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Conserved domains on  [gi|19112203|ref|NP_595411|]
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anamorsin family protein [Schizosaccharomyces pombe]

Protein Classification

COG5636 family protein( domain architecture ID 11475737)

COG5636 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
1-288 9.73e-166

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


:

Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 461.15  E-value: 9.73e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203   1 MSSSVLVLTSPGFASKEESLKKVFDLIDNGASRELQMIDRVQsQLVNLPINRYDSVIAAIDDGAWSSTLGPILSQAFASV 80
Cdd:COG5636   1 KYETVHYLTPEAQTDIKFPKKLISVLADNGSLIGLSDIYKVD-ALINEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203  81 HPGGTLRVYSTADEADESFEMTALLSGWLIESKSPWILSRPNQVEAVPIKLSNKNGQSASKNKILDFLKSDKENLISGDD 160
Cdd:COG5636  80 QSGSKLPTFKKASSSTSNLPKKADHSRQPIVKETDSFKPPSFKMTTEPKVYRVVDDLMEDKEELRKLLRSKAQYMMRKDT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203 161 DQELIDEDELLDESAHDNVLKVPECKPEPGKKKRACKNCTCGLREMEEHESSKTSaQLEAVKLTDTTEVDFTEKLKSKNa 240
Cdd:COG5636 160 DPRTIMEDELLDEDSEDKAIQRSECPPSKTKKKRACKDCTCGLKEEEENEIVRTR-QDKVVKFTEDELTEIDFTIDGKK- 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19112203 241 VSSCGNCYLGDAFRCSGCPYIGMPAFNPGDTVILAENRDKmSWMADDI 288
Cdd:COG5636 238 VSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFSMNLDN-EFQGDDA 284
 
Name Accession Description Interval E-value
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
1-288 9.73e-166

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 461.15  E-value: 9.73e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203   1 MSSSVLVLTSPGFASKEESLKKVFDLIDNGASRELQMIDRVQsQLVNLPINRYDSVIAAIDDGAWSSTLGPILSQAFASV 80
Cdd:COG5636   1 KYETVHYLTPEAQTDIKFPKKLISVLADNGSLIGLSDIYKVD-ALINEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203  81 HPGGTLRVYSTADEADESFEMTALLSGWLIESKSPWILSRPNQVEAVPIKLSNKNGQSASKNKILDFLKSDKENLISGDD 160
Cdd:COG5636  80 QSGSKLPTFKKASSSTSNLPKKADHSRQPIVKETDSFKPPSFKMTTEPKVYRVVDDLMEDKEELRKLLRSKAQYMMRKDT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203 161 DQELIDEDELLDESAHDNVLKVPECKPEPGKKKRACKNCTCGLREMEEHESSKTSaQLEAVKLTDTTEVDFTEKLKSKNa 240
Cdd:COG5636 160 DPRTIMEDELLDEDSEDKAIQRSECPPSKTKKKRACKDCTCGLKEEEENEIVRTR-QDKVVKFTEDELTEIDFTIDGKK- 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19112203 241 VSSCGNCYLGDAFRCSGCPYIGMPAFNPGDTVILAENRDKmSWMADDI 288
Cdd:COG5636 238 VSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFSMNLDN-EFQGDDA 284
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 178-272 2.91e-48

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 155.89  E-value: 2.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203   178 NVLKVPECKPEPGKKKRACKNCTCGLREMEEHESSKTSAQ----LEAVKLT--DTTEVDFTEKLKsknaVSSCGNCYLGD 251
Cdd:pfam05093   1 NLITPPECEPNGKKRRKACKDCTCGLKELEEAEDAAQRALqdkaLGKVKFTedDLTEIDFTVQGK----TGSCGSCALGD 76

                          90       100
                  ....*....|....*....|.
gi 19112203   252 AFRCSGCPYIGMPAFNPGDTV 272
Cdd:pfam05093  77 AFRCSGCPYLGLPAFKPGEEV 97
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 148-241 1.38e-03

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 39.92  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203 148 LKSDKENLISGDDDQELIDEDElldesahDNVLKVPECKPEPGKKKRAcKNCTCGLremEEHESSKTSAQLEA---VKLT 224
Cdd:cd11486 537 LRNSKEERIDLDADDETEDQDS-------NSMIETDEMREEPGCCKKA-YNWFCGL---DQGNAPKLTKEEEAalkMKLT 605

