NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24646032|ref|NP_650098|]
View 

elongator complex protein 1, isoform A [Drosophila melanogaster]

Protein Classification

elongator complex 1 family protein( domain architecture ID 12057718)

elongator complex 1 family protein is a component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-883 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


:

Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1032.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032      1 MRNLKLRYCKELNAVAHPQHLLLQPEL--NGGASDIYFVVADNKIYAV----QESGDVRLKVIADLP---------DIVG 65
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDPDLTLLASafDTTSDSITFVLGPTESEGAievqQFMKDGQVSVLASFPaplpvgpddKILS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032     66 VEFLQLDNAICVASGAGEVILV----DPQTGATSEGTFCDVGIESMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPLD 141
Cdd:pfam04762   81 FQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPISETSLD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    142 AELDPDQQFVNVGWGKKETQFHGSEGKQAAKQ-KESDSTFIRDEQELNQD---VSISWRGDGEFFVVSYVAAQLG--RTF 215
Cdd:pfam04762  161 PDDLKISKHVSVGWGKKETQFHGKGAKAAERPlRDPTMPEKVDEKLSSLDdhrVTISWRGDGEYFAVSSIEPETGsrRAI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    216 KVYDSEGKLNHTAEKSANLKDSVVWRPTGNWIAVPQQFPNKSTIALFEKNGLRHRELVLPFDLQEEPVVQLRWSEDSDIL 295
Cdd:pfam04762  241 RVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWNSDSEVL 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    296 AIRTcakeEQRVYLYTIGNYHWYLKQVLIFEQADPLAL--LHWDTRcgAEHTLHVLKESGKHLVYRWAFAVDR------- 366
Cdd:pfam04762  321 AVVL----EDRVQLWTTGNYHWYLKQELYYPQSASLAGvfLKWHPE--KPLTLMVGTSGGQILVYDFAWKTARgptsspn 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    367 NNSIVGVIDGKRLLLTDFDEAIVPPPMSKIVLKFETYIN--AFISHGTSLWVYTCDRKIYLNE---------HIHTLGKE 435
Cdd:pfam04762  395 DNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNdvAFSKSNSKLAALTSDGDISISVlslapmkagAHPKLVSE 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    436 LQKPIMLMPDAELSGLHLANLTHFSPHYLLATHSSAGSTRLLLLSYKDNDNKpgewfYRVHSSVRINGLVNAVAVAPYAM 515
Cdd:pfam04762  475 FSKNEIANSDFETALDSLRQLAFINDSTLLVLSDSDNLSEILLVDIDDISNP-----LLVSSSTSLEKIVLAKSSNDYSH 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    516 neFYVQTVNnGHTYEVSLKADKTLKverSYVQLHEPADQIDWVIVKGCIWdgyTGALVTLRNQHLLHIDGYRIGEDVTSF 595
Cdd:pfam04762  550 --VVVETSD-GKVHEGSLSAEGELL---EITKFPQLCRDFRVVRVHNEGM---KGVAFGLTSNGKLYANGRLLASNVTSF 620

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    596 CVVTNYLVYTQLNA-MHFVQLDD--------------RRQVASRNIERGAKIVTAVARKARVVLQLPRGNLEAICPRVLV 660
Cdd:pfam04762  621 AVTDSHLLFTTAQHlLKFVHLNSsvkdlevveddreeSHDERIRQIERGSRLVTVVPSKASVVLQMPRGNLETIYPRILV 700

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    661 LELVGDLLERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQWLCLFLSELQNEDFTKGMYSSNY---- 736
Cdd:pfam04762  701 LAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFVDQINKVDYLDLFLSCLKEEDVTKTMYKDTLslpp 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    737 ---DASKQTYPSDYRVDQKVEYVCR-LLEQQMNRFVSRFRLPLITAYVKLG--CLEMALQVIWKEQQEDASLADQLLQHL 810
Cdd:pfam04762  781 ptsMPPYNKKKSFDPKDSKVNKVCDaILKALEPEYSDKYLLTILTAYACKNppNLEAALQLIASLREEDEEQAEEALKHL 860

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24646032    811 LYLVDVNDLYNVALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACG 883
Cdd:pfam04762  861 CFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQELQKMEELRRKFLIDDYLKRYEKALGHLVEAG 933
 
Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-883 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1032.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032      1 MRNLKLRYCKELNAVAHPQHLLLQPEL--NGGASDIYFVVADNKIYAV----QESGDVRLKVIADLP---------DIVG 65
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDPDLTLLASafDTTSDSITFVLGPTESEGAievqQFMKDGQVSVLASFPaplpvgpddKILS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032     66 VEFLQLDNAICVASGAGEVILV----DPQTGATSEGTFCDVGIESMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPLD 141
Cdd:pfam04762   81 FQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPISETSLD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    142 AELDPDQQFVNVGWGKKETQFHGSEGKQAAKQ-KESDSTFIRDEQELNQD---VSISWRGDGEFFVVSYVAAQLG--RTF 215
Cdd:pfam04762  161 PDDLKISKHVSVGWGKKETQFHGKGAKAAERPlRDPTMPEKVDEKLSSLDdhrVTISWRGDGEYFAVSSIEPETGsrRAI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    216 KVYDSEGKLNHTAEKSANLKDSVVWRPTGNWIAVPQQFPNKSTIALFEKNGLRHRELVLPFDLQEEPVVQLRWSEDSDIL 295
Cdd:pfam04762  241 RVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWNSDSEVL 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    296 AIRTcakeEQRVYLYTIGNYHWYLKQVLIFEQADPLAL--LHWDTRcgAEHTLHVLKESGKHLVYRWAFAVDR------- 366
Cdd:pfam04762  321 AVVL----EDRVQLWTTGNYHWYLKQELYYPQSASLAGvfLKWHPE--KPLTLMVGTSGGQILVYDFAWKTARgptsspn 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    367 NNSIVGVIDGKRLLLTDFDEAIVPPPMSKIVLKFETYIN--AFISHGTSLWVYTCDRKIYLNE---------HIHTLGKE 435
Cdd:pfam04762  395 DNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNdvAFSKSNSKLAALTSDGDISISVlslapmkagAHPKLVSE 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    436 LQKPIMLMPDAELSGLHLANLTHFSPHYLLATHSSAGSTRLLLLSYKDNDNKpgewfYRVHSSVRINGLVNAVAVAPYAM 515
Cdd:pfam04762  475 FSKNEIANSDFETALDSLRQLAFINDSTLLVLSDSDNLSEILLVDIDDISNP-----LLVSSSTSLEKIVLAKSSNDYSH 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    516 neFYVQTVNnGHTYEVSLKADKTLKverSYVQLHEPADQIDWVIVKGCIWdgyTGALVTLRNQHLLHIDGYRIGEDVTSF 595
Cdd:pfam04762  550 --VVVETSD-GKVHEGSLSAEGELL---EITKFPQLCRDFRVVRVHNEGM---KGVAFGLTSNGKLYANGRLLASNVTSF 620

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    596 CVVTNYLVYTQLNA-MHFVQLDD--------------RRQVASRNIERGAKIVTAVARKARVVLQLPRGNLEAICPRVLV 660
Cdd:pfam04762  621 AVTDSHLLFTTAQHlLKFVHLNSsvkdlevveddreeSHDERIRQIERGSRLVTVVPSKASVVLQMPRGNLETIYPRILV 700

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    661 LELVGDLLERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQWLCLFLSELQNEDFTKGMYSSNY---- 736
Cdd:pfam04762  701 LAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFVDQINKVDYLDLFLSCLKEEDVTKTMYKDTLslpp 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    737 ---DASKQTYPSDYRVDQKVEYVCR-LLEQQMNRFVSRFRLPLITAYVKLG--CLEMALQVIWKEQQEDASLADQLLQHL 810
Cdd:pfam04762  781 ptsMPPYNKKKSFDPKDSKVNKVCDaILKALEPEYSDKYLLTILTAYACKNppNLEAALQLIASLREEDEEQAEEALKHL 860

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24646032    811 LYLVDVNDLYNVALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACG 883
Cdd:pfam04762  861 CFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQELQKMEELRRKFLIDDYLKRYEKALGHLVEAG 933
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
13-1203 5.49e-117

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 394.37  E-value: 5.49e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032   13 NAVAHPQHLLlqPELNGGASDIYFVVADNKIYAV---------------QESGDVRLKVIADLP----DIVGVEFLQLDN 73
Cdd:COG5290    3 NLFTRYMSTF--PTASGDEDELGFDSVGDWIYITcvlgstdkgievakeSSIYDESGLKRFEIPffpdKLLSFKHFHVLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032   74 AICVASGAGEVILV--DPqTGATSE----GTFCDvGIESMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPL-DAELDP 146
Cdd:COG5290   81 FEYFLIDEGDIIHLvnDP-TPAELEmeivGKVSN-GIVAASWSADEKTWCVVTSTREILLFDKYFDPISEYHLkKSDLVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  147 DQQFVNVGWGKKETQFHGSEGKqaAKQKESDSTFIRDEQEL----NQDVSISWRGDGEFFVVSYVAAQLGRTFKVYDSEG 222
Cdd:COG5290  159 FGKHIRVGWGKKETQFRGKGAR--AQLRDPTMPYMVDYGDLfavdTNKKIIFWRGDTEYNLVGRSEERPRRAFRVYSREG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  223 KLNHTAEKSANLKDSVVWRPTGNWIAVPQQFP--NKSTIALFEKNGLRHRElvlpFDLQ---EEPVVQLRWSEDSDILAI 297
Cdd:COG5290  237 QLDSASEPVTGMEHQLSWKPQGSKYATIGTDGcsTSESVIFFERNGLRHGE----FDLRvgcDEKAFLENWNLLSTVLAV 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  298 rtcaKEEQRVYLYTIGNYHWYLKQVLifeQADPLALLHWdtRCGAEHTLHVlkeSGKHLVYRWAFAVDR---------NN 368
Cdd:COG5290  313 ----AEGNLLKLWTTKNYHWYLKVER---QIPGISYVKW--HPEEKNTLLF---RDGERILRVFFSEKKthhgseypfDN 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  369 SIVGVIDGKRLLLTDFDEAIVPPPMSKIVLKFETYI-NAFISHGTSLWVYTCDRKIYLnehIHTLGKELQKPIMLMPDAE 447
Cdd:COG5290  381 GTSYVIDGSYMLYTPLSLKNLPPPMFSVRVGFDTNVvDVFPSFAEKKGAALLRDRLIM---FRWDSEEFINKRTEFLESE 457

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  448 L-SGLHLANLTHFSPHYLLATHSSAGSTRLLLLSYKDNDnkpgEWFYRVHSSVRINGLVNAvavapyamnefyvQTVNNG 526
Cdd:COG5290  458 FdSIVLFDGFLVLKSGHVFLLKDTNNESDTYITRNGDVD----ERKKRGTVETRRTSTLVH-------------QLCQTL 520

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  527 HTYEVSLKADKTLKVE-RSYVQLHEPADQIDWVIVK---GCIWDGYTGALVTLRNQHLLhidgyriGEDVTSFCVVTNYL 602
Cdd:COG5290  521 LRYGTCVGVVKHYNFEeKLYELLKFPNGVIDFSVDPvhsTLVAIGITDIGQLFALQVLL-------KKSVFSHNGTKLFV 593

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  603 VYTQL-NAMHFVQLD--------------DRRQVASRNIERGAKIVTAVARKARVVLQLPRGNLEAICPRVLVLELVGDL 667
Cdd:COG5290  594 LFTTTeNILSFVHLEstfkplitveegtvRFFDERKRSVERGSHKVELLPSKDFVVLQVTRGNLETIYPRIMVLAFVRKL 673

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  668 LERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQWLCLFLSELQNEDFTKGMYsSNYDASKQTYPSDY 747
Cdd:COG5290  674 IAAKKYKDAFDVCRTHRVPLGILLDYDPELFIENLEVFVTECRRVDYLSLFSEALQRDDVTKTDY-SFISKSEQARRFRK 752

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  748 RVDQKVEYVCRLLEQQM--NRFVSRFRLPLITAYV--KLGCLEMALQVIwKEQQEDASLADQLLQHLLYLVDVNDLYNVA 823
Cdd:COG5290  753 VFDLKVNLECKDTREHLesLIYNDESIQTIITAYLigNPGNGKAALMRI-SPLSRCSESLDEDVKNLCFLRDVNFFNEFA 831

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  824 LGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACgEQHYEEALEYIRKHGLYTDG 903
Cdd:COG5290  832 LSLYDKSLALLIAQLSQKDPREYLPFLVERQDLEALRRKFSIDNYLSIYESALGHLNED-LNVIREVMKYICRHDLYDFL 910

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  904 LAFYREHIEFQKNIYVAYADHLRAIAKLDNASLMYERGGQLQQALLSAKHTLDWQRVLVLA-KKLSEPLDQVAQSLVGPL 982
Cdd:COG5290  911 LLLYRYDGELQKFKINIFAGNLVDNLYHISAAKAYEVEGKYIEAHGAYDSALMWRECGSIStQEKGYEFNLCAELLPSDL 990

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  983 QQQGR-HMEAYELVKEHCQDRKRQFDVLLEGHLYSRAIYEAGLEDDDVSEKiapaLLAYGVQLESSLQADLQLFLDYKQ- 1060
Cdd:COG5290  991 LVEFRkAGDAEKILLTYLENLYEAVAMDCKGSEYREAFCEAMVSRLVESEK----HYEAGQLGEEFGGKPELAADEYVQi 1066

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032 1061 -----RLLDIRRNQAKSGEGYIDTDVNLKEVDLLSDTTSLHSSQYSGTSRRTGK------TFRSSKNRRKHERKLFSLKP 1129
Cdd:COG5290 1067 ksqgdRLRVLRDKKCEMPEAREILREELLTLDDVSEAFVKYSTRLSALTEYTKDecmsktSRSTTKNMRRGERKRARGKK 1146

                       1210      1220      1230      1240      1250      1260      1270
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24646032 1130 GNPFEDIALIdalhNHVTKIAQQQQPVRDTCKALLQLANAADADPLAAALQREFKTLLQAVDAALDEIWTPELR 1203
Cdd:COG5290 1147 GTRYEEEYLV----SSIRRLILRLVGWRPETERLVEILKRFNMEEQARAHQTNFDEVGRAIKTEVDSIFSVERR 1216
 
Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-883 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1032.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032      1 MRNLKLRYCKELNAVAHPQHLLLQPEL--NGGASDIYFVVADNKIYAV----QESGDVRLKVIADLP---------DIVG 65
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDPDLTLLASafDTTSDSITFVLGPTESEGAievqQFMKDGQVSVLASFPaplpvgpddKILS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032     66 VEFLQLDNAICVASGAGEVILV----DPQTGATSEGTFCDVGIESMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPLD 141
Cdd:pfam04762   81 FQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPISETSLD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    142 AELDPDQQFVNVGWGKKETQFHGSEGKQAAKQ-KESDSTFIRDEQELNQD---VSISWRGDGEFFVVSYVAAQLG--RTF 215
Cdd:pfam04762  161 PDDLKISKHVSVGWGKKETQFHGKGAKAAERPlRDPTMPEKVDEKLSSLDdhrVTISWRGDGEYFAVSSIEPETGsrRAI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    216 KVYDSEGKLNHTAEKSANLKDSVVWRPTGNWIAVPQQFPNKSTIALFEKNGLRHRELVLPFDLQEEPVVQLRWSEDSDIL 295
Cdd:pfam04762  241 RVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWNSDSEVL 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    296 AIRTcakeEQRVYLYTIGNYHWYLKQVLIFEQADPLAL--LHWDTRcgAEHTLHVLKESGKHLVYRWAFAVDR------- 366
Cdd:pfam04762  321 AVVL----EDRVQLWTTGNYHWYLKQELYYPQSASLAGvfLKWHPE--KPLTLMVGTSGGQILVYDFAWKTARgptsspn 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    367 NNSIVGVIDGKRLLLTDFDEAIVPPPMSKIVLKFETYIN--AFISHGTSLWVYTCDRKIYLNE---------HIHTLGKE 435
Cdd:pfam04762  395 DNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNdvAFSKSNSKLAALTSDGDISISVlslapmkagAHPKLVSE 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    436 LQKPIMLMPDAELSGLHLANLTHFSPHYLLATHSSAGSTRLLLLSYKDNDNKpgewfYRVHSSVRINGLVNAVAVAPYAM 515
Cdd:pfam04762  475 FSKNEIANSDFETALDSLRQLAFINDSTLLVLSDSDNLSEILLVDIDDISNP-----LLVSSSTSLEKIVLAKSSNDYSH 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    516 neFYVQTVNnGHTYEVSLKADKTLKverSYVQLHEPADQIDWVIVKGCIWdgyTGALVTLRNQHLLHIDGYRIGEDVTSF 595
Cdd:pfam04762  550 --VVVETSD-GKVHEGSLSAEGELL---EITKFPQLCRDFRVVRVHNEGM---KGVAFGLTSNGKLYANGRLLASNVTSF 620

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    596 CVVTNYLVYTQLNA-MHFVQLDD--------------RRQVASRNIERGAKIVTAVARKARVVLQLPRGNLEAICPRVLV 660
Cdd:pfam04762  621 AVTDSHLLFTTAQHlLKFVHLNSsvkdlevveddreeSHDERIRQIERGSRLVTVVPSKASVVLQMPRGNLETIYPRILV 700

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    661 LELVGDLLERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQWLCLFLSELQNEDFTKGMYSSNY---- 736
Cdd:pfam04762  701 LAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFVDQINKVDYLDLFLSCLKEEDVTKTMYKDTLslpp 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032    737 ---DASKQTYPSDYRVDQKVEYVCR-LLEQQMNRFVSRFRLPLITAYVKLG--CLEMALQVIWKEQQEDASLADQLLQHL 810
Cdd:pfam04762  781 ptsMPPYNKKKSFDPKDSKVNKVCDaILKALEPEYSDKYLLTILTAYACKNppNLEAALQLIASLREEDEEQAEEALKHL 860

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24646032    811 LYLVDVNDLYNVALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACG 883
Cdd:pfam04762  861 CFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQELQKMEELRRKFLIDDYLKRYEKALGHLVEAG 933
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
13-1203 5.49e-117

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 394.37  E-value: 5.49e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032   13 NAVAHPQHLLlqPELNGGASDIYFVVADNKIYAV---------------QESGDVRLKVIADLP----DIVGVEFLQLDN 73
Cdd:COG5290    3 NLFTRYMSTF--PTASGDEDELGFDSVGDWIYITcvlgstdkgievakeSSIYDESGLKRFEIPffpdKLLSFKHFHVLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032   74 AICVASGAGEVILV--DPqTGATSE----GTFCDvGIESMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPL-DAELDP 146
Cdd:COG5290   81 FEYFLIDEGDIIHLvnDP-TPAELEmeivGKVSN-GIVAASWSADEKTWCVVTSTREILLFDKYFDPISEYHLkKSDLVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  147 DQQFVNVGWGKKETQFHGSEGKqaAKQKESDSTFIRDEQEL----NQDVSISWRGDGEFFVVSYVAAQLGRTFKVYDSEG 222
Cdd:COG5290  159 FGKHIRVGWGKKETQFRGKGAR--AQLRDPTMPYMVDYGDLfavdTNKKIIFWRGDTEYNLVGRSEERPRRAFRVYSREG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  223 KLNHTAEKSANLKDSVVWRPTGNWIAVPQQFP--NKSTIALFEKNGLRHRElvlpFDLQ---EEPVVQLRWSEDSDILAI 297
Cdd:COG5290  237 QLDSASEPVTGMEHQLSWKPQGSKYATIGTDGcsTSESVIFFERNGLRHGE----FDLRvgcDEKAFLENWNLLSTVLAV 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  298 rtcaKEEQRVYLYTIGNYHWYLKQVLifeQADPLALLHWdtRCGAEHTLHVlkeSGKHLVYRWAFAVDR---------NN 368
Cdd:COG5290  313 ----AEGNLLKLWTTKNYHWYLKVER---QIPGISYVKW--HPEEKNTLLF---RDGERILRVFFSEKKthhgseypfDN 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  369 SIVGVIDGKRLLLTDFDEAIVPPPMSKIVLKFETYI-NAFISHGTSLWVYTCDRKIYLnehIHTLGKELQKPIMLMPDAE 447
Cdd:COG5290  381 GTSYVIDGSYMLYTPLSLKNLPPPMFSVRVGFDTNVvDVFPSFAEKKGAALLRDRLIM---FRWDSEEFINKRTEFLESE 457

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  448 L-SGLHLANLTHFSPHYLLATHSSAGSTRLLLLSYKDNDnkpgEWFYRVHSSVRINGLVNAvavapyamnefyvQTVNNG 526
Cdd:COG5290  458 FdSIVLFDGFLVLKSGHVFLLKDTNNESDTYITRNGDVD----ERKKRGTVETRRTSTLVH-------------QLCQTL 520

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  527 HTYEVSLKADKTLKVE-RSYVQLHEPADQIDWVIVK---GCIWDGYTGALVTLRNQHLLhidgyriGEDVTSFCVVTNYL 602
Cdd:COG5290  521 LRYGTCVGVVKHYNFEeKLYELLKFPNGVIDFSVDPvhsTLVAIGITDIGQLFALQVLL-------KKSVFSHNGTKLFV 593

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  603 VYTQL-NAMHFVQLD--------------DRRQVASRNIERGAKIVTAVARKARVVLQLPRGNLEAICPRVLVLELVGDL 667
Cdd:COG5290  594 LFTTTeNILSFVHLEstfkplitveegtvRFFDERKRSVERGSHKVELLPSKDFVVLQVTRGNLETIYPRIMVLAFVRKL 673

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  668 LERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQWLCLFLSELQNEDFTKGMYsSNYDASKQTYPSDY 747
Cdd:COG5290  674 IAAKKYKDAFDVCRTHRVPLGILLDYDPELFIENLEVFVTECRRVDYLSLFSEALQRDDVTKTDY-SFISKSEQARRFRK 752

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  748 RVDQKVEYVCRLLEQQM--NRFVSRFRLPLITAYV--KLGCLEMALQVIwKEQQEDASLADQLLQHLLYLVDVNDLYNVA 823
Cdd:COG5290  753 VFDLKVNLECKDTREHLesLIYNDESIQTIITAYLigNPGNGKAALMRI-SPLSRCSESLDEDVKNLCFLRDVNFFNEFA 831

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  824 LGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACgEQHYEEALEYIRKHGLYTDG 903
Cdd:COG5290  832 LSLYDKSLALLIAQLSQKDPREYLPFLVERQDLEALRRKFSIDNYLSIYESALGHLNED-LNVIREVMKYICRHDLYDFL 910

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  904 LAFYREHIEFQKNIYVAYADHLRAIAKLDNASLMYERGGQLQQALLSAKHTLDWQRVLVLA-KKLSEPLDQVAQSLVGPL 982
Cdd:COG5290  911 LLLYRYDGELQKFKINIFAGNLVDNLYHISAAKAYEVEGKYIEAHGAYDSALMWRECGSIStQEKGYEFNLCAELLPSDL 990

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032  983 QQQGR-HMEAYELVKEHCQDRKRQFDVLLEGHLYSRAIYEAGLEDDDVSEKiapaLLAYGVQLESSLQADLQLFLDYKQ- 1060
Cdd:COG5290  991 LVEFRkAGDAEKILLTYLENLYEAVAMDCKGSEYREAFCEAMVSRLVESEK----HYEAGQLGEEFGGKPELAADEYVQi 1066

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646032 1061 -----RLLDIRRNQAKSGEGYIDTDVNLKEVDLLSDTTSLHSSQYSGTSRRTGK------TFRSSKNRRKHERKLFSLKP 1129
Cdd:COG5290 1067 ksqgdRLRVLRDKKCEMPEAREILREELLTLDDVSEAFVKYSTRLSALTEYTKDecmsktSRSTTKNMRRGERKRARGKK 1146

                       1210      1220      1230      1240      1250      1260      1270
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24646032 1130 GNPFEDIALIdalhNHVTKIAQQQQPVRDTCKALLQLANAADADPLAAALQREFKTLLQAVDAALDEIWTPELR 1203
Cdd:COG5290 1147 GTRYEEEYLV----SSIRRLILRLVGWRPETERLVEILKRFNMEEQARAHQTNFDEVGRAIKTEVDSIFSVERR 1216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH