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Conserved domains on  [gi|45550112|ref|NP_608761|]
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uncharacterized protein Dmel_CG15406 [Drosophila melanogaster]

Protein Classification

sugar porter family MFS transporter( domain architecture ID 13024188)

sugar porter family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar or polyol substrates such as glucose, galactose, trehalose, and arabinose, among others

CATH:  1.20.1250.20
SCOP:  3000310
TCDB:  2.A.1.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
19-469 2.18e-165

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 473.60  E-value: 2.18e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  19 LLVSLSATLITFCHGIALGWLSPMLPKLLSpqETPLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALA 98
Cdd:cd17358   1 LLATFVANLGSFSFGIAVGWSSPALPSLMS--DNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  99 VPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHVI 178
Cdd:cd17358  79 IPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 179 PCAVVGLPVLYVLLATRYPEPPQQLIRWKREEEAEKSLRYYRRCDGPNVSKEEERAYQKHFDEMRLaiqqqnndtddNGL 258
Cdd:cd17358 159 ALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEA-----------KES 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 259 SMSDFLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILL 338
Cdd:cd17358 228 SFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLL 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 339 IVSCAGSGIGTSAFGLYaFYAEEQKVDLSAFSaWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLS 418
Cdd:cd17358 308 LVSAIGMGIGLLALGLY-FYLQEHGALLSSVS-WLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNW 385
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 45550112 419 FFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRSMYD 469
Cdd:cd17358 386 LFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
 
Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
19-469 2.18e-165

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 473.60  E-value: 2.18e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  19 LLVSLSATLITFCHGIALGWLSPMLPKLLSpqETPLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALA 98
Cdd:cd17358   1 LLATFVANLGSFSFGIAVGWSSPALPSLMS--DNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  99 VPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHVI 178
Cdd:cd17358  79 IPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 179 PCAVVGLPVLYVLLATRYPEPPQQLIRWKREEEAEKSLRYYRRCDGPNVSKEEERAYQKHFDEMRLaiqqqnndtddNGL 258
Cdd:cd17358 159 ALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEA-----------KES 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 259 SMSDFLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILL 338
Cdd:cd17358 228 SFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLL 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 339 IVSCAGSGIGTSAFGLYaFYAEEQKVDLSAFSaWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLS 418
Cdd:cd17358 308 LVSAIGMGIGLLALGLY-FYLQEHGALLSSVS-WLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNW 385
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 45550112 419 FFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRSMYD 469
Cdd:cd17358 386 LFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
26-466 4.36e-41

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 152.88  E-value: 4.36e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    26 TLITFCHGIALGWLSPMLPKLLSPQ--ETPLSFYIDVNEASWLGAVI----SIGGISGNFSFSYLMNRFGRKVSIYA--- 96
Cdd:TIGR00879  30 SLIAAIGGLMFGYDTGVIGGALALPafEFKFTSANSDSYSSSLWGLVvsifLVGGFIGALFAGWLSDRFGRKKSLLIial 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    97 LAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYH 176
Cdd:TIGR00879 110 LFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSL 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   177 V------IPCAVVGLPVLYVLLA-TRYPEPPQQLIRWKREEEAEKSLRYYRRcdgpnvSKEEERAYQKHFDEMRLAIQQQ 249
Cdd:TIGR00879 190 NntlgwrIPLGLQLIPAGLLFLGlFFLPESPRWLVGKGRVEEARKSLARLRG------TSGEDKELLDELELIDIKRSIE 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   250 NNDTDDNGLSMSDFlTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLDPN-TNTIIIGAVQILGTLASIYL 328
Cdd:TIGR00879 264 KRSVQPSWGSLFSS-TRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAfLVSIIVGAVNFAFTFVAIFL 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   329 VDRYGRKILLIVSCAGSGIGTSAFGLYAFYAEeqkVDLSAFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAV 408
Cdd:TIGR00879 343 VDRFGRRPLLLIGAAGMAICLFVLGILGASFV---TGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPK 419
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45550112   409 ATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRS 466
Cdd:TIGR00879 420 GISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRT 477
Sugar_tr pfam00083
Sugar (and other) transporter;
64-469 4.48e-41

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 152.43  E-value: 4.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    64 SWLGAVISIGGISGNFSFSYLMNRFGRKVSIY---ALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIG 140
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLianVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   141 EIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHV------IPCAVVGLP-VLYVLLATRYPEPPQQLIRWKREEEAE 213
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSnsdgwrIPLGLQLVPaLLLIIGLLFLPESPRWLVEKGRLEEAR 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   214 KSLRYYRRCDGPNVSKEEERayqkhfDEMRLAIQQQNNDTDdnglsmSDFLTKRSLKALATGLVLMVANIFTGTFAFNNY 293
Cdd:pfam00083 209 EVLAKLRGVPDVDRELDEIK------DSLEAGQEAEKASWK------ELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYY 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   294 MSNIFDAVHTQlDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGsgigtsAFGLYAFYAEEQKVDLSAFSAWL 373
Cdd:pfam00083 277 STTIFENLGLS-DSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAG------MAICFVILGIVALLGVSKSDWAG 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   374 PVTLMAFIIFIA--NVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFCAAVSVIC 451
Cdd:pfam00083 350 IVAIVFIALFIAffAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLF 429
                         410
                  ....*....|....*...
gi 45550112   452 LFYVVVCLEETKGRSMYD 469
Cdd:pfam00083 430 IIFVFFFVPETKGRTLEE 447
xylE PRK10077
D-xylose transporter XylE; Provisional
46-469 6.56e-20

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 92.06  E-value: 6.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   46 LLSPQETPLSFyidvnEASWLGAVIS---IGGISGNFSFSYLMNRFGRKVS--IYAL-----AVPHTCIWFLFYFAQSIE 115
Cdd:PRK10077  42 FVAPQNLSESA-----ANSLLGFCVAsalIGCIIGGALGGYCSNRFGRRDSlkIAAVlffisALGSAWPEFGFTSIGPDN 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  116 WLYVA-----RVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIA---------------- 174
Cdd:PRK10077 117 TGYVPefviyRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIArsgdaswlntdgwrym 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  175 --YHVIPCAVVGLPVLYVllatryPEPPQQLIRWKREEEAEKSLRyyrRCDGPNVSKEEerayqkhFDEMRLAIQQQNND 252
Cdd:PRK10077 197 faSEAIPALLFLMLLYFV------PETPRYLMSRGKQEQAEGILR---KIMGNTLATQA-------LQEIKHSLDHGRKT 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  253 TDDnglsmsdfLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLD-PNTNTIIIGAVQILGTLASIYLVDR 331
Cdd:PRK10077 261 GGK--------LLMFGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDiALLQTIIVGVINLTFTVLAIMTVDK 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  332 YGRKILLIVSCAGSGIGtsAFGL-YAFYAeeqkvdlsAFSAWLPVTlmaFIIFIANVGVIS---VTMVVLVEILPQKIRA 407
Cdd:PRK10077 333 FGRKPLQIIGALGMAIG--MFSLgTAFYT--------QAPGIVALL---SMLFYVAAFAMSwgpVCWVLLSEIFPNAIRG 399
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550112  408 VATSFCLGCLSFFAFASLKTFPLMMFHLGLAA------TMWFCAAVSVICLFYVVVCLEETKGRSMYD 469
Cdd:PRK10077 400 KALAIAVAAQWIANYFVSWTFPMMDKNSWLVAhfhngfSYWIYGCMGVLAALFMWKFVPETKGKTLEE 467
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-424 8.04e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.42  E-value: 8.04e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITFCHGIALGWLSPMLPKLLSpqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIY 95
Cdd:COG2814   6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAA------DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  96 ALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAY 175
Cdd:COG2814  80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 176 HV---------IPCAVVGLPVLYVLLATRYPEPPQQLIRwkreeeaekslryyrrcdgpnvskeeerayqkhfdemrlai 246
Cdd:COG2814 160 LFgwrwvflvnAVLALLALLLLLRLLPESRPAARARLRG----------------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 247 qqqnndtddnglSMSDFLTKRSLkalaTGLVLMVANIFTGTFAFNNYMSNIFDAVHtQLDPNTNTIII---GAVQILGTL 323
Cdd:COG2814 199 ------------SLRELLRRPRL----LLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLalfGLGGVLGAL 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 324 ASIYLVDRYGRKILLIVSCAGSGIGTSAFGLyafyaeeqkvdlsaFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQ 403
Cdd:COG2814 262 LAGRLADRFGRRRLLLIGLLLLALGLLLLAL--------------AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
                       410       420
                ....*....|....*....|.
gi 45550112 404 KIRAVATSFCLGCLSFFAFAS 424
Cdd:COG2814 328 EARGRASGLYNSAFFLGGPLA 348
 
Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
19-469 2.18e-165

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 473.60  E-value: 2.18e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  19 LLVSLSATLITFCHGIALGWLSPMLPKLLSpqETPLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALA 98
Cdd:cd17358   1 LLATFVANLGSFSFGIAVGWSSPALPSLMS--DNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  99 VPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHVI 178
Cdd:cd17358  79 IPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 179 PCAVVGLPVLYVLLATRYPEPPQQLIRWKREEEAEKSLRYYRRCDGPNVSKEEERAYQKHFDEMRLaiqqqnndtddNGL 258
Cdd:cd17358 159 ALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEA-----------KES 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 259 SMSDFLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILL 338
Cdd:cd17358 228 SFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLL 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 339 IVSCAGSGIGTSAFGLYaFYAEEQKVDLSAFSaWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLS 418
Cdd:cd17358 308 LVSAIGMGIGLLALGLY-FYLQEHGALLSSVS-WLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNW 385
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 45550112 419 FFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRSMYD 469
Cdd:cd17358 386 LFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
20-467 6.55e-51

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 178.15  E-value: 6.55e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  20 LVSLSATLITFCHGIALGWLSPMLPKLLSPQetPLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAV 99
Cdd:cd17433   2 LATFAAVLGPLSFGFVLGYSSPAIPSLQRIA--DPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 100 PHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHVIP 179
Cdd:cd17433  80 PFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDWRWLA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 180 CAVVGLPVLYVLLATRYPEPPQQLIRWKREEEAEKSLRYYRrcdGPNVSKEEErayqkhfdemrLAIQQQNNDTDDNGLS 259
Cdd:cd17433 160 VLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLR---GPDQGWEWE-----------CIGIEQSFHLEEQSFS 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 260 MSDFLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQlDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLI 339
Cdd:cd17433 226 LALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFK-DSSVASVIVAAIQVLFTAVAALIMDRAGRKVLLV 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 340 VSCAGSGIGTSAFGlyafyaeeqkvdlsafsaWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSF 419
Cdd:cd17433 305 LSGVVMVFSTAAFG------------------WLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWL 366
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 45550112 420 FAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRSM 467
Cdd:cd17433 367 MAFLVTKEFSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTL 414
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
26-466 4.36e-41

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 152.88  E-value: 4.36e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    26 TLITFCHGIALGWLSPMLPKLLSPQ--ETPLSFYIDVNEASWLGAVI----SIGGISGNFSFSYLMNRFGRKVSIYA--- 96
Cdd:TIGR00879  30 SLIAAIGGLMFGYDTGVIGGALALPafEFKFTSANSDSYSSSLWGLVvsifLVGGFIGALFAGWLSDRFGRKKSLLIial 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    97 LAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYH 176
Cdd:TIGR00879 110 LFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSL 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   177 V------IPCAVVGLPVLYVLLA-TRYPEPPQQLIRWKREEEAEKSLRYYRRcdgpnvSKEEERAYQKHFDEMRLAIQQQ 249
Cdd:TIGR00879 190 NntlgwrIPLGLQLIPAGLLFLGlFFLPESPRWLVGKGRVEEARKSLARLRG------TSGEDKELLDELELIDIKRSIE 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   250 NNDTDDNGLSMSDFlTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLDPN-TNTIIIGAVQILGTLASIYL 328
Cdd:TIGR00879 264 KRSVQPSWGSLFSS-TRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAfLVSIIVGAVNFAFTFVAIFL 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   329 VDRYGRKILLIVSCAGSGIGTSAFGLYAFYAEeqkVDLSAFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAV 408
Cdd:TIGR00879 343 VDRFGRRPLLLIGAAGMAICLFVLGILGASFV---TGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPK 419
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45550112   409 ATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRS 466
Cdd:TIGR00879 420 GISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRT 477
Sugar_tr pfam00083
Sugar (and other) transporter;
64-469 4.48e-41

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 152.43  E-value: 4.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    64 SWLGAVISIGGISGNFSFSYLMNRFGRKVSIY---ALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIG 140
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLianVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   141 EIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHV------IPCAVVGLP-VLYVLLATRYPEPPQQLIRWKREEEAE 213
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSnsdgwrIPLGLQLVPaLLLIIGLLFLPESPRWLVEKGRLEEAR 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   214 KSLRYYRRCDGPNVSKEEERayqkhfDEMRLAIQQQNNDTDdnglsmSDFLTKRSLKALATGLVLMVANIFTGTFAFNNY 293
Cdd:pfam00083 209 EVLAKLRGVPDVDRELDEIK------DSLEAGQEAEKASWK------ELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYY 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   294 MSNIFDAVHTQlDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGsgigtsAFGLYAFYAEEQKVDLSAFSAWL 373
Cdd:pfam00083 277 STTIFENLGLS-DSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAG------MAICFVILGIVALLGVSKSDWAG 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   374 PVTLMAFIIFIA--NVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFCAAVSVIC 451
Cdd:pfam00083 350 IVAIVFIALFIAffAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLF 429
                         410
                  ....*....|....*...
gi 45550112   452 LFYVVVCLEETKGRSMYD 469
Cdd:pfam00083 430 IIFVFFFVPETKGRTLEE 447
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
20-467 1.52e-40

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 150.37  E-value: 1.52e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  20 LVSLSATLITFCHGIALGWLSPMLPKLLSPQETPLsfYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAV 99
Cdd:cd17434   2 LAVFSAVLGNFSFGYALVYTSPVIPALEQGDDPRL--HLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 100 PHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHVIp 179
Cdd:cd17434  80 PSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYALGLLLPWRWL- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 180 cAVVG-LPVL-YVLLATRYPEPPQQLIRWKREEEAEKSLRYYRrcdGPNVSkeeeraYQKHFDEMRLAIQQQNNDtddng 257
Cdd:cd17434 159 -AVAGeVPVViMILLLCFMPNSPRFLISKGKDEKALKALAWLR---GPNTD------YMTEFEQIKDNIRKQSSR----- 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 258 LSMSDFLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKIL 337
Cdd:cd17434 224 LSWAELKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVILEPKYDAALVGAVRLLSVAIAASLMDKAGRKIL 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 338 LIVSCAGSGIGTSAFGLyafyaeeqkvdlsafsawLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCL 417
Cdd:cd17434 304 LFTSAFLMFAANLSMGL------------------IPLIAAMLFIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVS 365
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|
gi 45550112 418 SFFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRSM 467
Cdd:cd17434 366 WITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTL 415
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
68-465 2.50e-37

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 142.02  E-value: 2.50e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  68 AVISIGGISGNFSFSYLMNRFGRKVSIY---ALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIAD 144
Cdd:cd17357  56 SIFFIGGAIGSFISAFLANRFGRKNGLLisnALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 145 NSIRGRLCSFFTLTMNTGIMVG------FVVSSHIAYHVIpCAVVGLPVLYVLLATR-YPE-PPQQLIRWKREEEAEKSL 216
Cdd:cd17357 136 SELRGALGSLTQIGVTLGILLGqvfglpSVLGTETLWPYL-LFFPGIPALLQLAALPfFPEsPKFLLISKGDEEEAEKSL 214
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 217 RYYRRCDGPnvskeeeraYQKHFDEMrlaIQQQNNDTDDNGLSMSDFLTKRSLK-ALATGLVLMVANIFTGTFAFNNYMS 295
Cdd:cd17357 215 KFLRGIEDD---------VDQELEEI---KKESEQMGDQKQVSLMQLLRDPSLRlPLLLVLVVSASQQFSGINAIFFYST 282
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 296 NIF-DAVHTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFGLYAFYAEEqkvdlsafSAWLP 374
Cdd:cd17357 283 FIFeNAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQ--------NSWMS 354
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 375 VTLMAFI---IFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMwFCAAVSVIC 451
Cdd:cd17357 355 YGCIVAIflfIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFI-IFAIPCALF 433
                       410
                ....*....|....
gi 45550112 452 LFYVVVCLEETKGR 465
Cdd:cd17357 434 LLYLYRYLPETKGR 447
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
65-461 4.33e-32

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 126.14  E-value: 4.33e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  65 WLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIAD 144
Cdd:cd17359  40 LVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAP 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 145 NSIRGRLCSFFTLTMNTGIMVGFVVSSHIAyHVIPCAVVGLP-------------VLYVLLATRYPEPPqqliRWkreee 211
Cdd:cd17359 120 AEIRGRLVSLNQLMIVFGQLLAYIVNYLIA-NAGGADWLGAEgwrwmlgleaipaILFLLGMLFIPESP----RW----- 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 212 aekslryyrrcdgpnvskeeerayqkhfdemrlaiqqqnndtddnglsmsdfLTKRSLKALATGLVLMVANIFTGTFAFN 291
Cdd:cd17359 190 ----------------------------------------------------LVSKGKPILIIGIGLAIFQQFVGINVIF 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 292 NYMSNIFDAVHTQLDPNT-NTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFGLYAFYAEeqkvdLSAFS 370
Cdd:cd17359 218 YYGPEIFQNAGFSENAALlQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAP-----GSQAS 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 371 AWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFCAAVSVI 450
Cdd:cd17359 293 GIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVL 372
                       410
                ....*....|.
gi 45550112 451 CLFYVVVCLEE 461
Cdd:cd17359 373 AFLFVWKFVPE 383
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
54-461 9.44e-32