                        90
                ....*....|....*..
gi 19112203 225 DTTEVDFTEKLKSKNAV 241
Cdd:cd11486 606 DTSEKPLWRNVVNANGI 622
 
Name Accession Description Interval E-value
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
1-288 9.73e-166

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 461.15  E-value: 9.73e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203   1 MSSSVLVLTSPGFASKEESLKKVFDLIDNGASRELQMIDRVQsQLVNLPINRYDSVIAAIDDGAWSSTLGPILSQAFASV 80
Cdd:COG5636   1 KYETVHYLTPEAQTDIKFPKKLISVLADNGSLIGLSDIYKVD-ALINEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203  81 HPGGTLRVYSTADEADESFEMTALLSGWLIESKSPWILSRPNQVEAVPIKLSNKNGQSASKNKILDFLKSDKENLISGDD 160
Cdd:COG5636  80 QSGSKLPTFKKASSSTSNLPKKADHSRQPIVKETDSFKPPSFKMTTEPKVYRVVDDLMEDKEELRKLLRSKAQYMMRKDT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203 161 DQELIDEDELLDESAHDNVLKVPECKPEPGKKKRACKNCTCGLREMEEHESSKTSaQLEAVKLTDTTEVDFTEKLKSKNa 240
Cdd:COG5636 160 DPRTIMEDELLDEDSEDKAIQRSECPPSKTKKKRACKDCTCGLKEEEENEIVRTR-QDKVVKFTEDELTEIDFTIDGKK- 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19112203 241 VSSCGNCYLGDAFRCSGCPYIGMPAFNPGDTVILAENRDKmSWMADDI 288
Cdd:COG5636 238 VSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFSMNLDN-EFQGDDA 284
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 178-272 2.91e-48

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 155.89  E-value: 2.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203   178 NVLKVPECKPEPGKKKRACKNCTCGLREMEEHESSKTSAQ----LEAVKLT--DTTEVDFTEKLKsknaVSSCGNCYLGD 251
Cdd:pfam05093   1 NLITPPECEPNGKKRRKACKDCTCGLKELEEAEDAAQRALqdkaLGKVKFTedDLTEIDFTVQGK----TGSCGSCALGD 76

                          90       100
                  ....*....|....*....|.
gi 19112203   252 AFRCSGCPYIGMPAFNPGDTV 272
Cdd:pfam05093  77 AFRCSGCPYLGLPAFKPGEEV 97
DRE2_N pfam16803
Fe-S cluster assembly protein DRE2 N-terminus; This is the N-terminal domain of the fungal ...
 3-131 5.85e-35

Fe-S cluster assembly protein DRE2 N-terminus; This is the N-terminal domain of the fungal Fe-S cluster assembly protein DRE2.


Pssm-ID: 435591  Cd Length: 129  Bit Score: 122.68  E-value: 5.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203     3 SSVLVLTSPGFASKEESLKKVFDLIDNGASRELQMIDRVQSQLVNLPINRYDSVIAAIDDGAWSSTLGP--ILSQAFASV 80
Cdd:pfam16803   1 KRTLLLAHPSVATHPEKLEAVKSAYDARSSTDQQMIDRLAAGLVSLPANTYDLILYLTPEDAPDSLLFPrkLISVLFDAL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19112203    81 HPGGTLRVYStaDEADESFEMTALLSGWLIESKSPWILSRPNQVEAVPIKL 131
Cdd:pfam16803  81 KPGGKLRGQD--GTFDGAEKLEALLAGFVIENEDDGGWVKPDQSEEVAVPL 129
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 148-241 1.38e-03

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 39.92  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112203 148 LKSDKENLISGDDDQELIDEDElldesahDNVLKVPECKPEPGKKKRAcKNCTCGLremEEHESSKTSAQLEA---VKLT 224
Cdd:cd11486 537 LRNSKEERIDLDADDETEDQDS-------NSMIETDEMREEPGCCKKA-YNWFCGL---DQGNAPKLTKEEEAalkMKLT 605

                        90
                ....*....|....*..
gi 19112203 225 DTTEVDFTEKLKSKNAV 241
Cdd:cd11486 606 DTSEKPLWRNVVNANGI 622
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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