|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
77-722 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 986.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 77 GALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPaGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTA 156
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 157 LNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQ 236
Cdd:TIGR01787 80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 237 VYLPMSYCYATRLSASEDPlvqslRQELYVQDyASIdwPAQRNNVSPDEMYTPHSWLLHVVYGLLNL-YERFHSTSLRKW 315
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 316 AVQMLYEHIAADDCftkcisIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTnGSQIWDTSFAIQ 395
Cdd:TIGR01787 232 ALQWLYEHIAADGS------IGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 396 ALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRK-GGFSFSTLDCGW-IVADCTAEGLKAVLLLQNqcp 473
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE--- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 474 siTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFhehfpDYR 553
Cdd:TIGR01787 382 --DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHR 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 554 AAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVAQACNFLLSQQMADGGWGED 633
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 634 FESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFN-KSCAISYTSYRNIF 712
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611
|
650
....*....|
gi 22122469 713 PIWALGRFSN 722
Cdd:TIGR01787 612 PLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
78-720 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 923.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 78 ALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTAL 157
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 158 NYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQV 237
Cdd:cd02892 81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 238 YLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVspDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAV 317
Cdd:cd02892 161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDL--YDYRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 318 QMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQAL 397
Cdd:cd02892 239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 398 LEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNqCPSITE 477
Cdd:cd02892 319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQE-LPPFGE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 478 HIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRaAEV 557
Cdd:cd02892 396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 558 RETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVAQACNFLLSQQMADGGWGEDFESC 637
Cdd:cd02892 475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 638 EQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWAL 717
Cdd:cd02892 552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631
|
...
gi 22122469 718 GRF 720
Cdd:cd02892 632 GRY 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
72-720 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 595.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 72 QTAHEGALNGVTFYAKLQAEDGHW----AGDYGGPLFLLPGLLITCHISHIsLPAGYREEMVRYLRSVQLPDGGWGLHIE 147
Cdd:PLN03012 93 EIATNALRKGIHFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIE 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 148 DKSTVFGTALNYVALRILGIGPD---DPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVP 224
Cdd:PLN03012 172 GHSTMFCTTLNYICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFP 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 225 AHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLY 304
Cdd:PLN03012 252 IHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIF 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 305 -ERF-----HSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPAFQEHVSRIKDYLWLGLDGMK 378
Cdd:PLN03012 332 aEPFlacwpFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMK 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 379 MQgTNGSQIWDTSFAIQALLEAGAHHrpEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRHMRKGGFSFSTLDCGWIVADC 457
Cdd:PLN03012 411 MQ-SFGSQLWDSGFALQALLASNLSN--EIPDVLRRGHDFIKNSQVGENpSGDFKNMYRHISKGAWTFSDRDHGWQASDC 487
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 458 TAEGLKAVLLLQNQCPSITEhiPR---ERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVEC 534
Cdd:PLN03012 488 TAEGFKCCLLFSMIAPDIVG--PKmdpEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNEC 565
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 535 TSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVA 614
Cdd:PLN03012 566 TSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIR 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 615 QACNFLLSQQMADGGWGEDFESCEQRRYVQSA--RSQVHSTCWALMGLM----AVRHPdiTAQERGIRCLLGKQLPNGDW 688
Cdd:PLN03012 643 KGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDF 720
|
650 660 670
....*....|....*....|....*....|..
gi 22122469 689 PQENISGVFNKSCAISYTSYRNIFPIWALGRF 720
Cdd:PLN03012 721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEY 752
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
73-724 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 570.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 73 TAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTV 152
Cdd:COG1657 19 SLLDAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 153 FGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWC 232
Cdd:COG1657 99 STTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSY 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 233 HCRQVYLPMSYCYATRLSASEDPLVqsLRQELYVQDYASID--WPAQRnnvspdeMYTPHSWLLHVVYGLLNLYERFHST 310
Cdd:COG1657 179 WARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPR-------DRSPWSRFFLALDRLLRAYERLPPK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 311 SLRKWAVQ-----MLyEHIAADDCFtkcISIGP-ISKTINMLvRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGtNG 384
Cdd:COG1657 250 PLRRRALRkaedwIL-ERLEGDGGL---GGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CV 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 385 SQIWDTSFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKA 464
Cdd:COG1657 324 SPVWDTALAVQALQEAG---LPEDHPALERAADWLLSKQILVK-GDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 465 VLLLQNQcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEvFGdIMIDYTYVECTSAVMQALKH 544
Cdd:COG1657 400 LLRLRLP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLGQ 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 545 fhehfpdYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLSQQ 624
Cdd:COG1657 474 -------LGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDPA----IRRAVAWLLSIQ 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 625 MADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGV-FNKSCAI 703
Cdd:COG1657 543 NADGGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYL 622
|
650 660
....*....|....*....|.
gi 22122469 704 SYTSYRNIFPIWALGRFSNLY 724
Cdd:COG1657 623 RYHLYRQYFPLWALARYRNLR 643
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
385-722 |
5.14e-50 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 177.91 E-value: 5.14e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 385 SQIWDTSFAIQALLEAGAhhrPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAeglkA 464
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLVK-GDWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 465 VLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLnPsevFGDI--MIDYTYVECTSAVMQAL 542
Cdd:pfam13243 74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKI-P---FADHgaLLDPPTADVTARVLEML 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 543 KHFHehFPDYRAAEVRetlnqGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLS 622
Cdd:pfam13243 150 GQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRPY----IRKAVDWLKS 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 623 QQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMA---VRHPditAQERGIRCLLGKQLPNGDWPQENISGV-FN 698
Cdd:pfam13243 219 RQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAageVDSP---AVRRGIQYLLETQKPDGTWDEPYFTGTgFP 295
|
330 340
....*....|....*....|....
gi 22122469 699 KSCAISYTSYRNIFPIWALGRFSN 722
Cdd:pfam13243 296 RVFYLKYHGYRNYFPLWALARYRN 319
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
77-722 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 986.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 77 GALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPaGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTA 156
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 157 LNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQ 236
Cdd:TIGR01787 80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 237 VYLPMSYCYATRLSASEDPlvqslRQELYVQDyASIdwPAQRNNVSPDEMYTPHSWLLHVVYGLLNL-YERFHSTSLRKW 315
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 316 AVQMLYEHIAADDCftkcisIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTnGSQIWDTSFAIQ 395
Cdd:TIGR01787 232 ALQWLYEHIAADGS------IGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 396 ALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRK-GGFSFSTLDCGW-IVADCTAEGLKAVLLLQNqcp 473
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE--- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 474 siTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFhehfpDYR 553
Cdd:TIGR01787 382 --DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHR 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 554 AAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVAQACNFLLSQQMADGGWGED 633
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 634 FESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFN-KSCAISYTSYRNIF 712
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611
|
650
....*....|
gi 22122469 713 PIWALGRFSN 722
Cdd:TIGR01787 612 PLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
78-720 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 923.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 78 ALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTAL 157
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 158 NYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQV 237
Cdd:cd02892 81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 238 YLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVspDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAV 317
Cdd:cd02892 161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDL--YDYRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 318 QMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQAL 397
Cdd:cd02892 239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 398 LEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNqCPSITE 477
Cdd:cd02892 319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQE-LPPFGE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 478 HIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRaAEV 557
Cdd:cd02892 396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 558 RETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVAQACNFLLSQQMADGGWGEDFESC 637
Cdd:cd02892 475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 638 EQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWAL 717
Cdd:cd02892 552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631
|
...