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 124.99  E-value: 9.44e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  54 LSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFV 133
Cdd:cd17315  27 LGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASV 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 134 VLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHV-----IPCAVVGLPVLYVLLAtrypeppqqlirwkr 208
Cdd:cd17315 107 LVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgwwrLMFALAAVPALLQLLL--------------- 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 209 eeeaekslryyrrcdgpnvskeeerayqkhfdemrlaiqqqnndtddnglsmsdFLTKRSLKALATGLVLMVANIFTGTF 288
Cdd:cd17315 172 ------------------------------------------------------MFFLPESRALLVGVGLQLLQQLTGIN 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 289 AFNNYMSNIFDAVHTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFGLYAFYAeeqkvDLSA 368
Cdd:cd17315 198 AVMYYAPTIFKSAGGGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLP-----ALAK 272
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 369 FSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFCAAVS 448
Cdd:cd17315 273 AAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVC 352
                       410
                ....*....|...
gi 45550112 449 VICLFYVVVCLEE 461
Cdd:cd17315 353 LLALVFVFFFVPE 365
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
68-466 2.71e-25

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 107.70  E-value: 2.71e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  68 AVISIGGISGNFSFSYLMNRFGRKVSIY---ALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIAD 144
Cdd:cd17432  57 SIFPLGGLFGSLLVGPLVIRLGRKGTLLlnnIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAP 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 145 NSIRGRLCSFFTLTMNTGIMVGFVVS-----SHIAYHVIPCAVVGLP-VLYVLLATRYPEPPQQ-LIRWKREEEAEKSLR 217
Cdd:cd17432 137 KNLRGAVGLVPAIFITLGILLGQVLGlrellGNEEGWPLLLALTGVPaLLQLLTLPFFPESPRYlLIEKGDEEAARKALQ 216
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 218 YYRRCDgpNVSKEEErayqkhfdEMRlaiQQQNNDTDDNGLSMSDFLTKRSLK-ALATGLVLMVANIFTGTFAFNNYMSN 296
Cdd:cd17432 217 RLRGKE--DVDDEME--------EML---EEQRAEKGVGTVSVLELFRDRSVRwQLISIIVLMAGQQLCGINAIYFYADS 283
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 297 IFDAVHTQLD--PNTnTIIIGAVQILGTLASIYLVDRYGRKILLIvscAGSGIGTSAFGLYAFyaeeqKVDLSAFSAWLP 374
Cdd:cd17432 284 IFLEAGIPEDkiQYV-TVGTGACEVLATITCVLVIERLGRRPLLI---GGFGLMAVWCAVLTV-----ALSLQNTVSWMP 354
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 375 VTLMAFII-FIAN--VGVISVTMVVLVEILPQKIRAVAtsFCLGC----LSFFAFASLktFPLMMFHLGLAATMWFCaav 447
Cdd:cd17432 355 YLSIVCIFaYIASfgIGPAGVPFILTTEIFDQSSRPAA--FMVAGslnwLSNFLVGLL--FPFIQEGLGAYCFLVFA--- 427
                       410       420
                ....*....|....*....|..
gi 45550112 448 sVICLF---YVVVCLEETKGRS 466
Cdd:cd17432 428 -VICLLtaiYIFFVLPETKGKT 448
xylE PRK10077
D-xylose transporter XylE; Provisional
46-469 6.56e-20

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 92.06  E-value: 6.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   46 LLSPQETPLSFyidvnEASWLGAVIS---IGGISGNFSFSYLMNRFGRKVS--IYAL-----AVPHTCIWFLFYFAQSIE 115
Cdd:PRK10077  42 FVAPQNLSESA-----ANSLLGFCVAsalIGCIIGGALGGYCSNRFGRRDSlkIAAVlffisALGSAWPEFGFTSIGPDN 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  116 WLYVA-----RVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIA---------------- 174
Cdd:PRK10077 117 TGYVPefviyRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIArsgdaswlntdgwrym 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  175 --YHVIPCAVVGLPVLYVllatryPEPPQQLIRWKREEEAEKSLRyyrRCDGPNVSKEEerayqkhFDEMRLAIQQQNND 252
Cdd:PRK10077 197 faSEAIPALLFLMLLYFV------PETPRYLMSRGKQEQAEGILR---KIMGNTLATQA-------LQEIKHSLDHGRKT 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  253 TDDnglsmsdfLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLD-PNTNTIIIGAVQILGTLASIYLVDR 331
Cdd:PRK10077 261 GGK--------LLMFGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDiALLQTIIVGVINLTFTVLAIMTVDK 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  332 YGRKILLIVSCAGSGIGtsAFGL-YAFYAeeqkvdlsAFSAWLPVTlmaFIIFIANVGVIS---VTMVVLVEILPQKIRA 407
Cdd:PRK10077 333 FGRKPLQIIGALGMAIG--MFSLgTAFYT--------QAPGIVALL---SMLFYVAAFAMSwgpVCWVLLSEIFPNAIRG 399
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550112  408 VATSFCLGCLSFFAFASLKTFPLMMFHLGLAA------TMWFCAAVSVICLFYVVVCLEETKGRSMYD 469
Cdd:PRK10077 400 KALAIAVAAQWIANYFVSWTFPMMDKNSWLVAhfhngfSYWIYGCMGVLAALFMWKFVPETKGKTLEE 467
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-424 8.04e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.42  E-value: 8.04e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITFCHGIALGWLSPMLPKLLSpqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIY 95
Cdd:COG2814   6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAA------DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  96 ALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAY 175
Cdd:COG2814  80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 176 HV---------IPCAVVGLPVLYVLLATRYPEPPQQLIRwkreeeaekslryyrrcdgpnvskeeerayqkhfdemrlai 246
Cdd:COG2814 160 LFgwrwvflvnAVLALLALLLLLRLLPESRPAARARLRG----------------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 247 qqqnndtddnglSMSDFLTKRSLkalaTGLVLMVANIFTGTFAFNNYMSNIFDAVHtQLDPNTNTIII---GAVQILGTL 323
Cdd:COG2814 199 ------------SLRELLRRPRL----LLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLalfGLGGVLGAL 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 324 ASIYLVDRYGRKILLIVSCAGSGIGTSAFGLyafyaeeqkvdlsaFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQ 403
Cdd:COG2814 262 LAGRLADRFGRRRLLLIGLLLLALGLLLLAL--------------AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
                       410       420
                ....*....|....*....|.
gi 45550112 404 KIRAVATSFCLGCLSFFAFAS 424
Cdd:COG2814 328 EARGRASGLYNSAFFLGGPLA 348
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
68-347 6.61e-19

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 88.93  E-value: 6.61e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  68 AVISIGGISGNFSFSYLMNRFGRKVSIYA---LAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIAD 144
Cdd:cd17431  57 AIFSVGGMIGSFSVGLFVNRFGRRNSMLYnnlLAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISP 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 145 NSIRGRLCSFFTLTMNTGIMVG------FVVSSHIAYHVIpCAVVGLP-VLYVLLATRYPEPPQQL-IRWKREEEAEKSL 216
Cdd:cd17431 137 TALRGALGTLHQLGIVVGILISqifgleFILGTEELWPLL-LGFTIVPaILQLALLPFCPESPRYLlINRNEEEEAKSVL 215
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 217 RYYRRCDGPNVSKEEERayqkhfDEMRLAIQQQNndtddngLSMSDFLTKRSLK-ALATGLVLMVANIFTGTFAFNNYMS 295
Cdd:cd17431 216 KKLRGTTDVSEDIQEMK------EESRQMMREKK-------VTILELFRSSSYRqPIIIAIVLQLSQQLSGINAVFYYST 282
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 45550112 296 NIFDAVHTQlDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGI 347
Cdd:cd17431 283 SIFEKAGVQ-QPVYATIGAGVVNTIFTVVSLFLVERAGRRTLHLIGLGGMAI 333
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
59-461 1.05e-16

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 81.16  E-value: 1.05e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  59 DVNEASWLGAVI----SIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVV 134
Cdd:cd17360  29 EVVLSTGWQELIvsstVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMT 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 135 LPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSShiAYHVIP------CAVVGLP-VLYVLLATRYPEPPqqliRWK 207
Cdd:cd17360 109 VPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVING--AFSYLPggwrwmLGLAAVPaVLQFIGLLFLPESP----RWP 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 208 ReeeaekslryyrrcdgpnvskeeerayqkhfdemrlaiqqqnndtddnglsmsdfltkrSLKALATGLVLMVANIFTGT 287
Cdd:cd17360 183 S-----------------------------------------------------------TRRALIVGCGLQAFQQFSGI 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 288 FAFNNYMSNIFDAVHTQLDPNTN--TIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGtsafglyafyaeeqkvd 365
Cdd:cd17360 204 NTVMYYSATILQMAGFKDNQNAIwlSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVA----------------- 266
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 366 LSAFSAWLP-VTLMAFIIFIANvGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFC 444
Cdd:cd17360 267 LVVLAVWLAlVGLILYLAFFAP-GMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTFLLF 345
                       410
                ....*....|....*..
gi 45550112 445 AAVSVICLFYVVVCLEE 461
Cdd:cd17360 346 AGLAVLGLIFIYFCVPE 362
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
25-453 1.09e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 75.54  E-value: 1.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  25 ATLITFCHGIALGWLSPMLPKLLspqetpLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCI 104
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALL------QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 105 WFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHV-----IP 179
Cdd:cd06174  75 ALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfgwrAV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 180 CAVVGLP-VLYVLLATRYPEPPQQLIRWKREEEAEKSLryyrrcdgpnvskeeerayqkhFDEMRLAIQQQNndtddngl 258
Cdd:cd06174 155 FLIAAALaLLAAILLLLVVPDPPESARAKNEEASSKSV----------------------LKLLKRVLKNPG-------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 259 smsdfLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHtqldpntNTIIIGAVQILGTLASIYLVDRY-GRKIL 337
Cdd:cd06174 205 -----LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL-------LLSLFGLAGALGSLLLGLLSDRLiGRKPL 272
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 338 LIVSCAGSGIGTSAFGLyafyaeeqkvdlsaFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSF--CLG 415
Cdd:cd06174 273 LLIGLLLMALGLALLLL--------------APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLlnTFG 338
                       410       420       430
                ....*....|....*....|....*....|....*...
gi 45550112 416 CLSFFAFASLKTFPLMMFHlGLAATMWFCAAVSVICLF 453
Cdd:cd06174 339 FLGGAIGPLLAGFLLAATF-GLTGAFLVLAVLLLLAAI 375
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
72-461 5.68e-14

