|
Name |
Accession |
Description |
Interval |
E-value |
| DDHD |
pfam02862 |
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ... |
1754-1981 |
4.08e-71 |
|
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.
Pssm-ID: 460725 Cd Length: 241 Bit Score: 238.49 E-value: 4.08e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1754 LIFHPKKFFALGSPIGMFVTIRGIDKLGLDFH-----LPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGR 1828
Cdd:pfam02862 1 LDFEVENFFLLGSPLGLFLALRGAQIAGRSRSdhiygSPACKQLYNIFHPYDPVAYRLEPLIDPAYSNLKPVLIPYYKKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1829 KRMHLELKETMTRVGADIKQRFMDTFKT-----TLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVA 1903
Cdd:pfam02862 81 GLRHLELGEGLTRIGAAVGQSVSGLWSSlssgaSLNRSLGLSDESSASSADSEQSHERSSEASSASESSLQAQSSSAPSS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1904 SSSCKLRNRTDSNSTTASDPEF-----IELDFPLGKLNDSKRVDYVLQEAPLEFinEYIFALSSHVCYWGSEDTILFVMK 1978
Cdd:pfam02862 161 TSSSNGIKEIEETELDWSESERkadklEREEAKVRALNPNGRIDYVLQEGALES--QYLSALTSHLSYWESEDVALFLLR 238
|
...
gi 20129359 1979 EIY 1981
Cdd:pfam02862 239 QLL 241
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
375-1012 |
1.13e-17 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 90.38 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 375 GGPNSTFPPGGNYFVP--GAPPSLPSTGVVGPPSVGNFFAPAAPlpvAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPL 452
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARRPDAP---PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 453 APQPFQSATVNQ-------SALPPNNPPTASAVGELFVP----APTTIAQGTSPAVPFVDTQAVPTI-PLTVPPGNPPPT 520
Cdd:PHA03247 2626 PPPPSPSPAANEpdphpppTVPPPERPRDDPAPGRVSRPrrarRLGRAAQASSPPQRPRRRAARPTVgSLTSLADPPPPP 2705
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 521 STlggffttGEVAPVVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLfPPAPAQPGVQTASNPN 600
Cdd:PHA03247 2706 PT-------PEPAPHALVSATPLPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAP 2775
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 601 plpgaaapppaagqasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSfnsvghlegqssqGV 680
Cdd:PHA03247 2776 ----------------------------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-------------AP 2814
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 681 PFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSST----SVAP-------PLTASIANPPPTSGFASVPLFAAPTISST 749
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRS 2894
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 750 PIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQffdTPLPTGTQPENQvasvsSERENLVQEPISNQ 829
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ---PPLAPTTDPAGA-----GEPSGAVPQPWLGA 2966
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 830 GIPFFAP-PQTNIFTPQLQQEFIAPAEDSKRSeiqeeflSAPPQESNLSTELREDTHTGPPviepvleetPASSSESSVP 908
Cdd:PHA03247 2967 LVPGRVAvPRFRVPQPAPSREAPASSTPPLTG-------HSLSRVSSWASSLALHEETDPP---------PVSLKQTLWP 3030
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 909 PASKVDQEDIvypepsapveqeiPLFVPVPGLPGLSQDIPLYPPPptgsttaSSIFAAPPVassaplfvpvPGPPSVSSL 988
Cdd:PHA03247 3031 PDDTEDSDAD-------------SLFDSDSERSDLEALDPLPPEP-------HDPFAHEPD----------PATPEAGAR 3080
|
650 660
....*....|....*....|....
gi 20129359 989 FSPSqvdstsSLFAPPPTSANTTI 1012
Cdd:PHA03247 3081 ESPS------SQFGPPPLSANAAL 3098
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
693-1098 |
9.90e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 60.55 E-value: 9.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 693 QVAAPTVAVPQSAPIAPPPGtsstsvaPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTGLSQQEN 772
Cdd:pfam03154 168 QTQPPVLQAQSGAASPPSPP-------PPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQ 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 773 E-ATASTTLEGLVQGPAPTLSASQffDTPLPTGTQPENQVASVSSERENLVQEPIsnqgipffaPPQTNIFTPQLQQEFI 851
Cdd:pfam03154 241 RlPSPHPPLQPMTQPPPPSQVSPQ--PLPQPSLHGQMPPMPHSLQTGPSHMQHPV---------PPQPFPLTPQSSQSQV 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 852 APAEDSKRSEIQEEFLSAPPQESNLSTElredthtGPPVIEPvLEETPASSSESSVPPASKVdqedivyPEPSAPVEQEI 931
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQ-------QPPREQP-LPPAPLSMPHIKPPPTTPI-------PQLPNPQSHKH 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 932 PLFVPVPGLPGLSQDIPlypPPPTGSTTASSIFAAPPVASSAPLFV-----PVPGPPSVSSLFSPSQVDSTSSLFAPPPT 1006
Cdd:pfam03154 375 PPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPLQLmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTS 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1007 SANTTILTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATNlfqgnteTQTVFSPFAQTKATPL 1086
Cdd:pfam03154 452 GLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPA-------AVSCPLPPVQIKEEAL 524
|
410
....*....|..
gi 20129359 1087 VQETKPELVPPP 1098
Cdd:pfam03154 525 DEAEEPESPPPP 536
|
|
| WWE |
pfam02825 |
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
1379-1446 |
6.24e-07 |
|
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.
Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 48.45 E-value: 6.24e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1379 HWFYKrsvDTKFIWTPFSHYDSALLETS--LNLDDSTLIIPVEGGRYDVNIKERTKTPVYwEGKAIEVRR 1446
Cdd:pfam02825 1 VWEWE---DDNGGWHPYDPEVSSLIEEAyqKGKPSVDLSITTAGFPYTIDFKSMTQTNKD-TGTTRPVRR 66
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
888-1179 |
1.39e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 47.07 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 888 PPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLFVPV-----------PGLPGLSQDI-PLYPPPPT 955
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhpQRLPSPHPPLqPMTQPPPP 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 956 GSTTASSIFAA------PPVA---SSAPLFVPVPGPPS---VSSLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTTSTL 1023
Cdd:pfam03154 259 SQVSPQPLPQPslhgqmPPMPhslQTGPSHMQHPVPPQpfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQ 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1024 FANN--IPTTTPSIPDIVP--TTSAELVDAPPGFQGSSDDTATNLFQGNTETQtvfSPFAQTKATPLVQETKPELVPPPI 1099
Cdd:pfam03154 339 PPREqpLPPAPLSMPHIKPppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPL 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1100 GFFapkSESEVLSQPPLAPSPLQSFFSTAPETATTTDFNFFGSPAPGSVFPDLPVQQGiAPPPLALESPPQNSVSNIATS 1179
Cdd:pfam03154 416 QLM---PQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPG-GPPPITPPSGPPTSTSSAMPG 491
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
362-526 |
3.96e-04 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 45.51 E-value: 3.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 362 TTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTP 441
Cdd:COG3469 55 GSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 442 SVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGeLFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTV--PPGNPPP 519
Cdd:COG3469 135 TSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTT-TSASTTPSATTTATATTASGATTPSATTTATTtgPPTPGLP 213
|
....*..
gi 20129359 520 TSTLGGF 526
Cdd:COG3469 214 KHVLVGY 220
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
38-590 |
1.89e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.39 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 38 DDFPNKPQLLPAaPPVVHATPPAAPVLIAGILNREPKSLVTVGQPSSIDDSEALDEINLNT-SSEDSVGAGGSSPylgag 116
Cdd:PHA03247 2606 GDPRGPAPPSPL-PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSP----- 2679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 117 DQNANPLLEPPTEAGNDSLLSQAASSFTALPAvasnvfstfskriyagSRETSEEPKLDIQPSYIQQASYVQPVAPVPAP 196
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----------------PHALVSATPLPPGPAAARQASPALPAAPAPPA 2743
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 197 FYAAPPAAANEVVAPEPPkfyapTEVPPPNVGVPAPPPTSGNPNTYRfTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQA 276
Cdd:PHA03247 2744 VPAGPATPGGPARPARPP-----TTAGPPAPAPPAAPAAGPPRRLTR-PAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 277 APSFQTPPYPPQLTYAANPAPfdiSAQPAAIPAEERKSGGglfsltSLVPTGVLQNiTGIVQSATGRSSEPEHTNVQQag 356
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTA---PPPPPGPPPPSLPLGG------SVAPGGDVRR-RPPSRSPAAKPAAPARPPVRR-- 2885
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 357 gyldiTTASAPAPSTNLFGGPnstfppggnyfvPGAPPSLPStgvvgppsvgnffaPAAPLPVAQTAAPPavgafftsAA 436
Cdd:PHA03247 2886 -----LARPAVSRSTESFALP------------PDQPERPPQ--------------PQAPPPPQPQPQPP--------PP 2926
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 437 PSVTPSVFTPG-TVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTtiaqgTSPAVPFVDTQAVPTIPLTVPP- 514
Cdd:PHA03247 2927 PQPQPPPPPPPrPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFR-----VPQPAPSREAPASSTPPLTGHSl 3001
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 515 ---------------GNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFFNPGEVRPNVPLA-EPVPTIPITSSGV 578
Cdd:PHA03247 3002 srvsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAhEPDPATPEAGARE 3081
|
570
....*....|..
gi 20129359 579 PPIGLFPPAPAQ 590
Cdd:PHA03247 3082 SPSSQFGPPPLS 3093
|
|
| half-pint |
TIGR01645 |
poly-U binding splicing factor, half-pint family; The proteins represented by this model ... |
684-824 |
7.28e-03 |
|
poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.
