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Conserved domains on  [gi|241896916|ref|NP_598672|]
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adhesion G protein-coupled receptor A3 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmB2_GPR125 cd15999
G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G ...
 745-1052 0e+00

G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR125 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan receptors GPR123 and GPR124. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


:

Pssm-ID: 320665  Cd Length: 312  Bit Score: 608.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  745 ASLLHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYS 824
Cdd:cd15999     1 ADLLHPVVYATAVVLLLCLLTIIVSYIYHHSLVRISRKSWHMLVNLCFHIFLTCAVFVGGINQTRNASVCQAVGIILHYS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  825 TLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSAPYCWMAWEP 904
Cdd:cd15999    81 TLATVLWVGVTARNIYKQVTRKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPNAPYCWMAWEP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  905 SLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDS----MSLSLISTSTLENEHS 980
Cdd:cd15999   161 SLGAFYGPAGFIIFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAASEHGELNHQDSgsssASCSLVSTSALENEHS 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 241896916  981 FQSQLLGASLTLLLYVILWMFGAMAVSLYYPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAWIMMCCP 1052
Cdd:cd15999   241 FQAQLLGASLALFLYVALWIFGALAVSLYYPMDLVFSCLFGATCLSLGAFLVVHHCVNREDVRRAWIATCCP 312
LRR_8 pfam13855
Leucine rich repeat;
74-130 1.27e-17

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 77.95  E-value: 1.27e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 241896916    74 TLILSNNKISELKNGSFSGLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNRI 130
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-179 4.09e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 4.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   65 PDTLPNRT--VTLILSNNKISELkNGSFSGLSLLERLDLRNNLISRIApgAFWGLSSLKRLDLTNNRIGCLnaDVFRGLT 142
Cdd:COG4886   198 PEPLGNLTnlEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLT 272

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 241896916  143 NLVRLNLSGNLFTSLSQGTFDYLGSLRSLEFQTEYLL 179
Cdd:COG4886   273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
GPS super family cl02559
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
 693-735 6.07e-05

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


The actual alignment was detected with superfamily member smart00303:

Pssm-ID: 470616  Cd Length: 49  Bit Score: 41.60  E-value: 6.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 241896916    693 WDFDllngQGGWKSDGCCILYSDENITTIQCGSLGNYAVLMDL 735
Cdd:smart00303    8 WDES----SGEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDV 46
LRRCT smart00082
Leucine rich repeat C-terminal domain;
178-212 1.05e-04

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.26  E-value: 1.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 241896916    178 LLCDCNILWMHRWVKERNITVR--DTRCVYPKSLQAQ 212
Cdd:smart00082    3 FICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
HRM pfam02793
Hormone receptor domain; This extracellular domain contains four conserved cysteines that ...
 352-405 4.94e-04

Hormone receptor domain; This extracellular domain contains four conserved cysteines that probably for disulphide bridges. The domain is found in a variety of hormone receptors. It may be a ligand binding domain.


:

Pssm-ID: 397086  Cd Length: 64  Bit Score: 39.66  E-value: 4.94e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 241896916   352 WPRTLAGITAYLQCTRNTHssGIYPgsaqdERKAWRRCDRGGFWAD---DDYSRCQY 405
Cdd:pfam02793   14 WPRTPAGETVEVPCPDYFS--GFDP-----RGNASRNCTEDGTWSEhppSNYSNCTS 63
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 238-330 3.32e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 3.32e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916    238 SHRQVVFEGDSLPFQCMASYiDQDMQVLWYQDGrIVETDESQGIFVEKSmihncSLIASaLTISNIQAGSTGNWGCHVQT 317
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYKQG-GKLLAESGRFSVSRS-----GSTST-LTISNVTPEDSGTYTCAATN 72

                            90
                    ....*....|...
gi 241896916    318 KRGNNTRTVDIVV 330
Cdd:smart00410   73 SSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
7tmB2_GPR125 cd15999
G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G ...
 745-1052 0e+00

G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR125 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan receptors GPR123 and GPR124. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320665  Cd Length: 312  Bit Score: 608.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  745 ASLLHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYS 824
Cdd:cd15999     1 ADLLHPVVYATAVVLLLCLLTIIVSYIYHHSLVRISRKSWHMLVNLCFHIFLTCAVFVGGINQTRNASVCQAVGIILHYS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  825 TLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSAPYCWMAWEP 904
Cdd:cd15999    81 TLATVLWVGVTARNIYKQVTRKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPNAPYCWMAWEP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  905 SLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDS----MSLSLISTSTLENEHS 980
Cdd:cd15999   161 SLGAFYGPAGFIIFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAASEHGELNHQDSgsssASCSLVSTSALENEHS 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 241896916  981 FQSQLLGASLTLLLYVILWMFGAMAVSLYYPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAWIMMCCP 1052
Cdd:cd15999   241 FQAQLLGASLALFLYVALWIFGALAVSLYYPMDLVFSCLFGATCLSLGAFLVVHHCVNREDVRRAWIATCCP 312
LRR_8 pfam13855
Leucine rich repeat;
74-130 1.27e-17

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 77.95  E-value: 1.27e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 241896916    74 TLILSNNKISELKNGSFSGLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNRI 130
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-172 2.12e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   74 TLILSNNKISELKNgSFSGLSLLERLDLRNNLISRIaPGAFWGLSSLKRLDLTNNRIGCLnADVFRGLTNLVRLNLSGNL 153
Cdd:COG4886   140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                          90
                  ....*....|....*....
gi 241896916  154 FTSLSQGtfdyLGSLRSLE 172
Cdd:COG4886   217 LTDLPEP----LANLTNLE 231
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-179 4.09e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 4.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   65 PDTLPNRT--VTLILSNNKISELkNGSFSGLSLLERLDLRNNLISRIApgAFWGLSSLKRLDLTNNRIGCLnaDVFRGLT 142
Cdd:COG4886   198 PEPLGNLTnlEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLT 272

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 241896916  143 NLVRLNLSGNLFTSLSQGTFDYLGSLRSLEFQTEYLL 179
Cdd:COG4886   273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR_8 pfam13855
Leucine rich repeat;
118-171 2.13e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.13e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 241896916   118 SSLKRLDLTNNRIGCLNADVFRGLTNLVRLNLSGNLFTSLSQGTFDYLGSLRSL 171
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
 751-952 3.01e-12

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 68.07  E-value: 3.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   751 VVYTTAITL-LLCLLAVIISYMYHHSLiRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNAS--------VCQAVGIIL 821
Cdd:pfam00002    6 VIYTVGYSLsLVALLLAIAIFLLFRKL-HCTRNYIHL--NLFASFILRALLFLVGDAVLFNKQdldhcswvGCKVVAVFL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   822 HYSTLATVLWVGVTARNIYKQVTKkakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGsrpSAPYCWMA 901
Cdd:pfam00002   83 HYFFLANFFWMLVEGLYLYTLLVE---------VFFSERKYFWWYLLIGWGVPALVVGIWAGVDPKGYG---EDDGCWLS 150

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 241896916   902 WE-PSLGAFYGPASFITFVNCMYFLSIFIQLKRHperkyeLKEPTEEQQRLA 952
Cdd:pfam00002  151 NEnGLWWIIRGPILLIILVNFIIFINIVRILVQK------LRETNMGKSDLK 196
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-172 8.56e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 8.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   66 DTLPNRTvTLILSNNKISELKNgsFSGLSLLERLDLRNNLISRIA---------------------------PGAFWGLS 118
Cdd:cd21340    43 EFLTNLT-HLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEglenltnleelhienqrlppgekltfdPRSLAALS 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 241896916  119 -SLKRLDLTNNRIGCLNAdvFRGLTNLVRLNLSGNLFTSLSQgTFDYLGSLRSLE 172
Cdd:cd21340   120 nSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEE-LLDLLSSWPSLR 171
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 124-225 3.48e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 3.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   124 DLTNNRIGCLNADVFRGLTNLVRLNLSGNLFTslsqgtfdylgslrslefqteyllCDCNILWMHRWVKERNITVRD--- 200
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFE------------------------CDCGLARLPRWAEEKGVKVRQpea 56

                           90       100
                   ....*....|....*....|....*
gi 241896916   201 TRCVYPKSLQAQPVTGVKQELLTCD 225
Cdd:TIGR00864   57 ALCAGPGALAGQPLLGIPLLDSGCD 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-183 1.51e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   69 PNRTVtLILSNNKISELKNgsFSGLSLLERLDLRNNLISRIAPgaFWGLSSLKRLDLTNNRIGCLNadvfrGLTN----- 143
Cdd:cd21340    24 KNLKV-LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENltnle 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 241896916  144 ----------------------------LVRLNLSGNLFTSLSQgtfdyLGSLRSLefqtEYLLCDCN 183
Cdd:cd21340    94 elhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEP-----LAPLRNL----EQLDASNN 152
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 693-735 6.07e-05

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 41.60  E-value: 6.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 241896916    693 WDFDllngQGGWKSDGCCILYSDENITTIQCGSLGNYAVLMDL 735
Cdd:smart00303    8 WDES----SGEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDV 46
LRRCT smart00082
Leucine rich repeat C-terminal domain;
178-212 1.05e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.26  E-value: 1.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 241896916    178 LLCDCNILWMHRWVKERNITVR--DTRCVYPKSLQAQ 212
Cdd:smart00082    3 FICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-155 1.09e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   75 LILSNNKIS-ELKNgsFSGLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNRIGCLNADVFRGLTNLVRLNLSGNL 153
Cdd:PLN00113  457 LSLARNKFFgGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQ 534


                  ..
gi 241896916  154 FT 155
Cdd:PLN00113  535 LS 536
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
 693-732 1.43e-04

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 40.37  E-value: 1.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 241896916   693 WDFDLlNGQGGWKSDGCCILYSDENITTIQCGSLGNYAVL 732
Cdd:pfam01825    6 WDFTN-STTGRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
HRM pfam02793
Hormone receptor domain; This extracellular domain contains four conserved cysteines that ...
 352-405 4.94e-04

Hormone receptor domain; This extracellular domain contains four conserved cysteines that probably for disulphide bridges. The domain is found in a variety of hormone receptors. It may be a ligand binding domain.


Pssm-ID: 397086  Cd Length: 64  Bit Score: 39.66  E-value: 4.94e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 241896916   352 WPRTLAGITAYLQCTRNTHssGIYPgsaqdERKAWRRCDRGGFWAD---DDYSRCQY 405
Cdd:pfam02793   14 WPRTPAGETVEVPCPDYFS--GFDP-----RGNASRNCTEDGTWSEhppSNYSNCTS 63
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-173 5.87e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 5.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   55 SSLELAQVLPPD--TLPNRTVTLILSNNKIS-ELKNGSfsgLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNrig 131
Cdd:PLN00113  101 SNNQLSGPIPDDifTTSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN--- 174

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 241896916  132 CLNADVFRGLTNLVRL---NLSGNLFTSlsqGTFDYLGSLRSLEF 173
Cdd:PLN00113  175 VLVGKIPNSLTNLTSLeflTLASNQLVG---QIPRELGQMKSLKW 216
HormR smart00008
Domain present in hormone receptors;
352-405 9.40e-04

Domain present in hormone receptors;


Pssm-ID: 214468  Cd Length: 70  Bit Score: 39.03  E-value: 9.40e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 241896916    352 WPRTLAGITAYLQCTRNThsSGIYPgsaqdERKAWRRCDRGGFWA--DDDYSRCQY 405
Cdd:smart00008   15 WPQTPAGQLVEVPCPKYF--SGFSY-----KTGASRNCTENGGWSppFPNYSNCTS 63
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 238-330 3.32e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 3.32e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916    238 SHRQVVFEGDSLPFQCMASYiDQDMQVLWYQDGrIVETDESQGIFVEKSmihncSLIASaLTISNIQAGSTGNWGCHVQT 317
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYKQG-GKLLAESGRFSVSRS-----GSTST-LTISNVTPEDSGTYTCAATN 72

                            90
                    ....*....|...
gi 241896916    318 KRGNNTRTVDIVV 330
Cdd:smart00410   73 SSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 231-315 4.09e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.55  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   231 PSFYMTPSHrQVVFEGDSLPFQCMASYIDQDmQVLWYQDGRIVETDESQGIFVEKSMihncsliaSALTISNIQAGSTGN 310
Cdd:pfam13927    2 PVITVSPSS-VTVREGETVTLTCEATGSPPP-TITWYKNGEPISSGSTRSRSLSGSN--------STLTISNVTRSDAGT 71


                   ....*
gi 241896916   311 WGCHV 315
Cdd:pfam13927   72 YTCVA 76
LRR smart00370
Leucine-rich repeats, outliers;
93-116 5.43e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 5.43e-03
                            10        20
                    ....*....|....*....|....
gi 241896916     93 LSLLERLDLRNNLISRIAPGAFWG 116
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
141-163 8.45e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 8.45e-03
                            10        20
                    ....*....|....*....|...
gi 241896916    141 LTNLVRLNLSGNLFTSLSQGTFD 163
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQ 23
 
Name Accession Description Interval E-value
7tmB2_GPR125 cd15999
G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G ...
 745-1052 0e+00

G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR125 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan receptors GPR123 and GPR124. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320665  Cd Length: 312  Bit Score: 608.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  745 ASLLHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYS 824
Cdd:cd15999     1 ADLLHPVVYATAVVLLLCLLTIIVSYIYHHSLVRISRKSWHMLVNLCFHIFLTCAVFVGGINQTRNASVCQAVGIILHYS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  825 TLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSAPYCWMAWEP 904
Cdd:cd15999    81 TLATVLWVGVTARNIYKQVTRKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPNAPYCWMAWEP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  905 SLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDS----MSLSLISTSTLENEHS 980
Cdd:cd15999   161 SLGAFYGPAGFIIFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAASEHGELNHQDSgsssASCSLVSTSALENEHS 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 241896916  981 FQSQLLGASLTLLLYVILWMFGAMAVSLYYPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAWIMMCCP 1052
Cdd:cd15999   241 FQAQLLGASLALFLYVALWIFGALAVSLYYPMDLVFSCLFGATCLSLGAFLVVHHCVNREDVRRAWIATCCP 312
7tmB2_GPR124-like_Adhesion_III cd15259
orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of ...
 745-1050 1.10e-128

orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group III adhesion GPCRs include orphan GPR123, GPR124, GPR125, and their closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 also interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Furthermore, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl.


Pssm-ID: 320387 [Multi-domain]  Cd Length: 260  Bit Score: 396.75  E-value: 1.10e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  745 ASLLHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYS 824
Cdd:cd15259     1 FELLHPVVYAGAALCLLCLLATIITYIVFHRLIRISRKGRHMLVNLCLHLLLTCVVFVGGINRTANQLVCQAVGILLHYS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  825 TLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYgsrPSAPYCWMAWEP 904
Cdd:cd15259    81 TLCTLLWVGVTARNMYKQVTKTAKPPQDEDQPPRPPKPMLRFYLIGWGIPLIICGITAAVNLDNY---STYDYCWLAWDP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  905 SLGAFYGPASFITFVNCMYFLSIFIQLKRHPErkyelkepteeqqrlaanengeinhqdsmslsliststlenehSFQSQ 984
Cdd:cd15259   158 SLGAFYGPAALIVLVNCIYFLRIYCQLKGAPV-------------------------------------------SFQSQ 194

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241896916  985 LLGASLTLLLYVILWMFGAMAVSLYYPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAWIMMC 1050
Cdd:cd15259   195 LRGAVITLFLYVAMWACGALAVSQRYFLDLVFSCLYGATCSSLGLFVLIHHCLSREDVRQSWRQCC 260
7tmB2_GPR123 cd16000
G protein-coupled receptor 123, member of the class B2 family of seven-transmembrane G ...
 747-1052 6.99e-117

G protein-coupled receptor 123, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR123 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, and also includes orphan receptors GPR124 and GPR125. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells, yet its biological function remains to be determined. Adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320666 [Multi-domain]  Cd Length: 275  Bit Score: 365.81  E-value: 6.99e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  747 LLHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTL 826
Cdd:cd16000     3 FLHPVVYACTAVMLLCLFASIITYIVHHSTIRISRKGWHMLLNFCFHTALTFAVFAGGINRTKYPIICQAVGIVLHYSTL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  827 ATVLWVGVTARNIYKQVTKKAKRCQDPDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSR-PSAPYCWMAWEPS 905
Cdd:cd16000    83 STMLWIGVTARNIYKQVTKKPHLCQDTDQPPYPKQPLLRFYLVSGGVPFIICGITAATNINNYGTEdEDTPYCWMAWEPS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  906 LGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKepteeqqrlaanengeinhqdsmslsliststleNEHSFQSQL 985
Cdd:cd16000   163 LGAFYGPVAFIVLVTCIYFLCTYVQLRRHPERKYELK----------------------------------NEHSFKAQL 208

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 241896916  986 LGASLTLLLYVILWMFGAMAVSLYYPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAWiMMCCP 1052
Cdd:cd16000   209 RAAAFTLFLFTATWAFGALAVSQGHFLDMIFSCLYGAFCVTLGLFILIHHCAKRDDVWHCW-WSCCP 274
7tmB2_GPR124 cd15998
G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G ...
 748-1052 4.77e-87

G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR124 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan GPR123 and GPR125. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Moreover, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320664 [Multi-domain]  Cd Length: 268  Bit Score: 283.77  E-value: 4.77e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  748 LHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLA 827
Cdd:cd15998     4 LHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  828 TVLWVGVTARNIYKQVTKKAKRCQDPDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYgsRPSAPYCWMAWEPSLG 907
Cdd:cd15998    84 TLLWMGVKARVLHKELTWRAPPPQEGDPALPTPRPMLRFYLIAGGIPLIICGITAAVNIHNY--RDHSPYCWLVWRPSLG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  908 AFYGPASFITFVNCMYFLSIFIQLKRHPerkyelkepteeqqrlaanengeinhQDSMSLsliststleneHSFQSQLLG 987
Cdd:cd15998   162 AFYIPVALILLVTWIYFLCAGLHLRGPS--------------------------ADGDSV-----------YSPGVQLGA 204

