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Conserved domains on  [gi|19920546|ref|NP_608647|]
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uncharacterized protein Dmel_CG11723, isoform A [Drosophila melanogaster]

Protein Classification

MADF and BESS domain-containing protein( domain architecture ID 10651986)

MADF and BESS domain-containing protein such as Drosophila protein 2d-2 that has been shown to interact with Bombyx mori NPV virus protein Bm8 which may play a role in regulation of gene expression.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
7-91 3.47e-22

subfamily of SANT domain;


:

Pssm-ID: 214738  Cd Length: 89  Bit Score: 89.34  E-value: 3.47e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920546      7 RLIQEVSKRRCLWDTNmSISYRN-QDAALQWASVAQIMQQDVSICKKRFKGMRDSYRAEVRKI---QQKRIEMSHWPYFR 82
Cdd:smart00595   1 RLIELVRERPCLWDRR-HPDYRNkEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLqngKSGGGKKSKWEYFD 79


                   ....*....
gi 19920546     83 SLEFMRQIF 91
Cdd:smart00595  80 RLSFLRPVI 88
BESS pfam02944
BESS motif; The BESS motif is named after the proteins in which it is found (BEAF, Suvar(3)7 ...
 236-270 1.07e-07

BESS motif; The BESS motif is named after the proteins in which it is found (BEAF, Suvar(3)7 and Stonewall). The motif is 40 amino acid residues long and is composed of two predicted alpha helices. Based on the protein in which it is found and the presence of conserved positively charged residues it is predicted to be a DNA binding domain. This domain appears to be specific to drosophila.


:

Pssm-ID: 460758  Cd Length: 35  Bit Score: 47.38  E-value: 1.07e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19920546   236 DSDLSFLMSMMPHVKSLSAISNLKFRMEMARVLVE 270
Cdd:pfam02944   1 DSDDLFLLSLLPTMKRLPPKQKLKFKIKILQLLQE 35
 
Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
7-91 3.47e-22

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 89.34  E-value: 3.47e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920546      7 RLIQEVSKRRCLWDTNmSISYRN-QDAALQWASVAQIMQQDVSICKKRFKGMRDSYRAEVRKI---QQKRIEMSHWPYFR 82
Cdd:smart00595   1 RLIELVRERPCLWDRR-HPDYRNkEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLqngKSGGGKKSKWEYFD 79


                   ....*....
gi 19920546     83 SLEFMRQIF 91
Cdd:smart00595  80 RLSFLRPVI 88
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 8-87 2.90e-20

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 83.88  E-value: 2.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920546     8 LIQEVSKRRCLWDTNMSiSYRNQDA-ALQWASVAQIMQQDVSI--CKKRFKGMRDSYRAEVRKIQ--QKRIEMSHWPYFR 82
Cdd:pfam10545   1 LIELVREHPCLWDRSHP-DYRNRDArERAWEEIAEELGSDVPVedCKKRWKNLRDQYRRELRRKRtnSGELYKSRWYYYE 79


                  ....*
gi 19920546    83 SLEFM 87
Cdd:pfam10545  80 ELSFL 84
BESS pfam02944
BESS motif; The BESS motif is named after the proteins in which it is found (BEAF, Suvar(3)7 ...
 236-270 1.07e-07

BESS motif; The BESS motif is named after the proteins in which it is found (BEAF, Suvar(3)7 and Stonewall). The motif is 40 amino acid residues long and is composed of two predicted alpha helices. Based on the protein in which it is found and the presence of conserved positively charged residues it is predicted to be a DNA binding domain. This domain appears to be specific to drosophila.


Pssm-ID: 460758  Cd Length: 35  Bit Score: 47.38  E-value: 1.07e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19920546   236 DSDLSFLMSMMPHVKSLSAISNLKFRMEMARVLVE 270
Cdd:pfam02944   1 DSDDLFLLSLLPTMKRLPPKQKLKFKIKILQLLQE 35
 
Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
7-91 3.47e-22

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 89.34  E-value: 3.47e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920546      7 RLIQEVSKRRCLWDTNmSISYRN-QDAALQWASVAQIMQQDVSICKKRFKGMRDSYRAEVRKI---QQKRIEMSHWPYFR 82
Cdd:smart00595   1 RLIELVRERPCLWDRR-HPDYRNkEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLqngKSGGGKKSKWEYFD 79


                   ....*....
gi 19920546     83 SLEFMRQIF 91
Cdd:smart00595  80 RLSFLRPVI 88
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 8-87 2.90e-20

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 83.88  E-value: 2.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920546     8 LIQEVSKRRCLWDTNMSiSYRNQDA-ALQWASVAQIMQQDVSI--CKKRFKGMRDSYRAEVRKIQ--QKRIEMSHWPYFR 82
Cdd:pfam10545   1 LIELVREHPCLWDRSHP-DYRNRDArERAWEEIAEELGSDVPVedCKKRWKNLRDQYRRELRRKRtnSGELYKSRWYYYE 79


                  ....*
gi 19920546    83 SLEFM 87
Cdd:pfam10545  80 ELSFL 84
BESS pfam02944
BESS motif; The BESS motif is named after the proteins in which it is found (BEAF, Suvar(3)7 ...
 236-270 1.07e-07

BESS motif; The BESS motif is named after the proteins in which it is found (BEAF, Suvar(3)7 and Stonewall). The motif is 40 amino acid residues long and is composed of two predicted alpha helices. Based on the protein in which it is found and the presence of conserved positively charged residues it is predicted to be a DNA binding domain. This domain appears to be specific to drosophila.


Pssm-ID: 460758  Cd Length: 35  Bit Score: 47.38  E-value: 1.07e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19920546   236 DSDLSFLMSMMPHVKSLSAISNLKFRMEMARVLVE 270
Cdd:pfam02944   1 DSDDLFLLSLLPTMKRLPPKQKLKFKIKILQLLQE 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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