gi 22122469 718 GRF 720
Cdd:cd02892 632 GRY 634
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
86-720 |
0e+00 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 610.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 86 AKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRIL 165
Cdd:TIGR03463 2 AALQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPDAEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALRLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 166 GIGPDDPDLVRARNVLH-KKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYC 244
Cdd:TIGR03463 82 GLGKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGIAWL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 245 YATRLSASE-DPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEH 323
Cdd:TIGR03463 162 SGRGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYERLAGKALRARALDFAFEQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 324 IAADDCFTKCISIGPISKTINMLVRWSVDgPSSPAFQEHVSRIKDYLWLGLD-GMKMQGTNGSQIWDTSFAIQALLEAGa 402
Cdd:TIGR03463 242 ILAEDEATHYICIGPINGLLNCLAIFAHD-PDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSNALWDTAFAVQALAALG- 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 403 HHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQ-CPSITEHIPR 481
Cdd:TIGR03463 320 ELDEEAKHALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELgDNRISEALGA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 482 ERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETL 561
Cdd:TIGR03463 400 ARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAAI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 562 NQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLSQQMADGGWGEDFESCEQRR 641
Cdd:TIGR03463 480 RKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPADMA----LQAAAAFLLEKQRADGAWGEHVESCLEAR 555
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22122469 642 YVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRF 720
Cdd:TIGR03463 556 WVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
72-720 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 595.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 72 QTAHEGALNGVTFYAKLQAEDGHW----AGDYGGPLFLLPGLLITCHISHIsLPAGYREEMVRYLRSVQLPDGGWGLHIE 147
Cdd:PLN03012 93 EIATNALRKGIHFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIE 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 148 DKSTVFGTALNYVALRILGIGPD---DPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVP 224
Cdd:PLN03012 172 GHSTMFCTTLNYICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFP 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 225 AHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLY 304
Cdd:PLN03012 252 IHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIF 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 305 -ERF-----HSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPAFQEHVSRIKDYLWLGLDGMK 378
Cdd:PLN03012 332 aEPFlacwpFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMK 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 379 MQgTNGSQIWDTSFAIQALLEAGAHHrpEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRHMRKGGFSFSTLDCGWIVADC 457
Cdd:PLN03012 411 MQ-SFGSQLWDSGFALQALLASNLSN--EIPDVLRRGHDFIKNSQVGENpSGDFKNMYRHISKGAWTFSDRDHGWQASDC 487
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 458 TAEGLKAVLLLQNQCPSITEhiPR---ERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVEC 534
Cdd:PLN03012 488 TAEGFKCCLLFSMIAPDIVG--PKmdpEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNEC 565
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 535 TSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVA 614
Cdd:PLN03012 566 TSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIR 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 615 QACNFLLSQQMADGGWGEDFESCEQRRYVQSA--RSQVHSTCWALMGLM----AVRHPdiTAQERGIRCLLGKQLPNGDW 688
Cdd:PLN03012 643 KGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDF 720
|
650 660 670
....*....|....*....|....*....|..
gi 22122469 689 PQENISGVFNKSCAISYTSYRNIFPIWALGRF 720
Cdd:PLN03012 721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEY 752
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
73-724 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 570.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 73 TAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTV 152
Cdd:COG1657 19 SLLDAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 153 FGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWC 232
Cdd:COG1657 99 STTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSY 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 233 HCRQVYLPMSYCYATRLSASEDPLVqsLRQELYVQDYASID--WPAQRnnvspdeMYTPHSWLLHVVYGLLNLYERFHST 310
Cdd:COG1657 179 WARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPR-------DRSPWSRFFLALDRLLRAYERLPPK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 311 SLRKWAVQ-----MLyEHIAADDCFtkcISIGP-ISKTINMLvRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGtNG 384
Cdd:COG1657 250 PLRRRALRkaedwIL-ERLEGDGGL---GGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CV 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 385 SQIWDTSFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKA 464
Cdd:COG1657 324 SPVWDTALAVQALQEAG---LPEDHPALERAADWLLSKQILVK-GDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 465 VLLLQNQcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEvFGdIMIDYTYVECTSAVMQALKH 544
Cdd:COG1657 400 LLRLRLP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLGQ 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 545 fhehfpdYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLSQQ 624
Cdd:COG1657 474 -------LGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDPA----IRRAVAWLLSIQ 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 625 MADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGV-FNKSCAI 703
Cdd:COG1657 543 NADGGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYL 622
|
650 660
....*....|....*....|.