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 241896916  988 ASLTLLLYVILWMFGAMAVSLYYPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAWiMMCCP 1052
Cdd:cd15998   205 LVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASW-RACCP 268
7tmB2_Adhesion cd15040
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ...
 748-1046 1.18e-44

adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320168 [Multi-domain]  Cd Length: 253  Bit Score: 162.36  E-value: 1.18e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  748 LHPVVYTTAITLLLCLLAVIISYMYHHSLIRisLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLA 827
Cdd:cd15040     4 LSIITYIGCGLSLLGLLLTIITYILFRKLRK--RKPTKILLNLCLALLLANLLFLFGINSTDNPVLCTAVAALLHYFLLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  828 TVLWVGVTARNIYKQVTKKAKRcqdpdeppAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSapYCWMAWE-PSL 906
Cdd:cd15040    82 SFMWMLVEALLLYLRLVKVFGT--------YPRHFILKYALIGWGLPLIIVIITLAVDPDSYGNSSG--YCWLSNGnGLY 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  907 GAFYGPASFITFVNCMYFLSIFIQLKRHPerkyeLKEPTEEQQRLAANengeinhqdsmslsLISTSTLenehsfqsqll 986
Cdd:cd15040   152 YAFLGPVLLIILVNLVIFVLVLRKLLRLS-----AKRNKKKRKKTKAQ--------------LRAAVSL----------- 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 241896916  987 gasltlllyVIL----WMFGAMAVSlyyPLDLVFSFFFGATClSFSAFMM-VHHCINREDVRLAW 1046
Cdd:cd15040   202 ---------FFLlgltWIFGILAIF---GARVVFQYLFAIFN-SLQGFFIfIFHCLRNKEVRKAW 253
7tm_classB cd13952
class B family of seven-transmembrane G protein-coupled receptors; The class B of ...
 760-1046 1.58e-33

class B family of seven-transmembrane G protein-coupled receptors; The class B of seven-transmembrane GPCRs is classified into three major subfamilies: subfamily B1 (secretin-like receptor family), B2 (adhesion family), and B3 (Methuselah-like family). The class B receptors have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi or prokaryotes. The B1 subfamily comprises receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the subfamily B1 receptors preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The subfamily B2 consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Furthermore, the subfamily B3 includes Methuselah (Mth) protein, which was originally identified in Drosophila as a GPCR affecting stress resistance and aging, and its closely related proteins.


Pssm-ID: 410627 [Multi-domain]  Cd Length: 260  Bit Score: 130.41  E-value: 1.58e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  760 LLCLLAVIISYMYHHSLIRISlksWHMLVNLCFHILLTCVVFVGGITQTRNAS--VCQAVGIILHYSTLATVLWVGVTAR 837
Cdd:cd13952    16 LVGLLLTIITYLLFPKLRNLR---GKILINLCLSLLLAQLLFLIGQLLTSSDRpvLCKALAILLHYFLLASFFWMLVEAF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  838 NIYKQVTKKakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRP--SAPYCWM-AWEPSLGAFYGPAS 914
Cdd:cd13952    93 DLYRTFVKV--------FGSSERRRFLKYSLYGWGLPLLIVIITAIVDFSLYGPSPgyGGEYCWLsNGNALLWAFYGPVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  915 FITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAAnengeinhqdsmSLSLIststlenehsfqsqllgasltlll 994
Cdd:cd13952   165 LILLVNLVFFILTVRILLRKLRETPKQSERKSDRKQLRA------------YLKLF------------------------ 208

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 241896916  995 yVIL---WMFGAMAVslYYPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAW 1046
Cdd:cd13952   209 -PLMgltWIFGILAP--FVGGSLVFWYLFDILNSLQGFFIFLIFCLKNKEVRRLL 260
7tmB2_CELSR_Adhesion_IV cd15441
cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 ...
 750-1051 2.18e-22

cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuron migration and axon guidance in the CNS.


Pssm-ID: 320557 [Multi-domain]  Cd Length: 254  Bit Score: 98.09  E-value: 2.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  750 PVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATV 829
Cdd:cd15441     3 LLKIVTYIGIGISLVLLVIAFLVLSCLRGLQSNSNSIHKNLVACLLLAELLFLLGINQTENLFPCKLIAILLHYFYLSAF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  830 LWVGVTARNIYKQVT--KKAKRCQdpdeppapprpMLRFYLIGGGIPIIVCGITAAANIKNYGsrpSAPYCWM-AWEPSL 906
Cdd:cd15441    83 SWLLVESLHLYRMLTepRDINHGH-----------MRFYYLLGYGIPAIIVGLSVGLRPDGYG---NPDFCWLsVNETLI 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  907 GAFYGPASFITFVNCMYF---LSIFIQLKRHPERKYELKepteeqQRLAANengeinhqdSMSLSLISTStlenehsfqs 983
Cdd:cd15441   149 WSFAGPIAFVIVITLIIFilaLRASCTLKRHVLEKASVR------TDLRSS---------FLLLPLLGAT---------- 203

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 241896916  984 qllgasltlllyvilWMFGAMAVSlyYPLDlVFSFFFGATCLSFSAFMMVHHCINREDVRLAWIMMCC 1051
Cdd:cd15441   204 ---------------WVFGLLAVN--EDSE-LLHYLFAGLNFLQGLFIFLFYCIFNKKVRRELKNALL 253
7tmB2_latrophilin-like_invertebrate cd15440
invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane ...
 760-943 2.69e-18

invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; This subgroup includes latrophilin-like proteins that are found in invertebrates such as insects and worms. Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of vertebrate latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320556 [Multi-domain]  Cd Length: 259  Bit Score: 86.16  E-value: 2.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  760 LLCLLAVIISYMYHHSL--IRISLKSwhmlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTAR 837
Cdd:cd15440    16 IVCLLLAFITFTCFRNLqcDRNTIHK-----NLCLCLLIAEIVFLLGIDQTENRTLCGVIAGLLHYFFLAAFSWMLLEGF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  838 NIYK---QVTKKAKRcqdpdeppapprPMLRFYLIGGGIPIIVCGITAAANIKNYGSRpsaPYCWMAWE-PSLGAFYGPA 913
Cdd:cd15440    91 QLYVmlvEVFEPEKS------------RIKWYYLFGYGLPALIVAVSAGVDPTGYGTE---DHCWLSTEnGFIWSFVGPV 155

                         170       180       190
                  ....*....|....*....|....*....|.
gi 241896916  914 SFITFVNCMyFLSIFIQLK-RHPERKYELKE 943
Cdd:cd15440   156 IVVLLANLV-FLGMAIYVMcRHSSRSASKKD 185
LRR_8 pfam13855
Leucine rich repeat;
74-130 1.27e-17

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 77.95  E-value: 1.27e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 241896916    74 TLILSNNKISELKNGSFSGLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNRI 130
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-172 2.12e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   74 TLILSNNKISELKNgSFSGLSLLERLDLRNNLISRIaPGAFWGLSSLKRLDLTNNRIGCLnADVFRGLTNLVRLNLSGNL 153
Cdd:COG4886   140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                          90
                  ....*....|....*....
gi 241896916  154 FTSLSQGtfdyLGSLRSLE 172
Cdd:COG4886   217 LTDLPEP----LANLTNLE 231
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-172 2.90e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   74 TLILSNNKISELKNgSFSGLSLLERLDLRNNLISRIaPGAFWGLSSLKRLDLTNNRIGCLNADvFRGLTNLVRLNLSGNL 153
Cdd:COG4886   163 SLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                          90
                  ....*....|....*....
gi 241896916  154 FTSLSqgtfdYLGSLRSLE 172
Cdd:COG4886   240 LTDLP-----ELGNLTNLE 253
LRR_8 pfam13855
Leucine rich repeat;
96-154 7.40e-17

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 75.64  E-value: 7.40e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 241896916    96 LERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNRIGCLNADVFRGLTNLVRLNLSGNLF 154
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmB2_CD97 cd15438
CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
 760-925 3.10e-16

CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320554 [Multi-domain]  Cd Length: 261  Bit Score: 80.19  E-value: 3.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  760 LLCLLAVIISYMYHHSlIRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNI 839
Cdd:cd15438    16 LFCLFLCILTFLFCRS-IRGTRNTIHL--HLCLSLFLAHLIFLLGINNTNNQVACAVVAGLLHYFFLAAFCWMSLEGVEL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  840 YKQVTKKAKrcqdpdeppAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRpsaPYCWMAWEPS-LGAFYGPASFITF 918
Cdd:cd15438    93 YLMVVQVFN---------TQSLKKRYLLLIGYGVPLVIVAISAAVNSKGYGTQ---RHCWLSLERGfLWSFLGPVCLIIL 160


                  ....*..
gi 241896916  919 VNCMYFL 925
Cdd:cd15438   161 VNAIIFV 167
7tmB2_GPR133-like_Adhesion_V cd15933
orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of ...
 760-920 4.80e-16

orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group V adhesion GPCRs include orphan receptors GPR133, GPR144, and closely related proteins. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the G(s) protein, leading to activation of adenylate cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320599 [Multi-domain]  Cd Length: 252  Bit Score: 79.29  E-value: 4.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  760 LLCLLAVIISYmyhhSLIRI-SLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTARN 838
Cdd:cd15933    16 IACLALTLIIF----LVLRVlSSDRFQIHKNLCVALLLAQILLLAGEWAEGNKVACKVVAILLHFFFMAAFSWMLVEGLH 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  839 IYKQVTKkakrcqdpdePPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSapyCWMA------WepslgAFYGP 912
Cdd:cd15933    92 LYLMIVK----------VFNYKSKMRYYYFIGWGLPAIIVAISLAILFDDYGSPNV---CWLSlddgliW-----AFVGP 153


                  ....*...
gi 241896916  913 ASFITFVN 920
Cdd:cd15933   154 VIFIITVN 161
7tmB2_EMR cd15439
epidermal growth factor-like module-containing mucin-like hormone receptors, member of the ...
 751-934 7.69e-15

epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4) and the leukocyte cell-surface antigen CD97, are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying number of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of EMR2, alternative splicing results in four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320555 [Multi-domain]  Cd Length: 263  Bit Score: 76.23  E-value: 7.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  751 VVYTTAITLLLCLLAVIISYMYHHSlIRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVL 830
Cdd:cd15439     7 ITYVGLIISLLCLFLAILTFLLCRS-IRNTSTSLHL--QLSLCLFLADLLFLVGIDRTDNKVLCSIIAGFLHYLFLACFA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  831 WVGVTARNIYKQVtkkakRCQDPDEPPAPPRPMLRF-YLIGGGIPIIVCGITAAANIKNYGSRpsaPYCWMAWEPS-LGA 908
Cdd:cd15439    84 WMFLEAVHLFLTV-----RNLKVVNYFSSHRFKKRFmYPVGYGLPAVIVAISAAVNPQGYGTP---KHCWLSMEKGfIWS 155

                         170       180
                  ....*....|....*....|....*.
gi 241896916  909 FYGPASFITFVNCMYFLSIFIQLKRH 934
Cdd:cd15439   156 FLGPVCVIIVINLVLFCLTLWILREK 181
7tmB2_CELSR1 cd15991
Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of ...
 750-1043 9.30e-15

Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320657 [Multi-domain]  Cd Length: 254  Bit Score: 75.65  E-value: 9.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  750 PVVYTTAITLLLCLLAVIISYMYHHSL--IRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLA 827
Cdd:cd15991     3 PLKIITYTTVSLSLVALLITFILLVLIrtLRSNLHSIHK--NLVAALFFSELIFLIGINQTENPFVCTVVAILLHYFYMS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  828 TVLWVGVTARNIYKQVTKkakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGsrpSAPYCWMAWEPSL- 906
Cdd:cd15991    81 TFAWMFVEGLHIYRMLTE---------VRNINTGHMRFYYVVGWGIPAIITGLAVGLDPQGYG---NPDFCWLSVQDTLi 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  907 GAFYGPASFITFVNCMYF-LSIFIQLKRhpERKYELKEPTEEQQRLAAnengeinhqdsMSLSLISTStlenehsfqsql 985
Cdd:cd15991   149 WSFAGPIGIVVIINTVIFvLAAKASCGR--RQRYFEKSGVISMLRTAF-----------LLLLLISAT------------ 203

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 241896916  986 lgasltlllyvilWMFGAMAVSlyyPLDLVFSFFFGA-TCLSfSAFMMVHHCINREDVR 1043
Cdd:cd15991   204 -------------WLLGLMAVN---SDTLSFHYLFAIfSCLQ-GIFIFFFHCIFNKEVR 245
7tmB3_Methuselah-like cd15039
Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G ...
 760-951 1.38e-14

Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G protein-coupled receptors; The subfamily B3 of class B GPCRs consists of Methuselah (Mth) and its closely related proteins found in bilateria. Mth was originally identified in Drosophila as a GPCR affecting stress resistance and aging. In addition to the seven transmembrane helices, Mth contains an N-terminal extracellular domain involved in ligand binding, and a third intracellular loop (IC3) required for the specificity of G-protein coupling. Drosophila Mth mutants showed an increase in average lifespan by 35% and greater resistance to a variety of stress factors, including starvation, high temperature, and paraquat-induced oxidative toxicity. Moreover, mutations in two endogenous peptide ligands of Methuselah, Stunted A and B, showed an increased in lifespan and resistance to oxidative stress induced by dietary paraquat. These results strongly suggest that the Stunted-Methuselah system plays important roles in stress response and aging.


Pssm-ID: 410632 [Multi-domain]  Cd Length: 270  Bit Score: 75.34  E-value: 1.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  760 LLCLLAVIISYMYHHSLIRISlksWHMLVNLCFHILLTCVVFV-GGITQTRNASVCQAVGIILHYSTLATVLWVGVTARN 838
Cdd:cd15039    16 LVFLLLTLAVYALLPELRNLH---GKCLMCLVLSLFVAYLLLLiGQLLSSGDSTLCVALGILLHFFFLAAFFWLNVMSFD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  839 IYKQVTKKAKRCQDPDEPPApprpmLRFY-LIGGGIPIIVCGITAAANIKN--YGSRPS--APYCWM--AWePSLGAFYG 911
Cdd:cd15039    93 IWRTFRGKRSSSSRSKERKR-----FLRYsLYAWGVPLLLVAVTIIVDFSPntDSLRPGygEGSCWIsnPW-ALLLYFYG 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 241896916  912 PASFITFVNCMYFLSIFIQLKRHP-ERKYELKEPTEEQQRL 951
Cdd:cd15039   167 PVALLLLFNIILFILTAIRIRKVKkETAKVQSRLRSDKQRF 207
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-179 4.09e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 4.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   65 PDTLPNRT--VTLILSNNKISELkNGSFSGLSLLERLDLRNNLISRIApgAFWGLSSLKRLDLTNNRIGCLnaDVFRGLT 142
Cdd:COG4886   198 PEPLGNLTnlEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLT 272

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 241896916  143 NLVRLNLSGNLFTSLSQGTFDYLGSLRSLEFQTEYLL 179
Cdd:COG4886   273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
7tmB2_GPR133 cd15256
orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G ...
 748-1046 6.54e-13

orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR133 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR144. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320384 [Multi-domain]  Cd Length: 260  Bit Score: 70.34  E-value: 6.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  748 LHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLA 827
Cdd:cd15256     4 LSSITYVGCSLSIFCLAITLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQILLLISFRFEPGTLPCKIMAILLHFFFLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  828 TVLWVGVTARNIYKQVTKkakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSapyCWMAWEP-SL 906
Cdd:cd15256    84 AFAWMLVEGLHLYSMVIK---------VFGSEESKHFYYYGIGWGSPLLICIISLTSALDSYGESDN---CWLSLENgAI 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  907 GAFYGPASFITFVNcmyfLSIFIQLKRHPERkyelkepteeqqrlAANENGEInHQDSMSLSLISTSTLenehsfqsqll 986
Cdd:cd15256   152 WAFVAPALFVIVVN----IGILIAVTRVISR--------------ISADNYKV-HGDANAFKLTAKAVA----------- 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 241896916  987 gasltlllyVIL------WMFGAMAVSLYyplDLVFSFFFgATCLSFSA-FMMVHHCINREDVRLAW 1046
Cdd:cd15256   202 ---------VLLpilgssWVFGVLAVNTH---ALVFQYMF-AIFNSLQGfFIFLFHCLLNSEVRAAF 255
7tmB2_BAI_Adhesion_VII cd15251
brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 ...
 761-931 7.44e-13

brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediate direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320379  Cd Length: 253  Bit Score: 69.98  E-value: 7.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  761 LCLLAVIISYMYHHSLIRiSLKSWhMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNIY 840
Cdd:cd15251    17 LALLTLLAIYAAFWRYIR-SERSI-ILINFCLSIISSNILILVGQTQTLNKGVCTMTAAFLHFFFLSSFCWVLTEAWQSY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  841 KQVTKKAKrcqdpdeppaPPRPMLRFYLIGGGIPIIVCGITAA-ANIKNYGsrpSAPYCWMAWEPS-LGAFYGPASFITF 918
Cdd:cd15251    95 MAVTGRMR----------TRLIRKRFLCLGWGLPALVVAVSVGfTRTKGYG---TSSYCWLSLEGGlLYAFVGPAAAVVL 161

                         170
                  ....*....|...
gi 241896916  919 VNCMYFLSIFIQL 931
Cdd:cd15251   162 VNMVIGILVFNKL 174
LRR_8 pfam13855
Leucine rich repeat;
118-171 2.13e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.13e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 241896916   118 SSLKRLDLTNNRIGCLNADVFRGLTNLVRLNLSGNLFTSLSQGTFDYLGSLRSL 171
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
7tmB2_GPR126-like_Adhesion_VIII cd15258
orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family ...
 753-1048 2.29e-12

orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Group VIII adhesion GPCRs include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. GPR126, on the other hand, is required for Schwann cells, but not oligodendrocyte myelination in the peripheral nervous system. Gpr64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. GPR114 is mainly found in granulocytes (polymorphonuclear leukocytes), and GPR114-transfected cells induced an increase in cAMP levels via coupling to G(s) protein. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320386 [Multi-domain]  Cd Length: 267  Bit Score: 68.98  E-value: 2.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  753 YTTAITLLLC------LLAVIISYMYHHSLIRISLKSWHMlvNLCFHILLTCVVFV--GGITQTRNASVCQAVGIILHYS 824
Cdd:cd15258     3 ILTFISYVGCgisaifLAITILTYIAFRKLRRDYPSKIHM--NLCAALLLLNLAFLlsSWIASFGSDGLCIAVAVALHYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  825 TLATVLWVGVTARNIYKQVTKkakrcqdpDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYG-----SRPSAPYCW 899
Cdd:cd15258    81 LLACLTWMGLEAFHLYLLLVK--------VFNTYIRRYILKLCLVGWGLPALLVTLVLSVRSDNYGpitipNGEGFQNDS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  900 MAWEPSLGAFY----GPASFITFVNCMYFLSIFIQLKRHPERKyELKEPTEEQQRLaanengeinhqdsmsLSLISTSTL 975
Cdd:cd15258   153 FCWIRDPVVFYitvvGYFGLTFLFNMVMLATVLVQICRLREKA-QATPRKRALHDL---------------LTLLGLTFL 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 241896916  976 enehsfqsqllgasltlllyviLWMFGAMAVSLYYPLDLVFSFFFgATCLSFSAFMM-VHHCINREDVRLAWIM 1048
Cdd:cd15258   217 ----------------------LGLTWGLAFFAWGPFNLPFLYLF-AIFNSLQGFFIfIWYCSMKENVRKQWRA 267
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
 751-952 3.01e-12

