NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19922858|ref|NP_611854|]
View 

fizzy-related 2 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
159-436 1.66e-47

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.17  E-value: 1.66e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 159 LAVGLGCSVYLWSAVSGQVTRLcdFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWC 238
Cdd:COG2319  94 ASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 239 --GNRLASGSRDRSILQRDIRNPPTHITrcLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVV 316
Cdd:COG2319 172 pdGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 317 KALGWSPhKSGLLASGggSADRCLRFWNVLTGKLVKCINT-GAQISNLAWARDSRELVTthGHAQPQVIAWRYPSLKQMA 395
Cdd:COG2319 250 RSVAFSP-DGRLLASG--SADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLR 324

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 19922858 396 RLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKI 436
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
159-436 1.66e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.17  E-value: 1.66e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 159 LAVGLGCSVYLWSAVSGQVTRLcdFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWC 238
Cdd:COG2319  94 ASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 239 --GNRLASGSRDRSILQRDIRNPPTHITrcLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVV 316
Cdd:COG2319 172 pdGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 317 KALGWSPhKSGLLASGggSADRCLRFWNVLTGKLVKCINT-GAQISNLAWARDSRELVTthGHAQPQVIAWRYPSLKQMA 395
Cdd:COG2319 250 RSVAFSP-DGRLLASG--SADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLR 324

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 19922858 396 RLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKI 436
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-446 8.16e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 8.16e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 190 ITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWC--GNRLASGSRDRSILQRDIRNPptHITRCL 267
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETG--ECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 268 RGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKsGLLASggGSADRCLRFWNVLT 347
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVAS--SSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 348 GKLVKCInTG--AQISNLAWARDSRELVTTHGhaQPQVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETL 425
Cdd:cd00200 167 GKCVATL-TGhtGEVNSVAFSPDGEKLLSSSS--DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                       250       260
                ....*....|....*....|....
gi 19922858 426 RFWTVFTK---QKISKEPNSVLRL 446
Cdd:cd00200 244 RVWDLRTGecvQTLSGHTNSVTSL 267
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 185-240 1.08e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 49.58  E-value: 1.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19922858   185 NEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWCGN 240
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 265-298 2.93e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.93e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19922858    265 RCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVW 298
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 254-428 1.38e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858  254 RDIRNPPTHItrclrGHKLEVCGLQWspsNRYL----ASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLL 329
Cdd:PLN00181 520 RDIHYPVVEL-----ASRSKLSGICW---NSYIksqvASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLL 591

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858  330 ASGggSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDS-RELvtTHGHAQPQVIAW--RYPSLKqMARLSGHTQRVLH 406
Cdd:PLN00181 592 ASG--SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESgRSL--AFGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSY 666

                        170       180
                 ....*....|....*....|..
gi 19922858  407 LSVSpDNESIVTGGADETLRFW 428
Cdd:PLN00181 667 VRFV-DSSTLVSSSTDNTLKLW 687
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
159-436 1.66e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.17  E-value: 1.66e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 159 LAVGLGCSVYLWSAVSGQVTRLcdFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWC 238
Cdd:COG2319  94 ASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 239 --GNRLASGSRDRSILQRDIRNPPTHITrcLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVV 316
Cdd:COG2319 172 pdGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 317 KALGWSPhKSGLLASGggSADRCLRFWNVLTGKLVKCINT-GAQISNLAWARDSRELVTthGHAQPQVIAWRYPSLKQMA 395
Cdd:COG2319 250 RSVAFSP-DGRLLASG--SADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLR 324

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 19922858 396 RLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKI 436
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
166-432 1.13e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.85  E-value: 1.13e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 166 SVYLWSAVSGQVTRlcDFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWC--GNRLA 243
Cdd:COG2319 143 TVRLWDLATGKLLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLA 220

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 244 SGSRDRSILQRDIRNPPTHITrcLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSP 323
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRT--LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 324 HkSGLLASGggSADRCLRFWNVLTGKLVKCIN-TGAQISNLAWARDSRELVTthGHAQPQVIAWRYPSLKQMARLSGHTQ 402
Cdd:COG2319 299 D-GKLLASG--SDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTG 373

                       250       260       270
                ....*....|....*....|....*....|
gi 19922858 403 RVLHLSVSPDNESIVTGGADETLRFWTVFT 432
Cdd:COG2319 374 AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
187-436 4.84e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 4.84e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 187 DNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAW--CGNRLASGSRDRSILQRDIRNPPTHIT 264
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRT 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 265 rcLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHkSGLLASggGSADRCLRFWN 344
Cdd:COG2319 158 --LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLAS--GSADGTVRLWD 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 345 VLTGKLVKCINT-GAQISNLAWARDSRELVTthGHAQPQVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADE 423
Cdd:COG2319 233 LATGKLLRTLTGhSGSVRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                       250
                ....*....|...
gi 19922858 424 TLRFWTVFTKQKI 436
Cdd:COG2319 311 TVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-446 8.16e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 8.16e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 190 ITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWC--GNRLASGSRDRSILQRDIRNPptHITRCL 267
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETG--ECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 268 RGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKsGLLASggGSADRCLRFWNVLT 347
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVAS--SSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 348 GKLVKCInTG--AQISNLAWARDSRELVTTHGhaQPQVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETL 425
Cdd:cd00200 167 GKCVATL-TGhtGEVNSVAFSPDGEKLLSSSS--DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                       250       260
                ....*....|....*....|....
gi 19922858 426 RFWTVFTK---QKISKEPNSVLRL 446
Cdd:cd00200 244 RVWDLRTGecvQTLSGHTNSVTSL 267
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 151-428 1.90e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 1.90e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 151 IDWS-SKNTLAVGLG-CSVYLWSAVSGQV-TRLCdfNNEDNlITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEE 227
Cdd:cd00200  15 VAFSpDGKLLATGSGdGTIKVWDLETGELlRTLK--GHTGP-VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 228 HSARVTALAWCGNR--LASGSRDRSILQRDIRNPPthITRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEP 305
Cdd:cd00200  92 HTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 306 IYAFDEHKAVVKALGWSPHKSGLLASgggSADRCLRFWNVLTGKLVKCINT-GAQISNLAWARDSRELVTthGHAQPQVI 384
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSS---SSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIR 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 19922858 385 AWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETLRFW 428
Cdd:cd00200 245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-436 4.96e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 4.96e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 222 INRLEEHSARVTALAW--CGNRLASGSRDRSILQRDIRNppTHITRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWT 299
Cdd:cd00200   2 RRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLET--GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 300 DDWPEPIYAFDEHKAVVKALGWSPHKSgLLASggGSADRCLRFWNVLTGKLVKCINT-GAQISNLAWARDSReLVTThGH 378
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGR-ILSS--SSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGT-FVAS-SS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19922858 379 AQPQVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKI 436
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 COG2319
WD40 repeat [General function prediction only];
157-345 2.46e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 2.46e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 157 NTLAVG-LGCSVYLWSAVSGQVTRLcdFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTAL 235
Cdd:COG2319 217 KLLASGsADGTVRLWDLATGKLLRT--LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 236 AWC--GNRLASGSRDRSILQRDIRNPPThiTRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHK 313
Cdd:COG2319 295 AFSpdGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372

                       170       180       190
                ....*....|....*....|....*....|..
gi 19922858 314 AVVKALGWSPHkSGLLASggGSADRCLRFWNV 345
Cdd:COG2319 373 GAVTSVAFSPD-GRTLAS--GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 151-344 4.46e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 109.73  E-value: 4.46e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 151 IDWSSKNTLAVGLG--CSVYLWSAVSGQVTRLCDFNNEDnlITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEH 228
Cdd:cd00200  99 VAFSPDGRILSSSSrdKTIKVWDVETGKCLTTLRGHTDW--VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858 229 SARVTALAWC--GNRLASGSRDRSILQRDIRNppTHITRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPI 306
Cdd:cd00200 177 TGEVNSVAFSpdGEKLLSSSSDGTIKLWDLST--GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 19922858 307 YAFDEHKAVVKALGWSPHKSGLLAsggGSADRCLRFWN 344
Cdd:cd00200 255 QTLSGHTNSVTSLAWSPDGKRLAS---GSADGTIRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 185-240 1.08e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 49.58  E-value: 1.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19922858   185 NEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWCGN 240
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 265-298 2.93e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.93e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19922858    265 RCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVW 298
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-428 5.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.99e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19922858    390 SLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETLRFW 428
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 254-428 1.38e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858  254 RDIRNPPTHItrclrGHKLEVCGLQWspsNRYL----ASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLL 329
Cdd:PLN00181 520 RDIHYPVVEL-----ASRSKLSGICW---NSYIksqvASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLL 591

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858  330 ASGggSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDS-RELvtTHGHAQPQVIAW--RYPSLKqMARLSGHTQRVLH 406
Cdd:PLN00181 592 ASG--SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESgRSL--AFGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSY 666

                        170       180
                 ....*....|....*....|..
gi 19922858  407 LSVSpDNESIVTGGADETLRFW 428
Cdd:PLN00181 667 VRFV-DSSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
264-298 3.39e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19922858   264 TRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVW 298
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
392-428 4.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 19922858   392 KQMARLSGHTQRVLHLSVSPDNESIVTGGADETLRFW 428
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 190-345 1.83e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858  190 ITAVSWHGEGR-QVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWCG---NRLASGSRDRSILQRDIRNpptHITR 265
Cdd:PLN00181 535 LSGICWNSYIKsQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQ---GVSI 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858  266 CLRGHKLEVCGLQW-SPSNRYLASGGSDNRLLVWTDDWPE-PIYAFDEHKAVVKALGWSpHKSGLLASgggSADRCLRFW 343
Cdd:PLN00181 612 GTIKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFV-DSSTLVSS---STDNTLKLW 687


                 ..
gi 19922858  344 NV 345
Cdd:PLN00181 688 DL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 218-251 8.00e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 19922858    218 NQKQINRLEEHSARVTALAWC--GNRLASGSRDRSI 251
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTI 36
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 397-437 1.06e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 1.06e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 19922858 397 LSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKIS 437
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR 45
PTZ00420 PTZ00420
coronin; Provisional
 192-298 1.88e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922858  192 AVSWHGEGrqvaigtqSGYVTIWDAENQKQ---INRLEEHSARVTALAW--CGNR-LASGSRDRSILQRDIRNPPTHIT- 264
Cdd:PTZ00420  42 AVPWEVEG--------GGLIGAIRLENQMRkppVIKLKGHTSSILDLQFnpCFSEiLASGSEDLTIRVWEIPHNDESVKe 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 19922858  265 ----RC-LRGHKLEVCGLQWSPSNRY-LASGGSDNRLLVW 298
Cdd:PTZ00420 114 ikdpQCiLKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIW 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 304-344 8.51e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 8.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19922858    304 EPIYAFDEHKAVVKALGWSPHkSGLLASggGSADRCLRFWN 344
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLAS--GSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
220-251 9.72e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 9.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 19922858   220 KQINRLEEHSARVTALAWC--GNRLASGSRDRSI 251
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH