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Conserved domains on  [gi|21450275|ref|NP_659143|]
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zinc finger CCCH-type with G patch domain-containing protein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 213-267 1.93e-19

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410455  Cd Length: 55  Bit Score: 81.89  E-value: 1.93e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21450275 213 DLSLLQTGSACLAKHQDGLWHPARITDVD-NGYYTVKFDSlLLKEAVVEGDSILPP 267
Cdd:cd20384   1 DFSSLKEGSRCLAKYDDGLWYPATVTDIDeDGKYTVKFDS-YGEVAVVELDDILPL 55
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 313-355 2.35e-12

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 61.37  E-value: 2.35e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 21450275   313 TRGIGSKLLVKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLD 355
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 177-197 8.32e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


:

Pssm-ID: 465626  Cd Length: 22  Bit Score: 45.27  E-value: 8.32e-07
                          10        20
                  ....*....|....*....|.
gi 21450275   177 KPCPFFLEGKCRFKENCRFSH 197
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSH 21
 
Name Accession Description Interval E-value
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 213-267 1.93e-19

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 81.89  E-value: 1.93e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21450275 213 DLSLLQTGSACLAKHQDGLWHPARITDVD-NGYYTVKFDSlLLKEAVVEGDSILPP 267
Cdd:cd20384   1 DFSSLKEGSRCLAKYDDGLWYPATVTDIDeDGKYTVKFDS-YGEVAVVELDDILPL 55
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 313-355 2.35e-12

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 61.37  E-value: 2.35e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 21450275   313 TRGIGSKLLVKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLD 355
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 311-354 8.59e-11

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 57.17  E-value: 8.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 21450275    311 VHTRGIGSKLLVKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSL 354
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGL 44
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 177-197 8.32e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 45.27  E-value: 8.32e-07
                          10        20
                  ....*....|....*....|.
gi 21450275   177 KPCPFFLEGKCRFKENCRFSH 197
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSH 21
ZnF_C3H1 smart00356
zinc finger;
177-198 3.17e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 40.69  E-value: 3.17e-05
                           10        20
                   ....*....|....*....|..
gi 21450275    177 KPCPFFLEGKCRFKENCRFSHG 198
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHP 26
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 220-250 1.57e-04

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 39.56  E-value: 1.57e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 21450275    220 GSACLAKHQDGLWHPARITDVD-NGYYTVKFD 250
Cdd:smart00333   6 GDKVAARWEDGEWYRARIVKVDgEQLYEVFFI 37
 
Name Accession Description Interval E-value
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 213-267 1.93e-19

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 81.89  E-value: 1.93e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21450275 213 DLSLLQTGSACLAKHQDGLWHPARITDVD-NGYYTVKFDSlLLKEAVVEGDSILPP 267
Cdd:cd20384   1 DFSSLKEGSRCLAKYDDGLWYPATVTDIDeDGKYTVKFDS-YGEVAVVELDDILPL 55
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 313-355 2.35e-12

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 61.37  E-value: 2.35e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 21450275   313 TRGIGSKLLVKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLD 355
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 311-354 8.59e-11

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 57.17  E-value: 8.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 21450275    311 VHTRGIGSKLLVKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSL 354
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGL 44
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 177-197 8.32e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 45.27  E-value: 8.32e-07
                          10        20
                  ....*....|....*....|.
gi 21450275   177 KPCPFFLEGKCRFKENCRFSH 197
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSH 21
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 179-197 5.96e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 42.79  E-value: 5.96e-06
                          10
                  ....*....|....*....
gi 21450275   179 CPFFLEGKCRFKENCRFSH 197
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
177-198 3.17e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 40.69  E-value: 3.17e-05
                           10        20
                   ....*....|....*....|..
gi 21450275    177 KPCPFFLEGKCRFKENCRFSHG 198
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHP 26
Tudor_SF cd04508
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 220-250 6.00e-05

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


Pssm-ID: 410449 [Multi-domain]  Cd Length: 47  Bit Score: 40.65  E-value: 6.00e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 21450275 220 GSACLAKH-QDGLWHPARITDV-DNGYYTVKFD 250
Cdd:cd04508   1 GDRVEAKWsDDGQWYPATVVAVnDDGKYTVLFD 33
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 220-250 1.57e-04

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 39.56  E-value: 1.57e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 21450275    220 GSACLAKHQDGLWHPARITDVD-NGYYTVKFD 250
Cdd:smart00333   6 GDKVAARWEDGEWYRARIVKVDgEQLYEVFFI 37
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
178-199 4.50e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 37.56  E-value: 4.50e-04
                          10        20
                  ....*....|....*....|...
gi 21450275   178 PCPFFLE-GKCRFKENCRFSHGQ 199
Cdd:pfam00642   5 LCRFFLRtGYCKYGDRCKFAHGQ 27
zf-CCCH_2 pfam14608
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented ...
 178-198 1.17e-03

RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA.


Pssm-ID: 464217  Cd Length: 19  Bit Score: 36.34  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|.
gi 21450275   178 PCPFFleGKCRFKENCRFSHG 198
Cdd:pfam14608   1 PCRFG--GNCTFGPKCPFSHP 19
Tudor_PHF20-like cd20386
Tudor domain found in PHD finger protein 20 (PHF20), PHF20-like protein 1 (PHF20L1), and ...
 220-250 8.24e-03

Tudor domain found in PHD finger protein 20 (PHF20), PHF20-like protein 1 (PHF20L1), and similar proteins; PHF20, also called Glioma-expressed antigen 2, hepatocellular carcinoma-associated antigen 58, novel zinc finger protein, or transcription factor TZP (referring to Tudor and zinc finger domain containing protein), is a regulator of NF-kappaB activation by disrupting recruitment of PP2A to p65. It also functions as a transcription factor that binds to Akt and plays a role in Akt cell survival/growth signaling. Moreover, it transcriptionally regulates p53. The phosphorylation of PHF20 on Ser291 mediated by protein kinase B (PKB) is essential in tumorigenesis via the regulation of p53-mediated signaling. PHF20L1 is an active malignant brain tumor (MBT) domain-containing protein that binds to monomethylated lysine 142 on DNA (cytosine-5) Methyltransferase 1 (DNMT1) (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner. Both PHF20 and PHF20L1 contain an N-terminal malignant brain tumor (MBT) domain, a Tudor domain, a plant homeodomain (PHD) finger and putative DNA-binding domains AT hook and C2H2-type zinc finger. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410457 [Multi-domain]  Cd Length: 50  Bit Score: 34.49  E-value: 8.24e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 21450275 220 GSACLAKHQDGLWHPARITDV-DNGYYTVKFD 250
Cdd:cd20386   4 GEEVLARWSDCKFYPAKILKVlDNGTYEVLFY 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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