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 68.07  E-value: 3.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   751 VVYTTAITL-LLCLLAVIISYMYHHSLiRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNAS--------VCQAVGIIL 821
Cdd:pfam00002    6 VIYTVGYSLsLVALLLAIAIFLLFRKL-HCTRNYIHL--NLFASFILRALLFLVGDAVLFNKQdldhcswvGCKVVAVFL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   822 HYSTLATVLWVGVTARNIYKQVTKkakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGsrpSAPYCWMA 901
Cdd:pfam00002   83 HYFFLANFFWMLVEGLYLYTLLVE---------VFFSERKYFWWYLLIGWGVPALVVGIWAGVDPKGYG---EDDGCWLS 150

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 241896916   902 WE-PSLGAFYGPASFITFVNCMYFLSIFIQLKRHperkyeLKEPTEEQQRLA 952
Cdd:pfam00002  151 NEnGLWWIIRGPILLIILVNFIIFINIVRILVQK------LRETNMGKSDLK 196
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-172 8.56e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 8.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   66 DTLPNRTvTLILSNNKISELKNgsFSGLSLLERLDLRNNLISRIA---------------------------PGAFWGLS 118
Cdd:cd21340    43 EFLTNLT-HLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEglenltnleelhienqrlppgekltfdPRSLAALS 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 241896916  119 -SLKRLDLTNNRIGCLNAdvFRGLTNLVRLNLSGNLFTSLSQgTFDYLGSLRSLE 172
Cdd:cd21340   120 nSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEE-LLDLLSSWPSLR 171
7tmB2_EMR_Adhesion_II cd15931
EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of ...
 760-924 2.15e-11

EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. On the other hand, EMR2 generates four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320597 [Multi-domain]  Cd Length: 262  Bit Score: 66.00  E-value: 2.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  760 LLCLLAVIISYMYHHSlIRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNI 839
Cdd:cd15931    16 LFCLGLAIFTFLLCRW-IPKINTTAHL--HLCLCLSMSHTLFLAGIEYVENELACTVMAGLLHYLFLASFVWMLLEALQL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  840 YKQVtkkaKRCQDPDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGsrpSAPYCWMAWEPS-LGAFYGPASFITF 918
Cdd:cd15931    93 HLLV----RRLTKVQVIQRDGLPRPLLCLIGYGVPFLIVGVSALVYSDGYG---EAKMCWLSQERGfNWSFLGPVIAIIG 165


                  ....*.
gi 241896916  919 VNCMYF 924
Cdd:cd15931   166 INWILF 171
7tmB2_ETL cd15437
Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; ...
 757-934 2.38e-11

Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; member of the class B2 family of seven-transmembrane G protein-coupled receptors; ETL (EGF-TM7-latrophilin-related protein) belongs to Group I adhesion GPCRs, which also include latrophilins (also called lectomedins or latrotoxin receptors). All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. ETL, for instance, contains EGF-like repeats, which also present in other EGF-TM7 adhesion GPCRs, such as Cadherin EGF LAG seven-pass G-type receptors (CELSR1-3), EGF-like module receptors (EMR1-3), CD97, and Flamingo. ETL is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320553 [Multi-domain]  Cd Length: 258  Bit Score: 65.67  E-value: 2.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  757 ITLLLCLLAVIISYMYHhSLIRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTA 836
Cdd:cd15437    13 IISLICLSMCIFTFWFF-SEIQSTRTTIHK--NLCCSLFLAELIFLIGINMNANKLFCSIIAGLLHYFFLAAFAWMCIEG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  837 RNIYKQVTkkakrcqdpDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGsrpSAPYCWMAWEPS-LGAFYGPASF 915
Cdd:cd15437    90 IHLYLIVV---------GVIYNKGFLHKNFYIFGYGSPAVVVGISAALGYKYYG---TTKVCWLSTENNfIWSFIGPACL 157

                         170
                  ....*....|....*....
gi 241896916  916 ITFVNCMYFLSIFIQLKRH 934
Cdd:cd15437   158 IILVNLLAFGVIIYKVFRH 176
7tmB2_CELSR3 cd15993
Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of ...
 789-1050 2.60e-11

Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuronal migration and axon guidance in the CNS. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320659 [Multi-domain]  Cd Length: 254  Bit Score: 65.63  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  789 NLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKkakrcqdpdEPPAPPRPMLRFYL 868
Cdd:cd15993    42 NIAAALFLSELLFLLGINRTENQFLCTVVAILLHYFFLSTFAWLFVQGLHIYRMQTE---------ARNVNFGAMRFYYA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  869 IGGGIPIIVCGITAAANIKNYGsrpSAPYCWMA-WEPSLGAFYGPASFITFVNCMYFLsIFIQLKRHPERKYELKEPTEE 947
Cdd:cd15993   113 IGWGVPAIITGLAVGLDPEGYG---NPDFCWISiHDKLVWSFAGPIVVVIVMNGVMFL-LVARMSCSPGQKETKKTSVLM 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  948 QQRlaanengeinhqDSMSLSLISTSTlenehsfqsqllgasltlllyvilWMFGAMAVSLYYpldLVFSFFFGATCLSF 1027
Cdd:cd15993   189 TLR------------SSFLLLLLISAT------------------------WLFGLLAVNNSV---LAFHYLHAILCCLQ 229

                         250       260
                  ....*....|....*....|...
gi 241896916 1028 SAFMMVHHCINREDVRLAWIMMC 1050
Cdd:cd15993   230 GLAVLLLFCVLNEEVQEAWKLAC 252
7tmB2_BAI3 cd15989
brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 ...
 754-944 5.46e-11

brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320655 [Multi-domain]  Cd Length: 293  Bit Score: 65.09  E-value: 5.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  754 TTAITLLL-----CLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLAT 828
Cdd:cd15989     5 TPSVTLIVgcglsCLALITLAVVYAALWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKGICTMTTAFLHFFFLAS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  829 VLWVGVTARNIYKQVTKKAKrcqdpdeppaPPRPMLRFYLIGGGIPIIVCGITAA-ANIKNYGSRpsaPYCWMAWEPS-L 906
Cdd:cd15989    85 FCWVLTEAWQSYMAVTGKIR----------TRLIRKRFLCLGWGLPALVVAISMGfTKAKGYGTP---HYCWLSLEGGlL 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 241896916  907 GAFYGPASFITFVNCMYFLSIFIQL--------KRHPERKYELKEP 944
Cdd:cd15989   152 YAFVGPAAAVVLVNMVIGILVFNKLvsrdgildKKLKHRAGQMSEP 197
7tmB2_Latrophilin_Adhesion_I cd15252
Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of ...
 757-934 8.59e-11

Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; Group I adhesion GPCRs consist of latrophilins (also called lectomedins or latrotoxin receptors) and ETL (EGF-TM7-latrophilin-related protein. These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320380 [Multi-domain]  Cd Length: 257  Bit Score: 64.06  E-value: 8.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  757 ITLLLCLLAVIISYMYHHSLiRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTA 836
Cdd:cd15252    13 IISLVCLAICIFTFWFFRGL-QSDRTTIHK--NLCISLFLAELVFLIGINTTTNKIFCSVIAGLLHYFFLAAFAWMFIEG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  837 RNIYKQVTKkakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGsrpSAPYCWMAWEPS-LGAFYGPASF 915
Cdd:cd15252    90 IQLYLMLVE---------VFENEGSRHKNFYIFGYGSPAVIVGVSAALGYRYYG---TTKVCWLSTENYfIWSFIGPATL 157

                         170
                  ....*....|....*....
gi 241896916  916 ITFVNCMYFLSIFIQLKRH 934
Cdd:cd15252   158 IILLNLIFLGVAIYKMFRH 176
7tmB2_BAI2 cd15988
brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 ...
 752-931 1.64e-10

brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320654 [Multi-domain]  Cd Length: 291  Bit Score: 63.82  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  752 VYTTAITLLLCLLAVIISYMYHHSLIrislkswhMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLW 831
Cdd:cd15988    14 VSCMALLILLAIYAAFWRFIRSERSI--------ILLNFCLSILASNILILVGQSQTLSKGVCTMTAAFLHFFFLSSFCW 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  832 VGVTARNIYKQVTKKAKrcqdpdeppaPPRPMLRFYLIGGGIPIIVCGITAA-ANIKNYGsrpSAPYCWMAWEPS-LGAF 909
Cdd:cd15988    86 VLTEAWQSYLAVIGRMR----------TRLVRKRFLCLGWGLPALVVAVSVGfTRTKGYG---TASYCWLSLEGGlLYAF 152

                         170       180
                  ....*....|....*....|..
gi 241896916  910 YGPASFITFVNCMYFLSIFIQL 931
Cdd:cd15988   153 VGPAAVIVLVNMLIGIIVFNKL 174
7tmB2_Latrophilin-1 cd16007
Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled ...
 747-925 2.36e-10

Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320673 [Multi-domain]  Cd Length: 258  Bit Score: 62.63  E-value: 2.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  747 LLHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTL 826
Cdd:cd16007     2 LLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHK--NLCINLFLAELLFLIGIDKTQYQIACPIFAGLLHFFFL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  827 ATVLWVGVTARNIYKQVTKkakrcqdpdePPAPPRPMLRFYLIGGGI-PIIVCGITAAANIKNYGSRPSapyCWMAWEPS 905
Cdd:cd16007    80 AAFSWLCLEGVQLYLMLVE----------VFESEYSRKKYYYLCGYCfPALVVGISAAIDYRSYGTEKA---CWLRVDNY 146

                         170       180
                  ....*....|....*....|.
gi 241896916  906 -LGAFYGPASFITFVNCMYFL 925
Cdd:cd16007   147 fIWSFIGPVSFVIVVNLVFLM 167
7tmB2_BAI1 cd15990
brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 ...
 761-931 6.82e-10

brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320656  Cd Length: 267  Bit Score: 61.54  E-value: 6.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  761 LCLLAVIISYMYHHSLIRISLKSwhMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNIY 840
Cdd:cd15990    20 LTLLLLIIIYVSVWRYIRSERSV--ILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSY 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  841 KQVTKKAKRcqdpdeppapPRPMLRFYLIGGGIPIIVCGITAA-ANIKNYGsrpSAPYCWMAWEPS-LGAFYGPASFITF 918
Cdd:cd15990    98 MAVTGRLRN----------RIIRKRFLCLGWGLPALVVAISVGfTKAKGYG---TVNYCWLSLEGGlLYAFVGPAAAVVL 164

                         170
                  ....*....|...
gi 241896916  919 VNCMYFLSIFIQL 931
Cdd:cd15990   165 VNMVIGILVFNKL 177
7tmB2_GPR112 cd15997
Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane ...
 786-1048 9.09e-10

Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR112 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR114, and GPR126. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320663  Cd Length: 269  Bit Score: 61.21  E-value: 9.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  786 MLVNLCFHILLTCVVFV--GGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKkakrcqdpDEPPAPPRPM 863
Cdd:cd15997    40 ILINLCTALLMLNLVFLlnSWLSSFNNYGLCITVAAFLHYFLLASFTWMGLEAVHMYFALVK--------VFNIYIPNYI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  864 LRFYLIGGGIPIIVCGITAAANIKNYGS-------RPSAPYCWMAwepSLGAFY----GPASFITFVNCMYFLSIFIQLk 932
Cdd:cd15997   112 LKFCIAGWGIPAVVVALVLAINKDFYGNelssdslHPSTPFCWIQ---DDVVFYisvvAYFCLIFLCNISMFITVLIQI- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  933 rhpeRKYELKEPTEEQQRLAANengeiNHQDSMSLSLISTSTlenehsfqsqllgasltlllyvilWMFGAMAvslYYPL 1012
Cdd:cd15997   188 ----RSMKAKKPSRNWKQGFLH-----DLKSVASLTFLLGLT------------------------WGFAFFA---WGPV 231

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 241896916 1013 DLVFSFFFgATCLSFSA-FMMVHHCINREDVRLAWIM 1048
Cdd:cd15997   232 RIFFLYLF-SICNTLQGfFIFVFHCLMKENVRKQWRI 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-159 9.77e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 9.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   74 TLILSNNKISELKngSFSGLSLLERLDLRNNLISRIAPGAfwGLSSLKRLDLTNNRIGCLNADVFRGLTNLVRLNLSGNL 153
Cdd:COG4886   232 TLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307


                  ....*.
gi 241896916  154 FTSLSQ 159
Cdd:COG4886   308 LNLLEL 313
7tmB2_GPR128 cd15257
orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G ...
 764-929 1.17e-09

orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR128 is an orphan receptor of the adhesion family (subclass B2) that belongs to the class B GPCRs. Expression of GPR128 was detected in the mouse intestinal mucosa and is thought to be involved in energy balance, as its knockout mice showed a decrease in body weight gain and an increase in intestinal contraction frequency compared to wild-type controls. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320385 [Multi-domain]  Cd Length: 303  Bit Score: 61.04  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  764 LAVIISYMYHHSLIRISLKSWhMLVNLCFHILLTCVVFVGGITQTRN-------------------------ASVCQAVG 818
Cdd:cd15257    19 LVITIIFHLHTRKLRKSSVTW-VLLNLCSSLLLFNIIFTSGVENTNNdyeistvpdretntvllseeyvepdTDVCTAVA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  819 IILHYSTLATVLWVGVTARNIYKQVTKKAKrcqdpdepPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRP----- 893
Cdd:cd15257    98 ALLHYFLLVTFMWNAVYSAQLYLLLIRMMK--------PLPEMFILQASAIGWGIPAVVVAITLGATYRFPTSLPvftrt 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 241896916  894 --SAPYCWMAWEPSLGAFYGPA--SFITFVNCMYFLSIFI 929
Cdd:cd15257   170 yrQEEFCWLAALDKNFDIKKPLlwGFLLPVGLILITNVIL 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-172 7.16e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 7.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   55 SSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLisriapgAFWGLSSLKRLDLTNNRIGCLN 134
Cdd:COG4886    57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLP 129

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 241896916  135 ADvFRGLTNLVRLNLSGNLFTSLSqgtfDYLGSLRSLE 172
Cdd:COG4886   130 EE-LANLTNLKELDLSNNQLTDLP----EPLGNLTNLK 162
7tmB2_Latrophilin-2 cd16006
Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled ...
 747-934 9.76e-09

Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320672 [Multi-domain]  Cd Length: 258  Bit Score: 58.00  E-value: 9.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  747 LLHPVVYTTAITLLLCLLAVIISYMYHHSLiRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTL 826
Cdd:cd16006     3 LLTVITWVGIVISLVCLAICIFTFCFFRGL-QSDRNTIHK--NLCINLFIAEFIFLIGIDKTEYKIACPIFAGLLHFFFL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  827 ATVLWVGVTARNIYKQVTKkakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSapyCWMAWEPS- 905
Cdd:cd16006    80 AAFAWMCLEGVQLYLMLVE---------VFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEKA---CWLRVDNYf 147

                         170       180
                  ....*....|....*....|....*....
gi 241896916  906 LGAFYGPASFITFVNCMYFLSIFIQLKRH 934
Cdd:cd16006   148 IWSFIGPVTFIILLNLIFLVITLCKMVKH 176
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 124-225 3.48e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 3.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   124 DLTNNRIGCLNADVFRGLTNLVRLNLSGNLFTslsqgtfdylgslrslefqteyllCDCNILWMHRWVKERNITVRD--- 200
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFE------------------------CDCGLARLPRWAEEKGVKVRQpea 56

                           90       100
                   ....*....|....*....|....*
gi 241896916   201 TRCVYPKSLQAQPVTGVKQELLTCD 225
Cdd:TIGR00864   57 ALCAGPGALAGQPLLGIPLLDSGCD 81
7tmB2_Latrophilin-3 cd16005
Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled ...
 747-924 6.93e-08

Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320671 [Multi-domain]  Cd Length: 258  Bit Score: 55.33  E-value: 6.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  747 LLHPVVYTTAITLLLCLLAVIISYMYHHSLiRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTL 826
Cdd:cd16005     3 LLDVITWVGILLSLVCLLICIFTFCFFRGL-QSDRNTIHK--NLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  827 ATVLWVGVTARNIYKQVTKKAKRCQDPDEPpapprpmlrFYLIGGGIPIIVCGITAAANIKNYGSRpsaPYCWMAWEPS- 905
Cdd:cd16005    80 AAFTWMFLEGVQLYIMLVEVFESEHSRRKY---------FYLVGYGMPALIVAVSAAVDYRSYGTD---KVCWLRLDTYf 147

                         170
                  ....*....|....*....
gi 241896916  906 LGAFYGPASFITFVNCMYF 924
Cdd:cd16005   148 IWSFIGPATLIIMLNVIFL 166
7tmB2_GPR64 cd15444
orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B ...
 786-1046 7.25e-08

orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors; GPR64 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR97, GPR112, GPR114, and GPR126. GPR64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320560 [Multi-domain]  Cd Length: 271  Bit Score: 55.22  E-value: 7.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  786 MLVNLCFHILLTCVVFV--GGITQTRNA-SVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKkakrcqdpDEPPAPPRP 862
Cdd:cd15444    40 ILIQLCVALLLLNLVFLldSWIALYKDIvGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVK--------VFNTYIRKY 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  863 MLRFYLIGGGIPIIVCGITAAANIKNYG--------SRPSAPYCWMAWEPslgAFY----GPASFITFVNCMYFLSIFIQ 930
Cdd:cd15444   112 ILKFCIVGWGVPAVVVAIVLAVSKDNYGlgsygkspNGSTDDFCWINNNI---VFYitvvGYFCVIFLLNISMFIVVLVQ 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  931 LKRhperkyelkepTEEQQRLAANENGEInhQDSMSLSLIStstlenehsfqsqllgasltlLLYVILWMFGAMAvslYY 1010
Cdd:cd15444   189 LCR-----------IKKQKQLGAQRKTSL--QDLRSVAGIT---------------------FLLGITWGFAFFA---WG 231

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 241896916 1011 PLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAW 1046
Cdd:cd15444   232 PVNLAFMYLFAIFNTLQGFFIFIFYCVAKENVRKQW 267
7tmB2_Latrophilin cd15436
Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
 747-934 7.49e-08

Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320552 [Multi-domain]  Cd Length: 258  Bit Score: 55.18  E-value: 7.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  747 LLHPVVYTTAITLLLCLLAVIISYMYHHSLiRISLKSWHMlvNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTL 826
Cdd:cd15436     3 LLFVITWVGIVISLVCLLICIFTFCFFRGL-QTDRNTIHK--NLCINLFIAELLFLIGINRTQYTIACPIFAGLLHFFFL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  827 ATVLWVGVTARNIYKQVTKkakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSapyCWMAWEPS- 905
Cdd:cd15436    80 AAFCWLCLEGVQLYLLLVE---------VFESEYSRRKYFYLCGYSFPALVVAVSAAIDYRSYGTEKA---CWLRVDNYf 147

                         170       180
                  ....*....|....*....|....*....
gi 241896916  906 LGAFYGPASFITFVNCMYFLSIFIQLKRH 934
Cdd:cd15436   148 IWSFIGPVTFVITLNLVFLVITLHKMVSH 176
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-183 1.51e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   69 PNRTVtLILSNNKISELKNgsFSGLSLLERLDLRNNLISRIAPgaFWGLSSLKRLDLTNNRIGCLNadvfrGLTN----- 143
Cdd:cd21340    24 KNLKV-LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENltnle 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 241896916  144 ----------------------------LVRLNLSGNLFTSLSQgtfdyLGSLRSLefqtEYLLCDCN 183
Cdd:cd21340    94 elhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEP-----LAPLRNL----EQLDASNN 152
7tmB2_CELSR2 cd15992
Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of ...
 750-926 1.59e-07

Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320658  Cd Length: 255  Bit Score: 54.06  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  750 PVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATV 829
Cdd:cd15992     3 PLKTLTWSSVGVTLGFLLLTFLFLLCLRALRSNKTSIRKNGATALFLSELVFILGINQADNPFACTVIAILLHFFYLCTF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  830 LWVGVTARNIYKQVTKkakrcqdpdEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGsrpSAPYCWMAWEPSL-GA 908
Cdd:cd15992    83 SWLFLEGLHIYRMLSE---------VRDINYGPMRFYYLIGWGVPAFITGLAVGLDPEGYG---NPDFCWLSIYDTLiWS 150

                         170
                  ....*....|....*....
gi 241896916  909 FYGPASFITFVNC-MYFLS 926
Cdd:cd15992   151 FAGPVAFAVSMNVfLYILS 169
7tmB2_GPR126 cd15996
orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G ...
 786-1046 9.29e-06

orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR126 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, and GPR114. GPR126 is required in Schwann cells for proper differentiation and myelination via G-Protein Activation. GPR126 is believed to couple to G(s)-protein, which leads to activation of adenylate cyclase for cAMP production. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320662  Cd Length: 271  Bit Score: 48.73  E-value: 9.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  786 MLVNLCFHILLTCVVFV--GGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKkakrcqdpDEPPAPPRPM 863
Cdd:cd15996    40 ILMNLSTALLFLNLVFLldGWIASFEIDELCITVAVLLHFFLLATFTWMGLEAIHMYIALVK--------VFNTYIRRYI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  864 LRFYLIGGGIPIIVCGITAAANIKNYGSRPSAP---------YCWMAwEPSLgaFY----GPASFITFVNCMYFLSIFIQ 930
Cdd:cd15996   112 LKFCIIGWGLPALIVSIVLASTNDNYGYGYYGKdkdgqggdeFCWIK-NPVV--FYvtcaAYFGIMFLMNVAMFIVVMVQ 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  931 L-KRHPERKYelKEPTEEQQRlaanengeiNHQDSMSLSLISTSTlenehsfqsqllgasltlllyvilWMFGAMAvslY 1009
Cdd:cd15996   189 IcGRNGKRSN--RTLREEILR---------NLRSVVSLTFLLGMT------------------------WGFAFFA---W 230

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 241896916 1010 YPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAW 1046
Cdd:cd15996   231 GPVNLAFMYLFTIFNSLQGLFIFVFHCALKENVQKQW 267
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 73-155 4.41e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 4.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   73 VTLILSNNKISElKNGS-----FSGLSLLERLDLRNNLI-----SRIAPGAFWGLSSLKRLDLTNNRIGCLNA-DVFRGL 141
Cdd:cd00116   196 EVLDLNNNGLTD-EGASalaetLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAkDLAEVL 274

                          90
                  ....*....|....*..
gi 241896916  142 TN---LVRLNLSGNLFT 155
Cdd:cd00116   275 AEkesLLELDLRGNKFG 291
7tmB2_GPR97 cd15442
orphan adhesion receptor GPR97, member of the class B2 family of seven-transmembrane G ...
 761-929 5.02e-05

orphan adhesion receptor GPR97, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR97 is an orphan receptor that has been classified into the group VIII of adhesion GPCRs. Other members of the Group VII include GPR56, GPR64, GPR112, GPR114, and GPR126. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320558 [Multi-domain]  Cd Length: 277  Bit Score: 46.72  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  761 LCLLAVIISYMYHHSLIRISLKSWHML---VNLCFHILLTCVVFV--GGITQTRNASVCQAVGIILHYSTLATVLWVGVT 835
Cdd:cd15442    16 MVFLIFTIILYFFLRFTYQKFKSEDAPkihVNLSSSLLLLNLAFLlnSGVSSRAHPGLCKALGGVTHYFLLCCFTWMAIE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  836 ARNIYKQVTKkakrcqdpDEPPAPPRPMLRFYLIGGGIPIIVCGITAAAN------IKNYGSRPSAPYCWMAwEPSLGAF 909
Cdd:cd15442    96 AFHLYLLAIK--------VFNTYIHHYFAKLCLVGWGFPALVVTITGSINsygaytIMDMANRTTLHLCWIN-SKHLTVH 166

                         170       180
                  ....*....|....*....|
gi 241896916  910 YgpasfITfvNCMYFLSIFI 929
Cdd:cd15442   167 Y-----IT--VCGYFGLTFL 179
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 59-171 5.89e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 5.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   59 LAQVLPPdtLPNRTVTLILSNNKISelkNGS-------FSGLSLLERLDLRNN-----LISRIAPGaFWGLSSLKRLDLT 126
Cdd:cd00116   128 LAKGLKD--LPPALEKLVLGRNRLE---GAScealakaLRANRDLKELNLANNgigdaGIRALAEG-LKANCNLEVLDLN 201

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 241896916  127 NNRIGCLN----ADVFRGLTNLVRLNLSGNLFTS-----LSQGTFDYLGSLRSL 171
Cdd:cd00116   202 NNGLTDEGasalAETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTL 255
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 693-735 6.07e-05

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 41.60  E-value: 6.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 241896916    693 WDFDllngQGGWKSDGCCILYSDENITTIQCGSLGNYAVLMDL 735
Cdd:smart00303    8 WDES----SGEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDV 46
LRRCT smart00082
Leucine rich repeat C-terminal domain;
178-212 1.05e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.26  E-value: 1.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 241896916    178 LLCDCNILWMHRWVKERNITVR--DTRCVYPKSLQAQ 212
Cdd:smart00082    3 FICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-155 1.09e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   75 LILSNNKIS-ELKNgsFSGLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNRIGCLNADVFRGLTNLVRLNLSGNL 153
Cdd:PLN00113  457 LSLARNKFFgGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQ 534


                  ..
gi 241896916  154 FT 155
Cdd:PLN00113  535 LS 536
7tmB2_GPR56 cd15995
orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G ...
 753-890 1.22e-04

orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR56 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320661  Cd Length: 269  Bit Score: 45.59  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  753 YTTAITLLLCLLA------VIISYMYHHSLIRISLKSWHMlvNLCFHILLTCVVFVGG--ITQTRNASVCQAVGIILHYS 824
Cdd:cd15995     3 YLTILTYVGCIISalasvfTIAFYLCSRRKPRDYTIYVHM--NLLLAIFLLDTSFLISepLALTGSEAACRAGGMFLHFS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241896916  825 TLATVLWVGVTARNIYKQVTKkakrcqdpDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYG 890
Cdd:cd15995    81 LLACLTWMGIEGYNLYRLVVE--------VFNTYVPHFLLKLCAVGWGLPIFLVTLIFLVDQDNYG 138
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
 693-732 1.43e-04

