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Conserved domains on  [gi|229608928|ref|NP_573488|]
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Golgi resident protein GCP60 [Mus musculus]

Protein Classification

acyl-CoA-binding domain-containing protein( domain architecture ID 10468367)

acyl-CoA-binding domain-containing protein binds acyl-CoA esters and may play a role in housekeeping and/or trafficking

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 394-524 3.96e-81

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


:

Pssm-ID: 464028  Cd Length: 133  Bit Score: 248.93  E-value: 3.96e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608928  394 VRRGEVVTVRVPTHEEGSYLFWEFATDSYDIGFGVYFEWTDSPNAAVSVHVSESSD--EEEEEEENVTCEEKAKKNANKP 471
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSESSDeeDEEEEEENPGDVEAGSVNANKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 229608928  472 LLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYT 524
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
81-162 2.17e-17

Acyl CoA binding protein;


:

Pssm-ID: 459982  Cd Length: 76  Bit Score: 76.48  E-value: 2.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608928   81 EELYGLALRFYKikdGKAFHPTYEEKLKFVALHKQVLLGPYNpdtSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVK 160
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCN---TPRPGMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 229608928  161 LL 162
Cdd:pfam00887  75 LV 76
 
Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 394-524 3.96e-81

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


Pssm-ID: 464028  Cd Length: 133  Bit Score: 248.93  E-value: 3.96e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608928  394 VRRGEVVTVRVPTHEEGSYLFWEFATDSYDIGFGVYFEWTDSPNAAVSVHVSESSD--EEEEEEENVTCEEKAKKNANKP 471
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSESSDeeDEEEEEENPGDVEAGSVNANKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 229608928  472 LLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYT 524
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
81-162 2.17e-17

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 76.48  E-value: 2.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608928   81 EELYGLALRFYKikdGKAFHPTYEEKLKFVALHKQVLLGPYNpdtSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVK 160
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCN---TPRPGMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 229608928  161 LL 162
Cdd:pfam00887  75 LV 76
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 101-167 1.25e-09

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 55.02  E-value: 1.25e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 229608928 101 PTYEEKLKFVALHKQVLLGPYNpdtSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNKCCP 167
Cdd:cd00435   19 PSNEEKLQLYSLYKQATVGDCN---TERPGMFDLKGRAKWDAWNSLKGMSKEDAMKAYIAKVEELIA 82
 
Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 394-524 3.96e-81

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


Pssm-ID: 464028  Cd Length: 133  Bit Score: 248.93  E-value: 3.96e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608928  394 VRRGEVVTVRVPTHEEGSYLFWEFATDSYDIGFGVYFEWTDSPNAAVSVHVSESSD--EEEEEEENVTCEEKAKKNANKP 471
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSESSDeeDEEEEEENPGDVEAGSVNANKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 229608928  472 LLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYT 524
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
81-162 2.17e-17

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 76.48  E-value: 2.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608928   81 EELYGLALRFYKikdGKAFHPTYEEKLKFVALHKQVLLGPYNpdtSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVK 160
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCN---TPRPGMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 229608928  161 LL 162
Cdd:pfam00887  75 LV 76
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 101-167 1.25e-09

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 55.02  E-value: 1.25e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 229608928 101 PTYEEKLKFVALHKQVLLGPYNpdtSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNKCCP 167
Cdd:cd00435   19 PSNEEKLQLYSLYKQATVGDCN---TERPGMFDLKGRAKWDAWNSLKGMSKEDAMKAYIAKVEELIA 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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