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Conserved domains on  [gi|28573738|ref|NP_611247|]
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swi2 [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
120-479 9.02e-06

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 9.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 120 LNHFRDLQKLPRLRSLTIEYSGFTEFKFDFPEMLELHTINISWTNLSYISSrTFKRVHPLKVLDLRWNQLIQLDGPLLLP 199
Cdd:COG4886 103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 200 RNFEQLYLAGNPWNctrnfkwlllqpekgrlvvdrdELictdrkykerqmlmvmhyklelkrqcqsHEDLRNCTclmhhi 279
Cdd:COG4886 182 TNLKELDLSNNQIT----------------------DL----------------------------PEPLGNLT------ 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 280 lpkthiPLYTVNCSHLQFHRLPDFLPDNT--TTLVINDNMISDINPLRDNPHYRHVVdmqLENNQISNVDNLEDtywLQN 357
Cdd:COG4886 206 ------NLEELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPELGNLTNLEELD---LSNNQLTDLPPLAN---LTN 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 358 FRLLNLRGNNLRKLHVYALDNalDDNENANLLLLSRNPWHCTCKFGSRMRELLTKYKDIVRDAWNVSCTYRLDDDQLLAK 437
Cdd:COG4886 274 LKTLDLSNNQLTDLKLKELEL--LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28573738 438 VLTLSRQEMCNLSVEGGTQIHPIDWLNGVLASLIFLILGKLA 479
Cdd:COG4886 352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-479 9.02e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 9.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 120 LNHFRDLQKLPRLRSLTIEYSGFTEFKFDFPEMLELHTINISWTNLSYISSrTFKRVHPLKVLDLRWNQLIQLDGPLLLP 199
Cdd:COG4886 103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 200 RNFEQLYLAGNPWNctrnfkwlllqpekgrlvvdrdELictdrkykerqmlmvmhyklelkrqcqsHEDLRNCTclmhhi 279
Cdd:COG4886 182 TNLKELDLSNNQIT----------------------DL----------------------------PEPLGNLT------ 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 280 lpkthiPLYTVNCSHLQFHRLPDFLPDNT--TTLVINDNMISDINPLRDNPHYRHVVdmqLENNQISNVDNLEDtywLQN 357
Cdd:COG4886 206 ------NLEELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPELGNLTNLEELD---LSNNQLTDLPPLAN---LTN 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 358 FRLLNLRGNNLRKLHVYALDNalDDNENANLLLLSRNPWHCTCKFGSRMRELLTKYKDIVRDAWNVSCTYRLDDDQLLAK 437
Cdd:COG4886 274 LKTLDLSNNQLTDLKLKELEL--LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28573738 438 VLTLSRQEMCNLSVEGGTQIHPIDWLNGVLASLIFLILGKLA 479
Cdd:COG4886 352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-479 9.02e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 9.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 120 LNHFRDLQKLPRLRSLTIEYSGFTEFKFDFPEMLELHTINISWTNLSYISSrTFKRVHPLKVLDLRWNQLIQLDGPLLLP 199
Cdd:COG4886 103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 200 RNFEQLYLAGNPWNctrnfkwlllqpekgrlvvdrdELictdrkykerqmlmvmhyklelkrqcqsHEDLRNCTclmhhi 279
Cdd:COG4886 182 TNLKELDLSNNQIT----------------------DL----------------------------PEPLGNLT------ 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 280 lpkthiPLYTVNCSHLQFHRLPDFLPDNT--TTLVINDNMISDINPLRDNPHYRHVVdmqLENNQISNVDNLEDtywLQN 357
Cdd:COG4886 206 ------NLEELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPELGNLTNLEELD---LSNNQLTDLPPLAN---LTN 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573738 358 FRLLNLRGNNLRKLHVYALDNalDDNENANLLLLSRNPWHCTCKFGSRMRELLTKYKDIVRDAWNVSCTYRLDDDQLLAK 437
Cdd:COG4886 274 LKTLDLSNNQLTDLKLKELEL--LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28573738 438 VLTLSRQEMCNLSVEGGTQIHPIDWLNGVLASLIFLILGKLA 479
Cdd:COG4886 352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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