gi 22122469 704 SYTSYRNIFPIWALGRFSNLY 724
Cdd:COG1657 623 RYHLYRQYFPLWALARYRNLR 643
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
29-720 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 561.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 29 NELGRQRWTYYQAEDDPGREQTGLEAHSLGLDTRSYF---TDL----------------PKAQT------AHEGALN--- 80
Cdd:PLN02993 21 NFVGRQTWEFDPKAGTPEERAAVEEARRSFLDNRSRVkgcSDLlwrmqflkeakfeqviPPVKIdrgeeiTYETATNalr 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 81 -GVTFYAKLQAEDGHWAGDYGGPLFLLPG----LLITCHISHIsLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGT 155
Cdd:PLN02993 101 rGVSFFSALQASDGHWPGEITGPLFFLPPlvfcLYITGHLEEV-FDAEHRKEMLRHIYCHQNEDGGWGLHIESKSVMFCT 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 156 ALNYVALRILGIGPD---DPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWC 232
Cdd:PLN02993 180 VLNYICLRMLGEGPNggrENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMPPEIWLLPSFLPIHLGKTLC 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 233 HCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTS- 311
Cdd:PLN02993 260 YTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLVQDLIWDTLHNFVEPFLTRw 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 312 -----LRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQgTNGSQ 386
Cdd:PLN02993 340 plnklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDHFKKHLARIPDYMWVAEDGMKMQ-SFGSQ 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 387 IWDTSFAIQALLeaGAHHRPEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAV 465
Cdd:PLN02993 418 LWDTGFAIQALL--ASDLSDETDDVLRRGHNYIKKSQVRENpSGDFKSMYRHISKGAWTLSDRDHGWQVSDCTAEALKCC 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 466 LLLQNQCPSIT-EHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKH 544
Cdd:PLN02993 496 MLLSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVEREYVECTSAVIQALVL 575
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 545 FHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVAQACNFLLSQQ 624
Cdd:PLN02993 576 FKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYND---CLAMRKGVHFLLTIQ 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 625 MADGGWGEDFESCEQRRYV--QSARSQVHSTCWALMGLMAVRHP--DITAQERGIRCLLGKQLPNGDWPQENISGVFNKS 700
Cdd:PLN02993 653 RDDGGWGESYLSCPEQRYIplEGNRSNLVQTAWAMMGLIHAGQAerDLIPLHRAAKLIITSQLENGDFPQQEILGAFMNT 732
|
730 740
....*....|....*....|
gi 22122469 701 CAISYTSYRNIFPIWALGRF 720
Cdd:PLN02993 733 CMLHYATYRNTFPLWALAEY 752
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
385-720 |
3.96e-168 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 486.73 E-value: 3.96e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 385 SQIWDTSFAIQALLEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKA 464
Cdd:cd02889 23 SQVWDTALALQALLEAGLA--PEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 465 VLLLQNqCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELlnPSEVFGDIMIDYTYVECTSAVMQALKH 544
Cdd:cd02889 101 LLRLQK-KPPDGKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 545 FHEHFPDYRAaEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTyqdgAACAEVAQACNFLLSQQ 624
Cdd:cd02889 178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGED----ENSPYVRKACDWLLSKQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 625 MADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAIS 704
Cdd:cd02889 253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332
|
330
....*....|....*.
gi 22122469 705 YTSYRNIFPIWALGRF 720
Cdd:cd02889 333 YHNYRNYFPLWALGRY 348
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
82-723 |
1.01e-58 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 210.13 E-value: 1.01e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 82 VTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHiSLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVA 161
Cdd:TIGR01507 22 VDYLLSCQKDEGYWWGELESNVTIEAEYVLLCHILD-RVDRDRMEKIRNYLLHEQREDGTWALYPGGPGDLSTTVEAYVA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 162 LRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPM 241
Cdd:TIGR01507 101 LKYIGMSRDEPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEFSSWARATVVPL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 242 SYCYATRLSAsedPLVQSLR-QELYVQDyasidwpaqrnnVSPDEMYTPHS-WLLHVVYGL---LNLYERFHSTSLRKWA 316
Cdd:TIGR01507 181 SIVCSRKPVF---PLPERARvPELYETD------------VPKPRRRGAKGgTGWGIFDALdraLHGYEKLSVHPFRRAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 317 VQM----LYEHIAADDCFTkcisiGPISKTINMLVRWSVDG-PSSPAF-QEHVSRIKDYLWLGLDGMKMQGTNgSQIWDT 390
Cdd:TIGR01507 246 EIRaldwLLERQAGDGSWG-----GIQPAMFNALIALKILGmTQHDAFiKLGWEGIDLYGVELDDSWMFQACV-SPVWDT 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 391 SFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVpeNCP-DYQKYYRHMRKGGFSFSTLDCGWIVADCTAeglkAVLLLQ 469
Cdd:TIGR01507 320 ALAVLALREAG---LPADHDALVKAGEWLLDKQI--TVPgDWAVKRPNLEPGGWAFQFDNVYYPDVDDTA----VVVWAL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 470 NQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNpsevFGDI--MIDYTYVECTSAVMQALKHFHE 547
Cdd:TIGR01507 391 NGLRLPDERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGY 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 548 HFPdyraaevRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaacAEVAQACNFLLSQQMAD 627
Cdd:TIGR01507 467 DDA-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGIDTRE----PYIQKALAWLESHQNPD 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 628 GGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGV-FNKSCAISYT 706
Cdd:TIGR01507 536 GGWGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYH 615
|
650
....*....|....*..
gi 22122469 707 SYRNIFPIWALGRFSNL 723
Cdd:TIGR01507 616 MYRHVFPLLALARYKQA 632
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
360-720 |
4.53e-52 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 182.75 E-value: 4.53e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 360 QEHVSRIKDYLwlGLDGMKMQGTNGSQIWDTSFAIQALLEAGAH--HRPEFLPCLQKAHEFLRLSQVPencpdyqkyyrh 437
Cdd:cd00688 2 EKHLKYLLRYP--YGDGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLS------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 438 mrKGGFSFSTLDcGWIVADCTAEGLKAVLLLQNqcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKkrggyllelln 517
Cdd:cd00688 68 --DGGFSGWGGN-DYPSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDGP----------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 518 pseVFGDIMIDYTYVECTSAVMQALKHFHEHFPDyraaevrETLNQGLDFCRRKQRADGSWeGSWGVCFTYGTWFGLEAF 597
Cdd:cd00688 129 ---GNHRIGGDESDVRLTAYALIALALLGKLDPD-------PLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAAL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 598 ACMGHTYQDgaacaEVAQACNFLLSQQMADGGWGEdfesceqRRYVQSARSQVHSTCWALMGLMA-VRHPDITAQERGIR 676
Cdd:cd00688 198 ALLGDLDSP-----DAKKALRWLLSRQRPDGGWGE-------GRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVK 265
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 22122469 677 CLLGKQLPNGDWPQENIsgvfnkscaISYTSYRNIFPIWALGRF 720
Cdd:cd00688 266 WLLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
385-722 |
5.14e-50 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 177.91 E-value: 5.14e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 385 SQIWDTSFAIQALLEAGAhhrPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAeglkA 464
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLVK-GDWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 465 VLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLnPsevFGDI--MIDYTYVECTSAVMQAL 542
Cdd:pfam13243 74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKI-P---FADHgaLLDPPTADVTARVLEML 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 543 KHFHehFPDYRAAEVRetlnqGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLS 622
Cdd:pfam13243 150 GQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRPY----IRKAVDWLKS 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 623 QQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMA---VRHPditAQERGIRCLLGKQLPNGDWPQENISGV-FN 698
Cdd:pfam13243 219 RQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAageVDSP---AVRRGIQYLLETQKPDGTWDEPYFTGTgFP 295
|
330 340
....*....|....*....|....
gi 22122469 699 KSCAISYTSYRNIFPIWALGRFSN 722
Cdd:pfam13243 296 RVFYLKYHGYRNYFPLWALARYRN 319
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
88-330 |
6.31e-43 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 157.26 E-value: 6.31e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 88 LQAEDGHWAGDYGgplfllpgllitchiSHISLPAGY--------------REEMVRYLRSVQLPDGGWGLHIEDKSTVF 153
Cdd:pfam13249 11 LQHPDGHWVGELE---------------ANVTITAEYillrhflgpddpelEAKIARYLRSQQREDGGWPLFHGGPGDLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 154 GTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCH 233
Cdd:pfam13249 76 TTVEAYFALKLLGDSPDAPHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFNIYKFSSW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 234 CRQVYLPMSYCYATRLSASEDPlvQSLRQELYVQDYASIDWPAQRnnvspdemYTPHSW--LLHVVYGLLNLYERFHSTS 311
Cdd:pfam13249 156 ARTTIVPLLILSALKPVAPLPP--GIGLDELFVEPPENVRYYPRP--------HRLFSWtnLFLGLDRVLKLYERLPPKP 225
|
250 260
....*....|....*....|....
gi 22122469 312 LRKWAVQ-----MLyEHIAADDCF 330
Cdd:pfam13249 226 LRRRALRkaeewIL-ERQEGDGGL 248
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
132-720 |
1.28e-23 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 106.26 E-value: 1.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 132 LRSVQLPDGGWgLHIEDKSTVFG----TALNYVALRILGIGPD-DPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSW 206
Cdd:TIGR04277 77 LLGSQFEDGSW-EQVEDANIETGqldaTIFNYWYLKAIGIDIHiDAALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPW 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 207 EGL----------NTLFPEMW---LFPEWVPAHPSTLwchcrqvylpmSYCYATRLSAseDPLVQSLRqELYvqdyasID 273
Cdd:TIGR04277 156 EDLfkiplfifkkKGIFKPLYikdITAQWVYPHLTAL-----------AYLQNQRIIF--NVAVADIR-ELW------IN 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 274 WPAQRNNVSPDEMYT--PHSWLLHVVYGLLNLYERFhsTSLRKWAVQMLYEHIAADDcFTkcisigpiSKTINMlvrwsv 351
Cdd:TIGR04277 216 KAKKGIKHQKKERPSffIDNDLLILMDEIFKLKQPL--GSFGAYTISTLLSLLAFKD-FQ--------GKHPHK------ 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 352 dgpsspafqeHVSRIKDYLWLGLDGMKM------QGTNGS----QIWDTSFAIQALLEAGaHHRPEFLPCLQKaheFLRL 421
Cdd:TIGR04277 279 ----------HKNEIQDALEDGLDFVEFnyfnfrEAYHGSlddgRWWDTILISWAMLESG-EDKEKIFPIVEN---MLKE 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 422 SQVPENCPDYqkyyrhmrkgGFSFStldcgwIVADCTAEGLKAVLLlqnqcpSITEHIPRERLCDAVDVLLSLRNADGGF 501
Cdd:TIGR04277 345 GLQPKGGIEY----------GYDFE------YAPDADDTGLLLQVL------SYYGEAFADAIDEGAEFLFSMQNDDGGF 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 502 ATYEK-KRGGYLL--------ELLNPSEVFgdimiDYTYVECTSAVMQALKHFhehfpDYRAAevRETLNQGLDFCRRKQ 572
Cdd:TIGR04277 403 PAFDKgKMEDNLLfkfafkiaGIADSAEIF-----DPSCPDITAHILEGLGEF-----GDQAN--HDQIQKMIKYFMDTQ 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 573 RADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLSQQMADGGWGEDFESC-EQRRYVQSARSQVH 651
Cdd:TIGR04277 471 EKFGSWEARWGINYIMAAGAVLPALAKMNYDLNEGW----AKNAINWLLNKQNADGGFGECTLSYnDPEKWNGIGKSTVT 546
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122469 652 STCWALMGLMAVR-HPDIT--AQERGIRCLLGK-QLPNGDWPQENISGVFNKSCA-ISYTSYRNIFPIWALGRF 720
Cdd:TIGR04277 547 QTSWGLLALLAVEdHNDQIkeAADKAAQYLLDQfKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIALGRF 620
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
125-166 |
1.33e-09 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 54.05 E-value: 1.33e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 22122469 125 REEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILG 166
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
479-686 |
2.12e-07 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 52.79 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 479 IPRERLCDAVDVLLSLRNADGGFATYEkkrggyllellNPSEVFgdimidYTYVECTSAVMQALKHFHEHFPdyraaevr 558
Cdd:COG5029 16 STADFTDSHLDYLRASQNPDGGFAGRS-----------GPSDLY------STYYAVRTLALLGESPKWRDRV-------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 559 etlnqgLDFCRRKQRADGSW----EGSWGvcFTYGTWFGLEAFACMGhtyqdgAACAEVAQACNFLLSQQMADGGWGEDF 634
Cdd:COG5029 71 ------ADLLSSLRVEDGGFakapEGGAG--STYHTYLATLLAELLG------RPPPDPDRLVRFLISQQNDDGGFEISP 136
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 22122469 635 esceqrryvqSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNG 686
Cdd:COG5029 137 ----------GRRSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
562-601 |
2.94e-07 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 47.51 E-value: 2.94e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 22122469 562 NQGLDFCRRKQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 601
Cdd:pfam00432 4 EKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
121-178 |
1.78e-05 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 47.01 E-value: 1.78e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 22122469 121 PAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGpDDPDLVRAR 178
Cdd:COG5029 111 PPPDPDRLVRFLISQQNDDGGFEISPGRRSDTNPTAAAIGALRALGAL-DDPIETKVI 167
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
613-659 |
3.93e-05 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 41.34 E-value: 3.93e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 22122469 613 VAQACNFLLSQQMADGGWGEDFESCeqrryVQSARSQVHSTCWALMG 659
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
418-577 |
6.05e-04 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 42.40 E-value: 6.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 418 FLRLSQVPENCPDYQKYYRHMRK--GGFSFS---TLDCGWivadctaeglkAVLLLQnqcpSITEHIPRERlcDAVDVLL 492
Cdd:COG1689 127 LEALGASEPEREKIREFLLSLRRpdGGFGGKkpnLEDTYW-----------ALAALR----RLGRDLPPAD--RVIAFIL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 493 SLRNADGGFAtyekkrggyllelLNPSevfgdimiDYTYVECTSAVMQALKHFHEHFPDYRAAevretlnqgLDFCRRKQ 572
Cdd:COG1689 190 ACQNEDGGFS-------------KTPG--------SYSDLEATYYALRALKLLGEPPKNVDKL---------LEFIASCQ 239
|
....*
gi 22122469 573 RADGS 577
Cdd:COG1689 240 NSDGG 244
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
555-630 |
3.40e-03 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 40.64 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122469 555 AEVRETLNQGLDFCRRKQRADGSWegswgvcftygtWFGLEAFACMG------HTYQDGAACAEVAQACNFLLSQQMADG 628
Cdd:TIGR01507 12 ARTVEAIDRAVDYLLSCQKDEGYW------------WGELESNVTIEaeyvllCHILDRVDRDRMEKIRNYLLHEQREDG 79
|
..
gi 22122469 629 GW 630
Cdd:TIGR01507 80 TW 81
|
|
| |
