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Conserved domains on  [gi|33238900|ref|NP_666522|]
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olfactory receptor family 10 subfamily V member 1 [Mus musculus]

Protein Classification

olfactory receptor( domain architecture ID 11607024)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 10, subfamily A olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
25-302 3.11e-144

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320353  Cd Length: 277  Bit Score: 407.23  E-value: 3.11e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15225   1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKT-ISFLGCATQMFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15225  80 FLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15225 160 VLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPK 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15225 240 SSYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
 
Name Accession Description Interval E-value
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
25-302 3.11e-144

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 407.23  E-value: 3.11e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15225   1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKT-ISFLGCATQMFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15225  80 FLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15225 160 VLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPK 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15225 240 SSYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
31-306 1.58e-44

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 153.04  E-value: 1.58e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900    31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFVFLGG 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLG-IFWFGLREISFEACLTQMFFIHKFSI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900   111 ADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVIRLAC 190
Cdd:pfam13853  80 MESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900   191 GDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYgcTSFIYLSPSSSYSPE 270
Cdd:pfam13853 160 ADIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFY--TPMIGLSMVHRFGHN 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 33238900   271 MGRMVSVV----YTFITPILNPLIYSMRNKELKDALRKAL 306
Cdd:pfam13853 238 VPPLLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
25-302 3.11e-144

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 407.23  E-value: 3.11e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15225   1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKT-ISFLGCATQMFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15225  80 FLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15225 160 VLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPK 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15225 240 SSYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-295 7.12e-121

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 347.55  E-value: 7.12e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKT-ISFSGCLTQLYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd13954  80 FFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd13954 160 LLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPS 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd13954 240 SSYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
25-295 1.25e-107

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 314.06  E-value: 1.25e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15230   1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKT-ISFAGCAAQFFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15230  80 FAVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15230 160 LLKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPS 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15230 240 SSYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
26-295 4.21e-105

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 307.67  E-value: 4.21e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15237   2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKT-ISFVGCAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15237 241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
26-302 4.79e-105

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 307.55  E-value: 4.79e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFFF 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLS-GRKSISFVGCGTQIFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15421  81 LTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15421 161 LKLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15421 241 YHSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
25-302 1.39e-104

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 306.50  E-value: 1.39e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15231   1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKT-ISYIGCLAQLFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15231  80 FVSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15231 160 LLKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPS 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15231 240 SGYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
25-295 3.21e-104

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 305.18  E-value: 3.21e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15912   1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKT-ISFAGCFAQSFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15912  80 YFFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15912 160 LLKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPS 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15912 240 QSSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
28-295 3.43e-104

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 305.18  E-value: 3.43e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  28 FVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFFVF 107
Cdd:cd15911   4 FLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRT-ISVSGCIVQFYFFGS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 108 LGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVIR 187
Cdd:cd15911  83 LAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 188 LACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSSSY 267
Cdd:cd15911 163 LSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNT 242
                       250       260
                ....*....|....*....|....*...
gi 33238900 268 SPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15911 243 SRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
26-304 2.09e-103

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 303.46  E-value: 2.09e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKT-ISYNGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15419  81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15419 161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15419 241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
11-306 6.68e-103

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 303.13  E-value: 6.68e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  11 QFFFRPFSPDPGVQMVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGK 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  91 TpVSITGCGTQMFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFC 170
Cdd:cd15943  81 T-ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 171 HNNEIYHFYCDMPAVIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVL 250
Cdd:cd15943 160 GSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVT 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33238900 251 LQYGCTSFIYLSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRKAL 306
Cdd:cd15943 240 IFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
27-302 9.27e-100

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 294.31  E-value: 9.27e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFFV 106
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKT-ISFASCVAQLFISL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15429  82 ALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSSS 266
Cdd:cd15429 162 RLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSG 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238900 267 YSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15429 242 SSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
24-302 1.28e-99

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 294.13  E-value: 1.28e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  24 QMVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMF 103
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKT-ISYAGCLAQMY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 104 FFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMP 183
Cdd:cd15235  80 FFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 184 AVIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSP 263
Cdd:cd15235 160 PLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQP 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 264 SSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15235 240 SSSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
25-304 4.63e-99

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 292.68  E-value: 4.63e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFF 104
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLS-GRKAISFAGCFVQMYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15411  80 FIALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15411 160 LLKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPS 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15411 240 SSYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
25-295 1.12e-98

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 291.05  E-value: 1.12e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPT-ISYSRCLAQMYI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLpLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15431  80 SLFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTV-IPVLTMPLHFCGPNVINHFFCEVQA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15431 159 LLKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQ 238
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15431 239 SKSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
25-302 2.93e-98

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 290.38  E-value: 2.93e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15420   1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKT-ISFAGCGTQMYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15420  80 FLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15420 160 VLKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPG 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15420 240 SSNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
25-302 7.66e-97

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 286.80  E-value: 7.66e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15229   1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKT-ISVEGCIAQIFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15229  80 FFFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15229 160 LLPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPN 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15229 240 SASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-299 1.45e-96

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 286.52  E-value: 1.45e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  12 FFFRPFSPDPGVQMVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKT 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  92 pVSITGCGTQMFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCH 171
Cdd:cd15408  81 -ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 172 NNEIYHFYCDMPAVIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLL 251
Cdd:cd15408 160 SNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 33238900 252 QYGCTSFIYLSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELK 299
Cdd:cd15408 240 FYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
26-304 3.77e-96

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 285.06  E-value: 3.77e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKT-ISFAGCFTQCYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15412  81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15412 161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15412 241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-306 3.82e-96

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 285.71  E-value: 3.82e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  12 FFFRPFSPDPGVQMVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKT 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  92 pVSITGCGTQMFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCH 171
Cdd:cd15410  81 -ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 172 NNEIYHFYCDMPAVIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLL 251
Cdd:cd15410 160 SNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITI 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33238900 252 QYGCTSFIYLSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRKAL 306
Cdd:cd15410 240 FHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-295 7.63e-96

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 284.13  E-value: 7.63e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKT-ISYGGCVTQLYI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15947  80 FLWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15947 160 LIKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPP 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15947 240 SSYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
26-304 8.44e-96

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 284.15  E-value: 8.44e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKT-ISFVGCATQYFVF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15417  81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15417 161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15417 241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
28-295 8.78e-96

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 283.96  E-value: 8.78e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  28 FVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFFVF 107
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSL-TNTRSISFLGCVAQVFLFIF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 108 LGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVIR 187
Cdd:cd15227  83 FAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 188 LACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSSSY 267
Cdd:cd15227 163 LSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDS 242
                       250       260
                ....*....|....*....|....*...
gi 33238900 268 SPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15227 243 PSLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
26-295 2.01e-95

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 282.97  E-value: 2.01e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15918   2 LLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKS-ISYAGCLTQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15918 241 SHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
25-295 3.26e-91

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 272.32  E-value: 3.26e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKT-ISFSGCAVQMYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15430  80 SLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15430 160 VLKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPK 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15430 240 SKNAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
26-304 1.25e-90

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 271.16  E-value: 1.25e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFF 105
Cdd:cd15416   2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFL-VEKTTISYPGCAAQLCSA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15416 241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-304 8.57e-89

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 267.00  E-value: 8.57e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  12 FFFRPFSPDPGVQMVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKT 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  92 pVSITGCGTQMFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCH 171
Cdd:cd15945  81 -IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 172 NNEIYHFYCDMPAVIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLL 251
Cdd:cd15945 160 SNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238900 252 QYGCTSFIYLSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15945 240 FYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
25-302 3.40e-88

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 265.11  E-value: 3.40e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15432   1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKT-ISYGGCVAQLFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15432  80 FLGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15432 160 LLKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPP 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15432 240 SNSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
25-295 6.09e-88

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 264.14  E-value: 6.09e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15224   1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKS-ISFVGCMTQLYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15224  80 FLSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15224 160 LLNLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPK 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15224 240 AISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
25-304 4.66e-87

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 261.96  E-value: 4.66e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKM-ISFSGCAAQFFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15409  80 FGFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15409 160 LLKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPS 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15409 240 SLYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
25-308 8.17e-87

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 261.59  E-value: 8.17e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15414   1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKA-ISFLGCAAQMWF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15414  80 FGLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15414 160 LLSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPS 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRKALRK 308
Cdd:cd15414 240 SSSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
26-302 5.67e-86

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 259.05  E-value: 5.67e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKS-ISYTGCLTQMCFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15234  81 LLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15234 161 LKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAV 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15234 241 THSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
26-295 9.55e-86

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 258.39  E-value: 9.55e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFFF 105
Cdd:cd15915   2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLS-EHKTISFQGCISQLHFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15915  81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRI-RSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15915 161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15915 241 SGDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
25-302 1.19e-85

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 258.46  E-value: 1.19e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKT-ISYVGCAIQLFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15434  80 ALGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15434 160 LIKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPK 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15434 240 NSVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
25-304 2.08e-85

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 258.02  E-value: 2.08e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15413   1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNT-ISFYACATQLAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15413  80 FLTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15413 160 LLALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPK 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15413 240 SSHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-304 5.82e-85

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 257.41  E-value: 5.82e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  12 FFFRPFSPDPGVQMVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKT 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  92 pVSITGCGTQMFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCH 171
Cdd:cd15944  81 -ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 172 NNEIYHFYCDMPAVIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLL 251
Cdd:cd15944 160 SNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238900 252 QYGCTSFIYLSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15944 240 FYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKK 292
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
25-295 1.71e-84

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 255.26  E-value: 1.71e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKT-ISFGGCMAQLYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15232  80 FTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYI--ISFIVLSIPLTLisISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLS 262
Cdd:cd15232 160 LLLLSCSDTSLNEIMAFVadVFFGVGNFLLTL--TSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIR 237
                       250       260       270
                ....*....|....*....|....*....|...
gi 33238900 263 PSSSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15232 238 PSSSYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
25-302 5.10e-84

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 254.33  E-value: 5.10e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15428   1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKI-ISFIRCAAQLYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15428  80 FLSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15428 160 LLKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPK 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15428 240 SSTSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
24-305 5.89e-84

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 254.32  E-value: 5.89e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  24 QMVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMF 103
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKS-ISFAGCAAQFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 104 FFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMP 183
Cdd:cd15418  80 FSAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 184 AVIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSP 263
Cdd:cd15418 160 PLVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRP 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 33238900 264 SSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRKA 305
Cdd:cd15418 240 SSSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
26-302 8.17e-84

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 253.89  E-value: 8.17e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFFF 105
Cdd:cd15424   2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLA-GNGAISFARCTTQMYIA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15424  81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15424 161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15424 241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
26-304 4.30e-83

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 251.95  E-value: 4.30e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15415   2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKT-ISYSACIAQHFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15415  81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15415 161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15415 241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
25-302 1.01e-82

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 250.81  E-value: 1.01e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15228   1 TILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRV-ISLGGCMSQVFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15228  80 YHFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15228 160 VLKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPT 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSpeMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15228 240 PSPV--LVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
25-304 1.02e-81

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 248.49  E-value: 1.02e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKV-ISYNACAAQMFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15407  80 FVVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15407 160 VLALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPS 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15407 240 SSHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
26-295 6.48e-81

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 246.24  E-value: 6.48e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKT-ISFTGCVAQMYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15946  81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15946 161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15946 241 NYSPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
26-295 8.33e-81

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 245.59  E-value: 8.33e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKT-ISFNGCMTQLFAE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVhrTALYIIS---FIVLSIPLTLIsISYVfIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLS 262
Cdd:cd15939 161 LKLACTDTYV--IGLLVVAnsgLICLLSFLILL-ISYI-VILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMR 236
                       250       260       270
                ....*....|....*....|....*....|...
gi 33238900 263 PSSSYSpeMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15939 237 PVTTFP--IDKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
25-295 1.03e-79

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 243.05  E-value: 1.03e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15914   1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKT-ISFNGCLLQMYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15914  80 FHSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15914 160 LLSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLS 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15914 240 KSYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
26-295 1.32e-79

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 242.62  E-value: 1.32e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKT-ISFNGCMAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15936  81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVfIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIylSPSS 265
Cdd:cd15936 161 IKLACTDTFLLELLMVSNSGLVTLLIFFILLISYT-VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYI--YARP 237
                       250       260       270
                ....*....|....*....|....*....|
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15936 238 FQTFPMDKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
21-306 5.65e-78

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 239.19  E-value: 5.65e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  21 PGVQMVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGT 100
Cdd:cd15406   6 PELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVS-EKNIISYPECMT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 101 QMFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYC 180
Cdd:cd15406  85 QLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFC 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 181 DMPAVIRLACGDTHVHRTALYII-SFIVLSIPLTLIsISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFI 259
Cdd:cd15406 165 DILPLLKLSCSSTYINELLLFIVgGFNVLATTLAIL-ISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFM 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33238900 260 YLSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRKAL 306
Cdd:cd15406 244 YLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
26-302 3.03e-76

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 234.30  E-value: 3.03e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRT-ISYAACLSQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15233  81 HLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15233 161 FQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15233 241 VYSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
27-302 2.50e-75

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 231.95  E-value: 2.50e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGKVISFGGCVAQLYFFH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSSS 266
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238900 267 YSPEmgRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15916 243 EALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
27-302 2.03e-73

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 227.32  E-value: 2.03e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFFV 106
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRI-ISFGGCVTQLFFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15942  82 FLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAML 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYI-ISFIVLSIPLtLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15942 162 KLACADTAFNELVTFIdIGLVAMTCFL-LILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238900 266 SYSpeMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15942 241 QDP--LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
27-302 4.71e-73

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 226.14  E-value: 4.71e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMgKTPVSITGCGTQMFFFV 106
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSE-KNTISYAGCMTQLFFFC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15405  82 FFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSSS 266
Cdd:cd15405 162 QLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSV 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238900 267 YSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15405 242 GSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
28-295 3.05e-72

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 224.12  E-value: 3.05e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  28 FVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFFVF 107
Cdd:cd15913   4 FSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKT-ISFSGCFLQFYFFFS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 108 LGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVIR 187
Cdd:cd15913  83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 188 LACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSSSY 267
Cdd:cd15913 163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242
                       250       260
                ....*....|....*....|....*...
gi 33238900 268 SPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15913 243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
25-295 3.73e-72

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 223.62  E-value: 3.73e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15226   1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKT-ISFGGCMAQIFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15226  80 LHFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVhrTALYIIS---FIVLSIPLTLIsISYVFIITAIlRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYL 261
Cdd:cd15226 160 VIKLACTDTYV--LELMVVAnsgLISLVCFLLLL-ISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYV 235
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238900 262 SPSSSYSPEmgRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15226 236 WPFSTFPVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
26-302 1.68e-71

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 222.36  E-value: 1.68e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15433   2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALT-ITRGGCVAQLFIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15433 241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
26-302 1.18e-68

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 215.02  E-value: 1.18e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFF 105
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQS-IPYAGCISQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15236  81 IFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSS 265
Cdd:cd15236 161 LKLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238900 266 SYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15236 241 NNSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
25-295 6.84e-68

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 212.69  E-value: 6.84e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKT-ISFNGCVTQLFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15940  80 LHLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVhrTALYIIS---FIVLSIPLTLIsISYVFIITAiLRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYL 261
Cdd:cd15940 160 VIKLACTDTYL--IDILIVSnsgLISLVCFVALL-GSYIVILVS-LRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYT 235
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238900 262 SPSSSYSPEmgRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15940 236 RPSTSFSED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
25-302 2.04e-66

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 209.32  E-value: 2.04e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHT-PMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMF 103
Cdd:cd15941   1 SLFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSGRTISFEGCVVQLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 104 FFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMP 183
Cdd:cd15941  81 AFHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 184 AVIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSP 263
Cdd:cd15941 161 PVLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQP 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 264 SSSYSPEmgRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15941 241 SSSQAGA--GAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
27-302 1.87e-64

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 204.45  E-value: 1.87e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFFV 106
Cdd:cd15223   3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANT-ISLPGCFAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQY--GCTSFIYLSPS 264
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYtaVLVSSLTYRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15223 242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
27-298 2.56e-61

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 195.95  E-value: 2.56e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALaNLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15953   3 ISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKAL-CIFWFNLKEITFSGCLTQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15953  82 TLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCT--SFIYLSPS 264
Cdd:cd15953 162 KLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPAlfSFLTHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15953 242 QGIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
31-298 2.92e-61

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 195.97  E-value: 2.92e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFVFLGG 110
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLG-IFWFNAREISFDACLAQMFFIHSFTA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 111 ADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVIRLAC 190
Cdd:cd15917  86 MESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 191 GDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQY--GCTSFIYLSPSSSYS 268
Cdd:cd15917 166 GDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYtpALFSFLTHRFGHHVP 245
                       250       260       270
                ....*....|....*....|....*....|
gi 33238900 269 PEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15917 246 PHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
25-295 3.98e-60

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 193.06  E-value: 3.98e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHIN-HSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMF 103
Cdd:cd15935   1 LLLFVLVLACYAAILLGNLLIVVTVHADpHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRT-ISFGGCMAQLF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 104 FFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMP 183
Cdd:cd15935  80 FLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 184 AVIRLACGDTHVHRtALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIylSP 263
Cdd:cd15935 160 QVIKLACMDTYVVE-VLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFV--YL 236
                       250       260       270
                ....*....|....*....|....*....|..
gi 33238900 264 SSSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15935 237 RPFSSSSVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
27-295 2.21e-59

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 190.85  E-value: 2.21e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFFFV 106
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKA-ISYEACIAQLFFLH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15938  82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIitaILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIYLSPSSS 266
Cdd:cd15938 162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238
                       250       260
                ....*....|....*....|....*....
gi 33238900 267 YSPEmgRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15938 239 FPVD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
27-297 4.28e-59

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 190.40  E-value: 4.28e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFF-- 104
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLG-IFWFNAREISFDACLAQMFFih 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 -FVFLGGAdcVLLAvMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMP 183
Cdd:cd15222  82 tFSFMESS--VLLA-MAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 184 AVIRLACGDTHVHRT-ALYIISFIVLSIPLtLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYgcTSFIYLS 262
Cdd:cd15222 159 DVMKLACSDTRVNSIyGLFVVLSTMGLDSL-LILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFY--VPMIGLS 235
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 263 PSSSYSPEMGRMVSV----VYTFITPILNPLIYSMRNKE 297
Cdd:cd15222 236 MVHRFGKHASPLVHVlmanVYLLVPPVLNPIIYSVKTKQ 274
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
25-295 1.34e-58

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 188.79  E-value: 1.34e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTpVSITGCGTQMFF 104
Cdd:cd15937   1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKT-ISYGGCMAQLFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd15937  80 LHFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIItAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCTSFIylSPS 264
Cdd:cd15937 160 VIKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYI--YAR 236
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd15937 237 PFRSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
27-298 1.34e-57

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 186.73  E-value: 1.34e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15221   3 ISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLA-IFWFGAGEISFDGCLTQMFFVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15221  82 FVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQY--GCTSFIYLSPS 264
Cdd:cd15221 162 RLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYtpAFFSFLTHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15221 242 RHIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
27-298 1.34e-57

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 186.47  E-value: 1.34e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15950   3 IAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLS-IFWLGSAEISFEACFTQMFFVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15950  82 SFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQY--GCTSFIYLSPS 264
Cdd:cd15950 162 KLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYipGLLSIYTQRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15950 242 QGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
27-298 8.05e-54

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 176.77  E-value: 8.05e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFFV 106
Cdd:cd15951   3 ISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFW-FNSREIDFSACLTQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15951  82 SFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQY--GCTSFIYLSPS 264
Cdd:cd15951 162 KLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYipALFSFLTHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15951 242 HNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
31-298 3.16e-51

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 170.25  E-value: 3.16e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFVFLGG 110
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLG-IFWFNLREISFGGCLAQMFFIHTFTG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 111 ADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVIRLAC 190
Cdd:cd15952  86 MESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 191 GDTHVHRT-ALYIISFIVLSipLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCT--SFIYLSPSSSY 267
Cdd:cd15952 166 ASIRINIIyGLFAISVLVLD--VILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPAlfSFLTHRFGHNI 243
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238900 268 SPEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15952 244 PRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
27-299 4.71e-45

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 154.29  E-value: 4.71e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15948   4 ISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILS-IFWFNSREINFNACLVQMFFLH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15948  83 SFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYG--CTSFIYLSPS 264
Cdd:cd15948 163 KLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTpvVLSSTMHRFA 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238900 265 SSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELK 299
Cdd:cd15948 243 RHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
31-306 1.58e-44

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 153.04  E-value: 1.58e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900    31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFVFLGG 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLG-IFWFGLREISFEACLTQMFFIHKFSI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900   111 ADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVIRLAC 190
Cdd:pfam13853  80 MESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900   191 GDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYgcTSFIYLSPSSSYSPE 270
Cdd:pfam13853 160 ADIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFY--TPMIGLSMVHRFGHN 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 33238900   271 MGRMVSVV----YTFITPILNPLIYSMRNKELKDALRKAL 306
Cdd:pfam13853 238 VPPLLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
27-298 8.50e-43

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 148.47  E-value: 8.50e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15956   3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLA-ILWFGATAISSYVCLSQMFLVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSlCVEMMVGSLVL-GFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15956  82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLE-VVAKAGLLLALrGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQY--GCTSFIYLSP 263
Cdd:cd15956 161 VKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYipGLLSVLMHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238900 264 SSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15956 241 GHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
27-299 7.45e-42

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 146.46  E-value: 7.45e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15949  19 ISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLA-IFWFSSNEIPLHACLLQMFLIH 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15949  98 SFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVV 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLlqygctSFIYLSPSSS 266
Cdd:cd15949 178 GLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL------AFYVPIAVSS 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238900 267 YSPEMGRMVSV--------VYTFITPILNPLIYSMRNKELK 299
Cdd:cd15949 252 LIHRFGQNVPPpthillanFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
27-298 7.88e-41

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 143.04  E-value: 7.88e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15954   3 ISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMC-IFWFNLKEISFNACLVQMFFVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15954  82 TFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGC---TSFIYLSP 263
Cdd:cd15954 162 KLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPaffTFFAHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238900 264 SSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15954 242 GHHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
27-298 1.46e-39

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 139.90  E-value: 1.46e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15955   3 IGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLA-IFWFQLREISFNACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILI-FHLPFCHNNEIYHFYCDMPAV 185
Cdd:cd15955  82 TLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIkLRLHHFRSTVISHSYCEHMAV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IRLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYGCT--SFIYLSP 263
Cdd:cd15955 162 VKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAffSFFAHRF 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238900 264 SSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKEL 298
Cdd:cd15955 242 GHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-291 1.75e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 115.47  E-value: 1.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900    41 GNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLGGADCVLLAVMA 120
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900   121 YDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHlpfCHNNEIYHFYCDMPAVIRLACGDTHVhrtal 200
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSKPVSYT----- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900   201 YIISFIVLSIPLTLISISYVFIITAILRIRSAEGR-------HRAFSTCSSHIVVVLLQYGCTSFIYLSPSSSYSPEMGR 273
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 33238900   274 ------MVSVVYTFITPILNPLIY 291
Cdd:pfam00001 233 lldkalSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
27-295 1.18e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 86.57  E-value: 1.18e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFFFV 106
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLL-GRWWFGDALCKLLGFLQS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAvi 186
Cdd:cd00637  80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 rlacgdthvHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSH-----------IVVVLLQYGC 255
Cdd:cd00637 158 ---------SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktlLIVVVVFLLC 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33238900 256 -------TSFIYLSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRN 295
Cdd:cd00637 229 wlpyfilLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
26-302 3.73e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 67.97  E-value: 3.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFF 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTL-LGYWPFGPVLCRFWIALD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYcdmpav 185
Cdd:cd14967  80 VLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEF------ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 irlacgdtHVHRTALYIISFIVLSIPLTLISISYVFIITAILRirsaegRHRAFSTCSshIVVVL-----LQYGCTSFIY 260
Cdd:cd14967 154 --------TPNKIYVLVSSVISFFIPLLIMIVLYARIFRVARR------ELKAAKTLA--IIVGAfllcwLPFFIIYLVS 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 33238900 261 LSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd14967 218 AFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
25-223 1.42e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 54.91  E-value: 1.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLS--------MGKT----- 91
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYrpwvfgevLCKAvpylq 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  92 PVSItgcgtqmfffvflgGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLtILIFHLPFCH 171
Cdd:cd14993  81 GVSV--------------SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPL-LVVYELEEII 145
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33238900 172 NNEIYHFYcdmpaviRLACGDTH---VHRTALYIISFIVL-SIPLTLISISYVFII 223
Cdd:cd14993 146 SSEPGTIT-------IYICTEDWpspELRKAYNVALFVVLyVLPLLIISVAYSLIG 194
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
26-302 3.93e-08

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 53.36  E-value: 3.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLT-SLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFF 104
Cdd:cd14969   1 YVLAVYLSLIGVlGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLS-GRWSFGDPGCVIYGFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVeMMVGSLVLGFLLSLPltilifhlPFCHNNEIyhfycdMPA 184
Cdd:cd14969  80 VTFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALI-LIAFIWLYGLFWALP--------PLFGWSSY------VPE 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLACG---DTHVHRTALYIISFIVLS--IPLTLISISYVFII----------TAILRIRSAEGRHRAFSTCSSHIVVV 249
Cdd:cd14969 145 GGGTSCSvdwYSKDPNSLSYIVSLFVFCffLPLAIIIFCYYKIYrtlrkmskraARRKNSAITKRTKKAEKKVAKMVLVM 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 250 LLQ-------YGCTSFIYLSPSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDAL 302
Cdd:cd14969 225 IVAfliawtpYAVVSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-226 1.02e-07

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 52.43  E-value: 1.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  28 FVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFyTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVF 107
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC-VGLINVLTDIIWRITVEWRAGDFACKVIRYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 108 LGGADCVLLAVMAYDRFVAICYPLRYTliMSWSLCVEMMVGSLVLGFLLSLPlTILIFHLPFCHNNEIyHFYCDMPAVIr 187
Cdd:cd15197  83 VTYASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSALFSIP-MLIIFEKTGLSNGEV-QCWILWPEPW- 157
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 33238900 188 lacgDTHVHRTalyIISFIVLSIPLTLISISYVFIITAI 226
Cdd:cd15197 158 ----YWKVYMT---IVAFLVFFIPATIISICYIIIVRTI 189
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
29-159 7.74e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 49.76  E-value: 7.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  29 VTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFL 108
Cdd:cd15005   5 TTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALSCKVIAFLAVLF 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238900 109 GGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLP 159
Cdd:cd15005  85 CFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
25-226 1.22e-06

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 48.90  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFF 104
Cdd:cd15392   1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQYWPFGEFMCPVVNYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLcvemMVGSLVLGFLLSLPLTILIFHLPFCHNNEiyhfYCDMPa 184
Cdd:cd15392  81 QAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQAL----LLIAVIWIFALATALPIAITSRLFEDSNA----SCGQY- 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 33238900 185 virlACGDTHVHRTALYIISFIVL----SIPLTLISISYVFIITAI 226
Cdd:cd15392 152 ----ICTESWPSDTNRYIYSLVLMilqyFVPLAVLVFTYTRIGIVV 193
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
26-237 1.70e-06

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 48.48  E-value: 1.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFF 105
Cdd:cd15134   2 PITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVFGEVFCKLRAFLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTIL-----IFHLPFCHNNEIYHFYC 180
Cdd:cd15134  82 EMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQtrivyLEYPPTSGEALEESAFC 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 33238900 181 DMPavirlacgDTHVHRTALYIISFIVL-SIPLTLISISYVFIITAILRIRSAEGRHR 237
Cdd:cd15134 162 AML--------NEIPPITPVFQLSTFLFfIIPMIAIIVLYVLIGLQLRRSTLLRRGQR 211
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
25-164 6.12e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 46.96  E-value: 6.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFF 104
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILI 164
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLM 140
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
32-307 6.33e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 46.87  E-value: 6.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  32 LVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFFVFLGGA 111
Cdd:cd15307   8 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLV-KGHFPLSSEHCLTWICLDVLFCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 112 DCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILifhLPFCHNNEIYHFYCDMPAVIRLACG 191
Cdd:cd15307  87 SIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLM---YSKDHASVLVNGTCQIPDPVYKLVG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 192 dthvhrtalyiiSFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIV-VVLLQY---GCTSFIYLSPSSSY 267
Cdd:cd15307 164 ------------SIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLgVVFFTFvilWSPFFVLNLLPTVC 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 33238900 268 SPEMGRMVSVVYTFIT------PILNPLIYSMRNKELKDALRKALR 307
Cdd:cd15307 232 AECEERISHWVFDVVTwlgyasSMVNPIFYTIFNKVFRQAFKKVLL 277
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
27-220 6.78e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 46.96  E-value: 6.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVmyLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFFV 106
Cdd:cd15065   4 IFLSLII--VLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDL-LGYWLFGETFCNIWISFDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSwslcVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPAVI 186
Cdd:cd15065  81 MCSTASILNLCAISLDRYIHIKKPLKYERWMT----TRRALVVIASVWILSALISFLPIHLGWHRLSQDEIKGLNHASNP 156
                       170       180       190
                ....*....|....*....|....*....|....
gi 33238900 187 RLACGDThVHRTALYIISFIVLSIPLTLISISYV 220
Cdd:cd15065 157 KPSCALD-LNPTYAVVSSLISFYIPCLVMLLIYS 189
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
31-222 7.22e-06

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 46.66  E-value: 7.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVsitgcGTQMFFFVFLGG 110
Cdd:cd15394   7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVF-----GRFMCYFVFLMQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 111 ADCVLLAVM-----AYDRFVAICYPLRYTliMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFC-HNNEIYHFYCDMPA 184
Cdd:cd15394  82 PVTVYVSVFtltaiAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKgLDFSICEEFWFGQE 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 33238900 185 VIRLAcgdthvhrtalYIISFIVLS--IPLTLISISYVFI 222
Cdd:cd15394 160 KQRLA-----------YACSTLLITyvLPLLAISLSYLRI 188
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
32-307 8.75e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 46.44  E-value: 8.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  32 LVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLGGA 111
Cdd:cd15305   8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 112 DCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFhlpfcHNNEiyhfycdmpaviRLACG 191
Cdd:cd15305  88 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIGL-----QDDE------------KVFVN 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 192 DTHVHRTALYII--SFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAfSTCSSHIVVVLLQYGCTSFIYLSPSSSYSP 269
Cdd:cd15305 151 GTCVLNDENFVLigSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRA-SKVLGIVFFLFLIMWCPFFITNILSVLCKE 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 33238900 270 EMGRM-------VSVVYTFITPILNPLIYSMRNKELKDALRKALR 307
Cdd:cd15305 230 ACDQKlmeellnVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIR 274
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
31-245 1.81e-05

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 45.67  E-value: 1.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLS----MGKTPVSITGC--GTQMFF 104
Cdd:cd15203   7 YGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTknwpFGSILCKLVPSlqGVSIFV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFlggadcvLLAVMAYDRFVAICYPLRYtlIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIY-HFYC--D 181
Cdd:cd15203  87 STL-------TLTAIAIDRYQLIVYPTRP--RMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYcGYFCteS 157
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33238900 182 MPAVIrlacgdthvHRTALYIISFIVLS-IPLTLISISYvFIITAILRIRSAEGRHRAFSTCSSH 245
Cdd:cd15203 158 WPSSS---------SRLIYTISVLVLQFvIPLLIISFCY-FRISLKLRKRVKKKRGKRTLSSRRR 212
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
39-165 2.65e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 45.06  E-value: 2.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  39 LSGNATIAVIV-HINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITgCGTQMFFFVFLGGADCVLLA 117
Cdd:cd15104  14 ITGNLLVIVALlKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVL-CLLRMCFVITSCAASVLSLA 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33238900 118 VMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLL-SLPLTILIF 165
Cdd:cd15104  93 AIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIgFLPLISPQF 141
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
26-159 3.88e-05

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 44.26  E-value: 3.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTsLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFF 105
Cdd:cd15059   3 ISSIVSVVILLI-IVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNEL-MGYWYFGSVWCEIWLALD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLP 159
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLP 134
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
30-247 4.80e-05

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 44.29  E-value: 4.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  30 TFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFyTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLG 109
Cdd:cd14986   6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLV-VAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 110 GADCVLLAVMAYDRFVAICYPLRyTLIMSWSLCVeMMVGSLVLGFLLSLPlTILIFHLPFCHNNEiyhFYCdmpavirLA 189
Cdd:cd14986  85 FASTYILVSMSLDRYQAIVKPMS-SLKPRKRARL-MIVVAWVLSFLFSIP-QLVIFVERELGDGV---HQC-------WS 151
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 190 CGDTHVHRTA-LYIISFIVLSIPLTLISISYVFIITAI-LRIRSAEGRHRAFSTCSSHIV 247
Cdd:cd14986 152 SFYTPWQRKVyITWLATYVFVIPLIILSYCYGRILRTIwIRSRQKTDRPIAPTAMSCRSV 211
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
22-138 5.03e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 44.11  E-value: 5.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  22 GVQMVIFVTFLVMyltslsGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLAlANLLSMGKTPVSITGCGTQ 101
Cdd:cd15325   4 GVILGGFILFGVL------GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFS-AIFEILGYWAFGRVFCNIW 76
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 33238900 102 MFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMS 138
Cdd:cd15325  77 AAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMT 113
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
26-223 8.04e-05

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 43.48  E-value: 8.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFFF 105
Cdd:cd15389   2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVN-STWVFGKIMCHLSRFAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTliMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYC--DMP 183
Cdd:cd15389  81 YCSVYVSTLTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRClpSFP 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 33238900 184 AVIRLacgdthvHRTALYIISFIVLS-IPLTLISISYVFII 223
Cdd:cd15389 159 EPSDL-------FWKYLDLATFILQYvLPLLIIGVAYTRVA 192
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
27-301 8.23e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 43.46  E-value: 8.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTsLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFV 106
Cdd:cd15052   4 ALLLLLLVIAT-IGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVWPLPLVLCLLWVTLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 107 FLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPfchnneiyhfycdMPAVI 186
Cdd:cd15052  83 LFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDT-------------TNVLN 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 187 RLACGDTHVHrtalYII--SFIVLSIPLTLISISYVFIITAILRIRSAEgrhRAFSTCSSHIVVVLLQYGCTSFIYLSPS 264
Cdd:cd15052 150 NGTCVLFNPN----FVIygSIVAFFIPLLIMVVTYALTIRLLSNEQKAS---KVLGIVFAVFVICWCPFFITNILTGLCE 222
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 265 SSYSPEMGRMVSVV--YTFITPILNPLIYSMRNKELKDA 301
Cdd:cd15052 223 ECNCRISPWLLSVFvwLGYVSSTINPIIYTIFNKTFRRA 261
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
32-158 8.36e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 43.38  E-value: 8.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  32 LVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALAnlLSMGKTpVSITGCGTQMFFFVFLGGA 111
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAIT--ISLGFC-TDFHSCLFLACFVLVLTQS 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 33238900 112 DCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSL 158
Cdd:cd15069  85 SIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGL 131
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
26-228 8.54e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 43.48  E-value: 8.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFFF 105
Cdd:cd15083   2 VLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFS-GRWIFGKTGCDMYGFSG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPltilifhlPFCHNNEIyhfycdMPAV 185
Cdd:cd15083  81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP--------PLFGWSRY------VLEG 146
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 33238900 186 IRLACGDTHVHRTA---LYII--SFIVLSIPLTLISISYVFIITAILR 228
Cdd:cd15083 147 LLTSCSFDYLSRDDanrSYVIclLIFGFVLPLLIIIYCYSFIFRAVRR 194
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
27-228 9.61e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 42.99  E-value: 9.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMYLTsLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFytssiapLALANLLsmgktpvsitgcgTQM---F 103
Cdd:cd15196   4 IAVLATILVLA-LFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLL-------VALFNVL-------------PQLiwdI 62
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 104 FFVFLGG----------------ADCVLLAVMAYDRFVAICYPLRYtliMSWSLC-VEMMVG-SLVLGFLLSLPlTILIF 165
Cdd:cd15196  63 TYRFYGGdllcrlvkylqvvgmyASSYVLVATAIDRYIAICHPLSS---HRWTSRrVHLMVAiAWVLSLLLSIP-QLFIF 138
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33238900 166 HLPFchnneiyhfycdmPAVIRLACGDTHVHRTAL--YI--ISFIVLSIPLTLISISYVFIITAILR 228
Cdd:cd15196 139 SYQE-------------VGSGVYDCWATFEPPWGLraYItwFTVAVFVVPLIILAFCYGRICYVVWR 192
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
29-238 9.65e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 43.39  E-value: 9.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  29 VTFLVMYLTSLSGNAtIAVIVHINHSLH---TPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFF 105
Cdd:cd14981   5 APPALMFVFGVLGNL-LALIVLARSSKShkwSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGQPLCDYFGFMM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLpltilifhLPFCHNNEIYHFYCDMPAV 185
Cdd:cd14981  84 SFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAS--------LPLLGLGSYVLQYPGTWCF 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238900 186 IRLAcGDTHVHRTALYIISFIVLSIPLTLISISYVFIITaILRIRSAEGRHRA 238
Cdd:cd14981 156 LDFY-SKNTGDAAYAYLYSILGLLILLVTLLCNLLVIIT-LLRMRRRKKRHRR 206
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
29-302 1.15e-04

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 43.05  E-value: 1.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  29 VTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFyTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFL 108
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLL-AGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 109 GGADCVLLAVmAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLpLTILIFHlpfCHNneiyhfyCDMPAVIRL 188
Cdd:cd14972  82 LASAYSLLAI-AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL-LPVLGWN---CVL-------CDQESCSPL 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 189 ACGDThvhrTALYIISFIVLSIPLTLISISYVFI--------ITAILRIRSAEGRHRAFSTCSSHIVVVLLQ---YGCTS 257
Cdd:cd14972 150 GPGLP----KSYLVLILVFFFIALVIIVFLYVRIfwclwrhaNAIAARQEAAVPAQPSTSRKLAKTVVIVLGvflVCWLP 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 33238900 258 FIYLSPSSSYSPEMGRMVSVVYTFITPIL-----NPLIYSMRNKELKDAL 302
Cdd:cd14972 226 LLILLVLDVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
17-133 3.09e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 41.45  E-value: 3.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  17 FSPDPGVQMVIFVTFLVMYltSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSIT 96
Cdd:cd15321   1 YSVQATAAIAAAITFLILF--TIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANEL-MGYWYFRKT 77
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 33238900  97 GCGTQMFFFVFLGGADCVLLAVMAYDRFVAICYPLRY 133
Cdd:cd15321  78 WCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEY 114
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
25-253 8.03e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 40.33  E-value: 8.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSiAPLALANLLSMGKTPVSITGCGTQMFF 104
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-LPFRIYYYLNGGWWPFGDFLCRLTGLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLImsWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIYHFYCDMPA 184
Cdd:cd14982  80 FYINMYGSILFLTCISVDRYLAVVHPLKSRRL--RRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSE 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33238900 185 VIRlacgdthvhRTALYIISFIVLS--IPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQY 253
Cdd:cd14982 158 WLA---------SAAPIVLIALVVGflIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMILIVLAVF 219
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
38-159 9.43e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 40.32  E-value: 9.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  38 SLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLGGADCVLLA 117
Cdd:cd15217  14 SLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFMAVLFCFHAAFMLF 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33238900 118 VMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLP 159
Cdd:cd15217  94 CISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFP 135
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
26-159 1.12e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 39.95  E-value: 1.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFF 105
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYEL-SGYWPFGEILCDVWISFD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLP 159
Cdd:cd15329  81 VLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIP 134
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
32-302 1.44e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 39.53  E-value: 1.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  32 LVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLGGA 111
Cdd:cd15304   8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 112 DCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHlpfCHNNEIYHFYCDMpavirlacg 191
Cdd:cd15304  88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQ---DDSKVFKEGSCLL--------- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 192 dthVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRAFSTCSSHIVVVLLqygCTSFIYLSPSSSYSPE- 270
Cdd:cd15304 156 ---ADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMW---CPFFITNVMAVICKESc 229
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238900 271 ----MGRMVSVVY--TFITPILNPLIYSMRNKELKDAL 302
Cdd:cd15304 230 nevvIGGLLNVFVwiGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
25-138 1.59e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 39.39  E-value: 1.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLAlANLLSMGKTPVSITGCGTQMFF 104
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFS-ATLEVLGYWAFGRIFCDVWAAV 79
                        90       100       110
                ....*....|....*....|....*....|....
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMS 138
Cdd:cd15062  80 DVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVT 113
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
25-168 1.60e-03

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 39.75  E-value: 1.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFF 104
Cdd:cd15358   1 TPVCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPFLLGAGGCYFKTLL 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33238900 105 FVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTIL--IFHLP 168
Cdd:cd15358  81 FETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLhgIFQLT 146
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
32-304 1.62e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 39.43  E-value: 1.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  32 LVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLGGA 111
Cdd:cd15306   8 LMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 112 DCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLPFCHNNEIyhfycdmPAVIRlacg 191
Cdd:cd15306  88 SIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNI-------TCVLT---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 192 dthVHRTALYII--SFIVLSIPLTLISISYvFIITAILRIRSAEGRHRAFSTCSSHIVVVLLQYgCTSFIYLSPSSS--- 266
Cdd:cd15306 157 ---KERFGDFILfgSLAAFFTPLAIMIVTY-FLTIHALRKQTITNEQRASKVLGIVFFLFLLMW-CPFFITNITSVLcds 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238900 267 ---YSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDALRK 304
Cdd:cd15306 232 cnqTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGR 272
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
32-158 1.63e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 39.36  E-value: 1.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  32 LVMYLTSLSGNAtiAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPV-SITGCGTQMFFFVFLGG 110
Cdd:cd15220   7 VLLDLTALVGNT--AVMVVIAKTPHLRKFAFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVfGEAECRVYIFLSVCLVS 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33238900 111 ADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSL 158
Cdd:cd15220  85 ASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGL 132
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
26-238 2.11e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 39.20  E-value: 2.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLS-------MGKTPVSITGC 98
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGywpfgevMCKIVLSVDAY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  99 GtqMFffvflggADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPltILIFHLPFCHNNEIYHF 178
Cdd:cd14970  82 N--MF-------TSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLP--VIIFARTLQEEGGTISC 150
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 179 YCDMPAVirlacgDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSAEGRHRA 238
Cdd:cd14970 151 NLQWPDP------PDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAR 204
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
54-230 2.13e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 39.15  E-value: 2.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  54 SLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLG---GADCVLLAV-MAYDRFVAICY 129
Cdd:cd14978  29 SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIYPLAntfQTASVWLTVaLTVERYIAVCH 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 130 PLRYTLIMSWSLCVEMMVGSLVLGFLLSLPlTILIFHLPFCHNNEIYHFYCDMPAVIRLACGDTHVHRTALYIISFIVls 209
Cdd:cd14978 109 PLKARTWCTPRRARRVILIIIIFSLLLNLP-RFFEYEVVECENCNNNSYYYVIPTLLRQNETYLLKYYFWLYAIFVVL-- 185
                       170       180
                ....*....|....*....|.
gi 33238900 210 IPLTLISISYVFIITAILRIR 230
Cdd:cd14978 186 LPFILLLILNILLIRALRKSK 206
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-158 2.35e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 38.72  E-value: 2.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  36 LTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLAlANLLSMGKTPVSITGCGTQMFFFVFLGGADCVL 115
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFS-ATLEILGYWVFGRIFCDIWAAVDVLCCTASILS 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 33238900 116 LAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSL 158
Cdd:cd15326  91 LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISI 133
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
31-138 2.48e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 39.01  E-value: 2.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQM------FF 104
Cdd:cd15103   7 FLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsMI 86
                        90       100       110
                ....*....|....*....|....*....|....
gi 33238900 105 FVFLGGADCVLLAVmAYDRFVAICYPLRYTLIMS 138
Cdd:cd15103  87 CSSLLASICSLLAI-AVDRYITIFYALRYHSIMT 119
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
32-133 2.49e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 38.66  E-value: 2.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  32 LVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLGGA 111
Cdd:cd15308   8 VLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTA 87
                        90       100
                ....*....|....*....|..
gi 33238900 112 DCVLLAVMAYDRFVAICYPLRY 133
Cdd:cd15308  88 SIFNLCAISVDRFIAVSVPLNY 109
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
28-133 2.67e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 38.78  E-value: 2.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  28 FVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALanLLSMGKtPVSITGCGTQMFFFVF 107
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAI--LISLGL-PTNFHGCLFMACLVLV 80
                        90       100
                ....*....|....*....|....*.
gi 33238900 108 LGGADCVLLAVMAYDRFVAICYPLRY 133
Cdd:cd14968  81 LTQSSIFSLLAIAIDRYLAIKIPLRY 106
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
31-138 2.84e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 38.76  E-value: 2.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQM------FF 104
Cdd:cd15354   7 FLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdsLI 86
                        90       100       110
                ....*....|....*....|....*....|....
gi 33238900 105 FVFLGGADCVLLAVmAYDRFVAICYPLRYTLIMS 138
Cdd:cd15354  87 CISVVASMCSLLAI-AVDRYVTIFYALRYHNIMT 119
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
31-148 2.94e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 38.62  E-value: 2.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSI-------------APLALANLLSMGKTPVSITG 97
Cdd:cd15351   7 FLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNlietlfmlllehgVLVCRAPMLQHMDNVIDTMI 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238900  98 CGTQMFFFVFLGgadcvllaVMAYDRFVAICYPLRYTLIMSWSLCVEMMVG 148
Cdd:cd15351  87 CSSVVSSLSFLG--------AIAVDRYITIFYALRYHSIMTLQRAVNAIAG 129
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
29-168 3.37e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 38.38  E-value: 3.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  29 VTFLVMYltSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLsMGKTPVSITGCGTQMFFFVFL 108
Cdd:cd15323   7 VGFLIVF--TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANEL-MGYWYFGQVWCNIYLALDVLF 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 109 GGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTILIFHLP 168
Cdd:cd15323  84 CTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDP 143
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
37-131 3.39e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 38.61  E-value: 3.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  37 TSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLlSMGKTPVSITGCGTQMFFFVFLGGADCVLL 116
Cdd:cd15075  13 ASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTN-AVGYFNLGRVGCVLEGFAVAFFGIAALCTV 91
                        90
                ....*....|....*
gi 33238900 117 AVMAYDRFVAICYPL 131
Cdd:cd15075  92 AVIAVDRLFVVCKPL 106
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
30-301 3.68e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 38.56  E-value: 3.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  30 TFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSItGCGTQMFFFVFLG 109
Cdd:cd15000   5 MFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSV-GCKLEGFLEGSLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 110 GADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVemMVGSLVLGFLLSLPLTI---------LIFHLPFCHNNeiyhfyc 180
Cdd:cd15000  84 LASVLALCAVSYDRLTAIVLPSEARLTKRGAKIV--IVITWIVGLLLALPLAIyrsyrerqwKNFLETYCAEN------- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 181 dmpavirlacgdTHVHRTALYIISFIVLSIPLTLISISYVFIITAI----LRIRSAEGRH------RAFSTCSSHIVV-V 249
Cdd:cd15000 155 ------------TQVLPIYWHVIITVLVWLPLGIMLICYSAIFWKLdkyeRRVLRREHPSvvrykkKAAKTLFIVLITfV 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33238900 250 LLQYGCTSFIYLSPSSSYSPEMGRMV----------SVVYTFITPILNPLIYSMRNKELKDA 301
Cdd:cd15000 223 VCRIPFTALIFYRYKLVPNDNTQNSVsgsfhilwfaSKYLMFLNAAVNPLIYGFTNENFRKA 284
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
32-301 3.91e-03

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 38.12  E-value: 3.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  32 LVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFLGGA 111
Cdd:cd15213   8 ILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 112 DCVLLAVMAyDRFVAICY------PLRYTLimswslcveMMVGSLVLGFLLSLPLTIlifhlpfchNNEIYHFYCDMPAV 185
Cdd:cd15213  88 VAILLIISV-DRYLIIVQrqdklnPHRAKI---------LIAVSWVLSFCVSFPPLV---------GWGKYEFPPRAPQC 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 186 IrLACGDTHVHRTALYIISFIVLSIPLTLISISYVFIITAILRIRSaegrhRAFSTCSSHIVVVL---LQYGCTSFIYLS 262
Cdd:cd15213 149 V-LGYTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFKT-----RAFTTILILFIGFSvcwLPYTVYSLLSVF 222
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238900 263 PSSSYSPEMGRMVSVVYTFITPILNPLIYSMRNKELKDA 301
Cdd:cd15213 223 SRYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-244 4.03e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 38.26  E-value: 4.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  29 VTFLVMYLtSLSGNATIAVIVHINHSLHTPMYFFLANLavleifytsSIAPLALANLLSMGKTPVSITG--------CGT 100
Cdd:cd15387   6 VLALILFL-ALTGNICVLLAIHTTRHKHSRMYFFMKHL---------SIADLVVAVFQVLPQLIWDITFrfygpdflCRL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 101 QMFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVemmVGSLVLGFLLSLPlTILIFHLPFChNNEIYHFYC 180
Cdd:cd15387  76 VKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYV---LFSWLLSLVFSIP-QVHIFSLREV-GNGVYDCWA 150
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33238900 181 DMPAVIRLACGDTHVhRTALYIISFIVLSIPLTLISisyvFIITAILRIRSAEGRHRAFSTCSS 244
Cdd:cd15387 151 DFIQPWGPKAYITWI-TLSVYIIPVLILSVCYGLIS----FKIWQNVKLKTRRETKTPLSSAAS 209
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
27-130 6.55e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 37.41  E-value: 6.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  27 IFVTFLVMY-LTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSmGKTPVSITGCGTQMFFF 105
Cdd:cd15073   2 IVAAYLIVAgIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLH-GSWKFGYAGCQWYAFLN 80
                        90       100
                ....*....|....*....|....*
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYP 130
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICRP 105
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
26-223 7.36e-03

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 37.41  E-value: 7.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMgKTPVSITGCGTQMFFF 105
Cdd:cd14992   2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSL-SWEYGHFLCKIVNYLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLP---LTILIFHLPFCHNNEIyhFYCDM 182
Cdd:cd14992  81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPqlyYATTEVLFSVKNQEKI--FCCQI 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 33238900 183 PAVirlacgDTHVHRTALYIISFIVL-SIPLTLISISYVFII 223
Cdd:cd14992 159 PPV------DNKTYEKVYFLLIFVVIfVLPLIVMTLAYARIS 194
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
25-223 8.10e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 37.15  E-value: 8.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  25 MVIFVTFLVMYLTSLSGNatIAVIVHINH--SLHTPMYFFLANLAVLEIfytssiaplaLANLLSMgktPVSI------- 95
Cdd:cd15055   1 VLLYIVLSSISLLTVLGN--LLVIISISHfkQLHTPTNLLLLSLAVADF----------LVGLLVM---PFSMirsietc 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  96 -----TGCGTQMFFFVFLGGADCVLLAVMAYDRFVAICYPLRYTLIMSwslcVEMMVGSLVLGFLLSL--PLTILIFHLP 168
Cdd:cd15055  66 wyfgdTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKIT----IRRVKICICLCWFVSAlySSVLLYDNLN 141
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 33238900 169 FCHNNEIYHFYCDMPAVIrlacgdTHVHRTALYIISFIvlsIPLTLISISY--VFII 223
Cdd:cd15055 142 QPGLIRYNSCYGECVVVV------NFIWGVVDLVLTFI---LPCTVMIVLYmrIFVV 189
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
31-138 8.15e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 37.20  E-value: 8.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSS------IAPLALANLLSMGKTPVSITGCGTQMFF 104
Cdd:cd15353   7 FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSngsetvVITLLNGNDTDAQSFTVNIDNVIDSVIC 86
                        90       100       110
                ....*....|....*....|....*....|....
gi 33238900 105 FVFLGGAdCVLLAVmAYDRFVAICYPLRYTLIMS 138
Cdd:cd15353  87 SSLLASI-CSLLSI-AVDRYFTIFYALQYHNIMT 118
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
31-226 8.34e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 37.17  E-value: 8.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  31 FLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIaPLALANllSMGKTPV-SITGCGTQMFFFVFLG 109
Cdd:cd15079   7 YIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYN--SFYEGWAlGPLGCQIYAFLGSLSG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 110 GADCVLLAVMAYDRFVAICYPLRYTLiMSWSLCVEMMVGSlvlgFLLSLPLTILifhlPFchnNEIYHFYcdMPAVIRLA 189
Cdd:cd15079  84 IGSIWTNAAIAYDRYNVIVKPLNGNP-LTRGKALLLILFI----WLYALPWALL----PL---LFGWGRY--VPEGFLTS 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 33238900 190 CG-----DTHVHRTALYIISFIVLSIPLTLISISYVFIITAI 226
Cdd:cd15079 150 CSfdyltRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAV 191
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
29-301 8.57e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 37.33  E-value: 8.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  29 VTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLALANLLSMGKTPVSITGCGTQMFFFVFL 108
Cdd:cd15053   5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 109 GGADCVLLAVMAYDRFVAICYPLRYTLIMSWSLCVEMMVGSLVLGFLLSLPLTilifhlpFCHNNEIYHfycdMPAVIRL 188
Cdd:cd15053  85 STASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLL-------FGLNNVPYR----DPEECRF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900 189 ACGDTHVHRTalyIISFIvlsIPLTLISISYVFIITAILRIRSAegrhrafsTCSSHIVVVLLQYGCTSFIYL------- 261
Cdd:cd15053 154 YNPDFIIYSS---ISSFY---IPCIVMLLLYYRIFRALRREKKA--------TKTLAIVLGVFLFCWLPFFTLnilnaic 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 33238900 262 SPSSSYSPEMGRMVSVVYTFITPI---LNPLIYSMRNKELKDA 301
Cdd:cd15053 220 PKLQNQSCHVGPALFSLTTWLGYVnsfLNPIIYTIFNIEFRKA 262
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-132 9.42e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 37.06  E-value: 9.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPLAlANLLSMGKTPVSITGCGTQMFFF 105
Cdd:cd14971   2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFT-ATIYPLPGWVFGDFMCKFVHYFQ 80
                        90       100
                ....*....|....*....|....*..
gi 33238900 106 VFLGGADCVLLAVMAYDRFVAICYPLR 132
Cdd:cd14971  81 QVSMHASIFTLVAMSLDRFLAVVYPLR 107
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-133 9.59e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 36.98  E-value: 9.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238900  26 VIFVTFLVMYLTSLSGNATIAVIVHINHSLHTPMYFFLANLAVLEIFYTSSIAPlalANLLS-------MGKtpvsiTGC 98
Cdd:cd15208   2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLP---ATLLVdvtetwfFGQ-----VLC 73
                        90       100       110
                ....*....|....*....|....*....|....*
gi 33238900  99 GTQMFFFVFLGGADCVLLAVMAYDRFVAICYPLRY 133
Cdd:cd15208  74 KIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMF 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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