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Conserved domains on  [gi|24585288|ref|NP_609989|]
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uncharacterized protein Dmel_CG13078 [Drosophila melanogaster]

Protein Classification

Cyt_b561 domain-containing protein( domain architecture ID 10504994)

Cyt_b561 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 48-184 2.56e-33

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


:

Pssm-ID: 427188  Cd Length: 137  Bit Score: 116.55  E-value: 2.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288    48 LHAWLVTFGFVFLMAEGMMCFYdgSWLTVRYSRNYKTAFHVVLQILGGGMGVAGCLIQLIRDDWS---ISVTLHARLGFA 124
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSgipHFYSLHSWLGLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288   125 AFVLCLISLLSGLVAFLARCLSRTISPLVNKTfHVVLSFTAFVIAMMAQFYGYTQTGIFR 184
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPL-HVFFGLVIFVLAIVTALLGLLEKLIFQ 137
 
Name Accession Description Interval E-value
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 48-184 2.56e-33

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 116.55  E-value: 2.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288    48 LHAWLVTFGFVFLMAEGMMCFYdgSWLTVRYSRNYKTAFHVVLQILGGGMGVAGCLIQLIRDDWS---ISVTLHARLGFA 124
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSgipHFYSLHSWLGLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288   125 AFVLCLISLLSGLVAFLARCLSRTISPLVNKTfHVVLSFTAFVIAMMAQFYGYTQTGIFR 184
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPL-HVFFGLVIFVLAIVTALLGLLEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 48-177 3.18e-28

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 103.47  E-value: 3.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288     48 LHAWLVTFGFVFLMAEGMMCFYdgsWLTVRYSRNYKTAFHVVLQILGGGMGVAGCLIQLIRDDWS---ISVTLHARLGFA 124
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVAR---PLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESgiaNFYSLHSWLGLA 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24585288    125 AFVLCLISLLSGLVAFLARCLSRTIsPLVNKTFHVVLSFTAFVIAMMAQFYGY 177
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSKY-RSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 48-177 6.64e-21

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 84.26  E-value: 6.64e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288  48 LHAWLVTFGFVFLMAEGMMCFYDGswltVRYSRNYKTAFHVVLQILGGGMGVAGCLIQLIR---DDWSISVTLHARLGFA 124
Cdd:cd08554   4 WHPLLMVIGFVFLMGEALLVYRVF----RLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFhnaGGIANLYSLHSWLGLA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24585288 125 AFVLCLISLLSGLVAFLARCLSRTIsPLVNKTFHVVLSFTAFVIAMMAQFYGY 177
Cdd:cd08554  80 TVLLFLLQFLSGFVLFLLPLLRLSY-RSSLLPFHRFFGLAIFVLAIATILLGI 131
 
Name Accession Description Interval E-value
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 48-184 2.56e-33

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 116.55  E-value: 2.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288    48 LHAWLVTFGFVFLMAEGMMCFYdgSWLTVRYSRNYKTAFHVVLQILGGGMGVAGCLIQLIRDDWS---ISVTLHARLGFA 124
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSgipHFYSLHSWLGLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288   125 AFVLCLISLLSGLVAFLARCLSRTISPLVNKTfHVVLSFTAFVIAMMAQFYGYTQTGIFR 184
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPL-HVFFGLVIFVLAIVTALLGLLEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 48-177 3.18e-28

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 103.47  E-value: 3.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288     48 LHAWLVTFGFVFLMAEGMMCFYdgsWLTVRYSRNYKTAFHVVLQILGGGMGVAGCLIQLIRDDWS---ISVTLHARLGFA 124
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVAR---PLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESgiaNFYSLHSWLGLA 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24585288    125 AFVLCLISLLSGLVAFLARCLSRTIsPLVNKTFHVVLSFTAFVIAMMAQFYGY 177
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSKY-RSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 48-177 6.64e-21

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 84.26  E-value: 6.64e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288  48 LHAWLVTFGFVFLMAEGMMCFYDGswltVRYSRNYKTAFHVVLQILGGGMGVAGCLIQLIR---DDWSISVTLHARLGFA 124
Cdd:cd08554   4 WHPLLMVIGFVFLMGEALLVYRVF----RLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFhnaGGIANLYSLHSWLGLA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24585288 125 AFVLCLISLLSGLVAFLARCLSRTIsPLVNKTFHVVLSFTAFVIAMMAQFYGY 177
Cdd:cd08554  80 TVLLFLLQFLSGFVLFLLPLLRLSY-RSSLLPFHRFFGLAIFVLAIATILLGI 131
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 27-203 1.40e-09

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 55.37  E-value: 1.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288  27 IGFVTIWISWTCLRQDLSGIRLHAWLVTFGFVFLMAEGMMCFYDGSWLTvRYSRNYKTAFHVVLQILGGGMGVAG-CLIQ 105
Cdd:cd08761   2 VAVVFAAFLLYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLT-KLARKTKVRLHWILQLLALLCILAGlVAIY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288 106 LIRDDWSIS--VTLHARLGFAAFVLCLISLLSGLVAFLARCLSRTISPLVN-KTFHVVLSFTAFVIAMMAQFYGYtQTGI 182
Cdd:cd08761  81 YNKERNGKPhfTSWHGILGLVTVILIVLQALGGLALLYPPGLRRGESKAKKlKKYHRLSGYVAYLLGLATLVLGL-ETRW 159

                       170       180
                ....*....|....*....|.
gi 24585288 183 FRGQGQDFVVLMQVVTMVLMV 203
Cdd:cd08761 160 FSKNVTHVALWYLALAVALAL 180
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 28-204 9.47e-07

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 47.72  E-value: 9.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288  28 GFVTIWISWTCLRQDLSGIRLHAWLVTFGFVFLMAEGMM-----CFYDGSWLTVrysrnyktafHVVLQILGGGMGVAG- 101
Cdd:cd08760  18 GSPFLLPNGSSVGSSDTLIKAHGVLMAIAWGILMPIGALlaryfLLGDPVWFYL----------HAGLQLLAVLLAIAGf 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288 102 -CLIQLIRDDWSISVTLHARLGFAAFVLCLISLLSGLVaflaRCLSRTISPLVNKTFHVVLSFTAFVIAMMAQFYGYTQT 180
Cdd:cd08760  88 vLGIVLVQGGGGSLNNAHAILGIIVLALAILQPLLGLL----RPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGLDLA 163

                       170       180
                ....*....|....*....|....
gi 24585288 181 GIFRGQGQDFVVLMQVVTMVLMVL 204
Cdd:cd08760 164 GAGTPKAWKIAYGVVVAVLALVYL 187
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 48-149 1.66e-05

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 43.45  E-value: 1.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288  48 LHAWLVTFGFVFLMAEGMMcfydgSWLTVRYSRNYKTAFHVVLQILGGGMGVAG-CLIQLIRDDWSIS--VTLHARLGFA 124
Cdd:cd08766  10 VHPVLMVIGFIFLAGEAIL-----AYKTVPGSREVQKAVHLTLHLVALVLGIVGiYAAFKFHNEVGIPnlYSLHSWLGIG 84

                        90       100
                ....*....|....*....|....*
gi 24585288 125 AFVLCLISLLSGLVAFLARCLSRTI 149
Cdd:cd08766  85 TISLFGLQWLFGFVTFWFPGASRNT 109
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 47-207 2.44e-04

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 40.78  E-value: 2.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288  47 RLHAWLVTFGFVFLMAEGMMCFYdgswlTVRYSRNYKTAF-HVVLQILGGGMGVAGclIQLIRDDWSISV-------TLH 118
Cdd:cd08764  25 NWHPLLMVLGLIFLYGNSILVYR-----VFRNTRKKRLKLlHAVLHLLAFILAVIG--LKAVFDSHNLAKppipnmySLH 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585288 119 ARLGFAAFVLCLISLLSGLVAFLARCLSRTISPLVNKTfHVVLSFTAFVIAMMAQFYGYTQTGIFR-GQGQDFV---VLM 194
Cdd:cd08764  98 SWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPL-HVFFGLFIFVLAVATALLGITEKAFFSlNKYSNLPaegVLG 176

                       170
                ....*....|...
gi 24585288 195 QVVTMVLMVLTSI 207
Cdd:cd08764 177 NFIGIVLVIFGGL 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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