWLLIFLLLLLLIVYACNLISNEAKKTGLLLRRLNLSLKDSRLERSIEKFLL 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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