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 73.44  E-value: 5.68e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  72 IGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRL 151
Cdd:cd17361  62 LAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGAL 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 152 CSFFTLTMNTGIMVGFVVSSHIAYHV-----IPCAVVGLPVLYVLLATRY-PEPPQQlirwkreeeaekslryyrrcdgp 225
Cdd:cd17361 142 NIGFQLAITIGILIANLINYGTSKIKpngwrLSLGLAAVPALILLLGSLFlPETPNS----------------------- 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 226 nvskeeerayqkhfdemrlaiqqqnndtddnglsmsdfltkrslKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQL 305
Cdd:cd17361 199 --------------------------------------------PQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGS 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 306 DPN-TNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFG-LYAFYAEEQKVDLSAFSAWLPVTLMAFIIF 383
Cdd:cd17361 235 DASlISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVAIGiLLAVKFGDGGELPKAYAIAVVVLICLYVAA 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 384 IAnvgvIS---VTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMM--FHLGLaatMWFCAAVSVICLFYVVVC 458
Cdd:cd17361 315 FA----WSwgpLGWLVPSEIFPLETRSAGQSLTVAVNFLFTFVIAQAFLSMLcaMKFGI---FLFFAGWVVVMSLFVYFL 387

                ...
gi 45550112 459 LEE 461
Cdd:cd17361 388 LPE 390
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
68-466 6.60e-14

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 73.05  E-value: 6.60e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  68 AVISIGGISGNFSFSYLMNRFGRKVSIYALAVPhTCIWFLFYFAQSIEW--LYVARVFAGLTGGGMFVVLPIFIGEIADN 145
Cdd:cd17356  52 SIVNLGSFFGALISSFLSDRIGRKKSIQIGCVI-YIIGAIIQVAAIGKWyqLIVGRIIAGLGVGFASVLVPVYQSEVAPK 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 146 SIRGRLCSFFTLTMNTGIMVGFVVS-------SHIAYHVIPCAVVGLPVLYVLLATRYPEPPqqlirwkreeeaekslRY 218
Cdd:cd17356 131 HIRGTLVSLYQLAITIGILVAYCINygthkldGSAQWRIPLGLQIVWGLLLLIGMFFLPESP----------------RW 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 219 YRRcdgpnvskeeerayqkhfdemrlaiqqqnndtddnglsmsdfltkrslkaLATGLVLMVANIFTGTFAFNNYMSNIF 298
Cdd:cd17356 195 LYR--------------------------------------------------TILGIMLQLFQQLTGINYFFYYGTTIF 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 299 DAV-HTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGI---GTSAFGLYAFYAEEQKVDLSAFSAWLP 374
Cdd:cd17356 225 QSTgLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSIclfIYAAVGVRYLIPNPQSGTSNKSAGNGM 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 375 VTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFHLGlAATMWFCAAVSVICLFY 454
Cdd:cd17356 305 IVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIV 383
                       410
                ....*....|..
gi 45550112 455 VVVCLEETKGRS 466
Cdd:cd17356 384 VFFFVPETKGLT 395
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
72-467 4.23e-13

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 70.46  E-value: 4.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  72 IGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRL 151
Cdd:cd17362  50 LGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLL 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 152 CSFFTLTMNTGIMVGFVVSSHIA------YHVIPCAVVgLPVLYVLLATRYPEPPqqliRWKreeeaekslryyrrcdgp 225
Cdd:cd17362 130 VSLKELFIVLGILLGYVSGYAFAdvvggwRYMYGLAAP-PALLLGIGMWFLPPSP----RWQ------------------ 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 226 nvskeeerayqkhfdemrlaiqqqnndtddnglsmsdfltKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAV--HT 303
Cdd:cd17362 187 ----------------------------------------GNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAgfSA 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 304 QLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFGLYAFYAEEQkvdlSAFSAWLPV-TLMAFII 382
Cdd:cd17362 227 ASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFLLAAYNLFVQMG----PAGLAWLSLvALLLYVG 302
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 383 FIaNVGVISVTMVVLVEILPQKIRAVATSFCLgcLSFF---AFASLkTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCL 459
Cdd:cd17362 303 AY-QISFGPISWLMVSEIFPLRVRGRAIALAV--LVNFgsnALVSL-AFLPLQELIGLPGTFLGFGVIGVLALLFIYFTV 378

                ....*...
gi 45550112 460 EETKGRSM 467
Cdd:cd17362 379 PETKGLSL 386
MFS_1 pfam07690
Major Facilitator Superfamily;
27-412 7.46e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.37  E-value: 7.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    27 LITFCHGIALGWLSPMLPKLLSpqetpLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWF 106
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLA-----EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   107 LFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYH-------VIP 179
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfgwraafLIL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   180 CAVVGLPVLYVLLATRYPEPPQQLIRWKREEEAEKSLRYYRRcdgpnvskeeerayqkhfdemrlaiqqqnndtddngls 259
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLR-------------------------------------- 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   260 msdfltKRSLKALATGLVLMVANIFTGTFAFnnymsniFDAVHTQLDPNTNTIIIGAVQILGTLASI---YLVDRYGRKI 336
Cdd:pfam07690 200 ------DPVLWLLLALLLFGFAFFGLLTYLP-------LYQEVLGLSALLAGLLLGLGGLLGAIGRLllgRLSDRLGRRR 266
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45550112   337 LLIVSCAGSGIGTSAFGLyafyaeeqkvdLSAFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSF 412
Cdd:pfam07690 267 RLLLALLLLILAALGLLL-----------LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL 331
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
19-453 8.34e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 69.55  E-value: 8.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  19 LLVSLSATLITFCHGIALGWLSPMLPKLLSPQETPLsfyidvnEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALA 98
Cdd:cd17316   1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLL-------QTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  99 VPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHV- 177
Cdd:cd17316  74 LLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLs 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 178 ------IPCAVVGLPVLYVLLatrypeppqqlirwkreeeaekslryyrrcdgpnvskeeerayqkhfdeMRLAIqqqnn 251
Cdd:cd17316 154 gdwgwrILFLIGALPALLALL-------------------------------------------------LRRRT----- 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 252 dtddnglsmsdfltkrslkalaTGLVLMVANIFTGTFAFNNYMSNIFDAVhTQLDPNT---NTIIIGAVQILGTLASIYL 328
Cdd:cd17316 180 ----------------------LLLILLWFFISFGYYGLTTFLPTYLQTV-LGLSPATsslYLLLISLGALVGALIAGLL 236
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 329 VDRYGRKILLIVSCAGSGIGTSAFGLyafyaeeqkvdLSAFSAWLpVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAV 408
Cdd:cd17316 237 SDRIGRKKTLVIGLILSGILALPLFY-----------LLSGSPTL-LLLLLFILSFFVGGVWGALYAYLAELFPTEVRAT 304
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*.
gi 45550112 409 ATSFCLGCLSF-FAFASLKTFPLMMFHLGLAATMWFCAAVSVICLF 453
Cdd:cd17316 305 GVGLSYNLGRLgGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
21-457 2.00e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.37  E-value: 2.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  21 VSLSATLITFCHGIalgwLSPMLPKLLSpqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSI------ 94
Cdd:cd17325   1 LSLALFLDMLGYGI----IIPILPLYAE------SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLllglll 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  95 YALAVphtciwFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIA 174
Cdd:cd17325  71 LAVST------LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 175 YHV------IPCAVVGLPVLyvLLATRYPEPPqqlirwkreeeaekslryyrrcdgpnvskeeerayqkhfdemRLAIQQ 248
Cdd:cd17325 145 DALgyrapfLVCAALALLAL--VLALLLLPEP------------------------------------------RPPPNK 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 249 QNNDTDDNGLSMSDFLTKRSLKALAtgLVLMVANIFTGTF--AFNNYMSNIFDavhtqLDPNTNTIIIGAVQILGTLASI 326
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALF--LAIFVLAFAFGALepFLPLYAAELGG-----LSPAQIGLLFGAQGLASALSQP 253
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 327 ---YLVDRYGRKILLIVSCAGSGIGTSAFGLyafyaeeqkvdlsaFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQ 403
Cdd:cd17325 254 pagKLSDRIGRKPLILIGLLLSAVALLLLPL--------------ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 45550112 404 KIRAVA-----TSFCLGclsfFAFASLkTFPLMMFHLGLAATMWFCAAVSVICLFYVVV 457
Cdd:cd17325 320 EGRGTAmglfnTAFSLG----MVLGPL-LGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
89-467 9.40e-12

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 66.27  E-value: 9.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  89 GRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFV 168
Cdd:cd17437  60 GRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYV 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 169 VS-------SHIAYHVIpCAVVGLPVLYVLLA-TRYPEPPqqliRWKreeeaekslryyrrcdgPNVSKEEERAYQKHFd 240
Cdd:cd17437 140 SNyafsglpLHVGWRLM-LGVGAVPSLFLAIGvLAMPESP----RWT-----------------PAVRRMLIAALGIHF- 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 241 emrlaIQQqnndtddnglsmsdfltkrslkalATGLVLMVAniftgtfafnnYMSNIFD--AVHTQLDPNTNTIIIGAVQ 318
Cdd:cd17437 197 -----FQQ------------------------ASGIDAVVL-----------YSPRIFKkaGIKSKDKLLLATVAVGVTK 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 319 ILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFGLYAFYAEEQKVDLSAFSAWLPVTLMAFIIFIAnVGVISVTMVVLV 398
Cdd:cd17437 237 TLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATSLTFIDRNGGGLTWALVLAITAVCSFVAFFS-IGAGPITWVYSS 315
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550112 399 EILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRSM 467
Cdd:cd17437 316 EIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSL 384
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
16-466 2.95e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 64.90  E-value: 2.95e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITFCHGIALGWLSPMLPKllspqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRK---- 91
Cdd:COG2223   4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAE---------EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRrvll 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  92 VSIYALAVPhtciWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSS 171
Cdd:COG2223  75 IGLLLLGIG----LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 172 HIAYHV---IPCAVVGLP--VLYVLLATRYPEPPQqlirwKREEEAEKSLRYYRRCdgpnvskeeerayqkhfdemrlai 246
Cdd:COG2223 151 LLIAAFgwrNAFLILGILllVVAVLAWLFLRDPPA-----GAAAAAKASLRDQLEA------------------------ 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 247 qqqnndtddngLSMSDFLtkrslkalatGLVLMVANIFTGTFAFNNYMSNIFDAVHtQLDPNTNTIIIGAVQILGTLASI 326
Cdd:COG2223 202 -----------LRDPRFW----------LLSLLYFGTFGSFIGFSSWLPPYLVDQF-GLSAATAGLLAALFALLGALGRP 259
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 327 ---YLVDRYGRKILLIVSCAGSGIGTSAFGLyafyaeeqkvdlsAFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQ 403
Cdd:COG2223 260 lggWLSDRIGGRRVLLIVFALMALGLLLLAL-------------ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPT 326
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45550112 404 KIRAVATSFCLGCLSFFAFASLKTFPLMMFHLG-LAATMWFCAAVSVICLFYVVVCLEETKGRS 466
Cdd:COG2223 327 KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
72-413 5.78e-11

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 64.27  E-value: 5.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    72 IGGISGNFSFSYLMNRFGRKvSIYALAVPHTCIW-FLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGR 150
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRK-KVLLLSTLVTAVSgVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   151 ----LCSFFTLtmntgimvGFVVSSHIAYHVIP----CAVVGLP-VLYVLLATRYPEPPQQLIRWKREEEAEKSLRYYRR 221
Cdd:TIGR00898 217 vgtlIQVFFSL--------GLVLLPLVAYFIPDwrwlQLAVSLPtFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAK 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   222 CDGPNVSKEEERA-YQKHFDEMRlaiqqqnndtddNGLSMSDFLtkRSLKALATGLVLMvANIFTGTFAfnnYMSNIFDA 300
Cdd:TIGR00898 289 INGKKLPAEVLSLsLEKDLSSSK------------KQYSFLDLF--RTPNLRKTTLCLM-MLWFTTAFS---YYGLVLDL 350
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   301 VHTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIgtsAFGLYAFYAEEQKvdlsafsaWLpVTLMAF 380
Cdd:TIGR00898 351 GNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGV---ALLLLLFVPVDLY--------FL-RTALAV 418
                         330       340       350
                  ....*....|....*....|....*....|...
gi 45550112   381 IIFIANVGVISVTMVVLVEILPQKIRAVATSFC 413
Cdd:TIGR00898 419 LGKFGITSAFQMVYLYTAELYPTVVRNLGVGVC 451
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-463 8.14e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 63.35  E-value: 8.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITFCHGIALGWLSPMLPKLLSpqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVsIY 95
Cdd:COG2271   6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQA------DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRR-VL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  96 ALAVphtCIW----FLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSS 171
Cdd:COG2271  79 AIGL---LLWglatLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 172 HIAYHV---IPCAVVGLPVLYVLLATRYpeppqqlirwkreeeaekslryyrrcdgpnvskeeerayqkhfdemrlaiqq 248
Cdd:COG2271 156 WLLAAFgwrAAFLILGLPGLLLALLRFW---------------------------------------------------- 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 249 qnndtddnglsmsdfltkrslkalatGLVLMVANIFTGTFAFNNYMSNIFDAVH--TQLDPNTNTIIIGAVQILGTLASI 326
Cdd:COG2271 184 --------------------------LLALAYFLVYFALYGFLTWLPTYLVEVRglSLAQAGLLLSLPFLAGIVGSLLGG 237
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 327 YLVDRYGR--KILLIVSCAGSGIGTSAFGLyafyaeeqkvdlsAFSAWLPVTLMaFIIFIANVGVISVTMVVLVEILPQK 404
Cdd:COG2271 238 WLSDRLGRrrKLVLAIGLLLAALALLLLAL-------------LPSPALAIALL-FLAGFGLGGAFGLLWALAAELFPKK 303
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 45550112 405 IRAVATSFCLGCLSFFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETK 463
Cdd:COG2271 304 ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
55-455 1.51e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 62.57  E-value: 1.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  55 SFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRK----VSIYALAVPHtciwFLFYFAQSIEWLYVARVFAGLTGGG 130
Cdd:cd17324  28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRrlllVLLLLFILGN----LLAALAPSFALLLLARALAGLAHGG 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 131 MFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHV---IPCAVVGLPVLYVLLATRYPEPPQQlirwk 207
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLgwrAAFLAIAVLALLAALLLWRLLPSLP----- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 208 reeeaekslryyrrcDGPNVSKEEERAYQKHFDEMRLAiqqqnndtddnglsmsdfltkrslkalatGLVLMVANIFTGT 287
Cdd:cd17324 179 ---------------PKKPGSLGLLSSLLLLLRNPRLR-----------------------------LAYLITFLLFGGF 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 288 FAFNNYMSNIFDAVhTQLDPNTNTIIIGAVQILGTLASI---YLVDRYGRKILLIvscagsGIGTSAFGLYAFYaeeqkv 364
Cdd:cd17324 215 FALYTYLAPFLTDV-PGFSSSAIIGLLLLFGVAGVVGSPlagRLADRGGRRALLI------ALLLLAAALLLLT------ 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 365 dlsAFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGClsFFAFASLKTFPLMMF--HLGLAATMW 442
Cdd:cd17324 282 ---LLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAA--YNLGGALGAALGGLVldHGGWAGVGW 356
                       410
                ....*....|...
gi 45550112 443 FCAAVSVICLFYV 455
Cdd:cd17324 357 VGAALLLLALLLA 369
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
35-462 8.99e-10

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 60.39  E-value: 8.99e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  35 ALGWL-----SPMLPKLLSPqeTPLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRkvsiyALAVPHTCIWFLFY 109
Cdd:cd17371   5 FLGWAldgfdLLLLGLVLPA--LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGR-----VRVLVITILLFAVF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 110 -----FAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFftltMNTGIMVGFVVSSHIAYHVIPCA--- 181
Cdd:cd17371  78 tllcgFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGY----VQSGWAVGWLLATLLAALLFPLLppe 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 182 --------VVGLPVLYVLLATRY-PEPPQqlirwkreeeaekslryyrrcdgpnvskeeeraYQKHfdemrlaiqQQNND 252
Cdd:cd17371 154 iawrvlflLGALPALLVLFIRRFvKEPPQ---------------------------------WQAA---------RAARR 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 253 TDDNGLSMSDFLTKRSLKALATGlVLMVANIFTGTFAFNNYMSNIFDAVH--TQLDPNTNTIIIGAVQILGTLASIYLVD 330
Cdd:cd17371 192 HFADRPSLRELFSPPLLRTTLLA-SLLATGALGGYYGITTWLPSYLTGERglSFEGSAGYLVVTILGGFLGYLAGGFLAD 270
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 331 RYGRKILLIVSCAGSGIGTSafgLYAFYAeeqkvdlsafsawLPVTLMAFIIFIAN---VGVISVTMVVLVEILPQKIRA 407
Cdd:cd17371 271 RIGRRNNFALFALGSAISIL---LYFFLP-------------LSPTLILILGFPLGffaSGPFSGMGAYLTELFPTAVRA 334
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45550112 408 VATSFC------LGCLSFFAFASLKTfplmmfHLGLAATMWFCAAVSVICLFYVVVCLEET 462
Cdd:cd17371 335 TAQGFCynvgriIGALFPFLVGFLAT------SGSLGTAIAVFAAVYYIAGLVLALLLPET 389
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
16-416 9.76e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 60.06  E-value: 9.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    16 RRQLLVSLSATLITFCHGIALGWLSPMLPKLLSpqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRK-VSI 94
Cdd:TIGR00895  13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISA------EWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRrVLL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    95 YALAVPHTCIwFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSS--- 171
Cdd:TIGR00895  87 WSILLFSVFT-LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGwli 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   172 -HIAYHVIPCAVVGLPVLYVLLATRY-PEPpqqlIRWKREEEAEKSLRYYRRCD-----GPNVSKEEERAYQKHFDEMRL 244
Cdd:TIGR00895 166 pVFGWRSLFYVGGIAPLLLLLLLMRFlPES----IDFLVSKRPETVRRIVNAIApqmqaEAQSALPEQKSTQGTKRSVFK 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   245 AIQQqnndtddnglsmsdfltkrslKALATGLVLMVANIFTGTFAFnnYMSNI---FDAVHTQLDPNTNTIIIGAVQ--- 318
Cdd:TIGR00895 242 ALFQ---------------------GKTARITVLLWLLYFMLLVGV--YFLTNwlpKLMVELGFSLSLAATGGALFNfgg 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   319 ILGTLASIYLVDRYGRKILLIVScagsgIGTSAFgLYAFYAEEQKVDLSAfsawlpvtLMAFIIFIANVGVISVTMVVLV 398
Cdd:TIGR00895 299 VIGSIIFGWLADRLGPRVTALLL-----LLGAVF-AVLVGSTLFSPTLLL--------LLGAIAGFFVNGGQSGLYALMA 364
                         410
                  ....*....|....*...
gi 45550112   399 EILPQKIRAVATSFCLGC 416
Cdd:TIGR00895 365 LFYPTAIRATGVGWAIGI 382
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
275-469 2.43e-09

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 59.04  E-value: 2.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 275 GLVLMVANIFTGTFAFNNYMSNIFDAVHTQLDPNT--NTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAF 352
Cdd:cd17436 196 GLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNSSAvlASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGI 275
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 353 GLyafyaeeqkvdlsafsaWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFClGCLSFFA--FASLkTFPL 430
Cdd:cd17436 276 GL-----------------WITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFC-NSFNWAAnlLITL-SFLD 336
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 45550112 431 MMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRSMYD 469
Cdd:cd17436 337 LIDVIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEE 375
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
16-195 6.57e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.13  E-value: 6.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITFCHGIALGWLSPMLPKLLSpqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRK---- 91
Cdd:COG0477  10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAA------DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKrvll 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  92 --VSIYALAVphtciwFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVV 169
Cdd:COG0477  84 igLLLFGLAS------LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
                       170       180       190
                ....*....|....*....|....*....|....*
gi 45550112 170 SSHIAYHV---------IPCAVVGLPVLYVLLATR 195
Cdd:COG0477 158 GGLLVAALgwrwiflinAPLGLLALVLRLRLPESR 192
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
16-194 1.43e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 56.40  E-value: 1.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITF-CHGIALGWLSPMLPKLlspqetplsFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSI 94
Cdd:cd17324 197 NPRLRLAYLITFLLFgGFFALYTYLAPFLTDV---------PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL 267
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  95 YALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSiRGRLCSFFTLTMNTGIMVGFVVSS--- 171
Cdd:cd17324 268 IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGlvl 346
                       170       180
                ....*....|....*....|....
gi 45550112 172 -HIAYHVIPCAVVGLPVLYVLLAT 194
Cdd:cd17324 347 dHGGWAGVGWVGAALLLLALLLAL 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-163 2.13e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.75  E-value: 2.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  13 WQYRRQLLVSLSATLITFCHGIALGWLSPMLPKLLSpqetplsfyIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKV 92
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG---------LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR 274
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45550112  93 SIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGI 163
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
287-462 1.34e-07

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 53.44  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 287 TFAFNNYMSNIFDAVHTQLDPNT----------NTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIgtsAFGLYA 356
Cdd:cd17364 212 FYGQNLFQSTIISAIGFSKTMNAyqelfniavgQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTI---FLLILA 288
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 357 FYAEEQKvdlsaFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGC------LSFFAFASLKTfpl 430
Cdd:cd17364 289 GPYDHWK-----ISTIGFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASgkigaiVGSFLFLSLTQ--- 360
                       170       180       190
                ....*....|....*....|....*....|..
gi 45550112 431 mmfHLGLAATMWFCAAVSVICLFYVVVCLEET 462
Cdd:cd17364 361 ---NIGVRNVLIILAGVALLGIILTLLFPEEK 389
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
72-467 1.73e-07

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 53.26  E-value: 1.73e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  72 IGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRL 151
Cdd:cd17435  47 IGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLL 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 152 CSFFTLTMNTGIMVGFVVSSHIAY----------HVIPCAVVGLPVLYVLlatryPEPPQQLIrwkreeeaekslryyrr 221
Cdd:cd17435 127 VSLNELMIVIGILLAYISNYAFANvsngwkymfgLVIPLAALQAIAMYFL-----PPSPRFLV----------------- 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 222 cdgpnvskeeerayqkhfdemrlaiqqqnndtddnglsMSDFLTKRSLKALAtgLVLMVAniFTGTFAFNNYMSNIFDAV 301
Cdd:cd17435 185 --------------------------------------MKDNMRARLLIGLT--LVFFVQ--ITGQPNILFYASTVLKSV 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 302 --HTQLDPNTNTIIIGAVQILGTLASIYLVDRYGRKILLivsCAGSGIgtsafglyafyaeeQKVDLSAFSAWLpvTLMA 379
Cdd:cd17435 223 gfQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFL---CIGSSV--------------MAVSLVTMGLWL--SLAS 283
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 380 FIIFIA--NVGVISVTMVVLVEILPQKIR----AVATSFCLGCLSFFAFaslkTFPLMMFHLGLAATMWFCAAVSVICLF 453
Cdd:cd17435 284 LLVYVAafSIGLGPMPWLVLSEIFPGGIRgramALTSSMNWGINLLISL----TFLTVTELIGLPWVCFIYTAMSLASLV 359
                       410
                ....*....|....
gi 45550112 454 YVVVCLEETKGRSM 467
Cdd:cd17435 360 FVIMFVPETKGCSL 373
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
33-455 2.32e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 52.56  E-value: 2.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  33 GIALGWLSPMLPKLLSPQETPLSFyidvneASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQ 112
Cdd:cd17477   9 GLGSGLLLPLLSLRLEREGVSTAL------IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 113 SIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVG------FVVSSHIAYHVipCAVVGLP 186
Cdd:cd17477  83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGplllalVGTAGALPFLI--AAVLLLL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 187 VLYVLLATRYPEPPqqlirwkREEEAEKSLRYYRRCdgpnvskeeerayqkhfdeMRLAIqqqnndtddnglsmsdfltk 266
Cdd:cd17477 161 ALVPLLLTRRAAPE-------IEEAESISLRRLLRI-------------------APLAL-------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 267 rsLKALATGLVLMVANIFTGTFAfnnyMSNIFDAVHTqldpntnTIIIGAVQILGTLASI---YLVDRYGRKILLIVSCA 343
Cdd:cd17477 195 --LGAFVAGFLEGAFYSLLPLYG----LRLGLSVAQA-------ALLLAAFVLGGLLLQWplgWLADRFDRRRVLLGCAL 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 344 GSGIGTSAFGLyafyaeeqkvdlsAFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFA 423
Cdd:cd17477 262 LGALAALLLPL-------------VPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVI 328
                       410       420       430
                ....*....|....*....|....*....|..
gi 45550112 424 SLKTFPLMMFHLGLAATMWFCAAVSVICLFYV 455
Cdd:cd17477 329 GPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
16-200 3.27e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.10  E-value: 3.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITFCHGIALGWLSPMLPKLLspQETPLSFyidvNEASWLGAVISIGGISGNFSFSYLMNRFG-RKVSI 94
Cdd:COG2807  14 AGRWLLLLAIVLVALNLRPAITSVGPLLPEIR--ADLGLSA----TQAGLLTTLPLLAFGLFAPLAPRLARRFGlERTLL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  95 YALAVPHTCIwFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIrGRLCSFFTLTMNTGIMVGFVVSSHIA 174
Cdd:COG2807  88 LALLLLAAGL-LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLA 165
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 45550112 175 YHV----------IPCAVVGLPVLYVLLATRYPEPP 200
Cdd:COG2807 166 AALgwrgalavwaLLALLALLLWLPLLRRRPAAAAA 201
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
265-463 3.71e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.82  E-value: 3.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 265 TKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHtqLDPNTNTIIIGA---VQILGTLASIYLVDRYGRKILLIVS 341
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG--ASPAQAGLVVTAyllGAALGAPLAGRLADRFGRRRVLLLG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 342 CAGSGIGTSAFGLyafyaeeqkvdlsAFSAWLpVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFA 421
Cdd:COG2814  82 LLLFALGSLLCAL-------------APSLWL-LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 45550112 422 FASLKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETK 463
Cdd:COG2814 148 ALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
4-195 1.68e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.80  E-value: 1.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   4 SIFKSGIFQWQYRRQLLVSLsatLITFCHGIALGWLSPMLPkLLSPQETPLSfyidvneASWLGAVISIGGISGNFS--- 80
Cdd:cd17325 186 ARLRSGLRLLLRDRRLLALF---LAIFVLAFAFGALEPFLP-LYAAELGGLS-------PAQIGLLFGAQGLASALSqpp 254
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  81 FSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMN 160
Cdd:cd17325 255 AGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS 334
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 45550112 161 TGIMVGFVVSSHIAYHV------IPCAVVGLPVLYVLLATR 195
Cdd:cd17325 335 LGMVLGPLLGGFLYDAFgfatpfLAAAALLLLAAVLFLLLR 375
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
63-192 3.00e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.03  E-value: 3.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  63 ASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEI 142
Cdd:cd17317  27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 45550112 143 ADNSIRGRLCSFFTLTMNTGIM----VGFVVSSHIAYHVIpcavVGLPVLYVLL 192
Cdd:cd17317 107 VGPKYRSFVGILFGLFWALGYMllalLAYLIRDWRWLQLA----ISLPGLLFLL 156
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-458 3.20e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.00  E-value: 3.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITFCHGIALGWLSPMLPKLLSpqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIY 95
Cdd:COG0738   4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKD------AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  96 ALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLC---SFFTL-TMNTGIMVGFVVSS 171
Cdd:COG0738  78 LGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNllhAFFSLgALLGPLLGGLLILL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 172 HIAYHVIP----CAVVGLPVLYVLLATRYPEppqqlirwkreeeaekslryyrrcdgpnvskeeerayqkhfdemrlaIQ 247
Cdd:COG0738 158 GLSLSWHLpyliLAVLLLLLALLFLRSKLPE-----------------------------------------------IE 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 248 QQNNDTDDNGLSMSDFLTKRSLKALATGLVLMVAniftGTFAFNNYMSNIFDAVHtQLDPNTNTIIIG---AVQILGTLA 324
Cdd:COG0738 191 EEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVG----AEGAIGDWLPLYLKDVL-GLSEATAALGLSlfwGGMTIGRFL 265
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 325 SIYLVDRYGRKILLIVSCAGSGIGTSafglyafyaeeqkvdLSAFSAWLPVTLMAFIIF-IANVGVISVTMVVLVEILPQ 403
Cdd:COG0738 266 GGFLLKRFGPVRLLRLSALLAAVGLL---------------LALLAPGPWLALIGLALVgLGLSLMFPTIFSLALDGLGK 330
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45550112 404 KIRAVATSfcLGCLSFFAFASLktFPLMMF---HLGLAATMWFCAAVSVICLFYVVVC 458
Cdd:COG0738 331 RTAAAVSA--VLIMGIVGGAIG--PPLIGFladAFGLRAAFLVPLVCYLLILLLALAL 384
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
65-212 4.80e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 45.74  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    65 WLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIAD 144
Cdd:TIGR01299 206 MLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLA 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   145 NSIRGR----LCSFFtltmntgiMVGFVVSSHIAYHVIP--------------------CAVVGLPVLYVLLA-TRYPEP 199
Cdd:TIGR01299 286 QEKRGEhlswLCMFW--------MIGGIYAAAMAWAIIPhygwsfqmgsayqfhswrvfVIVCAFPCVFAIGAlTFMPES 357
                         170
                  ....*....|...
gi 45550112   200 PQQLIRWKREEEA 212
Cdd:TIGR01299 358 PRFFLENGKHDEA 370
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
266-453 5.82e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 45.21  E-value: 5.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 266 KRSLKALATGLVLMVAniFTGTFafnnYMSNIFDAVHTQ----LDPNT--NTIIIGAV-QILGTLASIYLVDRYGRKILL 338
Cdd:cd17369 224 RRHWRALLLAIGLRLA--ENVLF----YLFTTFALSYATqtlgVDRSTvlLAVLIASVvAAITIPLFGWLSDRVGRRPVY 297
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 339 IVSCAGSGIgtSAFGLYAFyaeeqkvdLSAFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIR--AVATSFCLGC 416
Cdd:cd17369 298 LAGALLAAL--FAFPFFWL--------LDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRytGASLGYQLGA 367
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 45550112 417 LSFFAFASLKTFPLMMFHLGLAATMWFCAAVSVICLF 453
Cdd:cd17369 368 ILGGGFAPLIATALVAATGSWWPVALYLAALAVISLV 404
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
13-146 7.26e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 7.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  13 WQYRRQLLVSLSATLITFCHGIALGWLSPMLpkllspqetpLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKV 92
Cdd:COG2807 212 WRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL----------RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRR 281
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 45550112  93 SIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNS 146
Cdd:COG2807 282 PLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTP 335
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
16-194 1.05e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.13  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVslsATLITFCHGIALGWLSPMLPKLLSpqetpLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIY 95
Cdd:cd17316 176 RRRTLL---LILLWFFISFGYYGLTTFLPTYLQ-----TVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLV 247
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  96 ALAVPHTCIWFLFYFAQSIEWLYVARVFAGL--TGGGMFVVLPIFIGEIADNSIRGRLCSFftlTMNTGIMVGFVVSSHI 173
Cdd:cd17316 248 IGLILSGILALPLFYLLSGSPTLLLLLLFILsfFVGGVWGALYAYLAELFPTEVRATGVGL---SYNLGRLGGGGAPPLI 324
                       170       180
                ....*....|....*....|.
gi 45550112 174 AYHVIPCAVVGLPVLYVLLAT 194
Cdd:cd17316 325 ALLLASTGGTGVPALILALLA 345
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
2-194 1.07e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.53  E-value: 1.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   2 LISIFKSGIFQWQYRRQLLVSLSATLITFCHGIALGWLSPMLPKLLspqetplsFYIDVNEASWLGAVISIGGISGNFSF 81
Cdd:cd06173 193 LLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV--------LGGGAAGYGLLLAAFGVGALLGALLL 264
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  82 SYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNT 161
Cdd:cd06173 265 GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSG 344
                       170       180       190
                ....*....|....*....|....*....|...
gi 45550112 162 GIMVGFVVSSHIAYHVIPCAVVGLPVLYVLLAT 194
Cdd:cd06173 345 AMPLGALLAGLLADALGLSAVFLLAGALLLLAA 377
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
320-423 1.26e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 44.24  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   320 LGTLASIYLVDRYGRKILLIVSCAGSGIgtsaFGLyafyaeeqkvdLSAFSAWLPVtlMAFIIFIANVGVISVTMVVLV- 398
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAV----SGV-----------LTAFSPNYTV--FLVFRLLVGMGIGGIWVQAVVl 204
                          90       100
                  ....*....|....*....|....*..
gi 45550112   399 --EILPQKIRAVAtsfclGCLSFFAFA 423
Cdd:TIGR00898 205 ntEFLPKKQRAIV-----GTLIQVFFS 226
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
6-149 1.26e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 44.27  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112     6 FKSGIFQWQYRRQLLVslsATLITFCHGIALGWLSPMLPKLLSPQETPLSfyidvnEASWLGAVISIGGISGNFSFSYLM 85
Cdd:TIGR00895 239 VFKALFQGKTARITVL---LWLLYFMLLVGVYFLTNWLPKLMVELGFSLS------LAATGGALFNFGGVIGSIIFGWLA 309
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45550112    86 NRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRG 149
Cdd:TIGR00895 310 DRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRA 373
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
63-212 2.15e-04

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 43.75  E-value: 2.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  63 ASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEI 142
Cdd:cd17440  36 SGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEV 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 143 ADNSIRGR----LCSFFtltmntgiMVGFVVSSHIAYHVIP--------------------CAVVGLPVLYVLLA-TRYP 197
Cdd:cd17440 116 LAREKRGEhlswLCMFW--------MIGGIYASAMAWAIIPhygwsfsmgsayqfhswrvfVIVCALPCVSSVVAlTFMP 187
                       170
                ....*....|....*
gi 45550112 198 EPPQQLIRWKREEEA 212
Cdd:cd17440 188 ESPRFLLEVGKHDEA 202
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
270-423 4.86e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 42.36  E-value: 4.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 270 KALATGLVLMVANifTGTFAFNNYMSNIFdaVHTQLDPNTN-----TIIIGAVQILGTLASIYLVDRYGRKILLIVSCAG 344
Cdd:cd17368 222 RIILLGMLLVAGS--TVTFYFTTVYTPTY--AKTVLGLSARdsflvTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLA 297
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 345 SGIgtSAFGLYAFYAEEQkvdlSAFSAWLPVTLMAFIIfianvGVISVTMVV-LVEILPQKIRAV--ATSFCLGCLSFFA 421
Cdd:cd17368 298 ALV--TLYPVFAWLTAAP----SFGRLLLVLLVLSFFF-----GMYGGAMVVaLVELFPVRVRSTgfSLVYALAVAIFGG 366

