|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
31-433 |
4.82e-154 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 440.45 E-value: 4.82e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 31 ITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLM 110
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 111 PTIIWTAgsiksyaIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGW 190
Cdd:cd17380 82 PLLAYSS-------LPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 191 SYVFRVIGLMGIAWALVLRYYAMagernriiniatpsrlcankspaetsavpwlryfrrlSFWACVLTHACEMNCFFVLL 270
Cdd:cd17380 155 PSVFYFFGLLGLLWALVWLIYLP-------------------------------------PVWAIIVAHFCMNWGFYILL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 271 SWLPTYFHDGF-PHAKGWVVNMIPWLALPPCTLFAKYLTTRLLAREWHTTTVRKVIQSCCFAAQNLALFVMSRTSDFHTA 349
Cdd:cd17380 198 SWLPTYFHEVLvPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 350 LICMTIIIGGTGFHNNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGINLVGWIIF 429
Cdd:cd17380 278 LLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVF 357
|
....
gi 19920686 430 IVFG 433
Cdd:cd17380 358 LLFG 361
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
60-433 |
6.42e-72 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 231.35 E-value: 6.42e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 60 WSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAgsiksyaIPFIVAIRILNGALQ 139
Cdd:cd17318 53 WSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGG-------YGALIVLRILQGLAQ 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 140 GVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLRYYAMAgernr 219
Cdd:cd17318 126 GVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVLP----- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 220 iiniatpsrlcankspaetsavpwlryfrrlsFWACVLTHACEMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLAL 297
Cdd:cd17318 201 --------------------------------VWAIVVAHFGHNWGFYTLLTELPTYMSDvlHFNIKSNGFLSSLPYLAM 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 298 PPCTLFAKYLTTRLLARE-WHTTTVRKVIQSCCFAAQNLALFVMS-RTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLA 375
Cdd:cd17318 249 WICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLGPGVFLIALGyLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLA 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19920686 376 PLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQS---WPMVFSAAAGINLVGWIIFIVFG 433
Cdd:cd17318 329 PNYAGTLMGITNTAATIAGIISPLIVGAIVKNDQTigqWRIVFFISAAIYILGAIFYLIFG 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-433 |
1.10e-42 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 153.87 E-value: 1.10e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 30 FITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFL 109
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 110 MptiiwtaGSIKSYAIpfIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFG 189
Cdd:COG2271 92 F-------GFATSFWQ--LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 190 WSYVFRVIGLMGIAWALvlryyamagernriiniatpsrlcankspaetsavpwlryfrrLSFWACVLTHACEMNCFFVL 269
Cdd:COG2271 163 WRAAFLILGLPGLLLAL-------------------------------------------LRFWLLALAYFLVYFALYGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 270 LSWLPTYFHD--GFPHAKGWVVNMIPWLALPPCTLFAKYLTTRLLARewhtttvRKVIQSCCFAAQNLALFVMSRTSDFH 347
Cdd:COG2271 200 LTWLPTYLVEvrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAALALLLLALLPSPA 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 348 TALICMTIIIGGTGFHNNAVTVNPQDLAPLH-SGSVFGLMNTVGAIPGFLGVYLAGHILELTqSWPMVFSAAAGINLVGW 426
Cdd:COG2271 273 LAIALLFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAA 351
|
....*..
gi 19920686 427 IIFIVFG 433
Cdd:COG2271 352 LLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-431 |
2.98e-40 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 147.33 E-value: 2.98e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 27 RVWFITLITGTCML-YSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSL 105
Cdd:cd17319 1 RWRIIPLLFLAYVInYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 106 ITFLMPTIiwtagsiksYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLL 185
Cdd:cd17319 81 FTALTGFA---------TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 186 DYFGWSYVFRVIGLMGIAWALVlryyamagernriiniatpsrlcankspaetsavpWLRYFRRlsFWACVLTHACEMNC 265
Cdd:cd17319 152 LLFGWRWAFIIEGLLGLLLAVL-----------------------------------WWFYLRQ--VWGLALGYFGINYA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 266 FFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLalppCTLFAKYLTTRLLarEWHTTTVRKVIQSCCFAAQNLALFVMSRT 343
Cdd:cd17319 195 LYGLLTWLPTYLKQarGFSLKQVGLLAAIPFL----AGAIGMILGGRLS--DRLLRGARRLVIIIGLLLAAVGLLLAYLT 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 344 SDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPL-HSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGIN 422
Cdd:cd17319 269 TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVA 348
|
....*....
gi 19920686 423 LVGWIIFIV 431
Cdd:cd17319 349 LLAALLVLL 357
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
60-433 |
5.45e-35 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 133.75 E-value: 5.45e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 60 WSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIiwtagsiKSYAIPFIVAIRILNGALQ 139
Cdd:cd17381 62 WDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLA-------ADLGAGYLIAVRALEGLGE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 140 GVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLRYYAMagernr 219
Cdd:cd17381 135 GVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVM------ 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 220 iiniatpsrlcankspaetsavpwlryfrrlSFWACVLTHACEMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLAL 297
Cdd:cd17381 209 -------------------------------PLWAIVVAHFSYNWTFYTLLTLLPTYMKEilRFDIQENGFLSALPYLGC 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 298 PPCTLFAKYLTTRLLARE-WHTTTVRKVIQSCCFAAQNLALFVMSRTS-DFHTALICMTIIIGGTGFHNNAVTVNPQDLA 375
Cdd:cd17381 258 WLFMILSGQIADNLREKQnFSTVCVRKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFSASGFNINHLDIA 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 376 PLHSGSVFGLMNTVGAIPGFLGVYLAGHILE--LTQSWPMVFSAAAGINLVGWIIFIVFG 433
Cdd:cd17381 338 PSYAGILLGITNTFATIPGMVGPVIAKSLTHnnTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
60-433 |
1.15e-31 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 124.37 E-value: 1.15e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 60 WSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTiiwtaGSIKSYAipFIVAIRILNGALQ 139
Cdd:cd17382 46 WTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPI-----AARVHYG--CVIFVRILQGLVE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 140 GVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLRYYAMAgernr 219
Cdd:cd17382 119 GVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLVSMP----- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 220 iiniatpsrlcankspaetsavpwlryfrrlsFWACVLTHACEMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLAL 297
Cdd:cd17382 194 --------------------------------VYAIIVANFCRSWTFYLLLISQPAYFKEvfGFDISKVGILSALPHLVM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 298 PPCTLFAKYLTTRLLARE-WHTTTVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAP 376
Cdd:cd17382 242 TIIVPIGGQLADYLRSRGiLSTTAVRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAP 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 19920686 377 LHSGSVFGLMNTVGAIPGFLGVYLAGHIL--ELTQSWPMVFSAAAGINLVGWIIFIVFG 433
Cdd:cd17382 322 RYASILMGISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-432 |
1.56e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 121.53 E-value: 1.56e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 26 KRVWFITLITGTCML--YSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGW 103
Cdd:COG2223 1 SGRWRVLLLATLAFFlaFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 104 SLITFLMptiiwtagsikSYAIPFIV--AIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMG 181
Cdd:COG2223 81 GIGLLLL-----------ALAVSYWLllLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 182 SFLLDYFGWSYVFRVIGLMGIAWALVLRYYAMAGERNRiiniatpsrlcanKSPAETSAVPWLRYFRRLSFWACVLTHAC 261
Cdd:COG2223 150 PLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGA-------------AAAAKASLRDQLEALRDPRFWLLSLLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 262 EMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLALPPCTLFAKYLTTRLLAREWHTTTvrkviqsccFAAQNLALFV 339
Cdd:COG2223 217 TFGSFIGFSSWLPPYLVDqfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV---------FALMALGLLL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 340 MSRTS-DFHTALICMTIIIGGTGFHNNAV-TVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSA 417
Cdd:COG2223 288 LALALgSLWLFLVLFLLLGLALGGGNGAVfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLV 367
|
410
....*....|....*
gi 19920686 418 AAGINLVGWIIFIVF 432
Cdd:COG2223 368 FAVLALVALVLTLLL 382
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
59-436 |
1.67e-30 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 122.54 E-value: 1.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 59 KWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPtiiWTAGSiksyAIPFIVAIRILNGAL 138
Cdd:TIGR00894 72 KWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIP---WAAGG----GIALVVFCRVIQGLA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 139 QGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYF-GWSYVFRVIGLMGIAWALVlrYYAMAGER 217
Cdd:TIGR00894 145 QGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLL--WFVFPADD 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 218 NRI-------INIATPSRLCANKSPAETSAvPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHD---------GF 281
Cdd:TIGR00894 223 PSIhpciskfEKKYINSSLQGQKGSTRQSL-PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWvlrvsgkenGL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 282 PHAkgwvvnmIPWLALPPCTLFAKYLTTRLLAREWHT-TTVRKViqsCCFAAQ----NLALFVMSRTSDFHTALICMTII 356
Cdd:TIGR00894 302 LSS-------LPYLFAWLCSIFAGYLADFLKSSKTLSlTAARKI---FNGIGGlgpgIFAYALPYLSAAFYLTIIILTLA 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 357 IGGTGFHNNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILEL--TQSWPMVFSAAAGINLVGWIIFIVFGS 434
Cdd:TIGR00894 372 NAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKNVWLIVFLIMAFVNILCVIFYLIFGS 451
|
..
gi 19920686 435 AE 436
Cdd:TIGR00894 452 AE 453
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-397 |
2.26e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.74 E-value: 2.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 32 TLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMp 111
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 112 tiiwtagsIKSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWS 191
Cdd:pfam07690 80 --------LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 192 YVFRVIGLMGIAWALVLRYYAMAGERNRIIniatpsrlcANKSPAETSAVPWLRYFRRLSFWaCVLTHACEMNCFFVLLS 271
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPK---------PAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 272 WLPTYFHD-GFPHAKGWVVNMIPWLALPPCTLFAKYLTTRLLARewhtttVRKVIQSCCFAAQNLALFVMSRTSDFHTAL 350
Cdd:pfam07690 222 YLPLYQEVlGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR------RRLLLALLLLILAALGLLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 19920686 351 ICMTIIIGGTGFHNNAVTVNPQDLAPLH-SGSVFGLMNTVGAIPGFLG 397
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEeRGTASGLYNTAGSLGGALG 343
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
36-432 |
6.93e-24 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 102.80 E-value: 6.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 36 GTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIiw 115
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 116 tagsiksYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFR 195
Cdd:TIGR00893 80 -------GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 196 VIGLMGIAWALVLRYY---------AMAGERNRIINIATPSRLcANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCF 266
Cdd:TIGR00893 153 IEGVLGIIWGVLWLKFipdppqkakWLTEEEKYIVVGGLLAEQ-QGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 267 FVLLSWLPTYFHDGFphakGWVVNMIPWLALPP-------CTLFAkYLTTRLLAREWHTTTVRKVIQSCCFaaqnLALFV 339
Cdd:TIGR00893 232 GFFLTWFPTYLVQER----GLSILEAGFMASLPgivgfigMILGG-RLSDLLLRRGKSLVFARKTAIIAGL----VLSLL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 340 MSRTSDFHTALICMTIIIGGTGFHNNAVTV--NPQDLAPLHS-GSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFS 416
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFFGLGAGAIGwaLISDNAPGNIaGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALM 382
|
410
....*....|....*.
