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Conserved domains on  [gi|24583057|ref|NP_723463|]
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organic anion transporting polypeptide 30B, isoform A [Drosophila melanogaster]

Protein Classification

solute carrier organic anion transporter family member 5A1( domain architecture ID 13024461)

solute carrier organic anion transporter family member 5A1 belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
170-758 0e+00

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 656.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  170 KIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGI 249
Cdd:cd17404    1 KAFLVCMCLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  250 GSLVFMVPHFTgepnpgiaivnktsdnICKSALVrdqdmdlgrlssglsnqplaphtlrednclegkasttgpvllfvla 329
Cdd:cd17404   81 GSFLFSLPHFF----------------ILAQILI---------------------------------------------- 98
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  330 qlllGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSsTTISITPGDRRWVGMWW 409
Cdd:cd17404   99 ----GMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLS-TPPDISPGDPRWIGAWW 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  410 GGFLLCGVILLVVAVPFFSFPKvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappkvdt 489
Cdd:cd17404  174 GGFLLCGIALLLVAFPFFTFPK---------------------------------------------------------- 195
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  490 gygkdikdipqsmlrlvknPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCI 569
Cdd:cd17404  196 -------------------MTFLVVSLGYCMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYI 256
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  570 LKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEqpfqVNLTAACNFGCECLTSEVE 649
Cdd:cd17404  257 LKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGITIPYTTGPSLSSTHG----RNLTSECNVNCGCSINEYE 332
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  650 PVCGNNGLTYFSPCHAGCTAFS--STSNTNYTNCACVRANISSSIYRGAGGSQAQalsanenfaevtvvpvatAGPCATP 727
Cdd:cd17404  333 PVCGSDGITYFSPCLAGCTSVGntSTGIRNYTNCACLQSRSSISPPTVGQGSQLQ------------------AGPCSRT 394
                        570       580       590
                 ....*....|....*....|....*....|.
gi 24583057  728 CRTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17404  395 CNTLIPFLILLFIVTLITACAQMPALMITLR 425
UhpC super family cl34453
Sugar phosphate permease [Carbohydrate transport and metabolism];
730-795 5.77e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG2271:

Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 5.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24583057  730 TIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIpAPILFGNLIDST 795
Cdd:COG2271  270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL-GPLLVGYLLDAT 334
 
Name Accession Description Interval E-value
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
170-758 0e+00

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 656.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  170 KIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGI 249
Cdd:cd17404    1 KAFLVCMCLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  250 GSLVFMVPHFTgepnpgiaivnktsdnICKSALVrdqdmdlgrlssglsnqplaphtlrednclegkasttgpvllfvla 329
Cdd:cd17404   81 GSFLFSLPHFF----------------ILAQILI---------------------------------------------- 98
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  330 qlllGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSsTTISITPGDRRWVGMWW 409
Cdd:cd17404   99 ----GMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLS-TPPDISPGDPRWIGAWW 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  410 GGFLLCGVILLVVAVPFFSFPKvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappkvdt 489
Cdd:cd17404  174 GGFLLCGIALLLVAFPFFTFPK---------------------------------------------------------- 195
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  490 gygkdikdipqsmlrlvknPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCI 569
Cdd:cd17404  196 -------------------MTFLVVSLGYCMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYI 256
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  570 LKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEqpfqVNLTAACNFGCECLTSEVE 649
Cdd:cd17404  257 LKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGITIPYTTGPSLSSTHG----RNLTSECNVNCGCSINEYE 332
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  650 PVCGNNGLTYFSPCHAGCTAFS--STSNTNYTNCACVRANISSSIYRGAGGSQAQalsanenfaevtvvpvatAGPCATP 727
Cdd:cd17404  333 PVCGSDGITYFSPCLAGCTSVGntSTGIRNYTNCACLQSRSSISPPTVGQGSQLQ------------------AGPCSRT 394
                        570       580       590
                 ....*....|....*....|....*....|.
gi 24583057  728 CRTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17404  395 CNTLIPFLILLFIVTLITACAQMPALMITLR 425
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
171-818 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 643.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    171 IFVVLLSLLVMMQqALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIG 250
Cdd:pfam03137    1 FFLVFLSLLGLAQ-ALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    251 SLVFMVPHFTgepnpgiaivnktsdnicksalvrdqdmdlgrlsSGLSNQplaphTLRednclegkasttgpvllfvlaq 330
Cdd:pfam03137   80 SLLFALPHFL----------------------------------SFFLGQ-----LLL---------------------- 98
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    331 lllGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDsLSSTTISITPGDRRWVGMWWG 410
Cdd:pfam03137   99 ---GIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVD-IGKVSITLTPKDPRWVGAWWL 174
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    411 GFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPvlpnnsratvatdemgkvkkleivavtSKEDQSQAPPKVDTG 490
Cdd:pfam03137  175 GFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKEPH---------------------------SQDIADLKKTKSLKK 227
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    491 YGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCIL 570
Cdd:pfam03137  228 LGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLII 307
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    571 KRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSnkhgstleQPFQVNLTAACNFGCECLTSEVEP 650
Cdd:pfam03137  308 KKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGT--------QQLSGNLTSSCNSDCSCSTSAYSP 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    651 VCGNNGlTYFSPCHAGCTAFSSTS---NTNYTNCACvranISSSIYRGAGGSqaqalsanenfaevtvvpvATAGPCATP 727
Cdd:pfam03137  380 VCGSDG-GYTSPCPCGAGCSSSSGagkSTYICNCCC----SCGSQDSGGNGS-------------------ATPGKCPSD 435
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    728 C-RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWKSSCGEK 806
Cdd:pfam03137  436 CsNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALIDSTCLLWGKTCGGR 515
                          650
                   ....*....|..
gi 24583057    807 gGRCLIYDIEKF 818
Cdd:pfam03137  516 -GNCWLYDNDKL 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
166-845 4.19e-164

