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Conserved domains on  [gi|24646712|ref|NP_650320|]
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uncharacterized protein Dmel_CG14362 [Drosophila melanogaster]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
114-182 1.40e-08

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 49.56  E-value: 1.40e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646712   114 DKKLRLIFNMYDNNKDGRITKYDLVVVVHKLF-SNLLDHVQImrivNTIMKEMDHTDSNQIMFQDFCKAF 182
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEeGEPLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
114-182 1.40e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 49.56  E-value: 1.40e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646712   114 DKKLRLIFNMYDNNKDGRITKYDLVVVVHKLF-SNLLDHVQImrivNTIMKEMDHTDSNQIMFQDFCKAF 182
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEeGEPLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 116-183 2.37e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 43.31  E-value: 2.37e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24646712 116 KLRLIFNMYDNNKDGRITKYDLVVVVHKLFSNLLDhvqimRIVNTIMKEMDHTDSNQIMFQDFCKAFA 183
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSE-----EEIDEMIREVDKDGDGKIDFEEFLELMA 63
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
114-182 1.40e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 49.56  E-value: 1.40e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646712   114 DKKLRLIFNMYDNNKDGRITKYDLVVVVHKLF-SNLLDHVQImrivNTIMKEMDHTDSNQIMFQDFCKAF 182
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEeGEPLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 116-183 2.37e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 43.31  E-value: 2.37e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24646712 116 KLRLIFNMYDNNKDGRITKYDLVVVVHKLFSNLLDhvqimRIVNTIMKEMDHTDSNQIMFQDFCKAFA 183
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSE-----EEIDEMIREVDKDGDGKIDFEEFLELMA 63
EF-hand_6 pfam13405
EF-hand domain;
116-144 7.86e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 32.92  E-value: 7.86e-03
                          10        20
                  ....*....|....*....|....*....
gi 24646712   116 KLRLIFNMYDNNKDGRITKYDLVVVVHKL 144
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSL 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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