gi 19920686 417 AAAGINLVGWIIFIVF 432
Cdd:TIGR00893 383 VVAALALIGALSYLLL 398
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-392 |
9.80e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.81 E-value: 9.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 22 TRHEKRVWFITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAI 101
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 102 GWSLITFLMPTiiwtagsikSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMG 181
Cdd:COG2814 84 LFALGSLLCAL---------APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 182 SFLLDYFGWSYVFRVIGLMGIAwALVLRYYAMAGERnriiniatpsrlcanKSPAETSAVPWLRYFRRLSFWACVLTHAC 261
Cdd:COG2814 155 GLLADLFGWRWVFLVNAVLALL-ALLLLLRLLPESR---------------PAARARLRGSLRELLRRPRLLLLLLLAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 262 EMNCFFVLLSWLPTYFHDGFPHAKGWVVNMIPWLALppCTLFAKYLTTRLLARewhttTVRKVIQSCCFAAQNLALFVMS 341
Cdd:COG2814 219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL--GGVLGALLAGRLADR-----FGRRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 19920686 342 RTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPLHS-GSVFGLMNTVGAI 392
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEArGRASGLYNSAFFL 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-430 |
1.85e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.49 E-value: 1.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 39 MLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTiiwtag 118
Cdd:cd06174 7 LTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF------ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 119 sikSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDY--FGWSYVFRV 196
Cdd:cd06174 81 ---APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 197 IGLMGIAWALVLryyamageRNRIINIATPSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTY 276
Cdd:cd06174 158 AAALALLAAILL--------LLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 277 FHDGFphAKGWVVNMIPWLALPPCTLFAKYLTTRLLAREWhtttVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTII 356
Cdd:cd06174 230 LLDLG--GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI----GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19920686 357 IGGTGFHNNAVTVNPQDLAPLHS-GSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGINLVGWIIFI 430
Cdd:cd06174 304 GFGLGGLLPLSFALIAELFPPEIrGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-432 |
3.20e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.71 E-value: 3.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 61 SKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTiiwtagsikSYAIPFIVAIRILNGALQG 140
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF---------ATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 141 VHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAwALVLRYYAMAGERNRI 220
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-ALVLALLLLPEPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 221 IniatpsrlcANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGFPHAKGWV--VNMIPWLALP 298
Cdd:cd17325 179 N---------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIglLFGAQGLASA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 299 PCTLFAKYLTTRLLArewhtttvRKVIQSCCFAAqNLALFVMSRTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPL- 377
Cdd:cd17325 250 LSQPPAGKLSDRIGR--------KPLILIGLLLS-AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPe 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 19920686 378 HSGSVFGLMNTVGAIPGFLGVYLAGHILElTQSWPMVFSAAAGINLVGWIIFIVF 432
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-208 |
4.12e-18 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 85.40 E-value: 4.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 30 FITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFL 109
Cdd:cd17312 5 FLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 110 MPTiiwtagsikSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFG 189
Cdd:cd17312 85 MGF---------STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG 155
|
170
....*....|....*....
gi 19920686 190 WSYVFRVIGLMGIAWALVL 208
Cdd:cd17312 156 WRAAFLVPGIVGLVVAIIL 174
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
46-430 |
7.70e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.66 E-value: 7.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 46 TMPLLvPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTiiwtagsikSYAI 125
Cdd:cd17324 18 IQGLL-PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL---------APSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 126 PFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWA 205
Cdd:cd17324 88 ALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 206 LVLRYYamagernriiniaTPSRLcANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGFPHAK 285
Cdd:cd17324 168 LLLWRL-------------LPSLP-PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 286 GWVVNMIPWLALppCTLFAKYLTTRLLAREWHtttvRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHNN 365
Cdd:cd17324 234 SAIIGLLLLFGV--AGVVGSPLAGRLADRGGR----RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19920686 366 AVTVNpQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTqSWPMVFSAAAGINLVGWIIFI 430
Cdd:cd17324 308 LQTRV-LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-429 |
2.83e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.65 E-value: 2.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 48 PLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMptiiwtaGSIKSYaiPF 127
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM-------ALVGSY--PV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 128 IVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALV 207
Cdd:cd17475 87 LLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 208 lryyAMAGERNRiiniATPSRLCANKSPAETSAvpwLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGF---PHA 284
Cdd:cd17475 167 ----FWLFYREP----PAASAATESASTLLRSL---KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLglsVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 285 KGWVVNMIPWLALPPCTLFAKyLTTRLLAREwhtttvRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIII----GGT 360
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGR-VSDRVFGGR------RRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLIllglFAI 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19920686 361 GFHNNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGINLVGWIIF 429
Cdd:cd17475 309 GWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
41-208 |
3.40e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 64.32 E-value: 3.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 41 YSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTiiwtagsi 120
Cdd:TIGR00881 8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGF-------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 121 kSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSAL-GTLLTGIMGSFLLDYFGWSYVFRVIGL 199
Cdd:TIGR00881 80 -STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGI 158
|
....*....
gi 19920686 200 MGIAWALVL 208
Cdd:TIGR00881 159 IAIIVSLIC 167
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-210 |
7.99e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.52 E-value: 7.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 16 DTQSIWTRHEKRVWFITLITGTCMLYSTrTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRV 95
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDF-TIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 96 ILFAAIGWSLITFLM---PTIIWtagsiksyaipfIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSAL 172
Cdd:COG0477 82 LLIGLLLFGLASLLCglaPSPEL------------LIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGL 149
|
170 180 190
....*....|....*....|....*....|....*...
gi 19920686 173 GTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLRY 210
Cdd:COG0477 150 GLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
29-432 |
9.38e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.06 E-value: 9.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 29 WFITLITGTCMLYS--TRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLI 106
Cdd:cd17355 2 WVVLAVTFLILILSwgIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 107 TFLMPTIIWTAGsiksyaipFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLD 186
Cdd:cd17355 82 LVLLALATSLWQ--------LYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 187 YFGWSYVFRVIGLMGIAwALVLRYYAMAGERnriiniATPSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHA-CEMNC 265
Cdd:cd17355 154 AFGWRTALLVLALLALL-VLVPVLLLLRRRP------ADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFlCGFAV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 266 FFVLLSWLPTYFHDGFPHAKGWVVNMIPWLALPPCTLFAKYLTTRLLARewHTTTVRKVIQSCCfaaqnLALFVMSRTSD 345
Cdd:cd17355 227 VGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR--RLLAASYALRALG-----LALLLLLPFPP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 346 FHTALICMTI--IIGGTGFHNNAVTVnpQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGINL 423
Cdd:cd17355 300 LALLLFAALFglGWGATVPLTAALAA--RYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGL 377
|
....*....
gi 19920686 424 VGWIIFIVF 432
Cdd:cd17355 378 IAALLVLPI 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-212 |
1.86e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.21 E-value: 1.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 23 RHEKRVWFITLITGTCML--YSTRTTMPLLVpavASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAA 100
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFafGALEPFLPLYA---AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 101 IGWSLITFLMPTiiwtagsikSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIM 180
Cdd:cd17325 273 LLSAVALLLLPL---------ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
170 180 190
....*....|....*....|....*....|..
gi 19920686 181 GSFLLDYFGWSYVFRVIGLMGIAWALVLRYYA 212
Cdd:cd17325 344 GGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
45-433 |
8.16e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 60.27 E-value: 8.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 45 TTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMptiiWTAGSIksya 124
Cdd:COG2807 35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR----SLAPSV---- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 125 iPFIVAIRILNGALQGVHFPSMISLTSQnLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMG--- 201
Cdd:COG2807 107 -ALLLAGTALIGAGIAVGNVLLPGLIKR-WFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLAlla 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 202 -IAWALVLRyyamagernriiniATPSRlcankSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHD- 279
Cdd:COG2807 185 lLLWLPLLR--------------RRPAA-----AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDa 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 280 GF-PHAKGWVVNMIPWLALPPcTLFAKYLTTRLLAREWHTTTVrkviqSCCFAAQNLALFVMSrtsdfHTALICMTIIIG 358
Cdd:COG2807 246 GLsAATAGLLLSLFQLAGIPG-SLLVPLLADRLGDRRPLLLLL-----GLLGLAGLLGLLLAP-----GSLPWLWAVLLG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19920686 359 -GTGFHNNAVTVNPQDLA--PLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGINLVGWIIFIVFG 433
Cdd:COG2807 315 lGQGGLFPLALTLIGLRArtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
52-275 |
1.34e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 59.68 E-value: 1.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 52 PAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILfaaigWSLITFlmptIIWTAGSIKSYAIPFIVAI 131
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL-----WSILLF----SVFTLLCALATNVTQLLIL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 132 RILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLRY- 210
Cdd:TIGR00895 112 RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRf 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 211 ----YAMAGERN-----RIINIATPSRLCANKS--PAETSAVPWLRYFRRLSF--------WACVLTHACEMNCFFVLLS 271
Cdd:TIGR00895 192 lpesIDFLVSKRpetvrRIVNAIAPQMQAEAQSalPEQKSTQGTKRSVFKALFqgktaritVLLWLLYFMLLVGVYFLTN 271
|
....
gi 19920686 272 WLPT 275
Cdd:TIGR00895 272 WLPK 275
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
67-319 |
2.42e-09 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 58.80 E-value: 2.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 67 TVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMptiiwtaGSIKSYaiPFIVAIRILNGALQGVHFPSM 146
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT-------AAVKNF--GGLIALRFFLGLFESGVFPGF 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 147 ISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDY------FGWSYVFRVIGLMGIAWALVLRYYAMAG----- 215
Cdd:cd17327 116 ILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNpskaw 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 216 ---ERNRIINIAtpsRLCANKSPAETSAVPW---LRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHD-GFPHAKGWV 288
Cdd:cd17327 196 fltEEEKELAVE---RLRANQTGKGDQKFKWkqiKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSlGFYSLQTNL 272
|
250 260 270
....*....|....*....|....*....|.
gi 19920686 289 VNMIPWLALPPCTLFAKYLTTRLLAREWHTT 319
Cdd:cd17327 273 LSVPIGALGAVSLLIAALLSDRFKKRGLFAI 303
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
25-211 |
4.49e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 58.00 E-value: 4.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 25 EKRVWFITLITGTCMLYSTRTTMPLlVPAVASAQKWSKTDSGTVLSSFFWGYTL-TQVVGGYFSDRFGGQRVILFAAIGW 103
Cdd:cd17490 193 DKKLLFFSLLAILQQMITFSTTFGF-TPLIAKQLGASSFQLGLLSIIYLLPNALaSLLSGTLFYKKLGERNTIIIGFLLL 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 104 SLITFLMPTIIWtagsiksyaIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSF 183
Cdd:cd17490 272 GAYCFLIPFAPN---------LTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGI 342
|
170 180
....*....|....*....|....*...
gi 19920686 184 LLDYFGWSYVFRVIGLMGIAWALVLRYY 211
Cdd:cd17490 343 ISEAFGLQTGFFVIGVIALLAAILSLAY 370
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
49-428 |
9.99e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.84 E-value: 9.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 49 LLVPAVASAQKW--SKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLM---PTIIWtagsiksy 123
Cdd:cd17316 20 FVAPVLAAEFSLglSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIgllPTPIL-------- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 124 aipfIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIA 203
Cdd:cd17316 92 ----LLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 204 WALVLryyamagernriiniatpsrlcankspaetsavpwlrYFRRLSFWACVLTHACEMNCFFVLLSWLPTYF--HDGF 281
Cdd:cd17316 168 PALLA-------------------------------------LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLqtVLGL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 282 PHAKGWVVNMIPWLALPPCTLFAKYLTTRLlarewhttTVRKVIQSCCFAAQNLA-LFVMSRTSDFHTALICMTIIIGGT 360
Cdd:cd17316 211 SPATSSLYLLLISLGALVGALIAGLLSDRI--------GRKKTLVIGLILSGILAlPLFYLLSGSPTLLLLLLFILSFFV 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19920686 361 GFHNNAVTVNPQDLAPLHS-GSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGINLVGWII 428
Cdd:cd17316 283 GGVWGALYAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
68-429 |
1.46e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 56.43 E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 68 VLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLmptiIWTAGSIksyaiPFIVAIRILNGAlqGVHFPSMI 147
Cdd:cd17320 39 TLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL----CALASSI-----EQLLIARFLQGL--GAAAGSVV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 148 SLTSQNLC--PNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAwALVLRYYAMagernriiniat 225
Cdd:cd17320 108 ARAIVRDLysGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLL-LLLLVLLFL------------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 226 PSRLCANKSPAETSAVP--WLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGF---PHAKGWvvnmipWLALPPC 300
Cdd:cd17320 175 PETLPEEKRKPLLSSLLraYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLglsPAQFGL------LFALNAI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 301 TLFAKYLTTRLLAREWHTTTVRKVIQSCCFAAqNLALFVMSRTSD--FHTALICMTIIIGGTGFHNNAVTVNPQDLAPLH 378
Cdd:cd17320 249 ALILGSLLNGRLVRRFGPRRLLRLGLLLLLAA-ALVLLLAALLGGlsLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHV 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 19920686 379 SGSVFGLMNTVGAIPGFLGVYLAGHILELTQsWPM--VFSAAAGINLVGWIIF 429
Cdd:cd17320 328 AGTASALLGFLQFLIGALAGALVGLLPNGTA-LPMglLILVLGLLALLLLILL 379
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
30-419 |
1.98e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 55.85 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 30 FITLITGTCMLYSTRTTMPLlvPAVASAQKWSKTDSGTV---LSSFFWGYTLTQVVGGYFSDRFGGQRVILFAaigwsLI 106
Cdd:TIGR00710 6 FALLLGCLSILGPLGIDMYL--PAFPEIAADLSTPASIVqmtLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLG-----LF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 107 TFLMPTIiwtaGSIKSYAIPFIVAIRILNGAlqGVHFPSMIS-LTSQNLCPNERSS-FFGLLTAGSALGTLLTGIMGSFL 184
Cdd:TIGR00710 79 IFALSSL----GLALSNNIETLLVLRFVQAF--GASAGSVISqALVRDIYPGEELSrIYSILMPVLALAPAVAPLLGGYI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 185 LDYFGWSYVFRVIGLMGIawALVLRYYAMAGERNRIIniatpsrlcaNKSPAETSAVPWLRYFRRLSFWACVLTHACEMN 264
Cdd:TIGR00710 153 LVWLSWHAIFAFLSLAGI--LLSALIFFILPETLPYE----------ARIQISTYFETFLLLLKSKMFWGYALIYGASFG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 265 CFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLALppctLFAKYLTTRLLaREWHTTTVrKVIQSCCFAAQNLALFVMSR 342
Cdd:TIGR00710 221 GFFAFFSGAPFVYIDimGVSPSVFGLLFALNIIAM----IFGGFLNGRFI-KKWGAKSL-LRMGLILFAVSAVLLEITAI 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 343 TSDFHTALICMTIIIGGTGfhNNAVTVNPQDLA----PLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTqSWPMVFSAA 418
Cdd:TIGR00710 295 LGLGSWAMIIGPMMFVGIG--NSMISSIAMAYAledfPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNT-AWPMSLSCL 371
|
.
gi 19920686 419 A 419
Cdd:TIGR00710 372 V 372
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
50-209 |
2.99e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 55.28 E-value: 2.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 50 LVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTiiwtAGSIKSYAIpfiv 129
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF----AQSVLQLAL---- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 130 aIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLR 209
Cdd:cd17365 93 -LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR 171
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
48-430 |
3.24e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 3.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 48 PLLvPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFaaigwSLITFlmptIIWTAGSIKSYAIPF 127
Cdd:cd17474 20 PIL-PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLP-----GLLLF----GIGGLLCGLSDSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 128 IVAIRilngALQGVHFPSMISLT----SQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDyFGWSYVFRVIG-LMGI 202
Cdd:cd17474 90 LLAGR----ALQGIGAAGLGPLAltliGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAaLIPV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 203 AWALVLryyamagernrIINIATPSRlcaNKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGF- 281
Cdd:cd17474 165 AFLAIL-----------FLLPEPKEK---AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYg 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 282 --PHAKGWVvnMIPWLALppcTLFAKYLTTRLLAREWHTTTVRKViqscCFAAQNLALFVMSRTSDFHTALICMTIIIGG 359
Cdd:cd17474 231 isPIIIGLL--FAGWSVL---LALGSLFVGRLLKKRFGARRILVI----GLLLYALSLLLLGFVPSLALLLIAIVLFGLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19920686 360 TGFHNNAVTVNPQDLAPLHS-GSVFGLMNTVGAIPGFLGVYLAGHILELtQSWPMVFSAAAGINLVGWIIFI 430
Cdd:cd17474 302 LGLNLPLLTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEI-FGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-281 |
3.80e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.93 E-value: 3.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 41 YSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLmptiiwtAGSI 120
Cdd:cd17328 12 YMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL-------SSFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 121 KSYAIpfIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYF-GWSYVFRVIGL 199
Cdd:cd17328 85 PNFWQ--LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 200 MGIAWALVLRYYAMAGERNRIINIATPSRLcANKSPAETSAVpwlryFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHD 279
Cdd:cd17328 163 LGVLLAILLLLFVREPPRGAAEGGVMAKST-ATSFLADLKAL-----AKNPSFILSTLGFTAVSFVTGALAFWAPTFFLR 236
|
..
gi 19920686 280 GF 281
Cdd:cd17328 237 AF 238
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
27-208 |
7.94e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.11 E-value: 7.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 27 RVWFITLItGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIgwSLI 106
Cdd:COG2271 181 RFWLLALA-YFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIG--LLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 107 TFLMPTIIWTAGSIKSYAIPFIVAirilnGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLD 186
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLA-----GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
170 180
....*....|....*....|..
gi 19920686 187 YFGWSYVFRVIGLMGIAWALVL 208
Cdd:COG2271 333 ATGYQAAFLLLAALALLAALLA 354
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
45-205 |
9.82e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 53.72 E-value: 9.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 45 TTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIG---WSLITFLMPTIiwtagsik 121
Cdd:cd17321 13 TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALfglASLLCALAPSL-------- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 122 syaiPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRV---IG 198
Cdd:cd17321 85 ----AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLInvpIG 160
|
....*..
gi 19920686 199 LMGIAWA 205
Cdd:cd17321 161 LVALLLA 167
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
78-431 |
5.50e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.44 E-value: 5.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 78 LTQVVGGYFSDRFG---GQR--VILFAAIGWSLITFLMPTIIWTAGSIKS-YAIPFIVAIRILNGALQGVHFpSMISLTS 151
Cdd:COG2211 61 ITDPLIGALSDRTRtrwGRRrpWILIGAIPLALSFVLLFTAPDLSPTGKLiYALVTYLLLGLAYTLVNIPYS-ALGAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 152 QNlcPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVlryyamagernrIINIATPSRLCA 231
Cdd:COG2211 140 PD--YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLG------------LLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 232 NKSPAETSAVPWLRYFRRL----SFWACVLTHACEMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLALPPCTLFAK 305
Cdd:COG2211 206 ERPVPEEEKVSLKESLKALlknrPFLLLLLAYLLFFLALALVAALLLYYFKYvlGLSAALVGLLLALYFLAALLGAPLWP 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 306 YLTTRLLAREWHTTtvrkviqSCCFAAQNLALFVMSRTSDFHTALICMTIIiggtGFHNNAVTVNPQ----DLAPLH--- 378
Cdd:COG2211 286 RLAKRFGKKKAFII-------GLLLAALGLLLLFFLGPGNLWLLLVLAALA----GIGLGAILVLPWamlaDVVDYDewk 354
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 19920686 379 -----SGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGINLVGWIIFIV 431
Cdd:COG2211 355 tgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
33-432 |
9.92e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.69 E-value: 9.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 33 LITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPT 112
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 113 IIWtagsiksyAIPFIVAIrILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYfGWSY 192
Cdd:cd17329 85 AHS--------PWLFAIAL-VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 193 VFRVIGLMGIAWALVLRYYamagernriINIATPSRLcanKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSW 272
Cdd:cd17329 155 LFLAAAVLFLLAALVLLFL---------LPETRPKRR---AAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 273 LPTYFHDgfphAKGWVVNMIPWLaLPPCTLFAKYLTTRLLAREWHTTTVRKVIQSCCFAAqnLALFVMSRTSDFHTALIC 352
Cdd:cd17329 223 LPVYVVE----ILGLGESLLGLL-LALNALLIVLLQFPVARLVERFRLRKILMIGILLFA--IGFAVLAFANTLAVLILA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 353 MTIIIGGTGFHNNAVTVNPQDLAPLHS-GSVFGLMNTVGAIPGFLGVYLAGHILELTQSWpMVFSAAAGINLVGWIIFIV 431
Cdd:cd17329 296 MIVLTLGEMLVFPAVQTLVAALAPPDKrGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG-LPWLILAALGLIAAALLLG 374
|
.
gi 19920686 432 F 432
Cdd:cd17329 375 L 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
50-281 |
1.02e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.62 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 50 LVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLM---PTIIWTAGSIksyaip 126
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFalaPSYPLLLLAL------ 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 127 FIVAirILNGALQGVHFPSMISLTsqnlcPNERSSFFGLLTAGSALGTLLTGIMGSFLLDY---FGWSYVFRVIGLMGIA 203
Cdd:COG0738 104 FLLG--LGLGLLDVAANPYVAALG-----PETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLL 176
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19920686 204 WALVLRYYAMAGERnriiniatpsrlcANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGF 281
Cdd:COG0738 177 LALLFLRSKLPEIE-------------EEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
30-210 |
1.47e-06 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 50.10 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 30 FITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQrviLFAAIGwslitfL 109
Cdd:cd17488 5 LASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPR---YFMGIG------L 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 110 MPTIIWTAGSIKSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFG 189
Cdd:cd17488 76 IATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYG 155
|
170 180
....*....|....*....|.
gi 19920686 190 WSYVFRVIGLMGIAWALVLRY 210
Cdd:cd17488 156 WRAGMYVPGIIAILMGIVLCW 176
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-176 |
1.61e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 23 RHEKRVWFITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIG 102
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19920686 103 WSLITFLMPTIIWTAGSIKSYAIPFIVairilnGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLL 176
Cdd:pfam07690 275 LILAALGLLLLSLTLSSLWLLLALLLL------GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
29-428 |
1.78e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 49.72 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 29 WFITLITG--TCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLI 106
Cdd:cd17314 2 WFVLYVSFllSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 107 TFLMPTIiwtagsikSYAIPFIVAIRILNGALQGVHFPSMISLTSQnLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLD 186
Cdd:cd17314 82 YTYLSYV--------FNSFPLSYACFVFIGAGTGILYGSAVLVTTQ-YFPDTKGLALGLPTTGYSLGLVLGSPLLRILWV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 187 YFGWSYVFRVIglmGIAWALVLRYYAMAGERnriiniaTPSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCF 266
Cdd:cd17314 153 FYGLALVYTIL---GILAAIVLSVVSLLGFK-------EPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 267 FVLLSWLPTYFHDGFPHAKGWVVNMIPWLALPP--CTLFAKYLTTRLLArewhtttvRKVIQSCCFAAQNLALFVMSRTS 344
Cdd:cd17314 223 FLFIANMASLVRSLQLDAPSFVTKLMSIYGLFNafGRLLWGIVADFFGG--------RLSTLSILLTILGLGLCAFLFLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 345 DFHTALICMTIIIGG---TGFHNNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGI 421
Cdd:cd17314 295 KMTPVGLVLTGSLLGfsyGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVI 374
|
....*..
gi 19920686 422 NLVGWII 428
Cdd:cd17314 375 VFLASAI 381
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
41-203 |
1.94e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 49.93 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 41 YSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSi 120
Cdd:cd17345 16 YLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSS- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 121 ksyaIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFG-----WSYVFR 195
Cdd:cd17345 95 ----VGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwwrGAFIFP 170
|
....*...