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 501.57  E-value: 4.19e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    166 FARIKIFVVLLSLLvMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAV 245
Cdd:TIGR00805   28 FSKIKMFSLLLTCA-RLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCA 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    246 IMGIGSLVFMVPHFTGEPnpgiaiVNKTSDNICKSALVRDQDMdlgrLSSGLSNQPLAPHTLREDNCLEGKASttgPVLL 325
Cdd:TIGR00805  107 IMGLGSLLSSLPHFLMGR------YSYSTTVSSTGNLSSANSF----LCMENLTQTLRPTQDPSECQKQHKSL---MWLL 173
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    326 FVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTT--ISITPGDRR 403
Cdd:TIGR00805  174 FLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTedLIITPTDPR 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    404 WVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKkirkssvvqpvlpnnsRATVATDEMGKVKKLEIVAVTSKEDqsqa 483
Cdd:TIGR00805  254 WIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGK----------------RVNVDVHEAEKLEKSRGEDRKKNSG---- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    484 ppkvdtgygkDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGI 563
Cdd:TIGR00805  314 ----------ITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGY 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    564 FLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPyytsnkhgsTLEQPFQVNLTAACNFGCEC 643
Cdd:TIGR00805  384 LIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNNP---------SNDQPLYVENRTDCNRQCSC 454
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    644 LTSEVEPVCGNNGLTYFSPCHAGCTAFSST-SNTNYTNCACVRANISSSiyrgaggsqaqalsanenfaevtvvpvATAG 722
Cdd:TIGR00805  455 DSSIWDPVCGDNGLAYLSPCHAGCRMSVGTgSNMVFTNCSCIQTPGNSS---------------------------AKKG 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    723 PCATPCRT-IYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWKS 801
Cdd:TIGR00805  508 LCDPPCATsLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQT 587
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 24583057    802 SCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVR 845
Cdd:TIGR00805  588 LKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILAR 631
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
164-602 7.70e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.48  E-value: 7.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  164 QRFARIKIFVVLLSLLVMMqqaLSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLG---SRRHIpvwI 240
Cdd:COG2814    5 PRRRWLALLALALGAFLSG---LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAdrfGRRRV---L 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  241 GIGAVIMGIGSLVF-MVPHFTgepnpgiaivnktsdnicksALVrdqdmdLGRLSSGLsnqplaphtlrednclegkast 319
Cdd:COG2814   79 LLGLLLFALGSLLCaLAPSLW--------------------LLL------AARFLQGL---------------------- 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  320 tgpvllfvlaqlllgcGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSfhmdslssttisitp 399
Cdd:COG2814  111 ----------------GAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD--------------- 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  400 gdrrWVGmWWGGFLLCGVILLVVAVP-FFSFPKVLAREKKKIRkssvvqpvlpnnsratvatdemgkvkkleivavtske 478
Cdd:COG2814  160 ----LFG-WRWVFLVNAVLALLALLLlLRLLPESRPAARARLR------------------------------------- 197
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  479 dqsqappkvdtgygkdikdipQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVpG 558
Cdd:COG2814  198 ---------------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL-G 255
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 24583057  559 ACIGIFLGGCILKRFqlkpkGAVQFVLITNVICLACYAMLFFLG 602
Cdd:COG2814  256 GVLGALLAGRLADRF-----GRRRLLLIGLLLLALGLLLLALAG 294
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
730-795 5.77e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 5.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24583057  730 TIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIpAPILFGNLIDST 795
Cdd:COG2271  270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL-GPLLVGYLLDAT 334
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
637-672 3.98e-03

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 36.50  E-value: 3.98e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 24583057     637 CNFGCeclTSEVEPVCGNNGLTYFSPCHAGCTAFSS 672
Cdd:smart00280    2 CPEAC---PREYDPVCGSDGVTYSNECHLCKAACES 34
 
Name Accession Description Interval E-value
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
170-758 0e+00

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 656.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  170 KIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGI 249
Cdd:cd17404    1 KAFLVCMCLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  250 GSLVFMVPHFTgepnpgiaivnktsdnICKSALVrdqdmdlgrlssglsnqplaphtlrednclegkasttgpvllfvla 329
Cdd:cd17404   81 GSFLFSLPHFF----------------ILAQILI---------------------------------------------- 98
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  330 qlllGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSsTTISITPGDRRWVGMWW 409
Cdd:cd17404   99 ----GMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLS-TPPDISPGDPRWIGAWW 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  410 GGFLLCGVILLVVAVPFFSFPKvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappkvdt 489
Cdd:cd17404  174 GGFLLCGIALLLVAFPFFTFPK---------------------------------------------------------- 195
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  490 gygkdikdipqsmlrlvknPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCI 569
Cdd:cd17404  196 -------------------MTFLVVSLGYCMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYI 256
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  570 LKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEqpfqVNLTAACNFGCECLTSEVE 649
Cdd:cd17404  257 LKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGITIPYTTGPSLSSTHG----RNLTSECNVNCGCSINEYE 332
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  650 PVCGNNGLTYFSPCHAGCTAFS--STSNTNYTNCACVRANISSSIYRGAGGSQAQalsanenfaevtvvpvatAGPCATP 727
Cdd:cd17404  333 PVCGSDGITYFSPCLAGCTSVGntSTGIRNYTNCACLQSRSSISPPTVGQGSQLQ------------------AGPCSRT 394
                        570       580       590
                 ....*....|....*....|....*....|.
gi 24583057  728 CRTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17404  395 CNTLIPFLILLFIVTLITACAQMPALMITLR 425
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
171-818 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 643.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    171 IFVVLLSLLVMMQqALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIG 250
Cdd:pfam03137    1 FFLVFLSLLGLAQ-ALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    251 SLVFMVPHFTgepnpgiaivnktsdnicksalvrdqdmdlgrlsSGLSNQplaphTLRednclegkasttgpvllfvlaq 330
Cdd:pfam03137   80 SLLFALPHFL----------------------------------SFFLGQ-----LLL---------------------- 98
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    331 lllGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDsLSSTTISITPGDRRWVGMWWG 410
Cdd:pfam03137   99 ---GIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVD-IGKVSITLTPKDPRWVGAWWL 174
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    411 GFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPvlpnnsratvatdemgkvkkleivavtSKEDQSQAPPKVDTG 490
Cdd:pfam03137  175 GFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKEPH---------------------------SQDIADLKKTKSLKK 227
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    491 YGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCIL 570
Cdd:pfam03137  228 LGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLII 307
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    571 KRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSnkhgstleQPFQVNLTAACNFGCECLTSEVEP 650
Cdd:pfam03137  308 KKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGT--------QQLSGNLTSSCNSDCSCSTSAYSP 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    651 VCGNNGlTYFSPCHAGCTAFSSTS---NTNYTNCACvranISSSIYRGAGGSqaqalsanenfaevtvvpvATAGPCATP 727
Cdd:pfam03137  380 VCGSDG-GYTSPCPCGAGCSSSSGagkSTYICNCCC----SCGSQDSGGNGS-------------------ATPGKCPSD 435
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    728 C-RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWKSSCGEK 806
Cdd:pfam03137  436 CsNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALIDSTCLLWGKTCGGR 515
                          650
                   ....*....|..
gi 24583057    807 gGRCLIYDIEKF 818
Cdd:pfam03137  516 -GNCWLYDNDKL 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
166-845 4.19e-164

