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Conserved domains on  [gi|21704134|ref|NP_663539|]
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F-box only protein 21 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yccV TIGR02097
hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV ...
 500-597 2.76e-45

hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV and its homologs in other Proteobacteria. YccV is now described as a hemimethylated DNA binding protein. The model also describes a domain in longer eukaryotic proteins.


:

Pssm-ID: 131152  Cd Length: 101  Bit Score: 155.99  E-value: 2.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134   500 DVCYSIGLVMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDGSCR----YAAQENLEYNVEPQ 575
Cdd:TIGR02097   1 AAKFRIGQVVRHKLFGYRGVVIDVDPEYSNTEEWLDAIPVEIRPL-RDQPFYHVLAEDDEGLpyvaYVAEQNLLYDDSDE 79

                          90       100
                  ....*....|....*....|..
gi 21704134   576 EISHPDVGRYFSEFTGTHYIPN 597
Cdd:TIGR02097  80 PIEHPQVDELFDGFDEGLQKPR 101
Transglut_core2 pfam13369
Transglutaminase-like superfamily;
258-388 5.59e-43

Transglutaminase-like superfamily;


:

Pssm-ID: 463859  Cd Length: 155  Bit Score: 151.55  E-value: 5.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134   258 QSQVLDAINYVLYDQLKFKGNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLRWCQGAE 337
Cdd:pfam13369  24 PLEKLEALNRLLFGELGFKGNSEDYYDPDNSYLDQVLERRRGIPISLGVIYLELARRLGLPLYGVNFPGHFLLRVDDTPD 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21704134   338 GatldifdYIYIDAFGKGKQLTVKECEYLI----GQHV--TAALYGVVNVKKVLQRM 388
Cdd:pfam13369 104 G-------EVYIDPFNGGEILSREDLEELLkgnlGPSAelDPEFLAPASNREILLRM 153
F-box_FBXO21 cd22096
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ...
 30-78 1.36e-17

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438868  Cd Length: 48  Bit Score: 76.58  E-value: 1.36e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 21704134  30 LVQLPGEVLEYILCSGSLTALDIGRVSSTCRRLREVCQsSGQVWKEQFR 78
Cdd:cd22096   1 LLELPDELLEYILCSDNLDHHDIIRLSCTCRRLREVCQ-SGKVWREKFF 48
 
Name Accession Description Interval E-value
yccV TIGR02097
hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV ...
 500-597 2.76e-45

hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV and its homologs in other Proteobacteria. YccV is now described as a hemimethylated DNA binding protein. The model also describes a domain in longer eukaryotic proteins.


Pssm-ID: 131152  Cd Length: 101  Bit Score: 155.99  E-value: 2.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134   500 DVCYSIGLVMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDGSCR----YAAQENLEYNVEPQ 575
Cdd:TIGR02097   1 AAKFRIGQVVRHKLFGYRGVVIDVDPEYSNTEEWLDAIPVEIRPL-RDQPFYHVLAEDDEGLpyvaYVAEQNLLYDDSDE 79

                          90       100
                  ....*....|....*....|..
gi 21704134   576 EISHPDVGRYFSEFTGTHYIPN 597
Cdd:TIGR02097  80 PIEHPQVDELFDGFDEGLQKPR 101
Transglut_core2 pfam13369
Transglutaminase-like superfamily;
258-388 5.59e-43

Transglutaminase-like superfamily;


Pssm-ID: 463859  Cd Length: 155  Bit Score: 151.55  E-value: 5.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134   258 QSQVLDAINYVLYDQLKFKGNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLRWCQGAE 337
Cdd:pfam13369  24 PLEKLEALNRLLFGELGFKGNSEDYYDPDNSYLDQVLERRRGIPISLGVIYLELARRLGLPLYGVNFPGHFLLRVDDTPD 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21704134   338 GatldifdYIYIDAFGKGKQLTVKECEYLI----GQHV--TAALYGVVNVKKVLQRM 388
Cdd:pfam13369 104 G-------EVYIDPFNGGEILSREDLEELLkgnlGPSAelDPEFLAPASNREILLRM 153
SirB1 COG2912
Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal ...
 186-441 1.19e-40

Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal transduction mechanisms];


Pssm-ID: 442156 [Multi-domain]  Cd Length: 264  Bit Score: 148.82  E-value: 1.19e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134 186 LQQPDDYESYLEGAVYIDQYCNPlsDISFRDIQAQIHSIVELVCKtlrginsrhpsltfragessMIMEIELQSQVLDAI 265
Cdd:COG2912   4 IALFDEQIDLAEAALLIAQDEYP--DLDIEQYLAQLDALAAELRE--------------------RLPAEADPLERLEAL 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134 266 NYVLYDQLKFKGNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLRwCQGAEGatldifd 345
Cdd:COG2912  62 NQLLYGELGFAGNDEDYYDPDNSYLNKVLDRRRGIPISLGILYLELARRLGLPLYGVNFPGHFLLR-VDLPDG------- 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134 346 YIYIDAFGkGKQLTVKECEYL----IGQHV--TAALYGVVNVKKVLQRMVGNLLSLGKREgidQSYQLLRDSLDLYLAMY 419
Cdd:COG2912 134 PVFIDPFN-GEILSEEELEELlkglLGPPAelEPEFLAPASNREILARMLRNLKAAYLRE---KDWERALRVVERLLLLD 209

                       250       260
                ....*....|....*....|..
gi 21704134 420 PDQVQLLLLQARLYFHLGIWPE 441
Cdd:COG2912 210 PDDPYEIRDRGLLYAQLGCYQA 231
YccV-like pfam08755
Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein ...
 501-593 9.45e-38

Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.


Pssm-ID: 430193  Cd Length: 96  Bit Score: 135.03  E-value: 9.45e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134   501 VCYSIGLVMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLphGHHQPFYNVLVED-----GSCRYAAQENLEYNVEPQ 575
Cdd:pfam08755   1 VKFRIGQVVRHRRYGYRGVIVGWDPECAASEEWIEQMGVDSL--GRDQPFYHVLVDNedgsyVSVRYVAEENLEPDESGE 78

                          90
                  ....*....|....*...
gi 21704134   576 EISHPDVGRYFSEFTGTH 593
Cdd:pfam08755  79 PIDHPEIGKYFKRFDGGR 96
YccV-like smart00992
Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein ...
 500-595 3.16e-35

Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.


Pssm-ID: 214961  Cd Length: 98  Bit Score: 128.12  E-value: 3.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134    500 DVCYSIGLVMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDG---SCRYAAQENLEYNVEPQE 576
Cdd:smart00992   1 HAKFRIGQVVRHKLFGYRGVVFDWDPEFANTEEWYDEIPEDSRPP-RDQPFYHVLVENDdssYVAYVSEQNLEPDTSGEP 79

                           90
                   ....*....|....*....
gi 21704134    577 ISHPDVGRYFSEFTGTHYI 595
Cdd:smart00992  80 IDHPLLDELFDEFDGGRYV 98
F-box_FBXO21 cd22096
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ...
 30-78 1.36e-17

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438868  Cd Length: 48  Bit Score: 76.58  E-value: 1.36e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 21704134  30 LVQLPGEVLEYILCSGSLTALDIGRVSSTCRRLREVCQsSGQVWKEQFR 78
Cdd:cd22096   1 LLELPDELLEYILCSDNLDHHDIIRLSCTCRRLREVCQ-SGKVWREKFF 48
PRK10941 PRK10941
tetratricopeptide repeat-containing protein;
253-331 5.75e-07

tetratricopeptide repeat-containing protein;


Pssm-ID: 182854 [Multi-domain]  Cd Length: 269  Bit Score: 51.55  E-value: 5.75e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21704134  253 MEIELQsqvLDAINYVLYDQLKFKGNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLR 331
Cdd:PRK10941  53 LPQDEQ---LEKLIALFYGEWGFGGASGVYRLSDALWLDKVLKTRQGSAVSLGAILLWIANRLDLPLMPVIFPTQLILR 128
 
Name Accession Description Interval E-value
yccV TIGR02097
hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV ...
 500-597 2.76e-45

hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV and its homologs in other Proteobacteria. YccV is now described as a hemimethylated DNA binding protein. The model also describes a domain in longer eukaryotic proteins.


Pssm-ID: 131152  Cd Length: 101  Bit Score: 155.99  E-value: 2.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134   500 DVCYSIGLVMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDGSCR----YAAQENLEYNVEPQ 575
Cdd:TIGR02097   1 AAKFRIGQVVRHKLFGYRGVVIDVDPEYSNTEEWLDAIPVEIRPL-RDQPFYHVLAEDDEGLpyvaYVAEQNLLYDDSDE 79

                          90       100
                  ....*....|....*....|..
gi 21704134   576 EISHPDVGRYFSEFTGTHYIPN 597
Cdd:TIGR02097  80 PIEHPQVDELFDGFDEGLQKPR 101
Transglut_core2 pfam13369
Transglutaminase-like superfamily;
258-388 5.59e-43

Transglutaminase-like superfamily;


Pssm-ID: 463859  Cd Length: 155  Bit Score: 151.55  E-value: 5.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134   258 QSQVLDAINYVLYDQLKFKGNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLRWCQGAE 337
Cdd:pfam13369  24 PLEKLEALNRLLFGELGFKGNSEDYYDPDNSYLDQVLERRRGIPISLGVIYLELARRLGLPLYGVNFPGHFLLRVDDTPD 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21704134   338 GatldifdYIYIDAFGKGKQLTVKECEYLI----GQHV--TAALYGVVNVKKVLQRM 388
Cdd:pfam13369 104 G-------EVYIDPFNGGEILSREDLEELLkgnlGPSAelDPEFLAPASNREILLRM 153
SirB1 COG2912
Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal ...
 186-441 1.19e-40

Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal transduction mechanisms];


Pssm-ID: 442156 [Multi-domain]  Cd Length: 264  Bit Score: 148.82  E-value: 1.19e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134 186 LQQPDDYESYLEGAVYIDQYCNPlsDISFRDIQAQIHSIVELVCKtlrginsrhpsltfragessMIMEIELQSQVLDAI 265
Cdd:COG2912   4 IALFDEQIDLAEAALLIAQDEYP--DLDIEQYLAQLDALAAELRE--------------------RLPAEADPLERLEAL 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134 266 NYVLYDQLKFKGNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLRwCQGAEGatldifd 345
Cdd:COG2912  62 NQLLYGELGFAGNDEDYYDPDNSYLNKVLDRRRGIPISLGILYLELARRLGLPLYGVNFPGHFLLR-VDLPDG------- 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134 346 YIYIDAFGkGKQLTVKECEYL----IGQHV--TAALYGVVNVKKVLQRMVGNLLSLGKREgidQSYQLLRDSLDLYLAMY 419
Cdd:COG2912 134 PVFIDPFN-GEILSEEELEELlkglLGPPAelEPEFLAPASNREILARMLRNLKAAYLRE---KDWERALRVVERLLLLD 209

                       250       260
                ....*....|....*....|..
gi 21704134 420 PDQVQLLLLQARLYFHLGIWPE 441
Cdd:COG2912 210 PDDPYEIRDRGLLYAQLGCYQA 231
YccV-like pfam08755
Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein ...
 501-593 9.45e-38

Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.