gi 19920686 196 VIGLMGIA 203
Cdd:cd17345 171 AIIAIIVA 178
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
61-433 |
2.01e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.51 E-value: 2.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 61 SKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTiiwtagsikSYAIPFIVAIRILNGALQG 140
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL---------ATSVALLLVLRLIHGIGWG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 141 VhFPSMISLTSQNLCPNER----SSFFGLltaGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMG-IAWALVLryyamag 215
Cdd:cd17489 100 A-FTTAAATLVADIIPPSRrgegIGYYGL---ATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAlLALLLVF------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 216 ernrIINIATPSrlcaNKSPAETSAVPWLRYFRRLSFWACVLTHACEMnCFFVLLSWLPTYFHDGfPHAKGWVVNMIPWL 295
Cdd:cd17489 169 ----LVKDPPPV----AAEEAEAGTRAFRRLVEKKVLPPALILFLASI-AYGAISTFLPLYAAER-GISNAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 296 ALppctlfakyLTTRLLAREWHTTTVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLA 375
Cdd:cd17489 239 AL---------LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 19920686 376 PLHS-GSVFGLMNTVGAIPGFLGVYLAGHILELTqSWPMVFSAAAGINLVGWIIFIVFG 433
Cdd:cd17489 310 PPHRrGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-428 |
5.59e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.38 E-value: 5.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 49 LLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLitflmptiIWTAGSIKSYAIPFI 128
Cdd:cd17353 24 VFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL--------GFILSAFAISLPLLF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 129 VAIRILNGALQGVHFPSMISlTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGL-MGIAWALV 207
Cdd:cd17353 96 LGYGVLGGIGAGIGYITPVS-TAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIiFLIIIVIG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 208 LRYYAMAGERNRIINIATPsrlcANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGFPHAKGW 287
Cdd:cd17353 175 AFLIRDPPKGWVPPGVDPL----ANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 288 VVNMIPWLALPPCT--LFAKYLTTRLlarewhtttVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGT--GFH 363
Cdd:cd17353 251 AALAVSILSIFNGGgrPFWGWLSDKI---------GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCygGGF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19920686 364 NNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILeLTQSWPMVFSAAAGINLVGWII 428
Cdd:cd17353 322 ALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVL-YTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
30-208 |
6.90e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 48.10 E-value: 6.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 30 FITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQrvILFAAigwSLITFL 109
Cdd:cd17343 5 FASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISAR--WLFSS---GLVLSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 110 MPTIIWTAGSiksyAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFG 189
Cdd:cd17343 80 LTTVAFSGSS----SVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYG 155
|
170
....*....|....*....
gi 19920686 190 WSYVFRVIGLMGIAWALVL 208
Cdd:cd17343 156 WRSTLSISGTVAVVMSVVC 174
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-211 |
8.66e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 8.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 25 EKRVWFITLIT-GTCMLYSTRTTMpllVPAVASAQKWSktDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAigw 103
Cdd:cd17489 193 EKKVLPPALILfLASIAYGAISTF---LPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGL--- 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 104 sLITFLMPTIIWTAGSIksyaiPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSF 183
Cdd:cd17489 265 -LLLALGLLLLSFAGSP-----WMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGL 338
|
170 180
....*....|....*....|....*...
gi 19920686 184 LLDYFGWSYVFRVIGLMGIAWALVLRYY 211
Cdd:cd17489 339 VAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
39-208 |
9.84e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 9.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 39 MLYSTRTTMPLLVpavaSAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIG--WSLITFLMPTIIWT 116
Cdd:cd17478 210 VLSSLTTFLPFYL----VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLaaPFLLLFLLTPGIWS 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 117 agsiksyaIPFIVAIrilnGALQGVHFPSMISLTsQNLCPNERSS----FFGLLTAGSALGTLLTGIMGsfllDYFGWSY 192
Cdd:cd17478 286 --------YILLVLA----GFLLFASFPVTVVLA-QELLPGNVGLasglMMGLSFGLGGIGAPVLGALA----DAFGLES 348
|
170
....*....|....*.
gi 19920686 193 VFRVIGLMGIAWALVL 208
Cdd:cd17478 349 VLLILALLPLLGALLA 364
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
82-274 |
1.18e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 47.26 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 82 VGGYFSDRFGGQRVILFAAIGWSLITfLMPTIIWTagsiksyaIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSS 161
Cdd:PRK11551 69 LGGRLADRIGRKRILIVSVALFGLFS-LATAQAWD--------FPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 162 FFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLRYY-----AMAGERNRIINIATPSRLCANKSPA 236
Cdd:PRK11551 140 AVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWlpesrAFAQAAGAGKQRAPVLRALFGEGRA 219
|
170 180 190
....*....|....*....|....*....|....*...
gi 19920686 237 ETSAVPWLRYFrrlsfwaCVLThacemnCFFVLLSWLP 274
Cdd:PRK11551 220 TATLLLWISYF-------FTLI------VLYFLLNWLP 244
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
28-208 |
2.21e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.49 E-value: 2.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 28 VWFITLITGTcmlySTRTTMP--------LLVPAVASAQKWSktdsGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFA 99
Cdd:cd17391 1 CWLGNFFTGI----GFSLIAPflplyieqLGVTSGGLVELWS----GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 100 AIGWSLITFLM---PTIIWtagsiksyaipfIVAIRILNGALQGVHFPSMISLTSQnlCPNERSSF-FGLLTAGSALGTL 175
Cdd:cd17391 73 SLGMAIVIGLMafvTNVWQ------------LLILRLLQGVFSGYVPNATALIASQ--TPKEKSGWaLGTLSTGVVAGTL 138
|
170 180 190
....*....|....*....|....*....|....
gi 19920686 176 LTGIMGSFLLDYFGWSYVFRVIG-LMGIAWALVL 208
Cdd:cd17391 139 IGPLLGGFLADLFGIRNVFFITGgLLFLAFLLTL 172
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
61-432 |
4.81e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.30 E-value: 4.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 61 SKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTagsiKSYAIPFIVAIRILNGALQG 140
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALL----GSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 141 VHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLryyamagernRI 220
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL----------LF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 221 INIATPSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCF-FVLLSWLPTYFHDGFPHAKGWV--VNMIPWLAL 297
Cdd:cd06173 178 IRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLgGALTVLLPLLAKEVLGGGAAGYglLLAAFGVGA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 298 ppctLFAKYLTTRLLAREWHTTTVRKviqscCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPL 377
Cdd:cd06173 258 ----LLGALLLGRLSKRRRRGRLLLI-----GALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPD 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 19920686 378 HS-GSVFGLMNTVGAIPGFLGVYLAGHILELTqSWPMVFSAAAGINLVGWIIFIVF 432
Cdd:cd06173 329 ELrGRVFSVYNALNSGAMPLGALLAGLLADAL-GLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
23-208 |
5.83e-05 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 45.09 E-value: 5.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 23 RHEKRVWFITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRfggQRVILFAAIG 102
Cdd:PRK11663 18 RYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDR---SNARYFMGIG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 103 wslitFLMPTIIWTAGSIKSYAIPFIvAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGS 182
Cdd:PRK11663 95 -----LIATGIINILFGFSSSLWAFA-LLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVG 168
|
170 180
....*....|....*....|....*.