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 40.37  E-value: 1.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 241896916   693 WDFDLlNGQGGWKSDGCCILYSDENITTIQCGSLGNYAVL 732
Cdd:pfam01825    6 WDFTN-STTGRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 74-173 2.27e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 42.53  E-value: 2.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916    74 TLILSNNkISELKNGSFSGLSLLERLDLRNNLISrIAPGAFWGlSSLKRLDLTNNrIGCLNADVFRGLTNLVRLNLSGNL 153
Cdd:pfam13306   15 SITIPSS-LTSIGEYAFSNCTSLKSITLPSSLTS-IGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSNL 90

                           90       100
                   ....*....|....*....|
gi 241896916   154 fTSLSQGTFdYLGSLRSLEF 173
Cdd:pfam13306   91 -TSIGSYAF-SNCSLKSITI 108
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 96-135 2.30e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 241896916    96 LERLDLRNNLISRIAPgaFWGLSSLKRLDLT-NNRIGCLNA 135
Cdd:pfam12799    3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSgNNKITDLSD 41
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 119-152 2.47e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 241896916   119 SLKRLDLTNNRIGCLnaDVFRGLTNLVRLNLSGN 152
Cdd:pfam12799    2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
7tmB1_NPR_B4_insect-like cd15260
insect neuropeptide receptor subgroup B4 and related proteins, member of the class B family of ...
 753-922 3.54e-04

insect neuropeptide receptor subgroup B4 and related proteins, member of the class B family of seven-transmembrane G protein-coupled receptors; This subgroup includes a neuropeptide receptor found in Nilaparvata lugens (brown planthopper) and its closely related proteins from mollusks and annelid worms. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 320388 [Multi-domain]  Cd Length: 267  Bit Score: 43.80  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  753 YTTAITLLLCLLAVIISYmyhHSL----IRIslkswHM-------LVNLCFHILLTCVVFVGGITQtRNASVCQAVGIIL 821
Cdd:cd15260    12 YSVSLIALIISLAIFFSF---RSLrctrITI-----HMnlfisfaLNNLLWIVWYKLVVDNPEVLL-ENPIWCQALHVLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  822 HYSTLATVLWV---GVTARNIYKQVTKKAKRCqdpdeppapprpMLRFYLIGGGIPIIVCGITAAAnikNYGSRPSAPYC 898
Cdd:cd15260    83 QYFMVCNYFWMfceGLYLHTVLVVAFISEKSL------------MRWFIAIGWGVPLVITAIYAGV---RASLPDDTERC 147

                         170       180       190
                  ....*....|....*....|....*....|
gi 241896916  899 WMAWEPSLGAFYGP------ASFITFVNCM 922
Cdd:cd15260   148 WMEESSYQWILIVPvvlsllINLIFLINIV 177
7tmB2_GPR113 cd15253
orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G ...
 757-933 3.82e-04

orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR113 is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR115, and GPR116. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain, and is primarily expressed in a subset of taste receptor cells. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320381 [Multi-domain]  Cd Length: 271  Bit Score: 43.98  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  757 ITLLLCLlavIISYMYHHSLIR--ISLKSWHMLVNLCFHILLTCVVFVGG--ITQTRNASVCQAVGIILHYSTLATVLWV 832
Cdd:cd15253    17 LALLLCL---GIYRLVWRSVVRnkISYFRHMTLVNIAFSLLLADTCFLGAtfLSAGHESPLCLAAAFLCHFFYLATFFWM 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916  833 GVTARNIYKQVT----KKAKRcqdpdeppAPPRPMLrfyLIGGGIPIIVCGIT-AAANIKNYGSRPSApyCWMAWEP-SL 906
Cdd:cd15253    94 LVQALMLFHQLLfvfhQLAKR--------SVLPLMV---TLGYLCPLLIAAATvAYYYPKRQYLHEGA--CWLNGESgAI 160

                         170       180
                  ....*....|....*....|....*..
gi 241896916  907 GAFYGPASFITFVNCMYFLSIFIQLKR 933
Cdd:cd15253   161 YAFSIPVLAIVLVNLLVLFVVLMKLMR 187
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-175 4.26e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   70 NRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISRIAPGA-FWGLSSLKRLDLTNNRigcLNADVFRG-LTNLVRL 147
Cdd:PLN00113   69 SRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNN---FTGSIPRGsIPNLETL 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 241896916  148 NLSGNLFTS---LSQGTFD------------------YLGSLRSLEFQT 175
Cdd:PLN00113  146 DLSNNMLSGeipNDIGSFSslkvldlggnvlvgkipnSLTNLTSLEFLT 194
HRM pfam02793
Hormone receptor domain; This extracellular domain contains four conserved cysteines that ...
 352-405 4.94e-04

Hormone receptor domain; This extracellular domain contains four conserved cysteines that probably for disulphide bridges. The domain is found in a variety of hormone receptors. It may be a ligand binding domain.


Pssm-ID: 397086  Cd Length: 64  Bit Score: 39.66  E-value: 4.94e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 241896916   352 WPRTLAGITAYLQCTRNTHssGIYPgsaqdERKAWRRCDRGGFWAD---DDYSRCQY 405
Cdd:pfam02793   14 WPRTPAGETVEVPCPDYFS--GFDP-----RGNASRNCTEDGTWSEhppSNYSNCTS 63
LRR_9 pfam14580
Leucine-rich repeat;
74-174 5.74e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.06  E-value: 5.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916    74 TLILSNNKISELKNgsFSGLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNRIGCL-NADVFRGLTNLVRLNLSGN 152
Cdd:pfam14580   46 TIDFSDNEIRKLDG--FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgDLDPLASLKKLTFLSLLRN 123

                           90       100
                   ....*....|....*....|....*....
gi 241896916   153 LFTSLSqgtfDY-------LGSLRSLEFQ 174
Cdd:pfam14580  124 PVTNKP----HYrlyviykVPQLRLLDFR 148
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-173 5.87e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 5.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   55 SSLELAQVLPPD--TLPNRTVTLILSNNKIS-ELKNGSfsgLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNrig 131
Cdd:PLN00113  101 SNNQLSGPIPDDifTTSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN--- 174

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 241896916  132 CLNADVFRGLTNLVRL---NLSGNLFTSlsqGTFDYLGSLRSLEF 173
Cdd:PLN00113  175 VLVGKIPNSLTNLTSLeflTLASNQLVG---QIPRELGQMKSLKW 216
HormR smart00008
Domain present in hormone receptors;
352-405 9.40e-04

Domain present in hormone receptors;


Pssm-ID: 214468  Cd Length: 70  Bit Score: 39.03  E-value: 9.40e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 241896916    352 WPRTLAGITAYLQCTRNThsSGIYPgsaqdERKAWRRCDRGGFWA--DDDYSRCQY 405
Cdd:smart00008   15 WPQTPAGQLVEVPCPKYF--SGFSY-----KTGASRNCTENGGWSppFPNYSNCTS 63
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 74-111 1.26e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 241896916    74 TLILSNNKISELknGSFSGLSLLERLDL-RNNLISRIAP 111
Cdd:pfam12799    5 VLDLSNNQITDI--PPLAKLPNLETLDLsGNNKITDLSD 41
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 238-330 3.32e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 3.32e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916    238 SHRQVVFEGDSLPFQCMASYiDQDMQVLWYQDGrIVETDESQGIFVEKSmihncSLIASaLTISNIQAGSTGNWGCHVQT 317
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYKQG-GKLLAESGRFSVSRS-----GSTST-LTISNVTPEDSGTYTCAATN 72

                            90
                    ....*....|...
gi 241896916    318 KRGNNTRTVDIVV 330
Cdd:smart00410   73 SSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 231-315 4.09e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.55  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   231 PSFYMTPSHrQVVFEGDSLPFQCMASYIDQDmQVLWYQDGRIVETDESQGIFVEKSMihncsliaSALTISNIQAGSTGN 310
Cdd:pfam13927    2 PVITVSPSS-VTVREGETVTLTCEATGSPPP-TITWYKNGEPISSGSTRSRSLSGSN--------STLTISNVTRSDAGT 71


                   ....*
gi 241896916   311 WGCHV 315
Cdd:pfam13927   72 YTCVA 76
LRR smart00370
Leucine-rich repeats, outliers;
93-116 5.43e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 5.43e-03
                            10        20
                    ....*....|....*....|....
gi 241896916     93 LSLLERLDLRNNLISRIAPGAFWG 116
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
93-116 5.43e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 5.43e-03
                            10        20
                    ....*....|....*....|....
gi 241896916     93 LSLLERLDLRNNLISRIAPGAFWG 116
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 242-326 7.64e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.79  E-value: 7.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896916   242 VVFEGDSLPFQCMASYIDQDMQVLWYQDGrivetdeSQGIFVEKSMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGN 321
Cdd:pfam00047    7 TVLEGDSATLTCSASTGSPGPDVTWSKEG-------GTLIESLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                   ....*
gi 241896916   322 NTRTV 326
Cdd:pfam00047   80 ATLST 84
LRR smart00370
Leucine-rich repeats, outliers;
141-163 8.45e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 8.45e-03
                            10        20
                    ....*....|....*....|...
gi 241896916    141 LTNLVRLNLSGNLFTSLSQGTFD 163
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
141-163 8.45e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 8.45e-03
                            10        20
                    ....*....|....*....|...
gi 241896916    141 LTNLVRLNLSGNLFTSLSQGTFD 163
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQ 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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