                ..
gi 45550112 422 FA 423
Cdd:cd17368 367 FA 368
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
315-463 7.37e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.79  E-value: 7.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 315 GAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFGLyafyaeeqkvdlsAFSAWlpvtLMAFIIFIANVG---VIS 391
Cdd:cd17325  41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF-------------ATSYW----QLLLARFLQGLAsaaVWP 103
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550112 392 VTMVVLVEILPQKIRAVATSFclgclsFFAFASLKTF--PLMM----FHLGLAATMWFCAAVSVICLFYVVVCLEETK 463
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGI------FSSAIGLGFLigPLLGgllaDALGYRAPFLVCAALALLALVLALLLLPEPR 175
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
313-466 7.44e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.64  E-value: 7.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 313 IIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFGLyafyaeeqkvdlsafsAWLPVTLMAFIIF--IANVGVI 390
Cdd:cd06174  39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF----------------APSFWLLLLGRFLlgLGSGLID 102
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550112 391 SVTMVVLVEILPQKIRAVATSFCLGCLSFFAFAS--LKTFPLMMFHLGLAATMWFCAAVSVICLFYVVVCLEETKGRS 466
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGplLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
59-170 7.65e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 7.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  59 DVNEASWLGAVISIGGISGNFSFSYLMNRFGRK----VSIYALAVphTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVV 134
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKkafiIGLLLAAL--GLLLLFFLGPGNLWLLLVLAALAGIGLGAILVL 339
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45550112 135 LPIFIGEIADNS-------IRGRLCSFFTLTMNTGIMVGFVVS 170
Cdd:COG2211 340 PWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALA 382
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
83-201 8.41e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.43  E-value: 8.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  83 YLMNRFGRK------VSIYALAVphtciwFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFT 156
Cdd:cd17489  53 RLLDRFGRKrllligLLIFALAT------LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYG 126
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 45550112 157 LTMNTGIMVGFVVSSHIA----YHVIPCAVVGLPVLYVLLATRYPEPPQ 201
Cdd:cd17489 127 LATTLAMALGPALGLFLYqhlgFAVLFIVAAVLALLALLLVFLVKDPPP 175
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
81-194 8.48e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 41.45  E-value: 8.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  81 FSYLMNRFGRKVsIYALAvphTCIW----FLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFT 156
Cdd:cd17328  54 FGYLGDRYNRKW-ILAVG---ILIWsaatLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY 129
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45550112 157 LTMNTGIMVGFVVSSHIAYHVIP--CAVVGLPVLYVLLAT 194
Cdd:cd17328 130 FAIPLGSGLGYVVGGLVAQATGGwrWAFRVTGVLGVLLAI 169
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
311-452 1.19e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.00  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 311 TIIIGAVqILGTLASIYLVDRYGRKILLIVSCAGSGIgtsAFGLYAFyaeeqkvdLSAFSAWLPVTLMAFIIFIAnvgvI 390
Cdd:cd17478 237 SLFLFAG-AIGTLIGGPLSDRFGRRRVIIASLLLAAP---FLLLFLL--------TPGIWSYILLVLAGFLLFAS----F 300
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45550112 391 SVTMVVLVEILPQKiRAVATSFCLGcLSFFAfASLKTFPLMMF--HLGLAATMWFCAAVSVICL 452
Cdd:cd17478 301 PVTVVLAQELLPGN-VGLASGLMMG-LSFGL-GGIGAPVLGALadAFGLESVLLILALLPLLGA 361
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
16-170 1.42e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.64  E-value: 1.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  16 RRQLLVSLSATLITfchGIALGWLSPMLPKLLsPQETPLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFG-RKVSI 94
Cdd:cd17504 176 RRNVLLANITALLA---GFGMFMVFQLLPQLL-QLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGpRRVLL 251
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45550112  95 YALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVS 170
Cdd:cd17504 252 IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
27-199 2.34e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.87  E-value: 2.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  27 LITFCHGIALGWLSPMLPKLLSPQetpLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTCIWF 106
Cdd:cd17330   3 LVVFLDALGFGIVFPVLPFYVREF---NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 107 LFYFAQSIEWLYVARVFAGLTGGGmFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVS---SHIAYHVIPCAVV 183
Cdd:cd17330  80 LLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGgflSTPYGYALPFLVA 158
                       170
                ....*....|....*..
gi 45550112 184 -GLPVLYVLLATRYPEP 199
Cdd:cd17330 159 aALALLNLVLVLFFLPP 175
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
19-453 2.43e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 2.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  19 LLVSLSATLITFchgIALGWLSPMLPKLLSpqetplSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRK-VSIYAL 97
Cdd:cd17474   1 LYAVFFATLLAV---LGVSIVDPILPAIAE------ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKkVLLPGL 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  98 AVpHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYH- 176
Cdd:cd17474  72 LL-FGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIs 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 177 -VIPCAVVGLPVLYVLLATRYPEPPQqlirwkreeeaekslryyrrcdgpnvSKEEERAYQKHFDEMRLAiqqqnndtdd 255
Cdd:cd17474 151 wRYPFFLLAALIPVAFLAILFLLPEP--------------------------KEKAKSSSATKLRDLKKA---------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 256 nglsmsdFLTKRSLKALATGLVLMVaniftGTFAFNNYMSNIFDAvHTQLDPNTNTIIIGAVQILGTLASI----YLVDR 331
Cdd:cd17474 195 -------LRGRGLLTFLVSAFLYFF-----LYFAFLTYLPFLLEL-LYGISPIIIGLLFAGWSVLLALGSLfvgrLLKKR 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 332 YGRKILLIVSCAGSGIGTSAFGLyafyaeeqkvdlsafsaWLPVTLMAFIIFIANVG---VISVTMVVLVEILPQKIRAV 408
Cdd:cd17474 262 FGARRILVIGLLLYALSLLLLGF-----------------VPSLALLLIAIVLFGLGlglNLPLLTTLVTELAPEEERGT 324
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 45550112 409 ATSFcLGCLSFF--AFASLkTFPLMMFHLGLAATMWFCAAVSVICLF 453
Cdd:cd17474 325 ASSL-YNFVRFLgqAVGPL-LFGLLLEIFGLSAPFLVGAAIALAAAV 369
MFS_1 pfam07690
Major Facilitator Superfamily;
62-166 2.53e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.09  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112    62 EASWLGAVISIGGISGNFSFSYLMNRFGRKVSIY---ALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIF 138
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLlalLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
                          90       100
                  ....*....|....*....|....*...
gi 45550112   139 IGEIADNSIRGRLCSFFTLTMNTGIMVG 166
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
43-149 2.61e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.88  E-value: 2.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  43 LPKLLspQETPLSfyidVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSI---YALAVphTCIWFLFYFAQSIEWLYV 119
Cdd:cd17365 194 LPKLM--VEAGYS----LSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLalfFALGA--VSLALLGVSPASLVLLYV 265
                        90       100       110
                ....*....|....*....|....*....|
gi 45550112 120 ARVFAGLTGGGMFVVLPIFIGEIADNSIRG 149
Cdd:cd17365 266 LVFLAGACVNGAQVGLYALAARFYPTEVRA 295
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
62-134 2.62e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 39.93  E-value: 2.62e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45550112  62 EASWLGAVISIGGISGNFSFSYLMNRFG-RKVSIYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLtGGGMFVV 134
Cdd:cd17341  35 QIGLLVAIPVLAGALLRLPYGFLCDRFGgRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGF-AGANFAS 107
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
66-212 2.83e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 39.91  E-value: 2.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  66 LGAVISIGGISGNFSFSYLMNRFGRK-VSIYALAVpHTCIWFLFYFAQSIEWLYVARVFAGLTGGGMFVVLPIFIGEIAD 144
Cdd:cd17438  39 LGLIVYLGMMAGAFIWGGLADKLGRKrCLIISLAI-NASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLA 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112 145 NSIRGR----LCSFFTL------TMNTGIMV----GFVVSSHIAYH-----VIPCAvvgLPVLYVLLATRY-PEPPQQLI 204
Cdd:cd17438 118 REKRGEhlswLCMFWMIgglyasAMAWSIIPhygwGFSMGTNYHFHswrvfVIICA---LPCIASIIALKFmPESPRFLL 194

                ....*...
gi 45550112 205 RWKREEEA 212
Cdd:cd17438 195 EMGKHDEA 202
MFS_1 pfam07690
Major Facilitator Superfamily;
272-457 6.59e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.55  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   272 LATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLdpNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSA 351
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEI--GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112   352 FGLyafyaeeqkvdlsaFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLM 431
Cdd:pfam07690  79 LLF--------------ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
                         170       180
                  ....*....|....*....|....*.
gi 45550112   432 MFHLGLAATMWFCAAVSVICLFYVVV 457
Cdd:pfam07690 145 ASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
63-165 9.61e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.32  E-value: 9.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550112  63 ASWLGAVISIGGISGNFSFSYLMNRFGRK------VSIYALAVphtciwFLFYFAQSIEWLYVARVFAGLTGGGMFVVLP 136
Cdd:cd17473 235 IGLALAIASLAGAIGALLFGRLKRRLGKRrllaigFALMALGF------LLLALASGLWVVLLGAILAGLGFGLLLPTLN 308
                        90       100
                ....*....|....*....|....*....
gi 45550112 137 IFIGEIADNSIRGRLCSFFTLTMNTGIMV 165
Cdd:cd17473 309 SWAMSLVPPELRGRAMGIVTSAFFLGQFL 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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