NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|22024078|ref|NP_610379|]
View 

COP9 signalosome subunit 7 [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CSN7a_helixI super family cl39730
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 175-223 2.85e-14

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


The actual alignment was detected with superfamily member pfam18392:

Pssm-ID: 465740  Cd Length: 50  Bit Score: 65.78  E-value: 2.85e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22024078   175 TGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKERVEQDLIN 223
Cdd:pfam18392   2 IGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 96-185 1.05e-09

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


:

Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 54.17  E-value: 1.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22024078     96 LTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDNVrHLEDIIIEAIYADIIHGKLFQNTRILEVDYAQGRDIPPGyt 175
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPL-- 78

                           90
                   ....*....|
gi 22024078    176 GQIVETLQAW 185
Cdd:smart00088  79 AQFAETLKKL 88
 
Name Accession Description Interval E-value
CSN7a_helixI pfam18392
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 175-223 2.85e-14

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


Pssm-ID: 465740  Cd Length: 50  Bit Score: 65.78  E-value: 2.85e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22024078   175 TGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKERVEQDLIN 223
Cdd:pfam18392   2 IGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 96-185 1.05e-09

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 54.17  E-value: 1.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22024078     96 LTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDNVrHLEDIIIEAIYADIIHGKLFQNTRILEVDYAQGRDIPPGyt 175
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPL-- 78

                           90
                   ....*....|
gi 22024078    176 GQIVETLQAW 185
Cdd:smart00088  79 AQFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 72-162 1.99e-06

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 45.67  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22024078    72 FETLNLFAYGTYKEYRA----------QPEKFIELTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDnVRHLEDIII 141
Cdd:pfam01399   4 RDLLRAFYSGDLSEFEEiladykeellLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLS-VDEVEKILA 82

                          90       100
                  ....*....|....*....|.
gi 22024078   142 EAIYADIIHGKLFQNTRILEV 162
Cdd:pfam01399  83 KLIRDGRIRAKIDQVNGIVVF 103
 
Name Accession Description Interval E-value
CSN7a_helixI pfam18392
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 175-223 2.85e-14

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


Pssm-ID: 465740  Cd Length: 50  Bit Score: 65.78  E-value: 2.85e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22024078   175 TGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKERVEQDLIN 223
Cdd:pfam18392   2 IGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 96-185 1.05e-09

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 54.17  E-value: 1.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22024078     96 LTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDNVrHLEDIIIEAIYADIIHGKLFQNTRILEVDYAQGRDIPPGyt 175
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPL-- 78

                           90
                   ....*....|
gi 22024078    176 GQIVETLQAW 185
Cdd:smart00088  79 AQFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 72-162 1.99e-06

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 45.67  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22024078    72 FETLNLFAYGTYKEYRA----------QPEKFIELTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDnVRHLEDIII 141
Cdd:pfam01399   4 RDLLRAFYSGDLSEFEEiladykeellLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLS-VDEVEKILA 82

                          90       100
                  ....*....|....*....|.
gi 22024078   142 EAIYADIIHGKLFQNTRILEV 162
Cdd:pfam01399  83 KLIRDGRIRAKIDQVNGIVVF 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH