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Conserved domains on  [gi|295293092|ref|NP_663538|]
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zinc finger protein 431 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-45 3.30e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 3.30e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 295293092    5 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLNAVG 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-487 7.76e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 7.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092  84 AFVHHSSLQMRKIIHTGEKRYKCNQ--CDKAYSRHSILQIHKRTHSGEKPYECN-QCGKAFTQHSHLKIHMVTHTGEKPY 160
Cdd:COG5048   42 SFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNN 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 161 KCDQCGKAFA--------FHSTLQVHKRTHTGEKPYECNQCSKAFAHH--------------CHLRVHKRIHTGEKPYKC 218
Cdd:COG5048  122 LLSSHSLPPSsrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssnLSLLISSNVSTSIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 219 DQCGKAFVGQNDLKRHERVHTGEKPYKCNECGkaFVCNASLRTHKTTHTGVK--------PYECKQCTKSFASHGQLQKH 290
Cdd:COG5048  202 NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSdssssaseSPRSSLPTASSQSSSPNESD 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 291 ERIHTG-EKPYKCDQCGKAFASHDKFQKHER--IHIGE--KPYKC--KQCTKSFASHDKLQKHERIHTGEKPYECK--QC 361
Cdd:COG5048  280 SSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNS 359

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 362 TKSF--ASHNKLQKHERIHTGEKPYKCDQCNKafvyesylqvhkkthtgekpykcNECGKAFARHSHLKVHKITHTGEKP 439
Cdd:COG5048  360 SSKFspLLNNEPPQSLQQYKDLKNDKKSETLS-----------------------NSCIRNFKRDSNLSLHIITHLSFRP 416

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 295293092 440 --YKCNQCGKALAYHSTLQVHQRTHTGEKPYECEQCGKAFANQSYFQVHK 487
Cdd:COG5048  417 ynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 2.94e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.94e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  482 YFQVHKRIHTGEKPYKCDQCGKAFV 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-45 3.30e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 3.30e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 295293092    5 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLNAVG 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
5-46 1.68e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.68e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 295293092     5 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLNAVGY 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-41 1.79e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 1.79e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 295293092   5 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNL 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-487 7.76e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 7.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092  84 AFVHHSSLQMRKIIHTGEKRYKCNQ--CDKAYSRHSILQIHKRTHSGEKPYECN-QCGKAFTQHSHLKIHMVTHTGEKPY 160
Cdd:COG5048   42 SFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNN 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 161 KCDQCGKAFA--------FHSTLQVHKRTHTGEKPYECNQCSKAFAHH--------------CHLRVHKRIHTGEKPYKC 218
Cdd:COG5048  122 LLSSHSLPPSsrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssnLSLLISSNVSTSIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 219 DQCGKAFVGQNDLKRHERVHTGEKPYKCNECGkaFVCNASLRTHKTTHTGVK--------PYECKQCTKSFASHGQLQKH 290
Cdd:COG5048  202 NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSdssssaseSPRSSLPTASSQSSSPNESD 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 291 ERIHTG-EKPYKCDQCGKAFASHDKFQKHER--IHIGE--KPYKC--KQCTKSFASHDKLQKHERIHTGEKPYECK--QC 361
Cdd:COG5048  280 SSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNS 359

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 362 TKSF--ASHNKLQKHERIHTGEKPYKCDQCNKafvyesylqvhkkthtgekpykcNECGKAFARHSHLKVHKITHTGEKP 439
Cdd:COG5048  360 SSKFspLLNNEPPQSLQQYKDLKNDKKSETLS-----------------------NSCIRNFKRDSNLSLHIITHLSFRP 416

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 295293092 440 --YKCNQCGKALAYHSTLQVHQRTHTGEKPYECEQCGKAFANQSYFQVHK 487
Cdd:COG5048  417 ynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 3.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.92e-04
                          10        20
                  ....*....|....*....|....*.
gi 295293092  230 DLKRHERVHTGEKPYKCNECGKAFVC 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 2.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.94e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  482 YFQVHKRIHTGEKPYKCDQCGKAFV 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-45 3.30e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 3.30e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 295293092    5 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLNAVG 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
5-46 1.68e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.68e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 295293092     5 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLNAVGY 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-41 1.79e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 1.79e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 295293092   5 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNL 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-487 7.76e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 7.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092  84 AFVHHSSLQMRKIIHTGEKRYKCNQ--CDKAYSRHSILQIHKRTHSGEKPYECN-QCGKAFTQHSHLKIHMVTHTGEKPY 160
Cdd:COG5048   42 SFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNN 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 161 KCDQCGKAFA--------FHSTLQVHKRTHTGEKPYECNQCSKAFAHH--------------CHLRVHKRIHTGEKPYKC 218
Cdd:COG5048  122 LLSSHSLPPSsrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssnLSLLISSNVSTSIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 219 DQCGKAFVGQNDLKRHERVHTGEKPYKCNECGkaFVCNASLRTHKTTHTGVK--------PYECKQCTKSFASHGQLQKH 290
Cdd:COG5048  202 NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSdssssaseSPRSSLPTASSQSSSPNESD 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 291 ERIHTG-EKPYKCDQCGKAFASHDKFQKHER--IHIGE--KPYKC--KQCTKSFASHDKLQKHERIHTGEKPYECK--QC 361
Cdd:COG5048  280 SSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNS 359

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 362 TKSF--ASHNKLQKHERIHTGEKPYKCDQCNKafvyesylqvhkkthtgekpykcNECGKAFARHSHLKVHKITHTGEKP 439
Cdd:COG5048  360 SSKFspLLNNEPPQSLQQYKDLKNDKKSETLS-----------------------NSCIRNFKRDSNLSLHIITHLSFRP 416

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 295293092 440 --YKCNQCGKALAYHSTLQVHQRTHTGEKPYECEQCGKAFANQSYFQVHK 487
Cdd:COG5048  417 ynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-525 2.95e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 130 KPYECNQCGKAFTQHSHLKIHMVTHTGEKPYKC--DQCGKAFAFHSTLQVHKRTHTGEKPYECNQCSKAFAHHChlRVHK 207
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA--SSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 208 RIHTGEKPYKCDQCgkAFVGQNDLKRHERVHTGEKPYKCNEC------GKAFVCNASLRTHKTTHTGVKPyeckqctKSF 281
Cdd:COG5048  110 LSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNplpgnnSSSVNTPQSNSLHPPLPANSLS-------KDP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 282 ASHGQLQKHERIHTGEKPYKCDQCGKAFASHDKFQKHERIHIGEKPYKCKQCTKSFASHDKLQ------KHERIHTGEKP 355
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslsSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 356 YECKQCTKSFASHNKLQKHERIHTG-EKPYKCDQCNKAFVYESYLQVHKKT--HTGE--KPYKCNE--CGKAFARHSHLK 428
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 429 VHKITHTGEKPYKCNQC-------GKALAYHSTLQVHQRTHTGEKPYECE--QCGKAFANQSYFQVHKRIHTGEKP--YK 497
Cdd:COG5048  341 RHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                        410       420
                 ....*....|....*....|....*...
gi 295293092 498 CDQCGKAFVGSSDLKRHERVHTGRETLQ 525
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-447 7.43e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 7.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092  65 RHERNHTGEKPyegiqygeafvHHSSLQMrkiihtgekrykcnqCDKAYSRHSILQIHKRTHSGEKPYECN-QCGKAFTQ 143
Cdd:COG5048   51 RHIRSHTGEKP-----------SQCSYSG---------------CDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 144 HSHLKIHMVTHTGEKPYKCDQCGKAFA--------FHSTLQVHKRTHTGEKPYECNQCSKAFAHH--------------C 201
Cdd:COG5048  105 ASSSSLSSSSSNSNDNNLLSSHSLPPSsrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssnL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 202 HLRVHKRIHTGEKPYKCDQCGKAFVGQNDLKRHERVHTGEKPYKCNECGkaFVCNASLRTHKTTHTGVK--------PYE 273
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSdssssaseSPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 274 CKQCTKSFASHGQLQKHERIHTG-EKPYKCDQCGKAFASHDKFQKHER--IHIGE--KPYKC--KQCTKSFASHDKLQKH 346
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 347 ERIHTGEKPYECK--QCTKSF--ASHNKLQKHERIHTGEKPYK---CD--QCNKAFVYESYLQVHKKTHTGEKP--YKCN 415
Cdd:COG5048  343 ILLHTSISPAKEKllNSSSKFspLLNNEPPQSLQQYKDLKNDKkseTLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNP 422

                        410       420       430
                 ....*....|....*....|....*....|..
gi 295293092 416 ECGKAFARHSHLKVHKITHTGEKPYKCNQCGK 447
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-518 1.22e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 172 HSTLQVHKRTHTGE----KPYECNQCSKAFAHHCHLRVHKRIHTGEKPYKC--DQCGKAFVGQNDLKRHERVHTGEKPYK 245
Cdd:COG5048   14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 246 CN-ECGKAFVCNASLRTHKTTHTGVKPYECKQCTKSFASHGQLQKHERIHTGEKPYKCDQCGKAFASHDKFQKHerIHIG 324
Cdd:COG5048   94 NSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSL--HPPL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 325 EKPYKCKQCTKSFASHdklqKHERIHTGEKPYECKQCTKSFASHNKLQKHERIHTGEKPYKCDQCNKAFVY----ESYLQ 400
Cdd:COG5048  172 PANSLSKDPSSNLSLL----ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsQSPSS 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 401 VHKKTHTGEKPYKCNECG--KAFARHSHLKVHKITHTG-EKPYKCNQCGKALAYHSTLQVHQRT--HTGE--KPYEC--E 471
Cdd:COG5048  248 LSSSDSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpyS 327

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 295293092 472 QCGKAFANQSYFQVHKRIHTGEKPYKC--DQCGKAFVGSSDLKRHERVH 518
Cdd:COG5048  328 LCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 3.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.92e-04
                          10        20
                  ....*....|....*....|....*.
gi 295293092  230 DLKRHERVHTGEKPYKCNECGKAFVC 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-311 5.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.02e-04
                          10        20
                  ....*....|....*....|....*
gi 295293092  287 LQKHERIHTGEKPYKCDQCGKAFAS 311
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-226 5.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.81e-04
                          10        20
                  ....*....|....*....|....*
gi 295293092  202 HLRVHKRIHTGEKPYKCDQCGKAFV 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-423 8.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.11e-04
                          10        20
                  ....*....|....*....|....*.
gi 295293092  398 YLQVHKKTHTGEKPYKCNECGKAFAR 423
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-367 1.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.33e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  343 LQKHERIHTGEKPYECKQCTKSFAS 367
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-170 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  146 HLKIHMVTHTGEKPYKCDQCGKAFA 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
175-199 1.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.65e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  175 LQVHKRTHTGEKPYECNQCSKAFAH 199
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-479 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  455 LQVHQRTHTGEKPYECEQCGKAFAN 479
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-395 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  371 LQKHERIHTGEKPYKCDQCNKAFVY 395
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 2.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.94e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  482 YFQVHKRIHTGEKPYKCDQCGKAFV 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 408-487 3.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092 408 GEKPYKCN--ECGKAFARHSHLKVHKithtgekpyKCNQCGKALAYHSTLQVHQRTHTGEKPYECEQCGKAFANQSYFQV 485
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 295293092 486 HK 487
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
119-143 4.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.02e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  119 LQIHKRTHSGEKPYECNQCGKAFTQ 143
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 212-267 4.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 4.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 295293092 212 GEKPYKCD--QCGKAFVGQNDLKRHeRVH--------------------TGEKPYKCNECGKAFVCNASLRTHKTTHT 267
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 73-183 5.45e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293092  73 EKPYEGIQYGEAFVHHSSLQM----RKIIHTGEKRYKCN--QCDKAYSRHSILQIHKRThsgekpyecNQCGKAFTQHSH 146
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIdtpsRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPS 385

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 295293092 147 LKIHMVTHTGEKPYKCDQCGKAFAFHSTLQVHkRTHT 183
Cdd:COG5189  386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-339 8.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.32e-03
                          10        20
                  ....*....|....*....|....*
gi 295293092  315 FQKHERIHIGEKPYKCKQCTKSFAS 339
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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