Pssm-ID: 130706 [Multi-domain] Cd Length: 612 Bit Score: 41.21 E-value: 7.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 684 TPPVQNPPGQVAAPTVAVPQSAPIAPPPG--TSSTSVAPPLTASIANPPPTSgfASVPLFAAPTISSTPIPFFNPQPTGA 761
Cdd:TIGR01645 344 NKAVVSSAKKEAEEVPPLPQAAPAVVKPGpmEIPTPVPPPGLAIPSLVAPPG--LVAPTEINPSFLASPRKKMKREKLPV 421
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20129359 762 EV-----TTGLSQQENEATASTTLEGLVQGPAPTLSASQFFDTPLPTGTQPENQVASVSSERENLVQE 824
Cdd:TIGR01645 422 TFgalddTLAWKEPSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKEKEGEELQPKLVMNSEDASLAS 489
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| DDHD |
pfam02862 |
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ... |
1754-1981 |
4.08e-71 |
|
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.
Pssm-ID: 460725 Cd Length: 241 Bit Score: 238.49 E-value: 4.08e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1754 LIFHPKKFFALGSPIGMFVTIRGIDKLGLDFH-----LPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGR 1828
Cdd:pfam02862 1 LDFEVENFFLLGSPLGLFLALRGAQIAGRSRSdhiygSPACKQLYNIFHPYDPVAYRLEPLIDPAYSNLKPVLIPYYKKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1829 KRMHLELKETMTRVGADIKQRFMDTFKT-----TLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVA 1903
Cdd:pfam02862 81 GLRHLELGEGLTRIGAAVGQSVSGLWSSlssgaSLNRSLGLSDESSASSADSEQSHERSSEASSASESSLQAQSSSAPSS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1904 SSSCKLRNRTDSNSTTASDPEF-----IELDFPLGKLNDSKRVDYVLQEAPLEFinEYIFALSSHVCYWGSEDTILFVMK 1978
Cdd:pfam02862 161 TSSSNGIKEIEETELDWSESERkadklEREEAKVRALNPNGRIDYVLQEGALES--QYLSALTSHLSYWESEDVALFLLR 238
|
...
gi 20129359 1979 EIY 1981
Cdd:pfam02862 239 QLL 241
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
375-1012 |
1.13e-17 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 90.38 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 375 GGPNSTFPPGGNYFVP--GAPPSLPSTGVVGPPSVGNFFAPAAPlpvAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPL 452
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARRPDAP---PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 453 APQPFQSATVNQ-------SALPPNNPPTASAVGELFVP----APTTIAQGTSPAVPFVDTQAVPTI-PLTVPPGNPPPT 520
Cdd:PHA03247 2626 PPPPSPSPAANEpdphpppTVPPPERPRDDPAPGRVSRPrrarRLGRAAQASSPPQRPRRRAARPTVgSLTSLADPPPPP 2705
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 521 STlggffttGEVAPVVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLfPPAPAQPGVQTASNPN 600
Cdd:PHA03247 2706 PT-------PEPAPHALVSATPLPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAP 2775
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 601 plpgaaapppaagqasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSfnsvghlegqssqGV 680
Cdd:PHA03247 2776 ----------------------------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-------------AP 2814
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 681 PFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSST----SVAP-------PLTASIANPPPTSGFASVPLFAAPTISST 749
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRS 2894
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 750 PIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQffdTPLPTGTQPENQvasvsSERENLVQEPISNQ 829
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ---PPLAPTTDPAGA-----GEPSGAVPQPWLGA 2966
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 830 GIPFFAP-PQTNIFTPQLQQEFIAPAEDSKRSeiqeeflSAPPQESNLSTELREDTHTGPPviepvleetPASSSESSVP 908
Cdd:PHA03247 2967 LVPGRVAvPRFRVPQPAPSREAPASSTPPLTG-------HSLSRVSSWASSLALHEETDPP---------PVSLKQTLWP 3030
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 909 PASKVDQEDIvypepsapveqeiPLFVPVPGLPGLSQDIPLYPPPptgsttaSSIFAAPPVassaplfvpvPGPPSVSSL 988
Cdd:PHA03247 3031 PDDTEDSDAD-------------SLFDSDSERSDLEALDPLPPEP-------HDPFAHEPD----------PATPEAGAR 3080
|
650 660
....*....|....*....|....
gi 20129359 989 FSPSqvdstsSLFAPPPTSANTTI 1012
Cdd:PHA03247 3081 ESPS------SQFGPPPLSANAAL 3098
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
210-975 |
4.35e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 81.91 E-value: 4.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 210 APEPPKFYAPTEVPPPNVGVPAPPptsgnpntyrftarkKLYAPIPGLSEQSGQPAQQPqvpqapqaapsfqTPPYPPql 289
Cdd:PHA03247 2508 APPAPSRLAPAILPDEPVGEPVHP---------------RMLTWIRGLEELASDDAGDP-------------PPPLPP-- 2557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 290 tyAANPAPFDIS---AQPAAIPAEErksggglfsltslvptgvlqnitgivqSATGRSSEPehtnvqqaggyldittaSA 366
Cdd:PHA03247 2558 --AAPPAAPDRSvppPRPAPRPSEP---------------------------AVTSRARRP-----------------DA 2591
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 367 PapstnlfggPNSTFPPggnyfVPGAPPslpstgvvgppsvGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTP 446
Cdd:PHA03247 2592 P---------PQSARPR-----APVDDR-------------GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPP 2644
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 447 GTVPPlaPQPFQSATVNQSALP-----PNNPPTASAVGELFVP--APTTIAQGTSPAVPfvdtqavptipltvPPGNPPP 519
Cdd:PHA03247 2645 TVPPP--ERPRDDPAPGRVSRPrrarrLGRAAQASSPPQRPRRraARPTVGSLTSLADP--------------PPPPPTP 2708
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 520 tstlggffttgEVAPVVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLfPPAPAQPGVQTASNP 599
Cdd:PHA03247 2709 -----------EPAPHALVSATPLPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAA 2774
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 600 NplpgaaapppaagqasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSfnsvghlegqssqG 679
Cdd:PHA03247 2775 P----------------------------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-------------A 2813
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 680 VPFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSST----SVAP-------PLTASIANPPPTSGFASVPLFAAPTISS 748
Cdd:PHA03247 2814 PAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSR 2893
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 749 TPIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQffdTPLPTGTQPENQvasvsSERENLVQEPISN 828
Cdd:PHA03247 2894 STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ---PPLAPTTDPAGA-----GEPSGAVPQPWLG 2965
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 829 QGIPFFAP-PQTNIFTPQLQQEFIAPAEDSKRSeiqeeflSAPPQESNLSTELREDTHTGPPviepvleetPASSSESSV 907
Cdd:PHA03247 2966 ALVPGRVAvPRFRVPQPAPSREAPASSTPPLTG-------HSLSRVSSWASSLALHEETDPP---------PVSLKQTLW 3029
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 908 PPaSKVDQEDIVYPEPSAPVEQEIPLFVPVPGLPGLSQDIPLYPPPPTGSTTAS--SIFAAPPVASSAPL 975
Cdd:PHA03247 3030 PP-DDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESpsSQFGPPPLSANAAL 3098
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
209-737 |
4.66e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 81.91 E-value: 4.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 209 VAPEPPKFYAPTEVPPPNvgvPAPPPtSGNPNTYRftARKKLYAPIPGLSEQSGQPAQQPQVPQAPQAAPSFQTPPYPPq 288
Cdd:PHA03247 2555 LPPAAPPAAPDRSVPPPR---PAPRP-SEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP- 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 289 lTYAANPAPFDI-SAQPAAIPAEERKSGGglfsltSLVPTGVLQNITGIVQSATGRSSEPEHTNVQQAGGYLDITTASA- 366
Cdd:PHA03247 2628 -PPSPSPAANEPdPHPPPTVPPPERPRDD------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAd 2700
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 367 -PAPSTNLFGGPNSTFP----PGGNYFVPGAPPSLPSTGVvgPPSVGNffAPAAPLPVAQTAAPPAvgaffTSAAPSVTP 441
Cdd:PHA03247 2701 pPPPPPTPEPAPHALVSatplPPGPAAARQASPALPAAPA--PPAVPA--GPATPGGPARPARPPT-----TAGPPAPAP 2771
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 442 SVFTPGTVPPLAPQP-FQSATVNQSALP-PNNPPTASAVGELFVPAPTTIAQGTSPAVPfvDTQAVPTIPLTvPPGNPPP 519
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPaVASLSESRESLPsPWDPADPPAAVLAPAAALPPAASPAGPLPP--PTSAQPTAPPP-PPGPPPP 2848
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 520 TSTLGGFFTTGevAPVVAPFGTQASPATQSAgffnpgEVRPNV-PLAEPVPTIPITSSGVPPIGLFPPAPAQPgvqtasn 598
Cdd:PHA03247 2849 SLPLGGSVAPG--GDVRRRPPSRSPAAKPAA------PARPPVrRLARPAVSRSTESFALPPDQPERPPQPQA------- 2913
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 599 pnplpgaaapppaagqasyrlqkgtrlyKSPLTPQETATSSGFAAPLPPTSVTPaifNPFGAPAPGsfnsvghlegqsSQ 678
Cdd:PHA03247 2914 ----------------------------PPPPQPQPQPPPPPQPQPPPPPPPRP---QPPLAPTTD------------PA 2950
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20129359 679 GVPFFTPPVQNP------PGQVAAPTVAVPQSAPIAPPPGTSStsvaPPLTASIAnpPPTSGFAS 737
Cdd:PHA03247 2951 GAGEPSGAVPQPwlgalvPGRVAVPRFRVPQPAPSREAPASST----PPLTGHSL--SRVSSWAS 3009
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
642-1165 |
2.19e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 66.50 E-value: 2.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 642 AAPLPPTSVTPAIF--NPFGAPAPGSF----NSVGHLEGQSSQGVPFFTPPVQNPPG------------QVAAPTV---- 699
Cdd:PHA03247 2507 DAPPAPSRLAPAILpdEPVGEPVHPRMltwiRGLEELASDDAGDPPPPLPPAAPPAApdrsvppprpapRPSEPAVtsra 2586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 700 ----AVPQSA-------PIAPPPGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTG-- 766
Cdd:PHA03247 2587 rrpdAPPQSArprapvdDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrr 2666
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 767 LSQQENEATASTTLEGLVQGPA-PTLSASQFFDTPLPTGTQPENQVASVSSErenLVQEPISNQGIPFFAPPQTNIFTPQ 845
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAArPTVGSLTSLADPPPPPPTPEPAPHALVSA---TPLPPGPAAARQASPALPAAPAPPA 2743
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 846 LQQEFIAPAEDSKRSeiqeeflsAPPqesnlstelredTHTGPPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSA 925
Cdd:PHA03247 2744 VPAGPATPGGPARPA--------RPP------------TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 926 PVEQEIPLFVPVPGLPGLSQDIPLYPPPPTGSTTASSIFAAP---------------PVASSAPLFVPVPGP-----PSV 985
Cdd:PHA03247 2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPpppslplggsvapggDVRRRPPSRSPAAKPaaparPPV 2883
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 986 SSLFSPSQVDSTSSLFAPPPTSANTTilTPAPDTTstlfanniPTTTPSIPdivpttSAELVDAPPGFQGSSDdtatnlf 1065
Cdd:PHA03247 2884 RRLARPAVSRSTESFALPPDQPERPP--QPQAPPP--------PQPQPQPP------PPPQPQPPPPPPPRPQ------- 2940
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1066 qgntetqtvfSPFAQTKATPLVQETKPELVPPPIGFFAPkseSEVLSQPPLAPSPLQSFFSTAPETATTTDfnfFGSPAP 1145
Cdd:PHA03247 2941 ----------PPLAPTTDPAGAGEPSGAVPQPWLGALVP---GRVAVPRFRVPQPAPSREAPASSTPPLTG---HSLSRV 3004
|
570 580
....*....|....*....|
gi 20129359 1146 GSVFPDLPVQQGIAPPPLAL 1165
Cdd:PHA03247 3005 SSWASSLALHEETDPPPVSL 3024
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
693-1098 |
9.90e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 60.55 E-value: 9.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 693 QVAAPTVAVPQSAPIAPPPGtsstsvaPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTGLSQQEN 772
Cdd:pfam03154 168 QTQPPVLQAQSGAASPPSPP-------PPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQ 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 773 E-ATASTTLEGLVQGPAPTLSASQffDTPLPTGTQPENQVASVSSERENLVQEPIsnqgipffaPPQTNIFTPQLQQEFI 851
Cdd:pfam03154 241 RlPSPHPPLQPMTQPPPPSQVSPQ--PLPQPSLHGQMPPMPHSLQTGPSHMQHPV---------PPQPFPLTPQSSQSQV 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 852 APAEDSKRSEIQEEFLSAPPQESNLSTElredthtGPPVIEPvLEETPASSSESSVPPASKVdqedivyPEPSAPVEQEI 931
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQ-------QPPREQP-LPPAPLSMPHIKPPPTTPI-------PQLPNPQSHKH 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 932 PLFVPVPGLPGLSQDIPlypPPPTGSTTASSIFAAPPVASSAPLFV-----PVPGPPSVSSLFSPSQVDSTSSLFAPPPT 1006
Cdd:pfam03154 375 PPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPLQLmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTS 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1007 SANTTILTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATNlfqgnteTQTVFSPFAQTKATPL 1086
Cdd:pfam03154 452 GLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPA-------AVSCPLPPVQIKEEAL 524
|
410
....*....|..
gi 20129359 1087 VQETKPELVPPP 1098
Cdd:pfam03154 525 DEAEEPESPPPP 536
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
375-744 |
1.76e-08 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 59.61 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 375 GGPNSTFPPGGNYFVPGAPPslPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVfTPGTVPPLAP 454
Cdd:PRK07764 390 GAGAPAAAAPSAAAAAPAAA--PAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP-PPAAAPSAQP 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 455 QPFQSATVNQSALPPNNPPTASA-VGELFVPAPTTIAQGTSPAVpfVDTQAVPTIPLTVPPGNPP--------------- 518
Cdd:PRK07764 467 APAPAAAPEPTAAPAPAPPAAPApAAAPAAPAAPAAPAGADDAA--TLRERWPEILAAVPKRSRKtwaillpeatvlgvr 544
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 519 --------PTSTLGGFFTTGEVAPVVAP-----FGTQASPATQSAGffNPGEVRPNVPLAEPvptipitSSGVPPIGLFP 585
Cdd:PRK07764 545 gdtlvlgfSTGGLARRFASPGNAEVLVTalaeeLGGDWQVEAVVGP--APGAAGGEGPPAPA-------SSGPPEEAARP 615
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 586 PAPAQPGVQTASnpnplpgaaapppaagqasyrlqkgtrlyksplTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGS 665
Cdd:PRK07764 616 AAPAAPAAPAAP---------------------------------APAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 666 FNSVGHLEGQSSQGVPFFTPPVQNPPGQVA----APTVAVPQSAPIAPPPGTSSTSVAPPLTASIANPPPTSGFASVPLF 741
Cdd:PRK07764 663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAApagaAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLP 742
|
...
gi 20129359 742 AAP 744
Cdd:PRK07764 743 PEP 745
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
675-1022 |
6.58e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 57.85 E-value: 6.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 675 QSSQGVPffTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSSTSVAPPLTASIAnpPPTSGFASVPLFAAPTISStPIPFF 754
Cdd:pfam03154 175 QAQSGAA--SPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTA--APHTLIQQTPTLHPQRLPS-PHPPL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 755 NPQPTGAEVttglSQQENEATASTTLEGLVQ-GPAPTLSASQFFDTPLPTGTQP-ENQVASVSSERENLVQEPISNQGIP 832
Cdd:pfam03154 250 QPMTQPPPP----SQVSPQPLPQPSLHGQMPpMPHSLQTGPSHMQHPVPPQPFPlTPQSSQSQVPPGPSPAAPGQSQQRI 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 833 FFAPPQTNIFTPQLQQEFIAPAEDSKRSEIQEEFLSAPPQESNLSTELREDTHTGPPVIE------PVLEETPASSSESS 906
Cdd:pfam03154 326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSLSTH 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 907 VPPASkvdqedivYPEPSAPVEQEIPLFVPVPGLPGLSQDiPLYPPPPTGSTTASSIFAAPPVASSAPLFVPVPGPPSVS 986
Cdd:pfam03154 406 HPPSA--------HPPPLQLMPQSQQLPPPPAQPPVLTQS-QSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPIT 476
|
330 340 350
....*....|....*....|....*....|....*.
gi 20129359 987 SLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTTST 1022
Cdd:pfam03154 477 PPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSC 512
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
381-597 |
1.97e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 56.42 E-value: 1.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 381 FPPGGNYfvPGAPPSLPSTGVVGPPSVgnffAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSA 460
Cdd:PRK12323 363 FRPGQSG--GGAGPATAAAAPVAQPAP----AAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAA 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 461 TVNQSALPPNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVP---PGNPPPTSTLGGFFttgevaPVVA 537
Cdd:PRK12323 437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPapaDDDPPPWEELPPEF------ASPA 510
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129359 538 PFGTQASPA-TQSAGFFNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTAS 597
Cdd:PRK12323 511 PAQPDAAPAgWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
|
|
| WWE |
pfam02825 |
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
1379-1446 |
6.24e-07 |
|
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.
Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 48.45 E-value: 6.24e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1379 HWFYKrsvDTKFIWTPFSHYDSALLETS--LNLDDSTLIIPVEGGRYDVNIKERTKTPVYwEGKAIEVRR 1446
Cdd:pfam02825 1 VWEWE---DDNGGWHPYDPEVSSLIEEAyqKGKPSVDLSITTAGFPYTIDFKSMTQTNKD-TGTTRPVRR 66
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
329-765 |
1.84e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.23 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 329 VLQNITGIVQSATGRSSEPEHTNVQQAGgyLDITTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVG 408
Cdd:pfam03154 166 ILQTQPPVLQAQSGAASPPSPPPPGTTQ--AATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLP 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 409 NFFAPAAPLPvaQTAAPPAVGA-------FFTSAAPSVTPSVFTPGTVP-PLAPQPF-QSATVNQSALPPNNPPTASAVG 479
Cdd:pfam03154 244 SPHPPLQPMT--QPPPPSQVSPqplpqpsLHGQMPPMPHSLQTGPSHMQhPVPPQPFpLTPQSSQSQVPPGPSPAAPGQS 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 480 ELFVPAPTTIAQGTSPAVPfvDTQAVPTIPLTVPPGNPPPTSTlggffttgeVAPVVAPFGTQASPATQSAGFFNPGEVR 559
Cdd:pfam03154 322 QQRIHTPPSQSQLQSQQPP--REQPLPPAPLSMPHIKPPPTTP---------IPQLPNPQSHKHPPHLSGPSPFQMNSNL 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 560 PNVPLAEPVPTIPI---TSSGVPPIGLFP------PAPAQPGVqtasnpnplpgaaapppaagqasyrlqkgtrlykspL 630
Cdd:pfam03154 391 PPPPALKPLSSLSThhpPSAHPPPLQLMPqsqqlpPPPAQPPV------------------------------------L 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 631 TPQETATSSGFAAPLPPTSVTPAIFNPFgapAPGSFnsvghlegqssqgVPFFTPPVQNPPGqvaaPTVAVPQSAPIAPP 710
Cdd:pfam03154 435 TQSQSLPPPAASHPPTSGLHQVPSQSPF---PQHPF-------------VPGGPPPITPPSG----PPTSTSSAMPGIQP 494
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 20129359 711 PGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTT 765
Cdd:pfam03154 495 PSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNT 549
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
393-761 |
2.58e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 52.76 E-value: 2.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 393 PPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAA-----PPAVGafftsaapsvtpsVFTPGTVPPLAPQPFQSAT--VNQS 465
Cdd:PHA03378 457 PPTQPLEGPTGPLSVQAPLEPWQPLPHPQVTPvilhqPPAQG-------------VQAHGSMLDLLEKDDEDMEqrVMAT 523
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 466 ALPPNNP-PTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTI---PLTVPPGNPPPTSTLGGFFT--TGEVAPVVAPF 539
Cdd:PHA03378 524 LLPPSPPqPRAGRRAPCVYTEDLDIESDEPASTEPVHDQLLPAPglgPLQIQPLTSPTTSQLASSAPsyAQTPWPVPHPS 603
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 540 GTQASPATQSAGFFNPGEVRPNVPLaEPVPTIPITSSGVPPIGLFPPAPAQPgvqtasnpnplpgaaapppAAGQASYRL 619
Cdd:PHA03378 604 QTPEPPTTQSHIPETSAPRQWPMPL-RPIPMRPLRMQPITFNVLVFPTPHQP-------------------PQVEITPYK 663
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 620 QKGTRLYKSPLTPqetaTSSGFAAPLPPTSVTPAIFNPFGAPAPGSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTV 699
Cdd:PHA03378 664 PTWTQIGHIPYQP----SPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAA 739
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20129359 700 AVPQsapiAPPPGTSSTSVAPPLTASIANPPPtsgfASVPLFAAPTISSTPIPFFNPQPTGA 761
Cdd:PHA03378 740 APGR----ARPPAAAPGRARPPAAAPGRARPP----AAAPGAPTPQPPPQAPPAPQQRPRGA 793
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
383-577 |
1.07e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 50.62 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 383 PGGNYFVPGAPPSLPSTGVVGPPSVgnffAPAAPLPVAQTAAPPAVGAFFTSAAP-SVTPSVFTPGTVPPLAPQPFQSAT 461
Cdd:PRK07003 362 VTGGGAPGGGVPARVAGAVPAPGAR----AAAAVGASAVPAVTAVTGAAGAALAPkAAAAAAATRAEAPPAAPAPPATAD 437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 462 VNQSALPpnNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGT 541
Cdd:PRK07003 438 RGDDAAD--GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAA 515
|
170 180 190
....*....|....*....|....*....|....*.
gi 20129359 542 QASPATQSAgffnPGEVRPNVPLAEPVPTIPITSSG 577
Cdd:PRK07003 516 ASREDAPAA----AAPPAPEARPPTPAAAAPAARAG 547
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
362-725 |
1.32e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.96 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 362 TTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVGnFFAPAAPLPVAQTAAPPAvgaffTSAAPSVTP 441
Cdd:pfam17823 95 TDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEA-FSAPRAAACRANASAAPR-----AAIAAASAP 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 442 SVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTAsavgelfvPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTS 521
Cdd:pfam17823 169 HAASPAPRTAASSTTAASSTTAASSAPTTAASSA--------PATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGT 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 522 TLGGFFTTGEVApvVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTAS---- 597
Cdd:pfam17823 241 VTAAVGTVTPAA--LATLAAAAGTVASAAGTINMGD--PHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTdqpv 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 598 -NPNPLPGAAAPPPAAGQASYRLQKGTRLYKSPLTPQETATSSGFAAPLPPTSVTPAI--FNPFGAPAPgsfnsVGHLEG 674
Cdd:pfam17823 317 hNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVeaTSPTTQPSP-----LLPTQG 391
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 20129359 675 QSSQGVPFftppvqnPPGQVAapTVAVPQSAPIAPPPgTSSTSVAPPLTAS 725
Cdd:pfam17823 392 AAGPGILL-------APEQVA--TEATAGTASAGPTP-RSSGDPKTLAMAS 432
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
528-990 |
3.32e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 49.14 E-value: 3.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 528 TTGEVAPVVAPFGTQASPATQSAGFfnpgevrpnvplAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAA 607
Cdd:pfam05109 415 TTHKVIFSKAPESTTTSPTLNTTGF------------AAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTT 482
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 608 PPPAAGQASYRLQKGTRLYKSPltpQETATSSGFAAPLP-PTSVTPAIFNPfgapapgSFNSVGHLEGQSSQgvpffTPP 686
Cdd:pfam05109 483 SGASPVTPSPSPRDNGTESKAP---DMTSPTSAVTTPTPnATSPTPAVTTP-------TPNATSPTLGKTSP-----TSA 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 687 VQNPPGQVAAPTVAVPQSAPIAPPPGTSSTSVAPPLTASIANPPP-----TSGFASVPLFAAPTISSTPIPFFNPQPTGA 761
Cdd:pfam05109 548 VTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSptvgeTSPQANTTNHTLGGTSSTPVVTSPPKNATS 627
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 762 EVTTGLSQQENEATASTTL--EGLVQGPAPTLSASQFFDTPLPTGTQPenqvasvsSERENLVQepisnqgipfFAPPQT 839
Cdd:pfam05109 628 AVTTGQHNITSSSTSSMSLrpSSISETLSPSTSDNSTSHMPLLTSAHP--------TGGENITQ----------VTPAST 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 840 NIFTPQLQQEFIAPAEDSKRSEIQEEFLSAPPQESNLSTELREDTHTGPPViePVLEETPASSSESSVPPASKVDQEDIV 919
Cdd:pfam05109 690 STHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQA--PSGQKTAVPTVTSTGGKANSTTGGKHT 767
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20129359 920 YPEPSAPVEQEIPLFVPVPGLPGLSQDIPLYPPPPTGSTTASS-IFAAPPVASSAplfVPVPGPPSVSSLFS 990
Cdd:pfam05109 768 TGHGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLRPRwTFTSPPVTTAQ---ATVPVPPTSQPRFS 836
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
445-664 |
8.36e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.56 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 445 TPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTStlg 524
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAP--- 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 525 gffttgevAPVVAPFGTQASPATQSAGffNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGV-QTASNPNPLP 603
Cdd:PRK12323 453 --------APAAAPAAAARPAAAGPRP--VAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPaQPDAAPAGWV 522
