uncharacterized protein Dmel_CG14921 [Drosophila melanogaster]
Protein Classification
p23_DYX1C1_like and 3a0801s09 domain-containing protein( domain architecture ID 10158101)
protein containing domains p23_DYX1C1_like, PTZ00121, and 3a0801s09
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| p23_DYX1C1_like | cd06469 | p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ... |
4-81 | 8.05e-33 | ||
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region. : Pssm-ID: 107226 Cd Length: 78 Bit Score: 113.91 E-value: 8.05e-33
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| Name | Accession | Description | Interval | E-value | ||
| p23_DYX1C1_like | cd06469 | p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ... |
4-81 | 8.05e-33 | ||
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region. Pssm-ID: 107226 Cd Length: 78 Bit Score: 113.91 E-value: 8.05e-33
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| CS | pfam04969 | CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ... |
5-71 | 2.76e-03 | ||
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2. Pssm-ID: 461503 Cd Length: 76 Bit Score: 35.70 E-value: 2.76e-03
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| Name | Accession | Description | Interval | E-value | ||
| p23_DYX1C1_like | cd06469 | p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ... |
4-81 | 8.05e-33 | ||
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region. Pssm-ID: 107226 Cd Length: 78 Bit Score: 113.91 E-value: 8.05e-33
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| p23_like | cd06463 | Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ... |
5-77 | 4.98e-10 | ||
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells. Pssm-ID: 107220 Cd Length: 84 Bit Score: 54.60 E-value: 4.98e-10
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| CS | pfam04969 | CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ... |
5-71 | 2.76e-03 | ||
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2. Pssm-ID: 461503 Cd Length: 76 Bit Score: 35.70 E-value: 2.76e-03
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