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 501.57  E-value: 4.19e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    166 FARIKIFVVLLSLLvMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAV 245
Cdd:TIGR00805   28 FSKIKMFSLLLTCA-RLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCA 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    246 IMGIGSLVFMVPHFTGEPnpgiaiVNKTSDNICKSALVRDQDMdlgrLSSGLSNQPLAPHTLREDNCLEGKASttgPVLL 325
Cdd:TIGR00805  107 IMGLGSLLSSLPHFLMGR------YSYSTTVSSTGNLSSANSF----LCMENLTQTLRPTQDPSECQKQHKSL---MWLL 173
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    326 FVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTT--ISITPGDRR 403
Cdd:TIGR00805  174 FLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTedLIITPTDPR 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    404 WVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKkirkssvvqpvlpnnsRATVATDEMGKVKKLEIVAVTSKEDqsqa 483
Cdd:TIGR00805  254 WIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGK----------------RVNVDVHEAEKLEKSRGEDRKKNSG---- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    484 ppkvdtgygkDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGI 563
Cdd:TIGR00805  314 ----------ITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGY 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    564 FLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPyytsnkhgsTLEQPFQVNLTAACNFGCEC 643
Cdd:TIGR00805  384 LIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNNP---------SNDQPLYVENRTDCNRQCSC 454
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    644 LTSEVEPVCGNNGLTYFSPCHAGCTAFSST-SNTNYTNCACVRANISSSiyrgaggsqaqalsanenfaevtvvpvATAG 722
Cdd:TIGR00805  455 DSSIWDPVCGDNGLAYLSPCHAGCRMSVGTgSNMVFTNCSCIQTPGNSS---------------------------AKKG 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    723 PCATPCRT-IYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWKS 801
Cdd:TIGR00805  508 LCDPPCATsLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQT 587
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 24583057    802 SCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVR 845
Cdd:TIGR00805  588 LKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILAR 631
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
169-758 8.40e-147

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 448.23  E-value: 8.40e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLLVMMQQAlSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17336    1 PKVFVVLLCLLGLLQGA-VVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFtgepnpgiaivnktsdnICKSALVrdqdmdlgrlssglsnqplaphtlrednclegkasttgpvllfvl 328
Cdd:cd17336   80 LGCFLLALPHF-----------------LFVGQFL--------------------------------------------- 97
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  329 aqllLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDsLSSTTISITPGDRRWVGMW 408
Cdd:cd17336   98 ----LGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVD-FSRVPLGITPDDPRWIGAW 172
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  409 WGGFLLCGVILLVVAVPFFSFPkvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappkvd 488
Cdd:cd17336  173 WLGFLILGILLLIVSIPLFFFP---------------------------------------------------------- 194
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  489 tgygkdikdipqsmlrlvknPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGC 568
Cdd:cd17336  195 --------------------PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGL 254
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  569 ILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNkhgstleqpfqVNLTAACNFGCECLTSEV 648
Cdd:cd17336  255 IIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAGVTTPYGSSS-----------SPITSSCNSDCNCSDSSF 323
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  649 EPVCGNNGLTYFSPCHAGCT-AFSSTSNTNYTNCACVranisssiyrgaggsqaqalsaNENFAEVTVVPvATAGPCATP 727
Cdd:cd17336  324 SPVCGSDGITYFSPCHAGCTsSDAGNGTKTYSNCSCI----------------------NSGTATSSGCP-PDCSVAPNC 380
                        570       580       590
                 ....*....|....*....|....*....|.
gi 24583057  728 CRTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17336  381 CSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
169-758 4.67e-125

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 391.23  E-value: 4.67e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17403    1 PKGFLFFLCIFAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFTgepnpgiaivnktsdnicksalvrdqdmdlgrlssglsnQPLAPHTLrednclegkasttgpvllfvl 328
Cdd:cd17403   81 IGSLVFALPHFT---------------------------------------VFILAQLL--------------------- 100
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  329 aqllLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTT-ISITPGDRRWVGM 407
Cdd:cd17403  101 ----HGAGATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQVDSeLGLTPDDPRWVGA 176
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  408 WWGGFLLCGVILLVVAVPFFSFPkvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappkv 487
Cdd:cd17403  177 WWLGFLISGALALIIAFPLLGFP--------------------------------------------------------- 199
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  488 dtgygkdikdipqsmlrlvknPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGG 567
Cdd:cd17403  200 ---------------------PTFMFLNLAGASEGMLLAGFATFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGG 258
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  568 CILKRFQLKPKGAVQFVLITNVICLACyAMLFFLGCDNLKMAGTTIPYYTSNKHGSTleqpfqvNLTAACNFGCECLTSE 647
Cdd:cd17403  259 LIVKKLKLKCKGILKFCIVCSIVAFLF-SFILLIYCPNAPFAGVTVPYGNSPLEGTS-------NLTSTCNADCHCSEDF 330
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  648 VEPVCGNNGLTYFSPCHAGCT-AFSSTSNTNYTNCACVRANISSSIYRGAGGsqaqalsanenfaevtvvpvatAGPCAT 726
Cdd:cd17403  331 YDPVCGSDGVTYYSPCHAGCTtSHGDDGQKVYSNCSCIQSNSSKTSTAATGK----------------------ACPCET 388
                        570       580       590
                 ....*....|....*....|....*....|..
gi 24583057  727 PCRTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17403  389 CCQKLYLFLAVFFLLIVFTFMSSTPALSATLR 420
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
169-758 3.43e-101

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 329.42  E-value: 3.43e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLLvMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17460    1 IKFFVLCHGLL-QLSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFTGEPnpgiaivnktsdnicksalVRDQDMDLGRLssglsnqplaphtlrednclegkasttgpvllfvl 328
Cdd:cd17460   80 LAGFLMALPHFISEP-------------------YEYGILFLGQL----------------------------------- 105
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  329 aqlLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWVG 406
Cdd:cd17460  106 ---LLGIGGVPIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDidKMSEDEISLEIGDPRWVG 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  407 MWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSvvqpvlpnnsratvatdemgkvKKLEIVAVTSKEDQSQAPPK 486
Cdd:cd17460  183 AWWLGFLIAATLVALSAVPYFFFPREMPKEVVELQPRE----------------------KKLAKTMLKKLKSLSDILQN 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  487 VDTGygKDIKDIPQSMLRLVKNPVYIVTCLG-ACMELMiVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFL 565
Cdd:cd17460  241 LSLL--QFIKKFPRILLRTLRNPIYLLVVLAqVNLSAM-VAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVV 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  566 GGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHgstleqpfqvNLTAACNFGCECLT 645
Cdd:cd17460  318 GGVILKRLQLTVRGCGAMCVLGMLLCLFFALPLLFIGCSTQKIAGITHRTSSSPGL----------ELSSQCSEACSCPP 387
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  646 SEVEPVCGNNGLTYFSPCHAGCTAFSST----SNTNYTNCACVranisssiyrGAGGSqaqalsanenfaevtvVPVATA 721
Cdd:cd17460  388 EAFNPVCGSDGVEYISPCHAGCKSVNVQaldnSVVNYTDCSCV----------SEGGP----------------VGAASP 441
                        570       580       590
                 ....*....|....*....|....*....|....*...
gi 24583057  722 GPCATPC-RTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17460  442 GTCGSGCsHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
169-758 1.55e-100

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 326.50  E-value: 1.55e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLLvMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17402    1 IKIFLVSECAL-MLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFtgepnpgiaIVNKTSDNICKSALVRDQDMdlgrlssglsnqplaphtlrednclegkasttgpvllfvl 328
Cdd:cd17402   80 LGALLSALPEF---------LTHQYKTNMMYLLLIGAQVL---------------------------------------- 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  329 aqllLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSL--SSTTISITPGDRRWVG 406
Cdd:cd17402  111 ----LGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVfiDTSKLDITPDDPRWIG 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  407 MWWGGFLLCGVILLVVAVPFFSFPKVLarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappk 486
Cdd:cd17402  187 AWWGGFLLCGALLFFSALLMFGFPQSL----------------------------------------------------- 213
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  487 vdtgygKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLG 566
Cdd:cd17402  214 ------QQLRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLG 287
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  567 GCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEqPFqvnltAACNFGCECLTS 646
Cdd:cd17402  288 GLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNDTAPGSSLD-PY-----APCNSNCECQTD 361
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  647 EVEPVCGNNGLTYFSPCHAGCTAfsstsnTNYTNCACVranisssiyrgaggsqaqALSANENfaeVTVVPvataGPCAT 726
Cdd:cd17402  362 SFSPVCGADGITYLSACFAGCSS------TNLSGCACL------------------SSVPAEN---ATVVP----GKCPS 410
                        570       580       590
                 ....*....|....*....|....*....|....
gi 24583057  727 P-CRTIY-PFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17402  411 PgCQEAFlTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
182-758 9.52e-99

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 321.01  E-value: 9.52e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  182 MQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTG 261
Cdd:cd17462   14 LQGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHFTV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  262 epnpgiaivnktsdnicksalvrdqdMDLGRLSSGLsnqplaphtlrednclegkasttgpvllfvlaqlllgcGGSPLF 341
Cdd:cd17462   94 --------------------------FMLGQFLHGI--------------------------------------GATPLY 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  342 TLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSlsSTTISITPGDRRWVGMWWGGFLLCGVILLV 421
Cdd:cd17462  110 TLGVTYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEI--GRQTELTPENPLWVGAWWIGFLGAGAAALL 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  422 VAVPFFSFPKvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsQAPPkvdtgygkdikdipqs 501
Cdd:cd17462  188 IALPILGYPR--------------------------------------------------QLPG---------------- 201
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  502 mlrLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAV 581
Cdd:cd17462  202 ---LLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGII 278
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  582 QFVLITNVICLACyAMLFFLGCDNLKMAGTTIPYYTSNKHGStleqpfQVNLTAACNFGCECLTSEVEPVCGNNGLTYFS 661
Cdd:cd17462  279 KFCLICTVVSLLA-IFIFSLHCPNVPMAGVTASYRGSVLPEG------SLNLTALCNADCRCLEEIYSPVCGADGLMYYS 351
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  662 PCHAGCTAFSSTSNTN---YTNCACVRANISSSiyrgaggsqaqalsanenFAEvtvvpvATAGPCATPCRTIYPFLILL 738
Cdd:cd17462  352 PCHAGCSEAYSDIRNGqkvYQDCSCVAGNLSVG------------------FGE------ASAGKCTSNCNHMPLLLAFV 407
                        570       580
                 ....*....|....*....|
gi 24583057  739 FFMTFLVASTQMPLLMIVLR 758
Cdd:cd17462  408 FLVILFTFLCSIPALTATLR 427
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
170-758 9.45e-96

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 312.83  E-value: 9.45e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  170 KIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGI 249
Cdd:cd17463    2 KGYLLFYSLLAVVQGIVVNGLVNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  250 GSLVFMVPHFTgepnpgIAIvnktsdnicksalvrdqdmdLGRLssglsnqplaphtlrednclegkasttgpvllfvla 329
Cdd:cd17463   82 GSLVFSLPHFF------VFI--------------------LGQL------------------------------------ 99
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  330 qlLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTTISITPGDRRWVGMWW 409
Cdd:cd17463  100 --LLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDLTEEDPRWLGAWW 177
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  410 GGFLLCGVILLVVAVPFFSFPKVLarekkkirkssvvqpvlPNnsratvatdemgkvkkleivavtskedqsqappkvdt 489
Cdd:cd17463  178 IGFLMCWLIAWCLIAPFSCFPKHL-----------------PG------------------------------------- 203
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  490 gygkdikdipqsmlrLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCI 569
Cdd:cd17463  204 ---------------LLKNPVFMCLTISSCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGII 268
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  570 LKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGstleqpfqvNLTAACNFGCECLTSEVE 649
Cdd:cd17463  269 VSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCGNDPFAGVSETYNGTGKIG---------NLTAPCNANCSCLSSFYY 339
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  650 PVCGNNGLTYFSPCHAGCTAFS-STSNTNYTNCACVranisssiyrgagGSQAQALSANENFAEvtvvpvaTAGPCATPC 728
Cdd:cd17463  340 PVCGADGVQYFSPCFAGCTNENlHDKKKVYYNCSCI-------------GNFTEEFSANTTKCE-------EGKKCETTC 399
                        570       580       590
                 ....*....|....*....|....*....|
gi 24583057  729 RTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17463  400 KNLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
169-759 1.26e-94

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 312.09  E-value: 1.26e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLlVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17459    1 LKIFLAALSF-AYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFTgepnpgiaivnktsdnicksalvrdqdmdLGRLSSGLSNQPLAPHTLREDNCLEgKASTTGPVLLFVL 328
Cdd:cd17459   80 IGTFLIALPHFF-----------------------------MGRYKYETAIQSSSNSTVSISPCSL-EPSPQLHSIESSD 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  329 AQLLLGC---------------------GGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHM 387
Cdd:cd17459  130 SKTGTGCekepgssmwiyvflgnllrgiGETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYV 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  388 DS--LSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLArekkkirkssvvqpvlpnnsratvatdemgk 465
Cdd:cd17459  210 DIgfVNLDSITITPKDARWVGAWWLGYLIAGVITLLSAVPFWFLPKSLP------------------------------- 258
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  466 vkkleivavtskedqsqappkvdtgygkdiKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKS 545
Cdd:cd17459  259 ------------------------------KDFLPSLKNLLGNPVYFLYLCTSILQFNSLIGMVTYKPKYIEQQYGQSAS 308
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  546 QANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYytsnkHGSTL 625
Cdd:cd17459  309 KANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENSDVAGLTVSY-----NGTKQ 383
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  626 EQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTA-FSSTSNTNYTNCACVraNISSSiyrGAGGSQaqal 704
Cdd:cd17459  384 VSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKAsNGSGKNTVFHNCSCI--GIPSS---ASGSSS---- 454
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 24583057  705 sanenfaevtvvpvATAGPC--ATPCRTIYP-FLILLFFMTFLVASTQMPLLMIVLRS 759
Cdd:cd17459  455 --------------AILGQCpkGNACARMFLyFLAISVISSFTLSLGGTPGYILLIRC 498
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
169-758 4.18e-92

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 304.42  E-value: 4.18e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLLvMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17461    2 IKVFVLCHGLL-QLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFTGEPNP----GIAIVnktsdnicksalvrdqdmdlGRLSSGLSNQPLAPhtlrednclegkasttgpvl 324
Cdd:cd17461   81 LGAFLLTLPHFLSEPYQysmwVLMVV--------------------AQLLAGIGTVPIQP-------------------- 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  325 lfvlaqlllgcggsplftLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDR 402
Cdd:cd17461  121 ------------------FGISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDigRVNTATVELTPADP 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  403 RWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKirkssvvqpvlpnnSRATVATDEMGKVKKLEIVAVTSkedqsq 482
Cdd:cd17461  183 RWIGAWWLGLLISSGLLVLTSLPYFFFPREMLVGKKP--------------SPEGDMLRKKEDEKKEEGSLLDF------ 242
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  483 appkvdtgygkdIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIG 562
Cdd:cd17461  243 ------------IKRFPKMFVKLLLNPLFMLLVLAQCTFSSVIAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALG 310
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  563 IFLGGCILKRF----QLKPKGAVQFVLITNVICLAcyamLFFLGCDNLKMAGTTIPYYTSNKHgstleqpfqvnLTAACN 638
Cdd:cd17461  311 MLLGGIIMKRFgfslRAIPRFSVVILSISIMLCVP----LFFMGCSTQDVAGVYPKTSNSSDG-----------PHLSCS 375
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  639 FGCECLTSEVEPVCGNNGLTYFSPCHAGCTAFSSTSNTN----YTNCACVranisssiyrgaggsqaQALSANENfaevt 714
Cdd:cd17461  376 ANCSCPESAFNPVCGENGIEYISPCHAGCTNSNMDSSTYrqqiYSNCSCI-----------------PDLSGEKP----- 433
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 24583057  715 vvpvATAGPCATPC-RTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17461  434 ----AKTGSCPNSCsHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
168-759 8.67e-91

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 302.54  E-value: 8.67e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  168 RIKIFVVLLSLlVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIM 247
Cdd:cd17458    1 KLKIFLLALSY-AYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  248 GIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVrdqdmdlgrlssgLSNQPLApHTLREDN--CLEGKASTTGpvLL 325
Cdd:cd17458   80 SLGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLC-------------LANQSLS-HNVTQLPseCEKESMSLMW--IF 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  326 FVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRR 403
Cdd:cd17458  144 VLVGNLLRGIGETPVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDlgSVNADDLTITPTDIR 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  404 WVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKkkirkssvvqpvLPNNSRATvatdemgkvkklEIVAVTSKEDQSQA 483
Cdd:cd17458  224 WVGAWWLGFLICAGVNFLAGLPFWFLPKSLPKEG------------EENETEPS------------KTLTVELEENKGQE 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  484 PPKVDTGYGKDIKDIPQSMLRlvkNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGI 563
Cdd:cd17458  280 TKQEMYEIAKDFLPFLKSLFR---NPIYMLFIIVTVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGY 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  564 FLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPyYTSNKHGSTLEQpfqvNLTAACNFGCEC 643
Cdd:cd17458  357 FFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAGLTVS-YEGIDQDSYYEN----TLLADCNRDCDC 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  644 LTSEVEPVCGNNGLTYFSPCHAGCTAFSSTS-NTNYTNCACVRANISSSiyrgaggsqaQALSAnenfaevtvVPVATAG 722
Cdd:cd17458  432 PLKVWDPVCGNNGLTYVSACLAGCKASVGTGkNMVFQNCSCVAASGFPS----------QNSSA---------VGQCDKG 492
                        570       580       590
                 ....*....|....*....|....*....|....*..
gi 24583057  723 PcaTPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRS 759
Cdd:cd17458  493 E--TCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
169-758 1.73e-84

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 282.12  E-value: 1.73e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLLvMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17401    1 IKVFVLCHGLL-QLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFTGEP-NPGIAIVNKTsdnicksalvrdqdmdlgrlssglsnqplaphtlrednclegkasttgpvllfv 327
Cdd:cd17401   80 AGAFLLTLPHFISEPyQYGIMVVAQL------------------------------------------------------ 105
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  328 laqlLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWV 405
Cdd:cd17401  106 ----LLGIGGVPIQPFGISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDigRMNTAAVNLVPGDPRWI 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  406 GMWWGGFLLCGVILLVVAVPFFSFPKVlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqapp 485
Cdd:cd17401  182 GAWWLGFLIAAALLVLTSFPYFFFPRF----------------------------------------------------- 208
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  486 kvdtgygkdIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFL 565
Cdd:cd17401  209 ---------IKRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILF 279
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  566 GGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHgstleqpfqvNLTAACNFGCECLT 645
Cdd:cd17401  280 GGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGVYPPSSSSSIH----------PQSPACRRDCSCPD 349
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  646 SEVEPVCGNNGLTYFSPCHAGCTAFS-----STSNTNYTNCACVRanisssiyrgaGGSqaqalsanenfaevtvvPVAT 720
Cdd:cd17401  350 SIFNPVCGDNGVEYLSPCHAGCSNINmstsaTSKQVIYTNCSCVT-----------GGS-----------------ASAK 401
                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 24583057  721 AGPCATPC-RTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17401  402 TGSCPSPCsHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
169-691 2.35e-78

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 265.55  E-value: 2.35e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLlVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17457    1 LKMFLAALSF-SYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFTGepnpgiaivnktsdNICKSALVRDQdmdlgrlSSGLSNQPLAPHTLRednclegkasttgpvllfvl 328
Cdd:cd17457   80 LGSVLTALPHFFM--------------GYYKYGCLKES-------GSYMWVYVLMGNMLR-------------------- 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  329 aqlllGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDS--LSSTTISITPGDRRWVG 406
Cdd:cd17457  119 -----GIGETPIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIgfVDLSTIRITPQDSRWVG 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  407 MWWGGFLLCGVILLVVAVPFFSFPkvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappk 486
Cdd:cd17457  194 AWWLGFLVSGLFSIISAIPFFFLP-------------------------------------------------------- 217
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  487 vdtgygkdikDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLG 566
Cdd:cd17457  218 ----------GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLG 287
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  567 GCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFqvnltAACNFGCECLTS 646
Cdd:cd17457  288 GYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSVAGITMTYDGNNPVTSHRDVIL-----SYCNSDCNCDES 362
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 24583057  647 EVEPVCGNNGLTYFSPCHAGCTAFS-STSNTNYTNCACVRANISSS 691
Cdd:cd17457  363 QWDPVCGNNGITYISACLAGCKSSSgNGKPIVFHNCSCLEVTGSQN 408
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
169-691 7.58e-78

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 263.62  E-value: 7.58e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLlVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17400    1 LKMFLLALSC-AFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFTgepnpgiaivnktsdnicksalvrdqdMDLGRLSSgLSNQPLAPHTLRednclegkasttgpvllfvl 328
Cdd:cd17400   80 LGCFLKALPHFF---------------------------MNQYEYSL-MWIYVFVGNILR-------------------- 111
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  329 aqlllGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDS--LSSTTISITPGDRRWVG 406
Cdd:cd17400  112 -----GIGETPILPLGISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIgfVNLDDIIITPTDTRWVG 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  407 MWWGGFLLCGVILLVVAVPFFSFPkvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappk 486
Cdd:cd17400  187 AWWLGFLICGGVSVLTAIPFFFLP-------------------------------------------------------- 210
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  487 vdtgygkdikdipqsmlrlvknPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLG 566
Cdd:cd17400  211 ----------------------PIYMLFILVSVIQFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIG 268
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  567 GCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFqvnltAACNFGCECLTS 646
Cdd:cd17400  269 GLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGLTTSYEGIPPVLYHENDIF-----SDCNSDCNCPEK 343
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 24583057  647 EVEPVCGNNGLTYFSPCHAGC-TAFSSTSNTNYTNCACVRANISSS 691
Cdd:cd17400  344 IWEPVCGNNGITYLSACLAGCeTSIGTGKNIVFYNCSCIQTSGNSS 389
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
169-758 7.12e-49

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 180.04  E-value: 7.12e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  169 IKIFVVLLSLLVMMQQALSsGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMG 248
Cdd:cd17405    1 IDGFMILYCILVLIQGAVF-GLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  249 IGSLVFMVPHFTgepnpgIAIVNKtsdnicksalvrdqdmdlgrlssglsnqplaphtlrednCLEGKAsttgpvllfvl 328
Cdd:cd17405   80 LGSMLFAFPFFT------FHIAGQ---------------------------------------CIQGIA----------- 103
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  329 aqlllgcgGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSfhmDSLSSTTISITPGD--RRWVG 406
Cdd:cd17405  104 --------GMPIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGYLLGYVGGLPNFQ---PPPNEKSVEIEVNKvyQLWQS 172
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  407 MWWGGFLLCGVILLVVAVPFFSFPkvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappk 486
Cdd:cd17405  173 GWWKTFLIAAAIAWCTSFPLVCFP-------------------------------------------------------- 196
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  487 vdtgygkdikdipQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLG 566
Cdd:cd17405  197 -------------TSLPGLLKNPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLG 263
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  567 GCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGstleqpfqvNLTAACNFGCECLTS 646
Cdd:cd17405  264 GLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQLG---------NLTAPCNEYCDCTSS 334
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  647 EVEPVCGNNGLTYFSPCHAGCTAfSSTSNTN--YTNCACVRANISSSiyrgaggsqaqalSANENFAEvtvvpvATAGPC 724
Cdd:cd17405  335 LYTSICGRDEIEYFSPCFAGCKA-SKVSNTEktYYNCSCIKEGLAAA-------------DDEGDFID------AIAGKC 394
                        570       580       590
                 ....*....|....*....|....*....|....
gi 24583057  725 ATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLR 758
Cdd:cd17405  395 DSKCYKLPLFFAFYFSATVFSNMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
633-684 5.99e-23

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 92.75  E-value: 5.99e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24583057  633 LTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTAFS-STSNTNYTNCACV 684
Cdd:cd01330    1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTgSGGSKIYTNCSCV 53
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
164-602 7.70e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.48  E-value: 7.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  164 QRFARIKIFVVLLSLLVMMqqaLSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLG---SRRHIpvwI 240
Cdd:COG2814    5 PRRRWLALLALALGAFLSG---LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAdrfGRRRV---L 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  241 GIGAVIMGIGSLVF-MVPHFTgepnpgiaivnktsdnicksALVrdqdmdLGRLSSGLsnqplaphtlrednclegkast 319
Cdd:COG2814   79 LLGLLLFALGSLLCaLAPSLW--------------------LLL------AARFLQGL---------------------- 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  320 tgpvllfvlaqlllgcGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSfhmdslssttisitp 399
Cdd:COG2814  111 ----------------GAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD--------------- 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  400 gdrrWVGmWWGGFLLCGVILLVVAVP-FFSFPKVLAREKKKIRkssvvqpvlpnnsratvatdemgkvkkleivavtske 478
Cdd:COG2814  160 ----LFG-WRWVFLVNAVLALLALLLlLRLLPESRPAARARLR------------------------------------- 197
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  479 dqsqappkvdtgygkdikdipQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVpG 558
Cdd:COG2814  198 ---------------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL-G 255
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 24583057  559 ACIGIFLGGCILKRFqlkpkGAVQFVLITNVICLACYAMLFFLG 602
Cdd:COG2814  256 GVLGALLAGRLADRF-----GRRRLLLIGLLLLALGLLLLALAG 294
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
178-601 1.16e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 80.16  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  178 LLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVP 257
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  258 hftgePNPGIAIVnktsdnicksalvrdqdmdlGRLSSGLsnqplaphtlrednclegkasttgpvllfvlaqlllgcGG 337
Cdd:cd06174   82 -----PSFWLLLL--------------------GRFLLGL--------------------------------------GS 98
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  338 SPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSlssttisitpgdrrwvgmWWGGFLLCGV 417
Cdd:cd06174   99 GLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG------------------WRAVFLIAAA 160
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  418 ILLVVAVPFFSFPKVLAREKKKIRKSsvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappkvdtgygKDIKD 497
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEE-------------------------------------------------ASSKS 191
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  498 IPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGAcIGIFLGGCILKR-FQLK 576
Cdd:cd06174  192 VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA-LGSLLLGLLSDRlIGRK 270
                        410       420
                 ....*....|....*....|....*
gi 24583057  577 PKGAVQFVLItnVICLACYAMLFFL 601
Cdd:cd06174  271 PLLLIGLLLM--ALGLALLLLAPSL 293
MFS_1 pfam07690
Major Facilitator Superfamily;
176-602 1.32e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 64.36  E-value: 1.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    176 LSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFM 255
Cdd:pfam07690    1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    256 VPHftgePNPGIAIvnktsdnicksalvrdqdmdlGRLSSGLsnqplaphtlrednclegkasttgpvllfvlaqlllgc 335
Cdd:pfam07690   81 FAS----SLWLLLV---------------------LRVLQGL-------------------------------------- 97
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    336 GGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFhmdslssttisitpgdrrwvGMWWGGFLLC 415
Cdd:pfam07690   98 GAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--------------------FGWRAAFLIL 157
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    416 GVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPnnsratvatdemgkvkkleivavtskedqsqappkvdtgygkdi 495
Cdd:pfam07690  158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-------------------------------------------- 193
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057    496 kdipqsmLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLEtQFSLGKSQANIFTGSIAVPGACIGIFLGGcILKRFql 575
Cdd:pfam07690  194 -------WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGR-LSDRL-- 262
                          410       420
                   ....*....|....*....|....*..
gi 24583057    576 kpkGAVQFVLITNVICLACYAMLFFLG 602
Cdd:pfam07690  263 ---GRRRRLLLALLLLILAALGLLLLS 286
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
645-683 1.57e-09

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 54.20  E-value: 1.57e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 24583057  645 TSEVEPVCGNNGLTYFSPCHAGCTA-FSSTSNTNYTNCAC 683
Cdd:cd00104    2 PKEYDPVCGSDGKTYSNECHLGCAAcRSGRSITVAHNGPC 41
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
641-683 5.44e-08

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 50.18  E-value: 5.44e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 24583057    641 CECLTSEVEPVCGNNGLTYFSPCH---AGC-TAFSSTSNTNYTNCAC 683
Cdd:pfam07648    4 CQCPKTEYEPVCGSDGVTYPSPCAlcaAGCkLGKEVKEEKVKYDGSC 50
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
168-602 1.23e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 55.25  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  168 RIKIFVVLLSLLVMMqqALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIM 247
Cdd:COG0738    6 YRRALIAIYLLFFLW--GFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  248 GIGSLVFMVPhftgePNPGIAIVnktsdnickSALVrdqdmdlgrlssglsnqplaphtlrednclegkasttgpvllfv 327
Cdd:COG0738   84 ALGLLLFALA-----PSYPLLLL---------ALFL-------------------------------------------- 105
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  328 laqllLGCGGSPLFTLGTTYVDDHVRTESSSMyIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLssttisitpgdrrwvgm 407
Cdd:COG0738  106 -----LGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLS----------------- 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  408 WWGGFLLCGVILLVVAVPFFSFPkvlarekkkirkssvvqpvLPnnsratvatdemgkvkkleivAVTSKEDQSQAPPKv 487
Cdd:COG0738  163 WHLPYLILAVLLLLLALLFLRSK-------------------LP---------------------EIEEEEEEAAGSAA- 201
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  488 dtgygkdikdipqSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVpGACIGIFLGG 567
Cdd:COG0738  202 -------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG-GMTIGRFLGG 267
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 24583057  568 CILKRFqlkpkGAVQFVLITNVICLACYAMLFFLG 602
Cdd:COG0738  268 FLLKRF-----GPVRLLRLSALLAAVGLLLALLAP 297
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
174-600 2.06e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.50  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  174 VLLSLLVMMqqaLSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSR--RHIPvwIGIGAVIMGIGS 251
Cdd:cd17325    1 LSLALFLDM---LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRfgRKRL--LLLGLLLLAVST 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  252 LVFM-VPHFTgepnpgiaivnktsdnicksALVrdqdmdLGRLSSGLsnqplaphtlrednclegkasttgpvllfvlaq 330
Cdd:cd17325   76 LLFAfATSYW--------------------QLL------LARFLQGL--------------------------------- 96
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  331 lllgcGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFhmdslssttisitpGDRRWVgmwwg 410
Cdd:cd17325   97 -----ASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------------LGYRAP----- 152
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  411 gFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappkvdtg 490
Cdd:cd17325  153 -FLVCAALALLALVLALLLLPEPRPPPNKRAVSA---------------------------------------------- 185
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  491 ygkdiKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGcIL 570
Cdd:cd17325  186 -----ARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK-LS 259
                        410       420       430
                 ....*....|....*....|....*....|
gi 24583057  571 KRFqlkpkGAVQFVLITNVICLACYAMLFF 600
Cdd:cd17325  260 DRI-----GRKPLILIGLLLSAVALLLLPL 284
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
167-430 2.33e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.05  E-value: 2.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  167 ARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRR-HIPVWIgIGAV 245
Cdd:COG0477    9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYgRKRVLL-IGLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  246 IMGIGSLVFMVPhftgePNPGIAIVnktsdnicksalvrdqdmdlGRLSSGLsnqplaphtlrednclegkasttgpvll 325
Cdd:COG0477   88 LFGLASLLCGLA-----PSPELLIA--------------------ARALQGI---------------------------- 114
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  326 fvlaqlllgcGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFhmdslssttisitpgdrrwv 405
Cdd:COG0477  115 ----------GAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA-------------------- 164
                        250       260
                 ....*....|....*....|....*.
gi 24583057  406 gMWWGG-FLLCGVILLVVAVPFFSFP 430
Cdd:COG0477  165 -LGWRWiFLINAPLGLLALVLRLRLP 189
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
168-602 8.70e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.56  E-value: 8.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  168 RIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIM 247
Cdd:COG2271    6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  248 GIGSLVFMvphFTgePNPGIAIVnktsdnicksalvrdqdmdlGRLSSGLsnqplaphtlrednclegkasttgpvllfv 327
Cdd:COG2271   86 GLATLLFG---FA--TSFWQLLL--------------------LRFLLGL------------------------------ 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  328 laqlllgcGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSfhmdslssttisitpgdrrWVGm 407
Cdd:COG2271  111 --------GEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA-------------------AFG- 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  408 WWGGFLLCGVILLVVAVPFFsfpkvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqsqappkv 487
Cdd:COG2271  163 WRAAFLILGLPGLLLALLRF------------------------------------------------------------ 182
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  488 dtgygkdikdipqsmlrlvknpvyIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVpGACIGIFLGG 567
Cdd:COG2271  183 ------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFL-AGIVGSLLGG 237
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 24583057  568 CILKRFQlkpKGAVQFVLITNVICLACYAMLFFLG 602
Cdd:COG2271  238 WLSDRLG---RRRKLVLAIGLLLAALALLLLALLP 269
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
334-601 1.21e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 49.11  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  334 GCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSfhmdslssttisitpgdrrWVGmWWGGFL 413
Cdd:COG2223  104 GIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA-------------------AFG-WRNAFL 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  414 LCGVILLVVAVPFFSFpkvlarekkkirkssvvqpvlpnnsratvatdemgkvkkleivavtskedqSQAPPKvdtGYGK 493
Cdd:COG2223  164 ILGILLLVVAVLAWLF---------------------------------------------------LRDPPA---GAAA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  494 DIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGAcIGIFLGGCILKRF 573
Cdd:COG2223  190 AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA-LGRPLGGWLSDRI 268
                        250       260
                 ....*....|....*....|....*...
gi 24583057  574 qlkpkGAVQFVLITNVICLACYAMLFFL 601
Cdd:COG2223  269 -----GGRRVLLIVFALMALGLLLLALA 291
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
478-606 4.99e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 47.23  E-value: 4.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  478 EDQSQAPPKVDTGYGKDIKDipqsmlrLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLG---KSQANIFTGSI 554
Cdd:cd17328  183 AEGGVMAKSTATSFLADLKA-------LAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGdlsSADVGLIFGAI 255
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24583057  555 AVPGACIGIFLGGCILKRFQLKPKGA----VQFVLITNVICL------------ACYAMLF---FLGCDNL 606
Cdd:cd17328  256 TCIAGVLGVLLGGILADRLRRKTPRAdplvCAVGLLAAAPFLflalvlalsnllLAWVLLFlgeFLLSLNW 326
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
174-256 3.96e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.09  E-value: 3.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  174 VLLSLLVmmqQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSR-RHIPVWIgIGAVIMGIGSL 252
Cdd:cd17477    1 LLLSVAL---LGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRvGHIRAFA-AGAAITAVSVL 76

                 ....
gi 24583057  253 VFMV 256
Cdd:cd17477   77 LLAL 80
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
730-795 5.77e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 5.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24583057  730 TIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIpAPILFGNLIDST 795
Cdd:COG2271  270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL-GPLLVGYLLDAT 334
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
637-672 3.98e-03

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 36.50  E-value: 3.98e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 24583057     637 CNFGCeclTSEVEPVCGNNGLTYFSPCHAGCTAFSS 672
Cdd:smart00280    2 CPEAC---PREYDPVCGSDGVTYSNECHLCKAACES 34
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
502-601 8.59e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 8.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583057  502 MLRLVKNPVYIVTCLGACMELMIVSG-FVVFLPKYLETQFSLGKSQANIFTGSIAvpgacIGIFLGGCILKRF--QLKPK 578
Cdd:cd06173  200 GLRYLRRSPLLRLLLLALALFALLGGaLTVLLPLLAKEVLGGGAAGYGLLLAAFG-----VGALLGALLLGRLskRRRRG 274
                         90       100
                 ....*....|....*....|...
gi 24583057  579 GAVQFVLITNVICLACYAMLFFL 601
Cdd:cd06173  275 RLLLIGALLLGLALLVLGLSPSL 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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