Pssm-ID: 430193  Cd Length: 96  Bit Score: 135.03  E-value: 9.45e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134   501 VCYSIGLVMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLphGHHQPFYNVLVED-----GSCRYAAQENLEYNVEPQ 575
Cdd:pfam08755   1 VKFRIGQVVRHRRYGYRGVIVGWDPECAASEEWIEQMGVDSL--GRDQPFYHVLVDNedgsyVSVRYVAEENLEPDESGE 78

                          90
                  ....*....|....*...
gi 21704134   576 EISHPDVGRYFSEFTGTH 593
Cdd:pfam08755  79 PIDHPEIGKYFKRFDGGR 96
YccV-like smart00992
Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein ...
 500-595 3.16e-35

Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.


Pssm-ID: 214961  Cd Length: 98  Bit Score: 128.12  E-value: 3.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704134    500 DVCYSIGLVMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDG---SCRYAAQENLEYNVEPQE 576
Cdd:smart00992   1 HAKFRIGQVVRHKLFGYRGVVFDWDPEFANTEEWYDEIPEDSRPP-RDQPFYHVLVENDdssYVAYVSEQNLEPDTSGEP 79

                           90
                   ....*....|....*....
gi 21704134    577 ISHPDVGRYFSEFTGTHYI 595
Cdd:smart00992  80 IDHPLLDELFDEFDGGRYV 98
F-box_FBXO21 cd22096
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ...
 30-78 1.36e-17

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438868  Cd Length: 48  Bit Score: 76.58  E-value: 1.36e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 21704134  30 LVQLPGEVLEYILCSGSLTALDIGRVSSTCRRLREVCQsSGQVWKEQFR 78
Cdd:cd22096   1 LLELPDELLEYILCSDNLDHHDIIRLSCTCRRLREVCQ-SGKVWREKFF 48
PRK10941 PRK10941
tetratricopeptide repeat-containing protein;
253-331 5.75e-07

tetratricopeptide repeat-containing protein;


Pssm-ID: 182854 [Multi-domain]  Cd Length: 269  Bit Score: 51.55  E-value: 5.75e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21704134  253 MEIELQsqvLDAINYVLYDQLKFKGNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLR 331
Cdd:PRK10941  53 LPQDEQ---LEKLIALFYGEWGFGGASGVYRLSDALWLDKVLKTRQGSAVSLGAILLWIANRLDLPLMPVIFPTQLILR 128
F-box_AtSKIP22-like cd22165
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar ...
 29-77 4.81e-05

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438936  Cd Length: 46  Bit Score: 41.11  E-value: 4.81e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 21704134  29 CLVQLPGEVLEYILcsGSLTALDIGRVSSTCRRLREVCqSSGQVWKEQF 77
Cdd:cd22165   1 CLMRLPTELKLKIL--ELLPGVDLARMACVCSELRFLA-SNDDLWKQKF 46
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 32-67 2.07e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 38.96  E-value: 2.07e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 21704134  32 QLPGEVLEYILcsGSLTALDIGRVSSTCRRLREVCQ 67
Cdd:cd09917   2 DLPDEILLKIL--SYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO24 cd22098
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ...
 29-73 3.68e-04

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438870  Cd Length: 47  Bit Score: 38.46  E-value: 3.68e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 21704134  29 CLVQLPGEVLEYILcsGSLTALDIGRVSSTCRRLREVCQSSGqVW 73
Cdd:cd22098   1 SLLDLPPEILDRII--SFLPVKDIVSLGQTCRYFHEVCNSEA-VW 42
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 30-74 7.35e-03

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 34.86  E-value: 7.35e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 21704134  30 LVQLPGEVLEYILcsGSLTALDIGRVSSTCRRLREVCqSSGQVWK 74
Cdd:cd22106   1 LVRLPDKLLLYII--SYLDLEDIARLSQTSKRFKKLC-NSDELWE 42
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 33-75 7.44e-03

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 34.91  E-value: 7.44e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 21704134  33 LPGEVLEYILcsGSLTALDIGRVSSTCRRLREVCQSSGQvWKE 75
Cdd:cd22117   4 LPYELIQLIL--SYLDLPSLCRLSQTCKLFRKHCYDPLL-WKE 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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