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Conserved domains on  [gi|23097250|ref|NP_690866|]
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TIP41-like protein isoform 1 [Homo sapiens]

Protein Classification

TIP41 family protein( domain architecture ID 10514483)

TIP41 family protein similar to Saccharomyces cerevisiae type 2A phosphatase activator TIP41 that is involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIP41 pfam04176
TIP41-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 50-218 6.59e-88

TIP41-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.


:

Pssm-ID: 461208  Cd Length: 168  Bit Score: 258.58  E-value: 6.59e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097250    50 FGDNVLRIQH-GSGFGIEFNATDALRCVNN-YQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGeslKL 127
Cdd:pfam04176   1 FGNNSLRLEHkPSGWTIEFNALDALKLVDKtGEEGLKVAYAKEWKKSREKSEGIKEVVKPYDWTYTTDYKGTLNG---GI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097250   128 KVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADK 207
Cdd:pfam04176  78 KVEPTEERIPIEKLKRPDPILFYDEVVLFEDELADNGISMLSVKIRVMPSCFFLLLRFFLRVDNVLFRIRDTRVYHEFGT 157

                         170
                  ....*....|.
gi 23097250   208 TYMLREYTSRE 218
Cdd:pfam04176 158 NYVIREYTGRE 168
 
Name Accession Description Interval E-value
TIP41 pfam04176
TIP41-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 50-218 6.59e-88

TIP41-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.


Pssm-ID: 461208  Cd Length: 168  Bit Score: 258.58  E-value: 6.59e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097250    50 FGDNVLRIQH-GSGFGIEFNATDALRCVNN-YQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGeslKL 127
Cdd:pfam04176   1 FGNNSLRLEHkPSGWTIEFNALDALKLVDKtGEEGLKVAYAKEWKKSREKSEGIKEVVKPYDWTYTTDYKGTLNG---GI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097250   128 KVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADK 207
Cdd:pfam04176  78 KVEPTEERIPIEKLKRPDPILFYDEVVLFEDELADNGISMLSVKIRVMPSCFFLLLRFFLRVDNVLFRIRDTRVYHEFGT 157

                         170
                  ....*....|.
gi 23097250   208 TYMLREYTSRE 218
Cdd:pfam04176 158 NYVIREYTGRE 168
 
Name Accession Description Interval E-value
TIP41 pfam04176
TIP41-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 50-218 6.59e-88

TIP41-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.


Pssm-ID: 461208  Cd Length: 168  Bit Score: 258.58  E-value: 6.59e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097250    50 FGDNVLRIQH-GSGFGIEFNATDALRCVNN-YQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGeslKL 127
Cdd:pfam04176   1 FGNNSLRLEHkPSGWTIEFNALDALKLVDKtGEEGLKVAYAKEWKKSREKSEGIKEVVKPYDWTYTTDYKGTLNG---GI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097250   128 KVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADK 207
Cdd:pfam04176  78 KVEPTEERIPIEKLKRPDPILFYDEVVLFEDELADNGISMLSVKIRVMPSCFFLLLRFFLRVDNVLFRIRDTRVYHEFGT 157

                         170
                  ....*....|.
gi 23097250   208 TYMLREYTSRE 218
Cdd:pfam04176 158 NYVIREYTGRE 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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