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Conserved domains on  [gi|24234708|ref|NP_700475|]
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pituitary homeobox 2 isoform b [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11079034)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; also contains an OAR domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
86-142 2.52e-28

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 2.52e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24234708    86 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRK 142
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 275-292 6.89e-06

OAR motif; The entry represents the OAR motif.


:

Pssm-ID: 461067  Cd Length: 19  Bit Score: 42.01  E-value: 6.89e-06
                          10
                  ....*....|....*...
gi 24234708   275 DTCNSSLASLRLKAKQHS 292
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
86-142 2.52e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 2.52e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24234708    86 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRK 142
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 85-141 1.89e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.16  E-value: 1.89e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24234708     85 QRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWR 141
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 86-144 2.41e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 90.77  E-value: 2.41e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24234708  86 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRE 144
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
40-142 1.48e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.68  E-value: 1.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234708  40 SPESRKEAA-SSKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQRRQRThfTSQQLQELEATFQRNRYPDMSTREEI 118
Cdd:COG5576   7 QPLSALESQrMPQIRTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKL 84

                        90       100
                ....*....|....*....|....
gi 24234708 119 AVWTNLTEARVRVWFKNRRAKWRK 142
Cdd:COG5576  85 SLLLNMPPKSVQIWFQNKRAKEKK 108
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 275-292 6.89e-06

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 42.01  E-value: 6.89e-06
                          10
                  ....*....|....*...
gi 24234708   275 DTCNSSLASLRLKAKQHS 292
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
86-142 2.52e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 2.52e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24234708    86 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRK 142
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 85-141 1.89e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.16  E-value: 1.89e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24234708     85 QRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWR 141
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 86-144 2.41e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 90.77  E-value: 2.41e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24234708  86 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRE 144
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
40-142 1.48e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.68  E-value: 1.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234708  40 SPESRKEAA-SSKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQRRQRThfTSQQLQELEATFQRNRYPDMSTREEI 118
Cdd:COG5576   7 QPLSALESQrMPQIRTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKL 84

                        90       100
                ....*....|....*....|....
gi 24234708 119 AVWTNLTEARVRVWFKNRRAKWRK 142
Cdd:COG5576  85 SLLLNMPPKSVQIWFQNKRAKEKK 108
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 275-292 6.89e-06

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 42.01  E-value: 6.89e-06
                          10
                  ....*....|....*...
gi 24234708   275 DTCNSSLASLRLKAKQHS 292
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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