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129359 604 GAAAPPPAAGQasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPG 664
Cdd:PRK12323 523 AESIPDPATAD--------------PDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRAS 569
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
412-597 |
1.39e-04 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 46.91 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 412 APAAPLPVAQTAAPPAvGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTTIAQ 491
Cdd:PRK12727 65 TAAAPAPAPQAPTKPA-APVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPRQAPAAAPVRAASIPSPAAQAL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 492 GTSPAVPFVDTQ--AVPTIP-------LTVPPGNPPPTSTLGGFFTTgEVAPVVAPFGTQASPATQSAGFFNPGEVRPNV 562
Cdd:PRK12727 144 AHAAAVRTAPRQehALSAVPeqlfadfLTTAPVPRAPVQAPVVAAPA-PVPAIAAALAAHAAYAQDDDEQLDDDGFDLDD 222
|
170 180 190
....*....|....*....|....*....|....*
gi 20129359 563 PLAEPVPTIPItssgvPPIGLFPPAPAQPGVQTAS 597
Cdd:PRK12727 223 ALPQILPPAAL-----PPIVVAPAAPAALAAVAAA 252
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
888-1179 |
1.39e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 47.07 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 888 PPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLFVPV-----------PGLPGLSQDI-PLYPPPPT 955
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhpQRLPSPHPPLqPMTQPPPP 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 956 GSTTASSIFAA------PPVA---SSAPLFVPVPGPPS---VSSLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTTSTL 1023
Cdd:pfam03154 259 SQVSPQPLPQPslhgqmPPMPhslQTGPSHMQHPVPPQpfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQ 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1024 FANN--IPTTTPSIPDIVP--TTSAELVDAPPGFQGSSDDTATNLFQGNTETQtvfSPFAQTKATPLVQETKPELVPPPI 1099
Cdd:pfam03154 339 PPREqpLPPAPLSMPHIKPppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPL 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1100 GFFapkSESEVLSQPPLAPSPLQSFFSTAPETATTTDFNFFGSPAPGSVFPDLPVQQGiAPPPLALESPPQNSVSNIATS 1179
Cdd:pfam03154 416 QLM---PQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPG-GPPPITPPSGPPTSTSSAMPG 491
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
702-981 |
3.42e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.85 E-value: 3.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 702 PQSAPIAPPPG--TSSTSVAPPLTASIANPPPTSGFASVplfAAPTISSTPIP-FFNPQPTGAEVTTGLSQQENEATAST 778
Cdd:PRK10263 315 PITEPVAVAAAatTATQSWAAPVEPVTQTPPVASVDVPP---AQPTVAWQPVPgPQTGEPVIAPAPEGYPQQSQYAQPAV 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 779 TLEGLVQGPAPTLSASQFFDTPLPTGTQPENQVASVSSERENLV-QEPISNQGIPFFAPPQTNIFTPQLQQEfiaPAEDS 857
Cdd:PRK10263 392 QYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYApAPEQPVAGNAWQAEEQQSTFAPQSTYQ---TEQTY 468
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 858 KRSEIQEEFLSAPPQEsnlstelrEDTHTGPPviEPVLEETpasssESSVPPA---SKVDQEDIVYPEPSAPVEQEIPLF 934
Cdd:PRK10263 469 QQPAAQEPLYQQPQPV--------EQQPVVEP--EPVVEET-----KPARPPLyyfEEVEEKRAREREQLAAWYQPIPEP 533
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 20129359 935 V--PVPGLPGLSQDIPLYPPPPTGSTTASSIFAAPPVASS---------APLFVPVPG 981
Cdd:PRK10263 534 VkePEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLatgaaatvaAPVFSLANS 591
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
362-526 |
3.96e-04 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 45.51 E-value: 3.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 362 TTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTP 441
Cdd:COG3469 55 GSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 442 SVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGeLFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTV--PPGNPPP 519
Cdd:COG3469 135 TSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTT-TSASTTPSATTTATATTASGATTPSATTTATTtgPPTPGLP 213
|
....*..
gi 20129359 520 TSTLGGF 526
Cdd:COG3469 214 KHVLVGY 220
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
335-760 |
6.09e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.16 E-value: 6.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 335 GIVQSATGRSSEPEHTNVQQAGGYLDITTASAPAPSTNLFGGPNSTFPPGGNyfVPGAPPSLPSTGVVGPPSVGNFfAPA 414
Cdd:PHA03307 19 EFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTG--PPPGPGTEAPANESRSTPTWSL-STL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 415 APLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSA-----TVNQSALPPNNPPTASAVGELFVPAPTTI 489
Cdd:PHA03307 96 APASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpPPAASPPAAGASPAAVASDAASSRQAALP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 490 AQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGTQASPA---------TQSAGFFNPGEVRP 560
Cdd:PHA03307 176 LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAgasssdsssSESSGCGWGPENEC 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 561 NVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKgtrlYKSPLTPQETATSSG 640
Cdd:PHA03307 256 PLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASS----SSSSSRESSSSSTSS 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 641 FAAPLPPTSVTPAifnPFGAPAPGSfnsvghlegQSSQGVPFFTPPVQNPPGQVAAPTVAvpQSAPIAPPPGTSSTSVAP 720
Cdd:PHA03307 332 SSESSRGAAVSPG---PSPSRSPSP---------SRPPPPADPSSPRKRPRPSRAPSSPA--ASAGRPTRRRARAAVAGR 397
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 20129359 721 PLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTG 760
Cdd:PHA03307 398 ARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSG 437
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
476-1017 |
6.87e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.08 E-value: 6.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 476 SAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIpltvppgnppptstlggffTTGEvaPVVAPFGTQASPATQSAgffnP 555
Cdd:PRK10263 334 AAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGP-------------------QTGE--PVIAPAPEGYPQQSQYA----Q 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 556 GEVRPNVPLAEPVPTIPI----TSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQ-----KGTRLY 626
Cdd:PRK10263 389 PAVQYNEPLQQPVQPQQPyyapAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFApqstyQTEQTY 468
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 627 KSPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAP-GSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSA 705
Cdd:PRK10263 469 QQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPlYYFEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPS 548
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 706 PIAPPPGTSSTSVApPLTASIANPPptsgfasvplFAAPTISSTPIPFFNPQPTGA---EVTTGLSQQ---ENEATASTT 779
Cdd:PRK10263 549 VAAVPPVEAAAAVS-PLASGVKKAT----------LATGAAATVAAPVFSLANSGGprpQVKEGIGPQlprPKRIRVPTR 617
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 780 LEGLVQG---PAPTLSASQFFDTplpTGTQPENQVASVSSERENLVQEPISNQgipfFAPPQTNIFTPQLQQEFIAPAED 856
Cdd:PRK10263 618 RELASYGiklPSQRAAEEKAREA---QRNQYDSGDQYNDDEIDAMQQDELARQ----FAQTQQQRYGEQYQHDVPVNAED 690
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 857 ---SKRSEIQEEFLSAPPQ------------------ESNLSTELREDTHTGP---PVIEPVLE--ETPASSSESSVPPA 910
Cdd:PRK10263 691 adaAAEAELARQFAQTQQQrysgeqpaganpfslddfEFSPMKALLDDGPHEPlftPIVEPVQQpqQPVAPQQQYQQPQQ 770
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 911 SKVDQEDIVYP-EPSAPVEQEIPLFVPVPGLPGLSQdiPLYPPPPTGSTTASSIFAAPPVASSAPLFVPVPGPPsvSSLF 989
Cdd:PRK10263 771 PVAPQPQYQQPqQPVAPQPQYQQPQQPVAPQPQYQQ--PQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ--DTLL 846
|
570 580 590
....*....|....*....|....*....|
gi 20129359 990 SPSQVDSTSSLFAPPPTS--ANTTILTPAP 1017
Cdd:PRK10263 847 HPLLMRNGDSRPLHKPTTplPSLDLLTPPP 876
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
382-526 |
7.16e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 44.71 E-value: 7.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 382 PPGGNYFVPGAPPSLPSTGVVGPPSVgnffAPAAPLPVAQTAAPPAVGAF-FTSAAPSVTPSvftPGTVPPLAPQPFQSA 460
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAA----APVAQAAAAPAPAAAPAAAAsAPAAPPAAAPP---APVAAPAAAAPAAAP 438
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20129359 461 TVNQSALPPNNPPTASAVGElFVPAPTTIAQGTSPAVPfvdtqavPTIPLTVPPGNPPPTSTLGGF 526
Cdd:PRK14951 439 AAAPAAVALAPAPPAQAAPE-TVAIPVRVAPEPAVASA-------APAPAAAPAAARLTPTEEGDV 496
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
871-1174 |
7.85e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 44.52 E-value: 7.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 871 PQESNLSTELREDTHTGPPV-IEPVLEETPASSSESSVP----PASKVDQEDIVYPEPSAPVEQeipLFVPVPG----LP 941
Cdd:pfam05109 449 PSSTHVPTNLTAPASTGPTVsTADVTSPTPAGTTSGASPvtpsPSPRDNGTESKAPDMTSPTSA---VTTPTPNatspTP 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 942 GLSQDIPLYPPPPTGSTTASSIFAAP-PVASSAPLFVPVPGPPSvsSLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTT 1020
Cdd:pfam05109 526 AVTTPTPNATSPTLGKTSPTSAVTTPtPNATSPTPAVTTPTPNA--TIPTLGKTSPTSAVTTPTPNATSPTVGETSPQAN 603
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1021 STLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATNLFQGNTETQTVFSPFAQTKATPLVQETKPELVPPPIG 1100
Cdd:pfam05109 604 TTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQ 683
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20129359 1101 FFAPKSESEVLSQPPLAPSPLQSFFSTAPETATTT----DFNFF-GSPAPGSVFPDLPVQQGIAPPPLALESPPQNSVS 1174
Cdd:pfam05109 684 VTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTStkpgEVNVTkGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTT 762
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
380-592 |
8.52e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 8.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 380 TFPPGGNYFVPGAPPsLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAvgafftsAAPSVTPSVFTPGTVPPLAPqpfqs 459
Cdd:PHA03247 245 SHPLRGDIAAPAPPP-VVGEGADRAPETARGATGPPPPPEAAAPNGAA-------APPDGVWGAALAGAPLALPA----- 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 460 atvnqsalPPNNPPTASAVGELFVPAPTTIAQGTSPaVPFVDTQAVPTIPLTVPPGNPPPTSTLGgfFTTGEVAPVVAPF 539
Cdd:PHA03247 312 --------PPDPPPPAPAGDAEEEDDEDGAMEVVSP-LPRPRQHYPLGFPKRRRPTWTPPSSLED--LSAGRHHPKRASL 380
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129359 540 GTQ--------ASPATQSAGFFNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPG 592
Cdd:PHA03247 381 PTRkrrsarhaATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPG 441
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
405-646 |
1.16e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.10 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 405 PSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVP 484
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 485 APTTIAQGTSPAVPfvdtqaVPTIPLTVPPGNPPPTSTlggffttgevAPVVAPFGTQASPATQSAGFFNPGEVRPNVPL 564
Cdd:PRK12323 445 GGAPAPAPAPAAAP------AAAARPAAAGPRPVAAAA----------AAAPARAAPAAAPAPADDDPPPWEELPPEFAS 508
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 565 AEPVPTIPiTSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTRLYKSPLTPQETATSSGFAAP 644
Cdd:PRK12323 509 PAPAQPDA-APAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAAR 587
|
..
gi 20129359 645 LP 646
Cdd:PRK12323 588 LP 589
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
855-1152 |
1.83e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 43.52 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 855 EDSKRSEIQEEflsappQESNLSTELREDTHTGPPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLF 934
Cdd:PTZ00449 535 EDSKESDEPKE------GGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPTR 608
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 935 VPVPGLPGLSqDIPLYPPPPTGSTTASSifaappvassaplfvpvpgPPSVSSLFSPSQVDSTSSLFAP-PPTSanttil 1013
Cdd:PTZ00449 609 PKSPKLPELL-DIPKSPKRPESPKSPKR-------------------PPPPQRPSSPERPEGPKIIKSPkPPKS------ 662
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1014 tpapdttstlfanniptttPSIPdIVPTTSAELVDAPPGFQGSSDDTATNLFQGNTETQTVFSPFAQTKATPLvqeTKPE 1093
Cdd:PTZ00449 663 -------------------PKPP-FDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPF---TTPR 719
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129359 1094 LVPPPIgffaPKSESEVLSQP--PLAPSPLQSFFSTAPETATTtdfnFFGSPAPGSVFPDL 1152
Cdd:PTZ00449 720 PLPPKL----PRDEEFPFEPIgdPDAEQPDDIEFFTPPEEERT----FFHETPADTPLPDI 772
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
540-794 |
1.87e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 43.33 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 540 GTQASPATQSAGffnpgevrpnvPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNP--LPGAAAPPPAAGQASY 617
Cdd:PRK12323 369 GGGAGPATAAAA-----------PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVaaAPARRSPAPEALAAAR 437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 618 RLQKGTRLYKSPLTPQetatssgfAAPLPPTSVTPAIFNPFGAPAPGSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAP 697
Cdd:PRK12323 438 QASARGPGGAPAPAPA--------PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 698 TVAVPQSAP------------IAPPPGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEV-- 763
Cdd:PRK12323 510 APAQPDAAPagwvaesipdpaTADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARlp 589
|
250 260 270
....*....|....*....|....*....|....
gi 20129359 764 TTGLSQQENEATASTTLEG---LVQGPAPTLSAS 794
Cdd:PRK12323 590 VRGLAQQLARQSELAGVEGdtvRLRVPVPALAEA 623
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
38-590 |
1.89e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.39 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 38 DDFPNKPQLLPAaPPVVHATPPAAPVLIAGILNREPKSLVTVGQPSSIDDSEALDEINLNT-SSEDSVGAGGSSPylgag 116
Cdd:PHA03247 2606 GDPRGPAPPSPL-PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSP----- 2679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 117 DQNANPLLEPPTEAGNDSLLSQAASSFTALPAvasnvfstfskriyagSRETSEEPKLDIQPSYIQQASYVQPVAPVPAP 196
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----------------PHALVSATPLPPGPAAARQASPALPAAPAPPA 2743
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 197 FYAAPPAAANEVVAPEPPkfyapTEVPPPNVGVPAPPPTSGNPNTYRfTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQA 276
Cdd:PHA03247 2744 VPAGPATPGGPARPARPP-----TTAGPPAPAPPAAPAAGPPRRLTR-PAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 277 APSFQTPPYPPQLTYAANPAPfdiSAQPAAIPAEERKSGGglfsltSLVPTGVLQNiTGIVQSATGRSSEPEHTNVQQag 356
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTA---PPPPPGPPPPSLPLGG------SVAPGGDVRR-RPPSRSPAAKPAAPARPPVRR-- 2885
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 357 gyldiTTASAPAPSTNLFGGPnstfppggnyfvPGAPPSLPStgvvgppsvgnffaPAAPLPVAQTAAPPavgafftsAA 436
Cdd:PHA03247 2886 -----LARPAVSRSTESFALP------------PDQPERPPQ--------------PQAPPPPQPQPQPP--------PP 2926
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 437 PSVTPSVFTPG-TVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTtiaqgTSPAVPFVDTQAVPTIPLTVPP- 514
Cdd:PHA03247 2927 PQPQPPPPPPPrPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFR-----VPQPAPSREAPASSTPPLTGHSl 3001
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 515 ---------------GNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFFNPGEVRPNVPLA-EPVPTIPITSSGV 578
Cdd:PHA03247 3002 srvsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAhEPDPATPEAGARE 3081
|
570
....*....|..
gi 20129359 579 PPIGLFPPAPAQ 590
Cdd:PHA03247 3082 SPSSQFGPPPLS 3093
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
209-588 |
2.01e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 43.37 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 209 VAPEPPKFYAPTEVPPPNVGVPAPPPTSGNPNTYrftarkklyAPIPGLSEQSGQPAQQPQVPQAPQAAPSFQTPPyppq 288
Cdd:pfam05109 488 VTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT---------SPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPN---- 554
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 289 ltyAANPAPFDISAQP-AAIPaeerksggglfSLTSLVPTGVLQNITGIVQSATGRSSEPEH--TNVQQAGGYLDITTAS 365
Cdd:pfam05109 555 ---ATSPTPAVTTPTPnATIP-----------TLGKTSPTSAVTTPTPNATSPTVGETSPQAntTNHTLGGTSSTPVVTS 620
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 366 APAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGvvgPPSVGNFFAPAAPLpvaQTAAPPAVGAFFTSAAPSVTPSVFT 445
Cdd:pfam05109 621 PPKNATSAVTTGQHNITSSSTSSMSLRPSSISETL---SPSTSDNSTSHMPL---LTSAHPTGGENITQVTPASTSTHHV 694
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 446 PGTVPplAPQPfqsATVNQSAlPPNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNppptSTLGG 525
Cdd:pfam05109 695 STSSP--APRP---GTTSQAS-GPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKAN----STTGG 764
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129359 526 FFTTGEVAPvvapfgTQASPATQSAGFFNPGEVRPNVPLAEPvptiPITSSGVPPIGLFPPAP 588
Cdd:pfam05109 765 KHTTGHGAR------TSTEPTTDYGGDSTTPRTRYNATTYLP----PSTSSKLRPRWTFTSPP 817
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
672-1018 |
2.51e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.05 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 672 LEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSSTSVAP---PLTASIANPPPTSGFASVPLFAAPTISS 748
Cdd:PRK07764 381 LERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPqpaPAPAPAPAPPSPAGNAPAGGAPSPPPAA 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 749 TPIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQFFDTP------LPTGTQPENQVASVSSERENLV 822
Cdd:PRK07764 461 APSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLrerwpeILAAVPKRSRKTWAILLPEATV 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 823 QEPISNQGIPFFAppqtnifTPQLQQEFIAP-AEDSKRSEIQEEF--------------------LSAPPQESNLSTELR 881
Cdd:PRK07764 541 LGVRGDTLVLGFS-------TGGLARRFASPgNAEVLVTALAEELggdwqveavvgpapgaaggeGPPAPASSGPPEEAA 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 882 EDTHTGPPViEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLFVPvPGLPGLSQDIPLYPPPPTGSTTAS 961
Cdd:PRK07764 614 RPAAPAAPA-APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD-GWPAKAGGAAPAAPPPAPAPAAPA 691
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 20129359 962 SIFAAPPVASSAPLFVPVPGPPSVSSLFSPSQVDSTSSlfAPPPTSANTTILTPAPD 1018
Cdd:PRK07764 692 APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGAS--APSPAADDPVPLPPEPD 746
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
319-779 |
3.36e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 42.60 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 319 FSLTSLVPTGVlQNITGIVqsATGRSSEPEHTNVQQAGGYLDITTASAPAPSTN----LFGGPNSTfppggnyfvpGAPP 394
Cdd:pfam05109 366 WTLTSGTPSGC-ENISGAF--ASNRTFDITVSGLGTAPKTLIITRTATNATTTThkviFSKAPEST----------TTSP 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 395 SLPSTGVVGPPSVGNFfaPAAPLPVAQTAAPPAVGAFFTSA-APSVTPSVFTPGTvPPLAPQPFQSATVNQSALPPNNPP 473
Cdd:pfam05109 433 TLNTTGFAAPNTTTGL--PSSTHVPTNLTAPASTGPTVSTAdVTSPTPAGTTSGA-SPVTPSPSPRDNGTESKAPDMTSP 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 474 TASavgelfVPAPTTIAQGTSPAVPfvdtqavptipltvppgNPPPTSTLGGFFTTGEVAPVVAPFGTQASPAtqsagff 553
Cdd:pfam05109 510 TSA------VTTPTPNATSPTPAVT-----------------TPTPNATSPTLGKTSPTSAVTTPTPNATSPT------- 559
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 554 npgevrPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTRLYKSPLTPQ 633
Cdd:pfam05109 560 ------PAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQ 633
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 634 ETATSSGFAA-PLPPTSVTPAIfnpfgAPAPgSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSAP------ 706
Cdd:pfam05109 634 HNITSSSTSSmSLRPSSISETL-----SPST-SDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPrpgtts 707
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129359 707 IAPPPGTSSTSVAPPLTASIANPPPTSgfASVPlfAAPTISSTPIPFFNPQPTGAEVTTGLSQQENEATASTT 779
Cdd:pfam05109 708 QASGPGNSSTSTKPGEVNVTKGTPPKN--ATSP--QAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTST 776
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
389-592 |
3.52e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.28 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 389 VPGAPPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPfqsatvnQSALP 468
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPK-------HVAVP 660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 469 PNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPtstlggffttgevAPVVAPFGTQASPATQ 548
Cdd:PRK07764 661 DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPA-------------GQADDPAAQPPQAAQG 727
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 20129359 549 SAGFFNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPG 592
Cdd:PRK07764 728 ASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPA 771
|
|
| COG4935 |
COG4935 |
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
314-816 |
3.79e-03 |
|
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 42.12 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 314 SGGGLFSLTSLVPTGVLQNITGIVQSATGRSSEPEHTNVQQAGGYLDITTASAPAPSTNLFGGPNSTFPPGGNYFVPGAP 393
Cdd:COG4935 40 AAVAGASAAAAAATAVGAGASSLAASAAAAAAAASGAAAGAVDAAPAAATVVGAALGVVAVAGAGLAATASGAAAGAVAA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 394 PSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSATVNQSALPPNNPP 473
Cdd:COG4935 120 AANGNTGAGPGSGGTGGGSGGAGAAAAAAALSAAGAAVGVAAVAGAAGGGGGVGVAAAVGVVLGAGLVADGGNGGGGAVA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 474 TASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFF 553
Cdd:COG4935 200 GGAAGGGGGGGGGGGLGGAAGGGGAGLAAAGGGGGGAAAAAAAGVGGLGAAATAAAADGGGGGGAGAAGAGGSAGAAAGG 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 554 NPGEVRPNVPLAEPVPT-----IPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTRLYKS 628
Cdd:COG4935 280 AGAGVVGAAAGGGDAALggavgAAGTGNAAAAAAASAGSGGGGGSAAAAGAAAAAAAAAAGAAAGVSGAASVVAGASGGG 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 629 PLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSAPIA 708
Cdd:COG4935 360 AGTAAAAGGGAAAAAAGGAAAAGAAAGAAAGAAAGAAAAGGVASAAGAVGAGTAAGASATAAVSTGAASGSSTTSSTGTT 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 709 PPPGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPA 788
Cdd:COG4935 440 ATATGLGGGADAGSTSTGTGSAAGAAGGTTTATSGLASSTTAAAAAAAAGLATTAAVAAGAAGAAAAAATAASVGGATGA 519
|
490 500
....*....|....*....|....*...
gi 20129359 789 PTLSASQFFDTPLPTGTQPENQVASVSS 816
Cdd:COG4935 520 AGTTNSTATFSNTTDVAIPDNGPAGVTS 547
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
210-570 |
4.78e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 210 APEPPKFYAPTEVPPPNVGVPAPPPTSGNPNTyrfTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQAAPSFQTPPYPPql 289
Cdd:PRK07764 411 APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP---SPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPP-- 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 290 tyaANPAPfdisAQPAAIPAEERKSGGGLF---------SLTSLVPTGVLQNITGIVQSAT------------------- 341
Cdd:PRK07764 486 ---AAPAP----AAAPAAPAAPAAPAGADDaatlrerwpEILAAVPKRSRKTWAILLPEATvlgvrgdtlvlgfstggla 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 342 GRSSEPEHTNV------QQAGGYLDITTASAPAPSTNLFGGPNSTFPPGGNYFV--PGAPPSLPSTGVVGPPSVGNFFAP 413
Cdd:PRK07764 559 RRFASPGNAEVlvtalaEELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAarPAAPAAPAAPAAPAPAGAAAAPAE 638
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 414 AAPLPVAQTAAPPAVGAFFTSAAPSVTPSvftPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTTIAQGT 493
Cdd:PRK07764 639 ASAAPAPGVAAPEHHPKHVAVPDASDGGD---GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD 715
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 494 SPA----VPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFFNPGEVRPNVPLAEPVP 569
Cdd:PRK07764 716 DPAaqppQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDD 795
|
.
gi 20129359 570 T 570
Cdd:PRK07764 796 E 796
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
711-973 |
5.32e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 41.99 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 711 PGTSSTSVAPPLTASIANPPPTSGFASVplfAAPTISSTPIPffnpqptGAEVTTGLSQQENEATASttleglVQGPAPT 790
Cdd:PRK10263 309 PLLNGAPITEPVAVAAAATTATQSWAAP---VEPVTQTPPVA-------SVDVPPAQPTVAWQPVPG------PQTGEPV 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 791 LSasqffdtPLPTGTQPENQVASVSSERENLVQEPISNQGIPFFAPPQTNIFTPQ--------LQQEFIAPAEDSKRSEI 862
Cdd:PRK10263 373 IA-------PAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYyapapeqpAQQPYYAPAPEQPVAGN 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 863 QEEflsAPPQESNLSTELREDTHTgpPVIEPVLEETPASSSEsSVPPASKVDQEDIVypEPSAPVEQEIPLFVPV----- 937
Cdd:PRK10263 446 AWQ---AEEQQSTFAPQSTYQTEQ--TYQQPAAQEPLYQQPQ-PVEQQPVVEPEPVV--EETKPARPPLYYFEEVeekra 517
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 20129359 938 ---PGLPGLSQDIP---LYPPPPTGSTTASSIFAAPPVASSA 973
Cdd:PRK10263 518 rerEQLAAWYQPIPepvKEPEPIKSSLKAPSVAAVPPVEAAA 559
|
|
| GGN |
pfam15685 |
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the ... |
501-1022 |
5.72e-03 |
|
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the maturation of sperm and is expressed virtually only in the testis. It is found to be associated with the intracellular membrane, binds with GGNBP1 and may be involved in vesicular trafficking.
Pssm-ID: 434857 [Multi-domain] Cd Length: 668 Bit Score: 41.68 E-value: 5.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 501 DTQAVPTIPLTVPPGNPP--PTSTLGGFFTTGEVAP-VVAPFGTQASPATQSAGFFNPgevRPNVPLAEPVPTIPITSSG 577
Cdd:pfam15685 24 DSRRTSLVEPEVTPSSPAmrLAQGLGVWFPGSSAPPgLLVPPEPQASPSPLPLTLELP---LPVTPPPEEAAAAAVSTAP 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 578 VPPIGLFPPAPAQ------------PGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTrLYKSPLTPQETATSSGFAAPL 645
Cdd:pfam15685 101 PPAVGSLLPAPSKwrkptgtavariRGLLEASHRGQGDPLSLRPLLPLLPRQLIEKDP-APGAPAPPPPTPLEPRKPPPL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 646 PPTS-------VTPAIFNPFGAPAPGSFNSVGhlEGQSSQGVPFFTPPvQNPPGQVAAPTVAVPQSAPIAPPPGTSstsv 718
Cdd:pfam15685 180 PPSDrqppnrgITPALATSATSPTDSQAKHIA--EGKTAGGACGGAPP-QAGEGEMARFAASESGLSLLCKVTFKS---- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 719 APPLTASIANPPPTS-----GFASVPLFAAPT-ISSTPIPFFNPQPTGAEVTTG---LSQQENEATASTTlEGLVQGPAP 789
Cdd:pfam15685 253 AAPLCPAAASGPLAAkaslgGGGGGGLFAASGaISCAEVLKQGPLAPGAARPLGevpRAALETEGGEGDG-EGCSGGPAA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 790 TLSASQFFDTPLPT---GTQPENQVASVSSERENLVQEPISNQGI------------PFFAPPqtnifTPQLQQEfiaPA 854
Cdd:pfam15685 332 PASHARALPPPAYTtfpGSKPKFDWVSPPDGPERHFRFNGAGGGIgaprrraaalsgPWGSPP-----PPPGKAH---PI 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 855 EDSKRSEiqeEFLSAPPQESNLSTELREDTHTGPPVIEPVLEETPASSSESSVPPASKvdqedivyPEPSAPVEQEIPLF 934
Cdd:pfam15685 404 PGPRRPA---PALLAPPMFIFPAPTNGEPVRPGPPAPQALLPRPPPPTPPATPPPVPP--------PIPQLPALQPMPLA 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 935 VPVPglpglsqdiplyPPPPTGSTTASSIFAAPPVAssaplfvpvPGPPSVSSLFSPSQVDSTSSLFAPPPTSANTTILT 1014
Cdd:pfam15685 473 AARP------------PTPRPCPGHGESALAPAPTA---------PLPPALAADQAPAPALAAAPAPSPAPAPATADPLP 531
|
....*...
gi 20129359 1015 PAPDTTST 1022
Cdd:pfam15685 532 PAPAPIKA 539
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
632-762 |
6.32e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 41.62 E-value: 6.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 632 PQETATSSGFAAPLPPTSVTPAifnpfgAPAPgsfnsvghlegqssqgvpffTPPVQNPPGQVAAPTVAVPQSAPIAPPP 711
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAA------APAA--------------------APVAQAAAAPAPAAAPAAAASAPAAPPA 419
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 20129359 712 GTSSTSVAPPLTASiANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAE 762
Cdd:PRK14951 420 AAPPAPVAAPAAAA-PAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPE 469
|
|
| half-pint |
TIGR01645 |
poly-U binding splicing factor, half-pint family; The proteins represented by this model ... |
684-824 |
7.28e-03 |
|
poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.
Pssm-ID: 130706 [Multi-domain] Cd Length: 612 Bit Score: 41.21 E-value: 7.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 684 TPPVQNPPGQVAAPTVAVPQSAPIAPPPG--TSSTSVAPPLTASIANPPPTSgfASVPLFAAPTISSTPIPFFNPQPTGA 761
Cdd:TIGR01645 344 NKAVVSSAKKEAEEVPPLPQAAPAVVKPGpmEIPTPVPPPGLAIPSLVAPPG--LVAPTEINPSFLASPRKKMKREKLPV 421
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20129359 762 EV-----TTGLSQQENEATASTTLEGLVQGPAPTLSASQFFDTPLPTGTQPENQVASVSSERENLVQE 824
Cdd:TIGR01645 422 TFgalddTLAWKEPSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKEKEGEELQPKLVMNSEDASLAS 489
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
616-781 |
7.29e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 41.30 E-value: 7.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 616 SYRLQKGTRLY------KSPLTPQETATSSGFAAPLPPTSvtPAIFNPFGAPAPGSFNSVGHLEGQSSQGV-PFFTPPVQ 688
Cdd:PRK14971 341 NYRASKNKRLLveltliQLAQLTQKGDDASGGRGPKQHIK--PVFTQPAAAPQPSAAAAASPSPSQSSAAAqPSAPQSAT 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 689 NPpgQVAAPTVAVPQSAPI-APPPGTSSTSVAPPLTASiANPPPTSgfasvplfaapTISSTPIPFFNPQPTGAEvttGL 767
Cdd:PRK14971 419 QP--AGTPPTVSVDPPAAVpVNPPSTAPQAVRPAQFKE-EKKIPVS-----------KVSSLGPSTLRPIQEKAE---QA 481
|
170
....*....|....
gi 20129359 768 SQQENEATASTTLE 781
Cdd:PRK14971 482 TGNIKEAPTGTQKE 495
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
949-1178 |
7.70e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 41.44 E-value: 7.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 949 LYPPPPTGSTTASSI----FAAPPVASSAP--------LFVPVPGPPSVSS--LFSPSQVDSTS--SLFAPPPTSANTTI 1012
Cdd:pfam05109 420 IFSKAPESTTTSPTLnttgFAAPNTTTGLPssthvptnLTAPASTGPTVSTadVTSPTPAGTTSgaSPVTPSPSPRDNGT 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1013 LTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATnlfqgnTETQTVFSPfaqtkaTPLVQETKP 1092
Cdd:pfam05109 500 ESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVT------TPTPNATSP------TPAVTTPTP 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129359 1093 ELVPPPIGFFAPKseSEVLSQPPLAPSPlqSFFSTAPEtATTTDFNFFGSPAPgsvfpdlPVqqgiappplaLESPPQNS 1172
Cdd:pfam05109 568 NATIPTLGKTSPT--SAVTTPTPNATSP--TVGETSPQ-ANTTNHTLGGTSST-------PV----------VTSPPKNA 625
|
....*.
gi 20129359 1173 VSNIAT 1178
Cdd:pfam05109 626 TSAVTT 631
|
|
| PRK14950 |
PRK14950 |
DNA polymerase III subunits gamma and tau; Provisional |
684-752 |
9.03e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 40.95 E-value: 9.03e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20129359 684 TPPVQNPPGQVAAPTVAVPQSAP-------IAPPPGTSSTSVAPPLTASIANPPPTSGfASVPLFAAPTISSTPIP 752
Cdd:PRK14950 376 PSPVRPTPAPSTRPKAAAAANIPpkepvreTATPPPVPPRPVAPPVPHTPESAPKLTR-AAIPVDEKPKYTPPAPP 450
|
|
|