gi 19920686 183 FLLDYFGWSYVFRVIGLMGIAWALVL 208
Cdd:PRK11663 169 AIALHYGWRYGMMIAGIIAIVVGLFL 194
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
75-209 |
9.02e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 9.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 75 GYTLTQVVG----GYFSDRFGGQRVILFAAIGWSLITFLMptiiWTAGSIksyaiPFIVAIRILNGALQGVHFPSMISLT 150
Cdd:cd17503 39 SYLLALAIMiplsGWLADRFGTRRLFLTALALFTLGSLLC----GLAPNL-----ASLIIFRILQGFGGGVLIPLAQTIL 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19920686 151 SQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRV---IGLMGIAWALVLR 209
Cdd:cd17503 110 LRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLLAPLLD 171
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
61-207 |
1.30e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.11 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 61 SKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVilfaaigwsLITFLMPTIIWTAGSIKSYAIPFIVAIRILNGALQG 140
Cdd:cd17504 29 SAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKV---------LLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19920686 141 VhFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALV 207
Cdd:cd17504 100 V-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-208 |
2.98e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 19 SIWTRHEKRVWFITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILF 98
Cdd:cd06174 195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 99 AAIGWSLITFLMPTIiwtagsikSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTG 178
Cdd:cd06174 275 IGLLLMALGLALLLL--------APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGP 346
|
170 180 190
....*....|....*....|....*....|.
gi 19920686 179 IMGSFLLD-YFGWSYVFRVIGLMGIAWALVL 208
Cdd:cd06174 347 LLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
76-208 |
3.00e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 76 YTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMptiiwtAGSIKSYAIPFIVairILNGALQGVHFPSMISLTSQNLC 155
Cdd:cd17370 247 YALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF------ALGSSLWLLLLGF---ILWGLYMGAQESIERAAVADLVP 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 19920686 156 PNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVL 208
Cdd:cd17370 318 AELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-208 |
3.62e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.64 E-value: 3.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 11 RGELVDTQSIWTR--HEKRVW--FITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYF 86
Cdd:cd17391 184 KKKMVSTKEVWNSvpNPSLLIslFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 87 SDRFGGQRVILFAAIGWSLITFLMP--TIIWTAGsiksyaipfivAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFG 164
Cdd:cd17391 264 GDRIGHHRILLGALLASALLYIPQAfvQTPWQLG-----------ILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFG 332
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 19920686 165 LLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVL 208
Cdd:cd17391 333 YNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
50-208 |
9.45e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 9.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 50 LVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIwtagsikSYAIPFIV 129
Cdd:cd17477 210 LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVP-------GLPLALLV 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19920686 130 AIRILNGALQGVhFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVL 208
Cdd:cd17477 283 LLFLWGGAAGPL-YTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
48-209 |
3.30e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.59 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 48 PLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLmptiiwtAGSIKSYAIPF 127
Cdd:cd17371 19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL-------CGFAQNYWQLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 128 IvaIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALG----TLLTGIMGSFLLDYFGWSYVFrVIGLMGIA 203
Cdd:cd17371 92 I--LRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLF-LLGALPAL 168
|
....*.
gi 19920686 204 WALVLR 209
Cdd:cd17371 169 LVLFIR 174
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
28-208 |
4.38e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 4.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 28 VWFITLITGTCMLYSTRTTMPLLVPAVASAqkwSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLIT 107
Cdd:cd17473 201 PIYFLAFLAMLLFYVIPIQLPFLLQERGGG---SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 108 FLMPTiiwtagsikSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTG-IMGSFLLD 186
Cdd:cd17473 278 LLLAL---------ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPlVLGPLVNL 348
|
170 180
....*....|....*....|..
gi 19920686 187 YFGWSYVFRVIGLMGIAWALVL 208
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
50-281 |
5.03e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.77 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 50 LVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIgwslitFLMPTIIWTAGSIKSYAIpfIV 129
Cdd:cd17341 21 LGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLL------LLLIPLLALALAVSSYWG--LL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 130 AIRILNGaLQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIM-------GSFLLDYFGWSYVFRVIGLMGI 202
Cdd:cd17341 93 VLGFLLG-FAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLapliagaIVFDGGFVGWRNAFFVPGILLA 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19920686 203 AWALVLRYYAmagernriiniatpSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGF 281
Cdd:cd17341 172 IAAVLVLLFG--------------DDLPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRF 236
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-208 |
7.42e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 21 WTRHEKRVWFITLITGTCMLYSTrTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAA 100
Cdd:cd06173 203 YLRRSPLLRLLLLALALFALLGG-ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 101 IGWSLITFLMPTiiwtagsikSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIM 180
Cdd:cd06173 282 LLLGLALLVLGL---------SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
170 180
....*....|....*....|....*...
gi 19920686 181 GSFLLDYFGWSYVFRVIGLMGIAWALVL 208
Cdd:cd06173 353 AGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
46-203 |
8.16e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 8.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 46 TMPLLVPAVASAQKWSKTD--SGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFaaigwSLITFLMPTIIWTAgsikSY 123
Cdd:cd17330 15 VFPVLPFYVREFNKLGASGyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLL-----SLAGSAVSYVLLGL----SR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 124 AIPFIVAIRILNGALQGVhFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIA 203
Cdd:cd17330 86 NLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
61-221 |
8.29e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 38.33 E-value: 8.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 61 SKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQ-RVILFAAIGWSLITFLMptiiWTAGSIKSYAIPFIVAIRILNGALQ 139
Cdd:cd17346 38 SEADAASIYGAYTALVYLTPIIGGWLADKVLGArRTVFIGGILMALGYLLL----ALSPFSVSMLYLGLALIIVGNGLFK 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920686 140 GvHFPSMIS-LTSQNlcPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIG-LMGIAWALVLRYYAMAGER 217
Cdd:cd17346 114 P-NISSLVGkLYDEN--DPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYGYHYGFGLAAvGMLLGLLIFLLGRKKLLER 190
|
....
gi 19920686 218 NRII 221
Cdd:cd17346 191 KKML 194
|
|
| |
